• 27765 Citations
  • 95 Scopus h-Index
1973 …2020

Research output per year

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Research Output

2020

An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort

Bakhshi, Z., Hilscher, M. B., Gores, G. J., Harmsen, W. S., Viehman, J. K., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N., Lindor, K. D. & Eaton, J. E., May 1 2020, In : Journal of gastroenterology. 55, 5, p. 523-532 10 p.

Research output: Contribution to journalArticle

A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis

AESOP Study Investigators, 2020, (Accepted/In press) In : Journal of hepatology.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis

Eaton, J. E., Sen, A., Hoodeshenas, S., Schleck, C. D., Harmsen, W. S., Gores, G. J., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N. & Venkatesh, S. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1576-1583.e1

Research output: Contribution to journalArticle

2 Scopus citations

Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes

Calderon, G., McRae, A., Rievaj, J., Davis, J., Zandvakili, I., Linker-Nord, S., Burton, D., Roberts, G., Reimann, F., Gedulin, B., Vella, A., LaRusso, N. F., Camilleri, M., Gribble, F. M. & Acosta, A., May 2020, In : EBioMedicine. 55, 102759.

Research output: Contribution to journalArticle

Open Access

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., LaRusso, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2020, In : Hepatology. 71, 1, p. 214-224 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets

Santos-Laso, A., Izquierdo-Sanchez, L., Rodrigues, P. M., Huang, B. Q., Azkargorta, M., Lapitz, A., Munoz-Garrido, P., Arbelaiz, A., Caballero-Camino, F. J., Fernández-Barrena, M. G., Jimenez-Agüero, R., Argemi, J., Aragon, T., Elortza, F., Marzioni, M., Drenth, J. P. H., LaRusso, N. F., Bujanda, L., Perugorria, M. J. & Banales, J. M., Jul 1 2020, In : Liver International. 40, 7, p. 1670-1685 16 p.

Research output: Contribution to journalArticle

The Spectrum of Reactive Cholangiocytes in Primary Sclerosing Cholangitis

Guicciardi, M. E., Trussoni, C. E., LaRusso, N. F. & Gores, G. J., Feb 1 2020, In : Hepatology. 71, 2, p. 741-748 8 p.

Research output: Contribution to journalReview article

2019

Cholangiocyte pathobiology

Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., LaRusso, N. F. & Gores, G. J., May 1 2019, In : Nature Reviews Gastroenterology and Hepatology. 16, 5, p. 269-281 13 p.

Research output: Contribution to journalReview article

22 Scopus citations

Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study

Eaton, J. E., Nelson, K. M., Gossard, A. A., Carey, E. J., Tabibian, J. H., Lindor, K. D. & LaRusso, N. F., May 4 2019, In : Scandinavian Journal of Gastroenterology. 54, 5, p. 633-639 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pancreatobiliary Ductal Dilatation: Unique Pathobiological Processes and Endoscopic Revelations

Abramyan, O., La Russo, N. F. & Tabibian, J. H., Mar 1 2019, In : Gastroenterology. 156, 4, p. 876-878 3 p.

Research output: Contribution to journalComment/debate

The Gut-Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link?

O’Hara, S. P. & LaRusso, N. F., Sep 1 2019, In : Hepatology. 70, 3, p. 1058-1060 3 p.

Research output: Contribution to journalComment/debate

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Guicciardi, M. E., Splinter, N. P., Al Suraih, M. S., Nasser-Ghodsi, N., Stollenwerk, D., Gores, G. J. & LaRusso, N. F., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18698-18713 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A 59-Year-Old Man With New Jaundice

Mouchli, M. A., Kurtin, P. J. & La Russo, N. F., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2035-2036 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Masyuk, A. I., Masyuk, T. V., Lorenzo Pisarello, M. J., Ding, J. F., Loarca, L., Huang, B. Q. & La Russo, N. F., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

14 Scopus citations

Cholangiocytes in health and disease: From basic science to novel treatments

Banales, J. M., Marzioni, M., LaRusso, N. F. & Jansen, P., Apr 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 4, p. 1217-1219 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Ding, J. F., Lee, P. Y. & LaRusso, N. F., Apr 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Hemobilia: Etiology, diagnosis, and treatment

Berry, R., Han, J., Kardashian, A. A., LaRusso, N. F. & Tabibian, J. H., Dec 2018, In : Liver Research. 2, 4, p. 200-208 9 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., La Russo, N. F. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J. K., Rosen, C. B., Nandakumar, M., Lazaridis, K. N., Larusso, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International journal of molecular sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

5 Scopus citations

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., LaRusso, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

MicroRNA-506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Erice, O., Munoz-Garrido, P., Vaquero, J., Perugorria, M. J., Fernandez-Barrena, M. G., Saez, E., Santos-Laso, A., Arbelaiz, A., Jimenez-Agüero, R., Fernandez-Irigoyen, J., Santamaria, E., Torrano, V., Carracedo, A., Ananthanarayanan, M., Marzioni, M., Prieto, J., Beuers, U., Oude Elferink, R. P., LaRusso, N. F., Bujanda, L. & 2 others, Marin, J. J. G. & Banales, J. M., Apr 2018, In : Hepatology. 67, 4, p. 1420-1440 21 p.

Research output: Contribution to journalArticle

22 Scopus citations

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history

on behalf of the GLOBAL PBC Study Group, May 1 2018, In : Hepatology. 67, 5, p. 1920-1930 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Physiology of Cholngiocytes

Masyuk, A. I., Masyuk, T. V. & La Russo, N. F., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1003-1023 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 1 2018, In : Hepatology. 67, 6, p. 2462-2464 3 p.

