• 27765 Citations
  • 95 Scopus h-Index
1973 …2020

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{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., LaRusso, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 1 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Abnormalities in tests of copper metabolism in primary sclerosing cholangitis

Gross, J. B., Ludwig, J., Wiesner, R. H., McCall, J. T. & LaRusso, N. F., Aug 1985, In : Gastroenterology. 89, 2, p. 272-278 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Abnormalities of Chemical Tests for Copper Metabolism in Chronic Active Liver Disease: Differentiation from Wilson's Disease

LaRusso, N. F., Summerskill, W. H. J. & McCall, J. T., Jan 1 1976, In : Gastroenterology. 70, 5, p. 653-655 3 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Absence of strand breaks in deoxyribonucleic acid treated with metronidazole

LaRusso, N. F., Tomasz, M., Kaplan, D. & Mueller, M., Jan 1 1978, In : Antimicrobial Agents and Chemotherapy. 13, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis in mice

Tabibian, J. H., O'Hara, S. P., Trussoni, C. E., Tietz, P. S., Splinter, P. L., Mounajjed, T., Hagey, L. R. & La Russo, N. F., 2015, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

98 Scopus citations

A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection

Chen, X. M., Splinter, P. L., O'Hara, S. P. & LaRusso, N. F., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28929-28938 10 p.

Research output: Contribution to journalArticle

337 Scopus citations

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

Gradilone, S. A., Masyuk, T. V., Huang, B. Q., Banales, J. M., Lehmann, G. L., Radtke, B. N., Stroope, A., Masyuk, A. I., Splinter, P. L. & LaRusso, N. F., Jul 2010, In : Gastroenterology. 139, 1, p. 304-314.e2

Research output: Contribution to journalArticle

62 Scopus citations

Acute administration of ursodeoxycholic acid decreases biliary cholesterol secretion in man

Sama, C., Lopez, V., LaRusso, N. F. & Thistle, J. L., Jan 1 1980, In : Gastroenterology. 79, 5 II, 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes

Tietz, P. S., Marinelli, R. A., Chen, X. M., Huang, B., Cohn, J., Kole, J., McNiven, M. A., Alper, S. & LaRusso, N. F., May 30 2003, In : Journal of Biological Chemistry. 278, 22, p. 20413-20419 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

A Learner‐centered Academic Career Development Curriculum

McDonald, F. S., Schultz, H. J., Larusso, N. F. & Anderson, M. BROWNELL., May 2002, In : Academic Medicine. 77, 5, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats

Myers, B. M., Prendergast, F. G., Holman, R., Kuntz, S. M. & Larusso, N. F., Dec 1993, In : Gastroenterology. 105, 6, p. 1814-1823 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload

Myers, B. M., Prendergast, F. G., Holman, R., Kuntz, S. M. & LaRusso, N. F., 1991, In : Journal of Clinical Investigation. 88, 4, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations
Open Access
99 Scopus citations

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation

Woollard, J. R., Punyashtiti, R., Richardson, S., Masyuk, T. V., Whelan, S., Huang, B. Q., Lager, D. J., Vandeursen, J., Torres, V. E., Gattone, V. H., Larusso, N. F., Harris, P. C. & Ward, C. J., Aug 1 2007, In : Kidney international. 72, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

An aluminum silicate binding assay for quantitationof degradation of cholecystokinin octapeptide and other short peptides

Janas, R. M., Marks, D. L. & LaRusso, N. F., Oct 1992, In : Analytical Biochemistry. 206, 1, p. 6-11 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Anatomy of the human biliary system studied by quantitative computer- aided three-dimensional imaging techniques

Ludwig, J., Ritman, E. L., LaRusso, N. F., Sheedy, P. F. & Zumpe, G., Apr 21 1998, In : Hepatology. 27, 4, p. 893-899 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

AN IMPROVED METHOD FOR FÆCAL COLLECTION: THE FÆCAL FIELD-KIT

Hoffman, N. E., Larusso, N. F. & Hofmann, A. F., Jun 23 1973, In : The Lancet. 301, 7817, p. 1422-1423 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

An Octogenarian with Acute Epigastric Pain: More Than Meets the Eye

Lynn, A., Tabibian, J. H. & La Russo, N. F., Feb 1 2016, In : Gastroenterology. 150, 2, p. e5-e6

Research output: Contribution to journalArticle

A novel incentive system for faculty in an academic medical center

Brandt, T. L., Romme, C. R., LaRusso, N. F. & Lindor, K. D., Nov 5 2002, In : Annals of internal medicine. 137, 9, p. 738-743 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

An update on primary sclerosing cholangitis epidemiology, outcomes and quantification of alkaline phosphatase variability in a population-based cohort

Bakhshi, Z., Hilscher, M. B., Gores, G. J., Harmsen, W. S., Viehman, J. K., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N., Lindor, K. D. & Eaton, J. E., May 1 2020, In : Journal of gastroenterology. 55, 5, p. 523-532 10 p.

