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  • 37 Scopus h-Index
1979 …2020
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Research Output 1979 2019

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2019

Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.

Research output: Contribution to journalArticle

Open Access
Protein Phosphatase 1
Osteoclasts
Bone Resorption
Phosphoric Monoester Hydrolases
Osteogenesis

Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

Ng, A. Y. H., Li, Z., Jones, M. M., Yang, S., Li, C., Fu, C., Tu, C., Oursler, M. J., Qu, J. & Yang, S., Sep 6 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
GTP-Binding Protein Regulators
Osteoclasts
Osteogenesis
Reactive Oxygen Species
Antioxidants
2 Citations (Scopus)

Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling

Li, Z., Liu, T., Gilmore, A., Gómez, N. M., Fu, C., Lim, J., Yang, S., Mitchell, C. H., Li, Y. P., Oursler, M. J. & Yang, S., Jan 1 2019, In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

RGS Proteins
Calcium Signaling
Calcium Channels
Osteoblasts
Osteoclasts
2017
133 Citations (Scopus)

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Bone
Bone and Bones
Caspase 8
2016
21 Citations (Scopus)

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Carpio, L. R., Bradley, E., McGee-Lawrence, M. E., Weivoda, M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In : Science Signaling. 9, 440, ra79.

Research output: Contribution to journalArticle

Chondrocytes
Janus Kinases
Osteogenesis
Bone
Genes
16 Citations (Scopus)

Sclerostin expression and functions beyond the osteocyte

Weivoda, M., Youssef, S. J. & Oursler, M. J., Jun 14 2016, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

Osteocytes
Osteogenesis
Joint Diseases
Chondrocytes
Rheumatic Diseases
2015
23 Citations (Scopus)

Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., Mc Niven, M. A., Farr, J., Khosla, S., Oursler, M. J. & Westendorf, J. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Adiposity
Glucocorticoids
Bone Marrow
Lipids
Osteoblasts
25 Citations (Scopus)

Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Weivoda, M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteoclasts
Bone Resorption
Osteogenesis
Osteoblasts
Bone and Bones
17 Citations (Scopus)

Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss

Yuan, X., Cao, J., Liu, T., Li, Y. P., Scannapieco, F., He, X., Oursler, M. J., Zhang, X., Vacher, J., Li, C., Olson, D. & Yang, S., Dec 1 2015, In : Cell Death and Differentiation. 22, 12, p. 2046-2057 12 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
Bone Remodeling
Osteoclasts
Osteogenesis
Bone and Bones
1 Citation (Scopus)

Response to Wnt Signaling Pathways

Oursler, M. J., Westendorf, J. J., Weivoda, M., Ruan, M., Hachfeld, C. M., Howe, A., Davey, R., Zajac, J., Williams, B. O. & Khosla, S., Nov 1 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 2135-2136 2 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
46 Citations (Scopus)

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Weivoda, M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Osteoclasts
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Catenins
Osteoblasts
2014
25 Citations (Scopus)
Gene Expression Regulation
Gene expression
Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
Osteochondrodysplasias
2013
119 Citations (Scopus)

MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

van Wijnen, A. J., Van De Peppel, J., Van Leeuwen, J. P., Lian, J. B., Stein, G. S., Westendorf, J. J., Oursler, M. J., Im, H. J., Taipaleenmäki, H., Hesse, E., Riester, S. & Kakar, S., Jun 2013, In : Current Osteoporosis Reports. 11, 2, p. 72-82 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Osteogenesis
Osteoporosis
Bone
Bone Diseases
33 Citations (Scopus)

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Conditioned Culture Medium
Osteogenesis
Bone Marrow
38 Citations (Scopus)

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Osteogenesis
Cell Movement
Bone
Phosphotransferases
35 Citations (Scopus)

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Bone Morphogenetic Protein 6
Bone Remodeling
Mitogen-Activated Protein Kinase Kinases
36 Citations (Scopus)

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P., Weivoda, M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 2013, In : Bone. 57, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Osteoclasts
Osteoblasts
Transforming Growth Factor beta
Bone Resorption
2012
214 Citations (Scopus)

Estrogen and the skeleton

Khosla, S., Oursler, M. J. & Monroe, D. G., Nov 2012, In : Trends in Endocrinology and Metabolism. 23, 11, p. 576-581 6 p.

Research output: Contribution to journalArticle

Skeleton
Estrogens
Bone Resorption
Osteogenesis
Osteocytes
23 Citations (Scopus)

TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Adipogenesis
Adipocytes
Estradiol
Osteoblasts
258 Citations (Scopus)

Update on Wnt signaling in bone cell biology and bone disease

Monroe, D. G., McGee-Lawrence, M. E., Oursler, M. J. & Westendorf, J. J., Jan 15 2012, In : Gene. 492, 1, p. 1-18 18 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Bone Diseases
Cell Biology
Bone and Bones
Bone Development
2011
54 Citations (Scopus)

Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 2011, In : Bone. 49, 2, p. 202-207 6 p.