Research output: Contribution to journalArticle

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

35 Scopus citations
2017

Cellular senescence, neuropeptides and hepatic fibrosis: Additional insights into increasing complexity

O'Hara, S. P. & La Russo, N. F., Aug 1 2017, In : Hepatology. 66, 2, p. 318-320 3 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Chapter 41 - Primary sclerosing cholangitis

Tabibian, J. H., Lazaridis, K. N. & LaRusso, N. F., Jan 1 2017, Blumgart's Surgery of the Liver, Biliary Tract and Pancreas: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 663-674.e5

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link?

O'Hara, S. P., Karlsen, T. H. & La Russo, N. F., Nov 1 2017, In : Gut. 66, 11, p. 1873-1877 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

Loarca, L., De Assuncao, T. M., Jalan-Sakrikar, N., Bronk, S., Krishnan, A., Huang, B., Morton, L., Trussoni, C., Bonilla, L. M., Krueger, E., O'Hara, S., Splinter, P., Shi, G., Pisarello, M. J. L., Gores, G. J., Huebert, R. C. & La Russo, N. F., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis

Cheung, A. C., Juran, B. D., Moore, R. M., La Russo, N. F. & Lazaridis, K. N., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

6 Scopus citations

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Cheung, A. C., La Russo, N. F., Gores, G. J. & Lazaridis, K. N., May 1 2017, In : Seminars in Liver Disease. 37, 2, p. 159-174 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

ETS proto-oncogene 1 transcriptionally up-regulates the cholangiocyte senescence-associated protein cyclin-dependent kinase inhibitor 2A

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Lorenzo Pisarello, M. J., Loarca, L., Splinter, N. S., Schutte, B. F. & La Russo, N. F., Mar 24 2017, In : Journal of Biological Chemistry. 292, 12, p. 4833-4846 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pathobiology of biliary epithelia

Cheung, A. C., Lorenzo Pisarello, M. J. & La Russo, N. F., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

11 Scopus citations

Primary cilia in tumor biology: The primary cilium as a therapeutic target in cholangiocarcinoma

Gradilone, S. A., Lorenzo Pisarello, M. J. & LaRusso, N. F., Jan 1 2017, In : Current drug targets. 18, 8, p. 958-963 6 p.

Research output: Contribution to journalReview article

9 Scopus citations

Role of the Intestinal Microbiome in Cholestatic Liver Disease

La Russo, N. F., Tabibian, J. H. & O'Hara, S. P., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 166-168 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Masyuk, T. V., Masyuk, A. I., Lorenzo Pisarello, M., Howard, B. N., Huang, B. Q., Lee, P. Y., Fung, X., Sergienko, E., Ardecky, R. J., Chung, T. D. Y., Pinkerton, A. B. & La Russo, N. F., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

10 Scopus citations

Therapeutic targets in polycystic liver disease

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., 2017, In : Current Drug Targets. 18, 8, p. 950-957 8 p.

Research output: Contribution to journalReview article

11 Scopus citations
2016

An Octogenarian with Acute Epigastric Pain: More Than Meets the Eye

Lynn, A., Tabibian, J. H. & La Russo, N. F., Feb 1 2016, In : Gastroenterology. 150, 2, p. e5-e6

Research output: Contribution to journalArticle

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

4 Scopus citations

Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease

Kittanamongkolchai, W., El-Zoghby, Z. M., Eileen Hay, J., Wiesner, R. H., Kamath, P. S., La Russo, N. F., Watt, K. D., Cramer, C. H. & Leung, N., Dec 8 2016, (Accepted/In press) In : Hepatology International. p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cholangiocyte biology

Loarca, L., Pisarello, M. J. L., Morton, L., Huang, B. Q., O’Hara, S., Splinter, P. & La Russo, N. F., Jan 1 2016, Primary Sclerosing Cholangitis: Current Understanding, Management, and Future Developments. Springer International Publishing, p. 83-97 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Extracellular vesicles in liver pathobiology: Small particles with big impact

Hirsova, P., Ibrahim, S. C., Verma, V. K., Morton, L. A., Shah, V., La Russo, N. F., Gores, G. J. & Malhi, H. M., Dec 1 2016, In : Hepatology. 64, 6, p. 2219-2233 15 p.

Research output: Contribution to journalReview article

61 Scopus citations

Hail to the chief-Keith Lindor, our new AASLD president

Shah, V., Gores, G. J. & La Russo, N. F., Feb 1 2016, In : Hepatology. 63, 2, p. 357-359 3 p.

Research output: Contribution to journalArticle

Performance of magnetic resonance elastography in primary sclerosing cholangitis

Eaton, J. E., Dzyubak, B., Venkatesh, S. K., Smyrk, T. C., Gores, G. J., Ehman, R. L., La Russo, N. F., Gossard, A. A. & Lazaridis, K. N., Jun 1 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 6, p. 1184-1190 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Polycystic Liver Disease: The Benefits of Targeting cAMP

La Russo, N. F., Masyuk, T. V. & Hogan, M. C., Jul 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 7, p. 1031-1034 4 p.

Research output: Contribution to journalEditorial

7 Scopus citations

Primary sclerosing cholangitis

Lazaridis, K. N. & La Russo, N. F., Sep 22 2016, In : New England Journal of Medicine. 375, 12, p. 1161-1170 10 p.

Research output: Contribution to journalReview article

110 Scopus citations

The authors reply

Lazaridis, K. N. & La Russo, N. F., Dec 22 2016, In : New England Journal of Medicine. 375, 25, p. 2501-2502 2 p.

Research output: Contribution to journalLetter

22 Scopus citations

The enteric microbiome in hepatobiliary health and disease

Tabibian, J. H., Varghese, C., Larusso, N. F. & O'Hara, S. P., Apr 1 2016, In : Liver International. 36, 4, p. 480-487 8 p.

Research output: Contribution to journalArticle

18 Scopus citations