Research output: Contribution to journalArticle

Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion

Chen, X. M., O'Hara, S. P., Huang, B. Q., Nelson, J. B., Lin, J. J. C., Zhu, G., Ward, H. D. & LaRusso, N. F., Dec 2004, In : Infection and Immunity. 72, 12, p. 6806-6816 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis

Bharucha, A. E., Jorgensen, R., Lichtman, S. N., LaRusso, N. F. & Lindor, K. D., Oct 2 2000, In : American Journal of Gastroenterology. 95, 9, p. 2338-2342 5 p.

Research output: Contribution to journalArticle

71 Scopus citations

Apolipoproteins of high, low, and very low density lipoproteins in human bile

Sewell, R. B., Mao, S. J. T., Kawamoto, T. & LaRusso, N. F., Jan 1 1983, In : Journal of Lipid Research. 24, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

AQP4 Transfected into Mouse Cholangiocytes Promotes Water Transport in Biliary Epithelia

Splinter, P. L., Masyuk, A. I., Marinelli, R. A. & LaRusso, N. F., Jan 1 2004, In : Hepatology. 39, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis

Huebert, R. C., Vasdev, M. M., Shergill, U., Das, A., Huang, B. Q., Charlton, M. R., LaRusso, N. F. & Shah, V. H., Jul 1 2010, In : Hepatology. 52, 1, p. 238-248 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive MicroRNAs

Huebert, R. C., Jagavelu, K., Hendrickson, H. I., Vasdev, M. M., Arab, J. P., Splinter, P. L., Trussoni, C. E., Larusso, N. F. & Shah, V. H., Oct 1 2011, In : American Journal of Pathology. 179, 4, p. 1851-1860 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon

Laforenza, U., Cova, E., Gastaldi, G., Tritto, S., Grazioli, M., LaRusso, N. F., Splinter, P. L., D'Adamo, P., Tosco, M. & Ventura, U., Oct 1 2005, In : Journal of Nutrition. 135, 10, p. 2329-2336 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis

AESOP Study Investigators, 2020, (Accepted/In press) In : Journal of hepatology.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer?

Harnois, D. M., Gores, G. J., Ludwig, J., Steers, J. L., Larusso, N. F. & Wiesner, R. H., Sep 1997, In : Journal of hepatology. 27, 3, p. 512-516 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

A revised natural history model for primary sclerosing cholangitis

Kim, W. R., Therneau, T. M., Wiesner, R. H., Poterucha, J. J., Benson, J. T., Malinchoc, M., Larusso, N. F., Lindor, K. D. & Dickson, E. R., Jan 1 2000, In : Mayo Clinic proceedings. 75, 7, p. 688-694 7 p.

Research output: Contribution to journalArticle

252 Scopus citations

ATP binding cassette transporter gene expression in rat liver progenitor cells

Ros, J. E., Roskams, T. A. D., Geuken, M., Havinga, R., Splinter, P. L., Petersen, B. E., LaRusso, N. F., Van Der Kolk, D. M., Kuipers, F., Faber, K. N., Müller, M. & Jansen, P. L. M., Jul 1 2003, In : Gut. 52, 7, p. 1060-1067 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: Summary statement of a First National Institutes of Health/Office of Rare Diseases conference

Gunay-Aygun, M., Avner, E. D., Bacallao, R. L., Choyke, P. L., Flynn, J. T., Germino, G. G., Guay-Woodford, L., Harris, P., Heller, T., Ingelfinger, J., Kaskel, F., Kleta, R., LaRusso, N. F., Mohan, P., Pazour, G. J., Shneider, B. L., Torres, V. E., Wilson, P., Zak, C., Zhou, J. & 1 others, Gahl, W. A., Aug 1 2006, In : Journal of Pediatrics. 149, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Odin, J. A., Huebert, R. C., Casciola-Rosen, L., LaRusso, N. F. & Rosen, A., Jul 28 2001, In : Journal of Clinical Investigation. 108, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

176 Scopus citations

Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line

Harnois, D. M., Que, F. G., Celli, A., LaRusso, N. F. & Gores, G. J., Oct 1997, In : Hepatology. 26, 4, p. 884-890 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Bilary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload

LeSage, G. D., Kost, L. J., Barham, S. S. & LaRusso, N. F., 1986, In : Journal of Clinical Investigation. 77, 1, p. 90-97 8 p.