Research output: Contribution to journalArticle

Estrogens
Cytokines
Bone Marrow
Bone and Bones
Adiponectin
146 Citations (Scopus)

Regulation of circulating sclerostin levels by sex steroids in women and in men

Mödder, U. I., Clowes, J. A., Hoey, K., Peterson, J. M., McCready, L., Oursler, M. J., Riggs, B. L. & Khosla, S., Jan 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

Steroids
Bone Resorption
Bone Remodeling
Collagen Type I
Serum
35 Citations (Scopus)

TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways

Cicek, M., Vrabel, A., Sturchio, C., Pederson, L., Hawse, J. R., Subramaniam, M., Spelsberg, T. C. & Oursler, M. J., 2011, In : PLoS One. 6, 3, e17522.

Research output: Contribution to journalArticle

osteoclasts
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Osteoclasts
mitogen-activated protein kinase
23 Citations (Scopus)

TIEG1/KLF10 modulates runx2 expression and activity in osteoblasts

Hawse, J. R., Cicek, M., Grygo, S. B., Bruinsma, E. S., Rajamannan, N. M., van Wijnen, A. J., Lian, J. B., Stein, G. S., Oursler, M. J., Subramaniam, M. & Spelsberg, T. C., 2011, In : PLoS One. 6, 4, e19429.

Research output: Contribution to journalArticle

osteoblasts
Osteoblasts
Knockout Mice
Bone
bones
39 Citations (Scopus)

Wnt10b activates the wnt, notch, and NFIκB pathways in u2os osteosarcoma cells

Mödder, U. I., Oursler, M. J., Khosla, S. & Monroe, D. G., May 2011, In : Journal of Cellular Biochemistry. 112, 5, p. 1392-1402 11 p.

Research output: Contribution to journalArticle

Osteosarcoma
Genes
Wnt Signaling Pathway
Chemical activation
Microarrays
2010
32 Citations (Scopus)

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

Syed, F. A., Mödder, U. I., Roforth, M., Hensen, I., Fraser, D. G., Peterson, J. M., Oursler, M. J. & Khosla, S., Nov 2010, In : Journal of Bone and Mineral Research. 25, 11, p. 2438-2446 9 p.

Research output: Contribution to journalArticle

Osteoporosis
Estrogens
Spine
Differentiation Antigens
Gene Expression
35 Citations (Scopus)

Recent advances in understanding the mechanisms of osteoclast precursor fusion

Oursler, M. J., Aug 1 2010, In : Journal of Cellular Biochemistry. 110, 5, p. 1058-1062 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Macrophages
Fusion reactions
Bone
Membrane Glycoproteins
21 Citations (Scopus)

TGFβ inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts

Subramaniam, M., Hawse, J. R., Bruinsma, E. S., Grygo, S. B., Cicek, M., Oursler, M. J. & Spelsberg, T. C., Jan 29 2010, In : Biochemical and Biophysical Research Communications. 392, 1, p. 72-76 5 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Osteoblasts
Genes
Gene Knockout Techniques
Genetic Promoter Regions
27 Citations (Scopus)

Transforming growth factor-β coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis

Ruan, M., Pederson, L., Bradley, E., Bamberger, A. M. & Oursler, M. J., Apr 2010, In : Endocrinology. 151, 4, p. 1713-1722 10 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Transforming Growth Factors
Osteoclasts
Apoptosis
Cytokines
2009
15 Citations (Scopus)

Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo

Clowes, J. A., Eghbali-Fatourechi, G. Z., McCready, L., Oursler, M. J., Khosla, S. & Riggs, B. L., May 2009, In : Osteoporosis International. 20, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Receptors, Tumor Necrosis Factor, Type II
Estrogens
Bone Marrow Cells
Bone Marrow
2008
266 Citations (Scopus)

Building bone to reverse osteoporosis and repair fractures

Khosla, S., Westendorf, J. J. & Oursler, M. J., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 421-428 8 p.

Research output: Contribution to journalArticle

Osteoporosis
Fracture Healing
Bone and Bones
Spinal Fractures
Bone Morphogenetic Protein 2
115 Citations (Scopus)

Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women

Syed, F. A., Oursler, M. J., Hefferanm, T. E., Peterson, J. M., Riggs, B. L. & Khosla, S., Sep 2008, In : Osteoporosis International. 19, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Adipocytes
Estrogens
Bone Marrow
Therapeutics
Placebos
35 Citations (Scopus)
Transforming Growth Factors
Osteoblasts
Estrogen Receptors
Protein Isoforms
Genes
36 Citations (Scopus)

Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

Hawse, J. R., Subramaniam, M., Ingle, J. N., Oursler, M. J., Rajamannan, N. M. & Spelsberg, T. C., Feb 1 2008, In : Journal of Cellular Biochemistry. 103, 2, p. 383-392 10 p.

Research output: Contribution to journalArticle

Bone
Estrogens
Transcription Factors
Bone and Bones
Tissue
15 Citations (Scopus)

Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells

Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In : Journal of Cellular Biochemistry. 103, 3, p. 896-907 12 p.

