• 27732 Citations
  • 95 Scopus h-Index
1973 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort

Bakhshi, Z., Hilscher, M. B., Gores, G. J., Harmsen, W. S., Viehman, J. K., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N., Lindor, K. D. & Eaton, J. E., May 1 2020, In : Journal of gastroenterology. 55, 5, p. 523-532 10 p.

Research output: Contribution to journalArticle

A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis

AESOP Study Investigators, Jan 1 2020, (Accepted/In press) In : Journal of hepatology.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis

Eaton, J. E., Sen, A., Hoodeshenas, S., Schleck, C. D., Harmsen, W. S., Gores, G. J., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N. & Venkatesh, S. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1576-1583.e1

Research output: Contribution to journalArticle

2 Scopus citations

Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes

Calderon, G., McRae, A., Rievaj, J., Davis, J., Zandvakili, I., Linker-Nord, S., Burton, D., Roberts, G., Reimann, F., Gedulin, B., Vella, A., LaRusso, N. F., Camilleri, M., Gribble, F. M. & Acosta, A., May 2020, In : EBioMedicine. 55, 102759.

Research output: Contribution to journalArticle

Open Access

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., LaRusso, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2020, In : Hepatology. 71, 1, p. 214-224 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets

Santos-Laso, A., Izquierdo-Sanchez, L., Rodrigues, P. M., Huang, B. Q., Azkargorta, M., Lapitz, A., Munoz-Garrido, P., Arbelaiz, A., Caballero-Camino, F. J., Fernández-Barrena, M. G., Jimenez-Agüero, R., Argemi, J., Aragon, T., Elortza, F., Marzioni, M., Drenth, J. P. H., LaRusso, N. F., Bujanda, L., Perugorria, M. J. & Banales, J. M., Jul 1 2020, In : Liver International. 40, 7, p. 1670-1685 16 p.

Research output: Contribution to journalArticle

2019

Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study

Eaton, J. E., Nelson, K. M., Gossard, A. A., Carey, E. J., Tabibian, J. H., Lindor, K. D. & LaRusso, N. F., May 4 2019, In : Scandinavian Journal of Gastroenterology. 54, 5, p. 633-639 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Guicciardi, M. E., Splinter, N. P., Al Suraih, M. S., Nasser-Ghodsi, N., Stollenwerk, D., Gores, G. J. & LaRusso, N. F., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18698-18713 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Masyuk, A. I., Masyuk, T. V., Lorenzo Pisarello, M. J., Ding, J. F., Loarca, L., Huang, B. Q. & La Russo, N. F., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

13 Scopus citations

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Ding, J. F., Lee, P. Y. & LaRusso, N. F., Apr 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., La Russo, N. F. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J., Rosen, C., Nandakumar, M., Lazaridis, K. N., Larusso, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International Journal of Molecular Sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

5 Scopus citations

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., LaRusso, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

MicroRNA-506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Erice, O., Munoz-Garrido, P., Vaquero, J., Perugorria, M. J., Fernandez-Barrena, M. G., Saez, E., Santos-Laso, A., Arbelaiz, A., Jimenez-Agüero, R., Fernandez-Irigoyen, J., Santamaria, E., Torrano, V., Carracedo, A., Ananthanarayanan, M., Marzioni, M., Prieto, J., Beuers, U., Oude Elferink, R. P., LaRusso, N. F., Bujanda, L. & 2 others, Marin, J. J. G. & Banales, J. M., Apr 2018, In : Hepatology. 67, 4, p. 1420-1440 21 p.

Research output: Contribution to journalArticle

22 Scopus citations

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history

on behalf of the GLOBAL PBC Study Group, May 1 2018, In : Hepatology. 67, 5, p. 1920-1930 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 1 2018, In : Hepatology. 67, 6, p. 2462-2464 3 p.

Research output: Contribution to journalArticle

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

35 Scopus citations
2017

Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link?