Research output: Contribution to journalArticle

Open Access
74 Scopus citations

Biliary and renal excretion, hepatic metabolism, and hepatic subcellular distribution of metronidazole in the rat

Larusso, N. F., Lindmark, D. G. & Müller, M., 1978, In : Biochemical Pharmacology. 27, 18, p. 2247-2254 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload

Gross, J. B., Myers, B. M., Kost, L. J., Kuntz, S. M. & LaRusso, N. F., Jan 1 1989, In : Journal of Clinical Investigation. 83, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Open Access
92 Scopus citations

Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

Masyuk, T. V., Huang, B. Q., Masyuk, A. I., Ritman, E. L., Torres, V. E., Wang, X., Harris, P. C. & LaRusso, N. F., Nov 2004, In : American Journal of Pathology. 165, 5, p. 1719-1730 12 p.

Research output: Contribution to journalArticle

82 Scopus citations
14 Scopus citations

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A., Banales, J. M., Masyuk, T. V., Radtke, B., Splinter, P. L. & LaRusso, N. F., Oct 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 4, p. G990-G999

Research output: Contribution to journalArticle

148 Scopus citations

Biliary proteins: Assessment of quantitative techniques and comparison in gallstone and nongallstone subjects

Yamazaki, K., Powers, S. P. & LaRusso, N. F., Jan 1 1988, In : Journal of Lipid Research. 29, 8, p. 1055-1063 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Biliary Secretion of Copper in Healthy Man: Quantitation by an intestinal perfusion technique

Van Berge Henegouwen, G. P., Tangedahl, T. N., Hofmann, A. F., Northfield, T. C., LaRusso, N. F. & McCall, J. T., Jan 1 1977, In : Gastroenterology. 72, 6, p. 1228-1231 4 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Biliary tract physiology

Prall, R. T. & LaRusso, N. F., Aug 26 1999, In : Current Opinion in Gastroenterology. 15, 5, p. 423-429 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Biological characteristics of primary cultures of human gallbladder epithelial cells

Hoerl, B. J., Vroman, B. T., Kasperbauer, J. L., LaRusso, N. F. & Scott, R. E., Jan 1 1992, In : Laboratory Investigation. 66, 2, p. 243-250 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease

Holditch, S. J., Schreiber, C. A., Harris, P. C., La Russo, N. F., Ramirez-Alvarado, M., Cataliotti, A., Torres, V. & Ikeda, Y. H., Jul 22 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

4 Scopus citations

Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: Are they independent or coordinated molecular events?

Masyuk, A. I., Gradilone, S. A. & La Russo, N. F., Nov 1 2014, In : Hepatology. 60, 5, p. 1783-1785 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cdc42 and the Actin-Related Protein/Neural Wiskott-Aldrich Syndrome Protein Network Mediate Cellular Invasion by Cryptosporidium parvum

Chen, X. M., Huang, B. Q., Splinter, P. L., Orth, J. D., Billadeau, D. D., McNiven, M. A. & LaRusso, N. F., May 1 2004, In : Infection and Immunity. 72, 5, p. 3011-3021 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia

Ward, C. J., Yuan, D., Masyuk, T. V., Wang, X., Punyashthiti, R., Whelan, S., Bacallao, R., Torra, R., LaRusso, N. F., Torres, V. E. & Harris, P. C., Oct 15 2003, In : Human molecular genetics. 12, 20, p. 2703-2710 8 p.

Research output: Contribution to journalArticle

236 Scopus citations

Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression

Masyuk, T. V., Lee, S. O., Radtke, B. N., Stroope, A. J., Huang, B., Banales, J. M., Masyuk, A. I., Splinter, P. L., Gradilone, S. A., Gajdos, G. B. & Larusso, N. F., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 110-121 12 p.

Research output: Contribution to journalArticle

13 Scopus citations