• 25442 Citations
  • 90 h-Index
1973 …2019
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Research Output 1973 2018

2018

A 59-Year-Old Man With New Jaundice

Mouchli, M. A., Kurtin, P. J. & La Russo, N. F., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2035-2036 2 p.

Research output: Contribution to journalComment/debate

Jaundice
2 Citations

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Masyuk, A. I., Masyuk, T. V., Lorenzo Pisarello, M. J., Ding, J. F., Loarca, L., Huang, B. Q. & La Russo, N. F., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Autophagy
Liver
Hydroxychloroquine
Polycystic Kidney Diseases
Therapeutics

Cholangiocytes in health and disease: From basic science to novel treatments

Banales, J. M., Marzioni, M., La Russo, N. F. & Jansen, P., Jan 1 2018, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

Health
1 Citations

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Ding, J. F., Lee, P. Y. & La Russo, N. F., Apr 1 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

Somatostatin Receptors
Histone Deacetylase Inhibitors
Polycystic Kidney Diseases
Histone Deacetylases
Animal Models

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., La Russo, N. F. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Macrophages
Liver
Monocytes
Wounds and Injuries

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J. K., Rosen, C. B., Nandakumar, M., Lazaridis, K. N., La Russo, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International Journal of Molecular Sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Metabolomics
metabolites
Bile
serums

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., La Russo, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 1 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cholangiocarcinoma
MicroRNAs
Karyopherins
Cilia
7 Citations

MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation

Erice, O., Munoz-Garrido, P., Vaquero, J., Perugorria, M. J., Fernandez-Barrena, M. G., Saez, E., Santos-Laso, A., Arbelaiz, A., Jimenez-Agüero, R., Fernandez-Irigoyen, J., Santamaria, E., Torrano, V., Carracedo, A., Ananthanarayanan, M., Marzioni, M., Prieto, J., Beuers, U., Oude Elferink, R. P., La Russo, N. F., Bujanda, L. & 2 othersMarin, J. J. G. & Banales, J. M., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Cholangitis
MicroRNAs
Dihydrolipoyllysine-Residue Acetyltransferase
Chloride-Bicarbonate Antiporters
Cytokines
2 Citations

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history

on behalf of the GLOBAL PBC Study Group, May 1 2018, In : Hepatology. 67, 5, p. 1920-1930 11 p.

Research output: Contribution to journalArticle

Cholangitis
Natural History
Ursodeoxycholic Acid
Paris
Gastroenterology

Physiology of Cholngiocytes

Masyuk, A. I., Masyuk, T. V. & La Russo, N. F., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1003-1023 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bile
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Ion Transport
Epithelial Cells

Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 1 2018, In : Hepatology. 67, 6, p. 2462-2464 3 p.

Research output: Contribution to journalArticle

Kidney
Liver
Genes
Polycystic liver disease
3 Citations

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 othersHarris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., La Russo, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 1 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

Free Radicals
Reactive Oxygen Species
Genes
Aging of materials
DNA
12 Citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

MDR Genes
Gene Knockout Techniques
B-Cell Lymphoma
Knockout Mice
Fibrosis
2017
2 Citations

Cellular senescence, neuropeptides and hepatic fibrosis: Additional insights into increasing complexity

O'Hara, S. P. & La Russo, N. F., Aug 1 2017, In : Hepatology. 66, 2, p. 318-320 3 p.

Research output: Contribution to journalEditorial

Cell Aging
Neuropeptides
Fibrosis
Liver
3 Citations

Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link?