O'Hara, S. P., Karlsen, T. H. & La Russo, N. F., Nov 1 2017, In : Gut. 66, 11, p. 1873-1877 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

Loarca, L., De Assuncao, T. M., Jalan-Sakrikar, N., Bronk, S., Krishnan, A., Huang, B., Morton, L., Trussoni, C., Bonilla, L. M., Krueger, E., O'Hara, S., Splinter, P., Shi, G., Pisarello, M. J. L., Gores, G. J., Huebert, R. C. & La Russo, N. F., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis

Cheung, A. C., Juran, B. D., Moore, R. M., La Russo, N. F. & Lazaridis, K. N., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

6 Scopus citations

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Cheung, A. C., La Russo, N. F., Gores, G. J. & Lazaridis, K. N., May 1 2017, In : Seminars in Liver Disease. 37, 2, p. 159-174 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

ETS proto-oncogene 1 transcriptionally up-regulates the cholangiocyte senescence-associated protein cyclin-dependent kinase inhibitor 2A

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Lorenzo Pisarello, M. J., Loarca, L., Splinter, N. S., Schutte, B. F. & La Russo, N. F., Mar 24 2017, In : Journal of Biological Chemistry. 292, 12, p. 4833-4846 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pathobiology of biliary epithelia

Cheung, A. C., Lorenzo Pisarello, M. J. & La Russo, N. F., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

11 Scopus citations

Role of the Intestinal Microbiome in Cholestatic Liver Disease

La Russo, N. F., Tabibian, J. H. & O'Hara, S. P., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 166-168 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Masyuk, T. V., Masyuk, A. I., Lorenzo Pisarello, M., Howard, B. N., Huang, B. Q., Lee, P. Y., Fung, X., Sergienko, E., Ardecky, R. J., Chung, T. D. Y., Pinkerton, A. B. & La Russo, N. F., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

10 Scopus citations
2016

An Octogenarian with Acute Epigastric Pain: More Than Meets the Eye

Lynn, A., Tabibian, J. H. & La Russo, N. F., Feb 1 2016, In : Gastroenterology. 150, 2, p. e5-e6

Research output: Contribution to journalArticle

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

4 Scopus citations

Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease

Kittanamongkolchai, W., El-Zoghby, Z. M., Eileen Hay, J., Wiesner, R. H., Kamath, P. S., La Russo, N. F., Watt, K. D., Cramer, C. H. & Leung, N., Dec 8 2016, (Accepted/In press) In : Hepatology International. p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hail to the chief-Keith Lindor, our new AASLD president

Shah, V., Gores, G. J. & La Russo, N. F., Feb 1 2016, In : Hepatology. 63, 2, p. 357-359 3 p.

Research output: Contribution to journalArticle

Performance of magnetic resonance elastography in primary sclerosing cholangitis

Eaton, J. E., Dzyubak, B., Venkatesh, S. K., Smyrk, T. C., Gores, G. J., Ehman, R. L., La Russo, N. F., Gossard, A. A. & Lazaridis, K. N., Jun 1 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 6, p. 1184-1190 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

The enteric microbiome in hepatobiliary health and disease

Tabibian, J. H., Varghese, C., Larusso, N. F. & O'Hara, S. P., Apr 1 2016, In : Liver International. 36, 4, p. 480-487 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis in mice

Tabibian, J. H., O'Hara, S. P., Trussoni, C. E., Tietz, P. S., Splinter, P. L., Mounajjed, T., Hagey, L. R. & La Russo, N. F., 2015, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

98 Scopus citations

Efficacy of 4 Years of Octreotide Long-Acting Release Therapy in Patients with Severe Polycystic Liver Disease

Hogan, M. C., Masyuk, T., Bergstralh, E., Li, B., Kremers, W. K., Vaughan, L. E., Ihrke, A., Severson, A. L., Irazabal Mira, M., Glockner, J., La Russo, N. F. & Torres, V., Aug 1 2015, In : Mayo Clinic Proceedings. 90, 8, p. 1030-1037 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Fusion innovation

