• 27577 Citations
  • 95 Scopus h-Index
1973 …2020

Research output per year

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Article
2007
25 Scopus citations

Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism

Sheth, P., Delos Santos, N., Seth, A., LaRusso, N. F. & Rao, R. K., Jul 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 1, p. G308-G318

Research output: Contribution to journalArticle

93 Scopus citations
199 Scopus citations

The human immunodeficiency virus type 1 Tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

O'Hara, S. P., Small, A. J., Nelson, J. B., Badley, A. D., Chen, X. M., Gores, G. J. & LaRusso, N. F., Feb 1 2007, In : Infection and Immunity. 75, 2, p. 684-696 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2006

Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: Summary statement of a First National Institutes of Health/Office of Rare Diseases conference

Gunay-Aygun, M., Avner, E. D., Bacallao, R. L., Choyke, P. L., Flynn, J. T., Germino, G. G., Guay-Woodford, L., Harris, P., Heller, T., Ingelfinger, J., Kaskel, F., Kleta, R., LaRusso, N. F., Mohan, P., Pazour, G. J., Shneider, B. L., Torres, V. E., Wilson, P., Zak, C., Zhou, J. & 1 others, Gahl, W. A., Aug 1 2006, In : Journal of Pediatrics. 149, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them Into Intracellular Ca2+ and cAMP Signaling

Masyuk, A. I., Masyuk, T. V., Splinter, P. L., Huang, B. Q., Stroope, A. J. & LaRusso, N. F., Sep 2006, In : Gastroenterology. 131, 3, p. 911-920 10 p.

Research output: Contribution to journalArticle

183 Scopus citations

Cloning and expression of SLC10A4, a putative organic anion transport protein

Splinter, P. L., Lazaridis, K. N., Dawson, P. A. & LaRusso, N. F., Nov 14 2006, In : World journal of gastroenterology. 12, 42, p. 6797-6805 9 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains

Nelson, J. B., O'hara, S. P., Small, A. J., Tietz, P. S., Choudhury, A. K., Pagano, R. E., Chen, X. M. & Larusso, N. F., Dec 1 2006, In : Cellular Microbiology. 8, 12, p. 1932-1945 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes

Tietz, P. S., McNiven, M. A., Splinter, P. L., Huang, B. Q. & LaRusso, N. F., Jan 1 2006, In : Biology of the Cell. 98, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease

Muff, M. A., Masyuk, T. V., Stroope, A. J., Huang, B. Q., Splinter, P. L., Lee, S. O. & LaRusso, N. F., Sep 5 2006, In : Laboratory Investigation. 86, 9, p. 940-950 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma

Blechacz, B., Splinter, P. L., Greiner, S., Myers, R., Peng, K. W., Federspiel, M. J., Russell, S. J. & LaRusso, N. F., Dec 1 2006, In : Hepatology. 44, 6, p. 1465-1477 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Isolation and characterization of cholangiocyte primary cilia

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & LaRusso, N. F., Sep 11 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 3, p. G500-G509

Research output: Contribution to journalArticle

62 Scopus citations

Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes

Mazzone, A., Tietz, P., Jefferson, J., Pagano, R. & LaRusso, N. F., Feb 1 2006, In : Hepatology. 43, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Primary sclerosing cholangitis: Summary of a workshop

LaRusso, N. F., Shneider, B. L., Black, D., Gores, G. J., James, S. P., Doo, E. & Hoofnagle, J. H., Sep 1 2006, In : Hepatology. 44, 3, p. 746-764 19 p.

Research output: Contribution to journalArticle

202 Scopus citations

Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C

Hiesberger, T., Gourley, E., Erickson, A., Koulen, P., Ward, C. J., Masyuk, T. V., Larusso, N. F., Harris, P. C. & Igarashi, P., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34357-34364 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., LaRusso, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 1 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
2005

Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon

Laforenza, U., Cova, E., Gastaldi, G., Tritto, S., Grazioli, M., LaRusso, N. F., Splinter, P. L., D'Adamo, P., Tosco, M. & Ventura, U., Oct 1 2005, In : Journal of Nutrition. 135, 10, p. 2329-2336 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells

O'Hara, S. P., Huang, B. Q., Chen, X. M., Nelson, J. & LaRusso, N. F., Oct 1 2005, In : Journal of Parasitology. 91, 5, p. 995-999 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B

Gradilone, S. A., Tietz, P. S., Splinter, P. L., Marinelli, R. A. & LaRusso, N. F., Aug 18 2005, In : BMC Physiology. 5