O'Hara, S. P., Karlsen, T. H. & La Russo, N. F., Nov 1 2017, In : Gut. 66, 11, p. 1873-1877 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangiocarcinoma
Environmental Health
Epithelial Cells
2 Citations

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

Loarca, L., De Assuncao, T. M., Jalan-Sakrikar, N., Bronk, S., Krishnan, A., Huang, B., Morton, L., Trussoni, C., Bonilla, L. M., Krueger, E., O'Hara, S., Splinter, P., Shi, G., Pisarello, M. J. L., Gores, G. J., Huebert, R. C. & La Russo, N. F., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Macrophages
Bile Duct Diseases
Keratin-7
Keratin-19
1 Citations

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis

Cheung, A. C., Juran, B. D., Moore, R. M., La Russo, N. F. & Lazaridis, K. N., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Protein Domains
2 Citations

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Immunomodulation
Microbiota
Pharmaceutical Preparations
Liver Transplantation
4 Citations

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Cheung, A. C., La Russo, N. F., Gores, G. J. & Lazaridis, K. N., May 1 2017, In : Seminars in Liver Disease. 37, 2, p. 159-174 16 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangitis
Epigenomics
Genes
Genome-Wide Association Study
6 Citations

ETS proto-oncogene 1 transcriptionally up-regulates the cholangiocyte senescence-associated protein cyclin-dependent kinase inhibitor 2A

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Lorenzo Pisarello, M. J., Loarca, L., Splinter, N. S., Schutte, B. F. & La Russo, N. F., Mar 24 2017, In : Journal of Biological Chemistry. 292, 12, p. 4833-4846 14 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p16
Sclerosing Cholangitis
Proto-Oncogenes
Up-Regulation
Luciferases
5 Citations

Pathobiology of biliary epithelia

Cheung, A. C., Lorenzo Pisarello, M. J. & La Russo, N. F., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

Biliary Tract
Cell Cycle Checkpoints
Bile Acids and Salts
Neurotransmitter Agents
Disease Progression
1 Citations

Primary cilia in tumor biology: The primary cilium as a therapeutic target in cholangiocarcinoma

Gradilone, S. A., Lorenzo Pisarello, M. J. & La Russo, N. F., 2017, In : Current Drug Targets. 18, 8, p. 958-963 6 p.

Research output: Contribution to journalReview article

Cholangiocarcinoma
Cilia
Tumors
Neoplasms
Cell membranes
1 Citations

Role of the Intestinal Microbiome in Cholestatic Liver Disease

La Russo, N. F., Tabibian, J. H. & O'Hara, S. P., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 166-168 3 p.

Research output: Contribution to journalArticle

Microbiota
Liver Diseases
Health
Epigenomics
Liver
8 Citations

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Masyuk, T. V., Masyuk, A. I., Lorenzo Pisarello, M., Howard, B. N., Huang, B. Q., Lee, P. Y., Fung, X., Sergienko, E., Ardecky, R. J., Chung, T. D. Y., Pinkerton, A. B. & La Russo, N. F., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Cyclic AMP
Rodentia
Liver
Oleanolic Acid
6 Citations

Therapeutic targets in polycystic liver disease

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., 2017, In : Current Drug Targets. 18, 8, p. 950-957 8 p.

Research output: Contribution to journalReview article

Liver
Autosomal Dominant Polycystic Kidney
Cysts
Cilia
Therapeutics
2016

An Octogenarian with Acute Epigastric Pain: More Than Meets the Eye

Lynn, A., Tabibian, J. H. & La Russo, N. F., Feb 1 2016, In : Gastroenterology. 150, 2, p. e5-e6

Research output: Contribution to journalArticle

Choledocholithiasis
Incidental Findings
X Ray Computed Tomography
Acute Pain
Abdominal Pain

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Brain Natriuretic Peptide
Vasopressins
Disease Progression
Kidney
2 Citations

Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease

Kittanamongkolchai, W., El-Zoghby, Z. M., Eileen Hay, J., Wiesner, R. H., Kamath, P. S., La Russo, N. F., Watt, K. D., Cramer, C. H. & Leung, N., Dec 8 2016, (Accepted/In press) In : Hepatology International. p. 1-6 6 p.

