• 5780 Citations
  • 38 Scopus h-Index
1979 …2020

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2019

Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.

Research output: Contribution to journalArticle

Open Access

Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

Ng, A. Y. H., Li, Z., Jones, M. M., Yang, S., Li, C., Fu, C., Tu, C., Oursler, M. J., Qu, J. & Yang, S., Sep 6 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access

Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling

Li, Z., Liu, T., Gilmore, A., Gómez, N. M., Fu, C., Lim, J., Yang, S., Mitchell, C. H., Li, Y. P., Oursler, M. J. & Yang, S., Jan 1 2019, In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

171 Scopus citations
2016

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Carpio, L. R., Bradley, E., McGee-Lawrence, M. E., Weivoda, M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In : Science Signaling. 9, 440, ra79.

Research output: Contribution to journalArticle

23 Scopus citations

Sclerostin expression and functions beyond the osteocyte

Weivoda, M., Youssef, S. J. & Oursler, M. J., Jun 14 2016, (Accepted/In press) In : Bone.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Age Dependence of Estrogen Responsiveness

Judd, J., Kremer, M. & Oursler, M. J., Mar 14 2015, In : Calcified Tissue International. 56, 1, p. S25-S26

Research output: Contribution to journalArticle

3 Scopus citations

Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., Mc Niven, M. A., Farr, J., Khosla, S., Oursler, M. J. & Westendorf, J. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

27 Scopus citations

Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

Weivoda, M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

26 Scopus citations

Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss

Yuan, X., Cao, J., Liu, T., Li, Y. P., Scannapieco, F., He, X., Oursler, M. J., Zhang, X., Vacher, J., Li, C., Olson, D. & Yang, S., Dec 1 2015, In : Cell Death and Differentiation. 22, 12, p. 2046-2057 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Response to Wnt Signaling Pathways

Oursler, M. J., Westendorf, J. J., Weivoda, M., Ruan, M., Hachfeld, C. M., Howe, A., Davey, R., Zajac, J., Williams, B. O. & Khosla, S., Nov 1 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 2135-2136 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Weivoda, M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

49 Scopus citations
2013

MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

Van Wijnen, A. J., Van De Peppel, J., Van Leeuwen, J. P., Lian, J. B., Stein, G. S., Westendorf, J. J., Oursler, M. J., Im, H. J., Taipaleenmäki, H., Hesse, E., Riester, S. & Kakar, S., Jun 1 2013, In : Current osteoporosis reports. 11, 2, p. 72-82 11 p.

Research output: Contribution to journalArticle

127 Scopus citations

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 1 2013, In : Journal of cellular biochemistry. 114, 8, p. 1901-1907 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P., Weivoda, M. M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 1 2013, In : Bone. 57, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 1 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 1 2011, In : Bone. 49, 2, p. 202-207 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Regulation of circulating sclerostin levels by sex steroids in women and in men

Mödder, U. I., Clowes, J. A., Hoey, K., Peterson, J. M., McCready, L., Oursler, M. J., Riggs, B. L. & Khosla, S., Jan 1 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

153 Scopus citations

TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways

Cicek, M., Vrabel, A., Sturchio, C., Pederson, L., Hawse, J. R., Subramaniam, M., Spelsberg, T. C. & Oursler, M. J., Mar 21 2011, In : PloS one. 6, 3, e17522.

Research output: Contribution to journalArticle

37 Scopus citations

TIEG1/KLF10 modulates runx2 expression and activity in osteoblasts

Hawse, J. R., Cicek, M., Grygo, S. B., Bruinsma, E. S., Rajamannan, N. M., van Wijnen, A. J., Lian, J. B., Stein, G. S., Oursler, M. J., Subramaniam, M. & Spelsberg, T. C., May 13 2011, In : PloS one. 6, 4, e19429.

Research output: Contribution to journalArticle

26 Scopus citations

Wnt10b activates the wnt, notch, and NFIκB pathways in u2os osteosarcoma cells

Mödder, U. I., Oursler, M. J., Khosla, S. & Monroe, D. G., May 1 2011, In : Journal of cellular biochemistry. 112, 5, p. 1392-1402 11 p.

Research output: Contribution to journalArticle

40 Scopus citations
2010

Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

Syed, F. A., Mödder, U. I., Roforth, M., Hensen, I., Fraser, D. G., Peterson, J. M., Oursler, M. J. & Khosla, S., Nov 1 2010, In : Journal of Bone and Mineral Research. 25, 11, p. 2438-2446 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

TGFβ inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts

Subramaniam, M., Hawse, J. R., Bruinsma, E. S., Grygo, S. B., Cicek, M., Oursler, M. J. & Spelsberg, T. C., Jan 29 2010, In : Biochemical and Biophysical Research Communications. 392, 1, p. 72-76 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Transforming growth factor-β coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis

Ruan, M., Pederson, L., Bradley, E. W., Bamberger, A. M. & Oursler, M. J., Apr 1 2010, In : Endocrinology. 151, 4, p. 1713-1722 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2009

Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo

Clowes, J. A., Eghbali-Fatourechi, G. Z., McCready, L., Oursler, M. J., Khosla, S. & Riggs, B. L., May 1 2009, In : Osteoporosis International. 20, 5, p. 761-769 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2008

Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women

Syed, F. A., Oursler, M. J., Hefferanm, T. E., Peterson, J. M., Riggs, B. L. & Khosla, S., Sep 1 2008, In : Osteoporosis International. 19, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

Estrogen receptor β isoform-specific induction of transforming growth factor β-inducible early gene-1 in human osteoblast cells: An essential role for the activation function 1 domain

Hawse, J. R., Subramaniam, M., Monroe, D. G., Hemmingsen, A. H., Ingle, J. N., Khosla, S., Oursler, M. J. & Spelsberg, T. C., Jul 1 2008, In : Molecular Endocrinology. 22, 7, p. 1579-1595 17 p.