Research output: Contribution to journalArticle

28 Scopus citations

Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion

Chen, X. M., O'Hara, S. P., Huang, B. Q., Splinter, P. L., Nelson, J. B. & LaRusso, N. F., May 3 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 18, p. 6338-6343 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Membrane microdomains in hepatocytes: Potential target areas for proteins involved in canalicular bile secretion

Tietz, P., Jefferson, J., Pagano, R. & LaRusso, N. F., Dec 1 2005, In : Journal of Lipid Research. 46, 7, p. 1426-1432 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-κB

Chen, X. M., O'Hara, S. P., Nelson, J. B., Splinter, P. L., Small, A. J., Tietz, P. S., Limper, A. H. & LaRusso, N. F., Dec 1 2005, In : Journal of Immunology. 175, 11, p. 7447-7456 10 p.

Research output: Contribution to journalArticle

149 Scopus citations

The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis

Levy, C., Lymp, J., Angulo, P., Gores, G. J., Larusso, N. & Lindor, K. D., Sep 1 2005, In : Digestive diseases and sciences. 50, 9, p. 1734-1740 7 p.

Research output: Contribution to journalArticle

216 Scopus citations
2004

Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion

Chen, X. M., O'Hara, S. P., Huang, B. Q., Nelson, J. B., Lin, J. J. C., Zhu, G., Ward, H. D. & LaRusso, N. F., Dec 1 2004, In : Infection and Immunity. 72, 12, p. 6806-6816 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

AQP4 Transfected into Mouse Cholangiocytes Promotes Water Transport in Biliary Epithelia

Splinter, P. L., Masyuk, A. I., Marinelli, R. A. & LaRusso, N. F., Jan 1 2004, In : Hepatology. 39, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

Masyuk, T. V., Huang, B. Q., Masyuk, A. I., Ritman, E. L., Torres, V. E., Wang, X., Harris, P. C. & LaRusso, N. F., Nov 2004, In : American Journal of Pathology. 165, 5, p. 1719-1730 12 p.

Research output: Contribution to journalArticle

79 Scopus citations

Cdc42 and the Actin-Related Protein/Neural Wiskott-Aldrich Syndrome Protein Network Mediate Cellular Invasion by Cryptosporidium parvum

Chen, X. M., Huang, B. Q., Splinter, P. L., Orth, J. D., Billadeau, D. D., McNiven, M. A. & LaRusso, N. F., May 1 2004, In : Infection and Immunity. 72, 5, p. 3011-3021 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Clinicopathological correlates of aspartyl (asparaginyl) β-hydroxylase over-expression in cholangiocarcinoma

Maeda, T., Taguchi, K. I., Aishima, S. I., Shimada, M., Hintz, D., Larusso, N., Gores, G., Tsuneyoshi, M., Sugimachi, K., Wands, J. R. & Monte, S. M. D. L., Nov 19 2004, In : Cancer Detection and Prevention. 28, 5, p. 313-318 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Cryptosporidium parvum attachment to and internalization by human biliary epithelia in vitro: A morphologic study

Huang, B. Q., Chen, X. M. & LaRusso, N. F., Apr 1 2004, In : Journal of Parasitology. 90, 2, p. 212-221 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion

Kip, N. S., Lazaridis, K. N., Masyuk, A. I., Splinter, P. L., Huebert, R. C. & LaRusso, N. F., May 15 2004, In : World journal of gastroenterology. 10, 10, p. 1440-1446 7 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42

Chen, X. M., Splinter, P. L., Tietz, P. S., Huang, B. Q., Billadeau, D. D. & LaRusso, N. F., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31671-31678 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

The cholangiopathies: Disorders of biliary epithelia

Lazaridis, K. N., Strazzabosco, M. & Larusso, N. F., Nov 2004, In : Gastroenterology. 127, 5, p. 1565-1577 13 p.

Research output: Contribution to journalArticle

263 Scopus citations
2003

Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes

Tietz, P. S., Marinelli, R. A., Chen, X. M., Huang, B., Cohn, J., Kole, J., McNiven, M. A., Alper, S. & LaRusso, N. F., May 30 2003, In : Journal of Biological Chemistry. 278, 22, p. 20413-20419 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

ATP binding cassette transporter gene expression in rat liver progenitor cells

Ros, J. E., Roskams, T. A. D., Geuken, M., Havinga, R., Splinter, P. L., Petersen, B. E., LaRusso, N. F., Van Der Kolk, D. M., Kuipers, F., Faber, K. N., Müller, M. & Jansen, P. L. M., Jul 1 2003, In : Gut. 52, 7, p. 1060-1067 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia

Ward, C. J., Yuan, D., Masyuk, T. V., Wang, X., Punyashthiti, R., Whelan, S., Bacallao, R., Torra, R., LaRusso, N. F., Torres, V. E. & Harris, P. C., Oct 15 2003, In : Human molecular genetics. 12, 20, p. 2703-2710 8 p.