Research output: Contribution to journalArticle

Response Elements
Gene expression
Estrogen Receptors
Bone
Estrogens
34 Citations (Scopus)
Kruppel-Like Transcription Factors
Macrophage Colony-Stimulating Factor
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Osteoclasts
12 Citations (Scopus)
Macrophage Colony-Stimulating Factor
Mitogen-Activated Protein Kinase Kinases
Osteoclasts
Chemical activation
MAP Kinase Signaling System
35 Citations (Scopus)

Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

Bradley, E., Ruan, M. M., Vrable, A. & Oursler, M. J., Jul 1 2008, In : Journal of Cellular Biochemistry. 104, 4, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
Mitogen-Activated Protein Kinase Kinases
Osteoclasts
Crosstalk
Phosphatidylinositol 3-Kinases
307 Citations (Scopus)
Osteoclasts
Chemokines
Osteogenesis
Osteoblasts
Bone and Bones
21 Citations (Scopus)

Regulation of bone turnover by sex steroids in men

Sanyal, A., Hoey, K. A., Mödder, U. I., Lamsam, J. L., McCready, L. K., Peterson, J. M., Achenbach, S. J., Oursler, M. J. & Khosla, S., May 2008, In : Journal of Bone and Mineral Research. 23, 5, p. 705-714 10 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone Resorption
Steroids
Follicle Stimulating Hormone
Interleukin-1
122 Citations (Scopus)

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

Gingery, A., Bradley, E., Pederson, L., Ruan, M., Horwood, N. J. & Oursler, M. J., Sep 10 2008, In : Experimental Cell Research. 314, 15, p. 2725-2738 14 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Osteoclasts
Phosphotransferases
Apoptosis
MAP Kinase Kinase Kinases
38 Citations (Scopus)

TIEG-null mice display an osteopenic gender-specific phenotype

Hawse, J. R., Iwaniec, U. T., Bensamoun, S. F., Monroe, D. G., Peters, K. D., Ilharreborde, B., Rajamannan, N. M., Oursler, M. J., Turner, R. T., Spelsberg, T. C. & Subramaniam, M., Jun 2008, In : Bone. 42, 6, p. 1025-1031 7 p.

Research output: Contribution to journalArticle

Phenotype
Genes
Femur
Osteoblasts
Bone and Bones
2007
34 Citations (Scopus)

2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo

Cicek, M., Iwaniec, U. T., Goblirsch, M. J., Vrabel, A., Ruan, M., Clohisy, D. R., Turner, R. R. & Oursler, M. J., Nov 1 2007, In : Cancer Research. 67, 21, p. 10106-10111 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Osteoclasts
Bone and Bones
Neoplasms
Neoplasm Metastasis
2006
19 Citations (Scopus)

2-Methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts

Maran, A., Corny, G., Oursler, M. J., Zhang, M., Shogren, K. L., Yaszemski, M. J. & Turner, R. T., Oct 1 2006, In : Journal of Cellular Biochemistry. 99, 2, p. 425-434 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Lymphotoxin-alpha
Cells
Cytotoxicity
43 Citations (Scopus)

Breast cancer bone metastasis and current small therapeutics

Cicek, M. & Oursler, M. J., Dec 2006, In : Cancer and Metastasis Reviews. 25, 4, p. 635-644 10 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Osteolysis
50 Citations (Scopus)

TGFβ inducible early gene-1 knockout mice display defects in bone strength and microarchitecture

Bensamoun, S. F., Hawse, J. R., Subramaniam, M., Ilharreborde, B., Bassillais, A., Benhamou, C. L., Fraser, D. G., Oursler, M. J., Amadio, P. C., An, K. N. & Spelsberg, T. C., Dec 2006, In : Bone. 39, 6, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

Gene Knockout Techniques
Knockout Mice
Bone and Bones
Osteoblasts
Genes
2005
23 Citations (Scopus)

Deletion of membrane-bound steel factor results in osteopenia in mice

Lotinun, S., Evans, G. L., Turner, R. T. & Oursler, M. J., Apr 2005, In : Journal of Bone and Mineral Research. 20, 4, p. 644-652 9 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Metabolic Bone Diseases
Osteoblasts
Membranes
Bone and Bones

Erratum: Deletion of membrane-bound steel factor results in osteopenia in mice (Journal of Bone and Mineral Research (April 2005) 20 (644-652))

Lotinun, S., Evans, G. L., Turner, R. T. & Oursler, M. J., Jun 2005, In : Journal of Bone and Mineral Research. 20, 6, p. 1075 1 p.

Research output: Contribution to journalArticle

Stem Cell Factor
Metabolic Bone Diseases
Minerals
Bone and Bones
Membranes
30 Citations (Scopus)
Mitochondria
Osteoclasts
Cytochromes c
Hydrogen Peroxide
Apoptosis
86 Citations (Scopus)

TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro

Subramaniam, M., Gorny, G., Johnsen, S., Monroe, D. G., Evans, G. L., Fraser, D. G., Rickard, D. J., Rasmussen, K., Van Deursen, J., Turner, R. T., Oursler, M. J. & Spelsberg, T. C., Feb 2005, In : Molecular and Cellular Biology. 25, 3, p. 1191-1199 9 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
In Vitro Techniques
Macrophage Colony-Stimulating Factor
Differentiation Antigens