La Russo, N. F., Spurrier, B. & Farrugia, G., Jan 1 2015, In : T and D. 69, 1

Research output: Contribution to journalArticle

Microbiome-immune interactions and liver disease

Tabibian, J. H., Varghese, C., O'Hara, S. P. & La Russo, N. F., Apr 1 2015, In : Clinical Liver Disease. 5, 4, p. 83-85 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

MicroRNAs and benign biliary tract diseases

Gradilone, S. A., O'Hara, S. P., Masyuk, T. V., Pisarello, M. J. L. & Larusso, N. F., Feb 1 2015, In : Seminars in liver disease. 35, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

TGR5 in the cholangiociliopathies

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 420-425 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

The achilles’ heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B. & 13 others, McGowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., Jan 1 2015, In : Aging Cell. 14, 4, p. 644-658 15 p.

Research output: Contribution to journalArticle

502 Scopus citations

The cholangiopathies

Lazaridis, K. N. & La Russo, N. F., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 791-800 10 p.

Research output: Contribution to journalArticle

96 Scopus citations

Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

Munoz-Garrido, P., Marin, J. J. G., Perugorria, M. J., Urribarri, A. D., Erice, O., Sáez, E., Úriz, M., Sarvide, S., Portu, A., Concepcion, A. R., Romero, M. R., Monte, M. J., Santos-Laso, Á., Hijona, E., Jimenez-Agüero, R., Marzioni, M., Beuers, U., Masyuk, T. V., Larusso, N. F., Prieto, J. & 3 others, Bujanda, L., Drenth, J. P. H. & Banales, J. M., Oct 1 2015, In : Journal of hepatology. 63, 4, p. 952-961 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014

Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: Are they independent or coordinated molecular events?

Masyuk, A. I., Gradilone, S. A. & La Russo, N. F., Nov 1 2014, In : Hepatology. 60, 5, p. 1783-1785 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression

Masyuk, T. V., Lee, S. O., Radtke, B. N., Stroope, A. J., Huang, B., Banales, J. M., Masyuk, A. I., Splinter, P. L., Gradilone, S. A., Gajdos, G. B. & Larusso, N. F., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis

Tabibian, J. H., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Heimbach, J. K. & LaRusso, N. F., Jan 1 2014, In : Laboratory Investigation. 94, 10, p. 1126-1133 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Cholangiocyte senescence by way of N-Ras activation is a characteristic of primary sclerosing cholangitis

Tabibian, J. H., O'Hara, S. P., Splinter, P. L., Trussoni, C. E. & Larusso, N. F., Jun 2014, In : Hepatology. 59, 6, p. 2263-2275 13 p.

Research output: Contribution to journalArticle

96 Scopus citations

HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis

Gradilone, S. A., Habringer, S., Masyuk, T. V., Howard, B. N., Masyuk, A. I. & Larusso, N. F., Mar 1 2014, In : American Journal of Pathology. 184, 3, p. 600-608 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases

Urribarri, A. D., Munoz-Garrido, P., Perugorria, M. J., Erice, O., Merino-Azpitarte, M., Arbelaiz, A., Lozano, E., Hijona, E., Jiménez-Agüero, R., Fernandez-Barrena, M. G., Jimeno, J. P., Marzioni, M., Marin, J. J. G., Masyuk, T. V., LaRusso, N. F., Prieto, J., Bujanda, L. & Banales, J. M., Oct 1 2014, In : Gut. 63, 10, p. 1658-1667 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Polycystic liver diseases: Advanced insights into the molecular mechanisms

Perugorria, M. J., Masyuk, T. V., Marin, J. J., Marzioni, M., Bujanda, L., La Russo, N. F. & Banales, J. M., Dec 11 2014, In : Nature Reviews Gastroenterology and Hepatology. 11, 12, p. 750-761 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Temporal elements in career selection decisions: An archival study investigating career decisions in medicine

Shah, P. P., Bechara, J. P., Kolars, J., Drefahl, M., LaRusso, N., Wood, D. & Spurrier, B., Jan 1 2014, In : Organization Science. 25, 1, p. 245-261 17 p.

Research output: Contribution to journalArticle