Research output: Contribution to journalArticle

235 Scopus citations

Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src

Chen, X. M., Huang, B. Q., Splinter, P. L., Cao, H., Zhu, G., McNiven, M. A. & Larusso, N. F., Jul 1 2003, In : Gastroenterology. 125, 1, p. 216-228 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes

Spirlì, C., Fabris, L., Duner, E., Fiorotto, R., Ballardini, G., Roskams, T., Larusso, N. F., Sonzogni, A., Okolicsanyi, L. & Strazzabosco, M., Mar 1 2003, In : Gastroenterology. 124, 3, p. 737-753 17 p.

Research output: Contribution to journalArticle

104 Scopus citations

Defects in Cholangiocyte Fibrocystin Expression and Ciliary Structure in the PCK Rat

Masyuk, T. V., Huang, B. Q., Ward, C. J., Masyuk, A. I., Yuan, D., Splinter, P. L., Punyashthiti, R., Ritman, E. L., Torres, V. E., Harris, P. C. & Larusso, N. F., Nov 2003, In : Gastroenterology. 125, 5, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes

Gradilone, S. A., García, F., Huebert, R. C., Tietz, P. S., Larocca, M. C., Kierbel, A., Carreras, F. I., LaRusso, N. F. & Marinelli, R. A., Jun 1 2003, In : Hepatology. 37, 6, p. 1435-1441 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Hepatic artery and portal vein remodeling in rat liver: Vascular response to selective cholangiocyte proliferation

Masyuk, T. V., Ritman, E. L. & LaRusso, N. F., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1175-1182 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis

Carreras, F. I., Gradilone, S. A., Mazzone, A., García, F., Huang, B. Q., Ochoa, J. E., Tietz, P. S., LaRusso, N. F., Calamita, G. & Marinelli, R. A., May 1 2003, In : Hepatology. 37, 5, p. 1026-1033 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

Gong, A. Y., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X. M. & LaRusso, N. F., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5, p. C1205-C1214

Research output: Contribution to journalArticle

52 Scopus citations

Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs

Splinter, P. L., Masyuk, A. I. & LaRusso, N. F., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6268-6274 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Strategies for improving attendance at medical grand rounds at an Academic Medical Center

Mueller, P. S., Litin, S. C., Sowden, M. L., Habermann, T. M. & LaRusso, N. F., May 1 2003, In : Mayo Clinic proceedings. 78, 5, p. 549-553 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

The "age" factor in adult medicine

Tefferi, A. & LaRusso, N. F., Jul 1 2003, In : Mayo Clinic proceedings. 78, 7, 1 p.

Research output: Contribution to journalArticle

4 Scopus citations

Water Transporting Properties of Hepatocyte Basolateral and Canalicular Plasma Membrane Domains

Marinelli, R. A., Tietz, P. S., Caride, A. J., Huang, B. Q. & LaRusso, N. F., Oct 31 2003, In : Journal of Biological Chemistry. 278, 44, p. 43157-43162 6 p.

Research output: Contribution to journalArticle

58 Scopus citations
2002

A Learner‐centered Academic Career Development Curriculum

McDonald, F. S., Schultz, H. J., Larusso, N. F. & Anderson, M. BROWNELL., May 2002, In : Academic Medicine. 77, 5, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

A novel incentive system for faculty in an academic medical center

Brandt, T. L., Romme, C. R., LaRusso, N. F. & Lindor, K. D., Nov 5 2002, In : Annals of internal medicine. 137, 9, p. 738-743 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units

Gong, A. Y., Masyuk, A. I., Splinter, P. L., Huebert, R. C., Tietz, P. S. & Larusso, N. F., Jul 3 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1, p. C338-C346

Research output: Contribution to journalArticle

19 Scopus citations

Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion

Huebert, R. C., Splinter, P. L., Garcia, F., Marinelli, R. A. & Larusso, N. F., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22710-22717 8 p.

Research output: Contribution to journalArticle

122 Scopus citations