Research output: Contribution to journalArticle

Hemoperfusion
Charcoal
Pruritus
Liver Diseases
Therapeutics

Cholangiocyte biology

Loarca, L., Pisarello, M. J. L., Morton, L., Huang, B. Q., O’Hara, S., Splinter, P. & La Russo, N. F., Jan 1 2016, Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments. Springer International Publishing, p. 83-97 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biliary Tract
Autophagy
Wounds and Injuries
Bile
Electrolytes
27 Citations

Extracellular vesicles in liver pathobiology: Small particles with big impact

Hirsova, P., Ibrahim, S. H., Verma, V. K., Morton, L. A., Shah, V., La Russo, N. F., Gores, G. J. & Malhi, H. M., Dec 1 2016, In : Hepatology. 64, 6, p. 2219-2233 15 p.

Research output: Contribution to journalReview article

Liver
Liver Diseases
Cell Communication
Extracellular Vesicles
Alcoholic Liver Diseases

Hail to the chief-Keith Lindor, our new AASLD president

Shah, V., Gores, G. J. & La Russo, N. F., Feb 1 2016, In : Hepatology. 63, 2, p. 357-359 3 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Medical Societies
Gastroenterology
19 Citations

Performance of magnetic resonance elastography in primary sclerosing cholangitis

Eaton, J. E., Dzyubak, B., Venkatesh, S. K., Smyrk, T. C., Gores, G. J., Ehman, R. L., La Russo, N. F., Gossard, A. A. & Lazaridis, K. N., Jun 1 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 6, p. 1184-1190 7 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Sclerosing Cholangitis
Liver
Fibrosis
Alkaline Phosphatase
6 Citations

Polycystic Liver Disease: The Benefits of Targeting cAMP

La Russo, N. F., Masyuk, T. V. & Hogan, M. C., Jul 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 7, p. 1031-1034 4 p.

Research output: Contribution to journalEditorial

Polycystic liver disease
41 Citations

Primary sclerosing cholangitis

Lazaridis, K. N. & La Russo, N. F., Sep 22 2016, In : New England Journal of Medicine. 375, 12, p. 1161-1170 10 p.

Research output: Contribution to journalReview article

Ursodeoxycholic Acid
Sclerosing Cholangitis
End Stage Liver Disease
Liver Transplantation
10 Citations

The authors reply

Lazaridis, K. N. & La Russo, N. F., Dec 22 2016, In : New England Journal of Medicine. 375, 25, p. 2501-2502 2 p.

Research output: Contribution to journalLetter

Sclerosing Cholangitis
2015
62 Citations

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis in mice

Tabibian, J. H., O'Hara, S. P., Trussoni, C. E., Tietz, P. S., Splinter, P. L., Mounajjed, T., Hagey, L. R. & La Russo, N. F., 2015, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Ursodeoxycholic Acid
Microbiota
Biochemistry
Liver
9 Citations

Efficacy of 4 Years of Octreotide Long-Acting Release Therapy in Patients with Severe Polycystic Liver Disease

Hogan, M. C., Masyuk, T., Bergstralh, E., Li, B., Kremers, W. K., Vaughan, L. E., Ihrke, A., Severson, A. L., Irazabal Mira, M., Glockner, J., La Russo, N. F. & Torres, V., Aug 1 2015, In : Mayo Clinic Proceedings. 90, 8, p. 1030-1037 8 p.

Research output: Contribution to journalArticle

Octreotide
Autosomal Dominant Polycystic Kidney
Quality of Life
Glomerular Filtration Rate
Therapeutics

Fusion innovation

La Russo, N. F., Spurrier, B. & Farrugia, G., Jan 1 2015, In : T and D. 69, 1

Research output: Contribution to journalArticle

Fusion
Innovation
1 Citations

Microbiome-immune interactions and liver disease

Tabibian, J. H., Varghese, C., O'Hara, S. P. & La Russo, N. F., Apr 1 2015, In : Clinical Liver Disease. 5, 4, p. 83-85 3 p.