Research output: Contribution to journalArticle

37 Scopus citations

Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

Hawse, J. R., Subramaniam, M., Ingle, J. N., Oursler, M. J., Rajamannan, N. M. & Spelsberg, T. C., Feb 1 2008, In : Journal of cellular biochemistry. 103, 2, p. 383-392 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells

Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In : Journal of cellular biochemistry. 103, 3, p. 896-907 12 p.

Research output: Contribution to journalArticle

15 Scopus citations
34 Scopus citations
12 Scopus citations

Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

Bradley, E. W., Ruan, M. M., Vrable, A. & Oursler, M. J., Jul 1 2008, In : Journal of cellular biochemistry. 104, 4, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
317 Scopus citations

Regulation of bone turnover by sex steroids in men

Sanyal, A., Hoey, K. A., Mödder, U. I., Lamsam, J. L., McCready, L. K., Peterson, J. M., Achenbach, S. J., Oursler, M. J. & Khosla, S., May 1 2008, In : Journal of Bone and Mineral Research. 23, 5, p. 705-714 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

Gingery, A., Bradley, E. W., Pederson, L., Ruan, M., Horwood, N. J. & Oursler, M. J., Sep 10 2008, In : Experimental Cell Research. 314, 15, p. 2725-2738 14 p.

Research output: Contribution to journalArticle

122 Scopus citations

TIEG-null mice display an osteopenic gender-specific phenotype

Hawse, J. R., Iwaniec, U. T., Bensamoun, S. F., Monroe, D. G., Peters, K. D., Ilharreborde, B., Rajamannan, N. M., Oursler, M. J., Turner, R. T., Spelsberg, T. C. & Subramaniam, M., Jun 1 2008, In : Bone. 42, 6, p. 1025-1031 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
2007

2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo

Cicek, M., Iwaniec, U. T., Goblirsch, M. J., Vrabel, A., Ruan, M., Clohisy, D. R., Turner, R. R. & Oursler, M. J., Nov 1 2007, In : Cancer research. 67, 21, p. 10106-10111 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
2006

2-Methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts

Maran, A., Corny, G., Oursler, M. J., Zhang, M., Shogren, K. L., Yaszemski, M. J. & Turner, R. T., Oct 1 2006, In : Journal of cellular biochemistry. 99, 2, p. 425-434 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

TGFβ inducible early gene-1 knockout mice display defects in bone strength and microarchitecture

Bensamoun, S. F., Hawse, J. R., Subramaniam, M., Ilharreborde, B., Bassillais, A., Benhamou, C. L., Fraser, D. G., Oursler, M. J., Amadio, P. C., An, K. N. & Spelsberg, T. C., Dec 1 2006, In : Bone. 39, 6, p. 1244-1251 8 p.

Research output: Contribution to journalArticle

52 Scopus citations
2005

Deletion of membrane-bound steel factor results in osteopenia in mice

Lotinun, S., Evans, G. L., Turner, R. T. & Oursler, M. J., Apr 1 2005, In : Journal of Bone and Mineral Research. 20, 4, p. 644-652 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis

Oursler, M. J., Bradley, E. W., Elfering, S. L. & Giulivi, C., Jan 1 2005, In : American Journal of Physiology - Cell Physiology. 288, 1 57-1, p. C156-C168

Research output: Contribution to journalArticle

30 Scopus citations

TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro

Subramaniam, M., Gorny, G., Johnsen, S. A., Monroe, D. G., Evans, G. L., Fraser, D. G., Rickard, D. J., Rasmussen, K., Van Deursen, J. M. A., Turner, R. T., Oursler, M. J. & Spelsberg, T. C., Feb 2005, In : Molecular and cellular biology. 25, 3, p. 1191-1199 9 p.

Research output: Contribution to journalArticle

89 Scopus citations
2004

IL-6, LIF, and TNF-α regulation of GM-CSF inhibition of osteoclastogenesis in vitro

Gorny, G., Shaw, A. & Oursler, M. J., Mar 10 2004, In : Experimental Cell Research. 294, 1, p. 149-158 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-β regulation of osteoclast differentiation

Krast, M., Gorny, G., Sells Galvin, R. J. & Oursler, M. J., Jul 1 2004, In : Journal of Cellular Physiology. 200, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

106 Scopus citations
2003

Direct and indirect effects of estrogen on osteoclasts

Oursler, M. J., Dec 1 2003, In : Journal of Musculoskeletal Neuronal Interactions. 3, 4, p. 363-366 4 p.

Research output: Contribution to journalArticle

12 Scopus citations
138 Scopus citations
2002

Temporal expression patterns of BMP receptors and collagen II (B) during periosteal chondrogenesis

Sanyal, A., Jo Oursler, M., Clemens, V. R., Fukumoto, T., Fitzsimmons, J. S. & O'Driscoll, S. W., Jan 1 2002, In : Journal of Orthopaedic Research. 20, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

The spatiotemporal expression of TGF-β1 and its receptors during periosteal chondrogenesis in vitro

Mizuta, H., Sanyal, A., Fukumoto, T., Fitzsimmons, J. S., Matsui, N., Bolander, M. E., Jo Oursler, M. & O'Driscoll, S. W., May 13 2002, In : Journal of Orthopaedic Research. 20, 3, p. 562-574 13 p.

Research output: Contribution to journalArticle

24 Scopus citations