Research output: Contribution to journalArticle

Microbiota
Immune System Diseases
Liver Diseases
7 Citations

MicroRNAs and benign biliary tract diseases

Gradilone, S. A., O'Hara, S. P., Masyuk, T. V., Pisarello, M. J. L. & La Russo, N. F., Feb 1 2015, In : Seminars in Liver Disease. 35, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

Biliary Tract Diseases
MicroRNAs
Biliary Tract
Small Untranslated RNA
Bile
13 Citations

TGR5 in the cholangiociliopathies

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 420-425 6 p.

Research output: Contribution to journalArticle

Cilia
Cysts
Sclerosing Cholangitis
Cholangiocarcinoma
Liver
256 Citations

The Achilles' heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., La Russo, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J., Khosla, S., Stout, M. B. & 13 othersMcgowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., 2015, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Transcriptome
Pharmaceutical Preparations
Quercetin
Transgenic Suicide Genes
Ephrins
68 Citations

The cholangiopathies

Lazaridis, K. N. & La Russo, N. F., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 791-800 10 p.

Research output: Contribution to journalArticle

Liver
Transplants
Biliary Atresia
Sclerosing Cholangitis
End Stage Liver Disease
12 Citations

The enteric microbiome in hepatobiliary health and disease

Tabibian, J. H., Varghese, C., La Russo, N. F. & O'Hara, S. P., 2015, (Accepted/In press) In : Liver International.

Research output: Contribution to journalArticle

Microbiota
Health
Disease Progression
Liver
Gastrointestinal Microbiome
18 Citations

Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

Munoz-Garrido, P., Marin, J. J. G., Perugorria, M. J., Urribarri, A. D., Erice, O., Sáez, E., Úriz, M., Sarvide, S., Portu, A., Concepcion, A. R., Romero, M. R., Monte, M. J., Santos-Laso, Á., Hijona, E., Jimenez-Agüero, R., Marzioni, M., Beuers, U., Masyuk, T. V., La Russo, N. F., Prieto, J. & 3 othersBujanda, L., Drenth, J. P. H. & Banales, J. M., Oct 1 2015, In : Journal of Hepatology. 63, 4, p. 952-961 10 p.

Research output: Contribution to journalArticle

Ursodeoxycholic Acid
Bile Acids and Salts
Theoretical Models
Liver
Bile
2014
2 Citations

Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: Are they independent or coordinated molecular events?

Masyuk, A. I., Gradilone, S. A. & La Russo, N. F., Nov 1 2014, In : Hepatology. 60, 5, p. 1783-1785 3 p.

Research output: Contribution to journalArticle

Calcium Signaling
Cilia
12 Citations

Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression

Masyuk, T. V., Lee, S. O., Radtke, B. N., Stroope, A. J., Huang, B., Banales, J. M., Masyuk, A. I., Splinter, P. L., Gradilone, S. A., Gajdos, G. B. & La Russo, N. F., Jan 2014, In : American Journal of Pathology. 184, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

Centrosome
Cilia
Rodentia
Cell Cycle
Cysts
24 Citations

Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis

Tabibian, J. H., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Heimbach, J. K. & La Russo, N. F., Jan 1 2014, In : Laboratory Investigation. 94, 10, p. 1126-1133 8 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Liver
Electric Impedance
Cell Adhesion
Epithelial Cells
69 Citations

Cholangiocyte senescence by way of N-Ras activation is a characteristic of primary sclerosing cholangitis

Tabibian, J. H., O'Hara, S. P., Splinter, P. L., Trussoni, C. E. & La Russo, N. F., 2014, In : Hepatology. 59, 6, p. 2263-2275 13 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Phenotype
Cholestanes
Secretory Component
Biliary Liver Cirrhosis
17 Citations

HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis

Gradilone, S. A., Habringer, S., Masyuk, T. V., Howard, B. N., Masyuk, A. I. & La Russo, N. F., Mar 2014, In : American Journal of Pathology. 184, 3, p. 600-608 9 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cysts
Cell Cycle
Liver
Pharmacology