Merry Jo Oursler, PhD

Research Output

Research Output per year

1979 2020

• 6242 Citations
• 40 Scopus h-Index
• 86 Article
• 10 Review article
• 3 Comment/debate
• 2 Chapter
• 2 More
  • 1 Conference contribution
  • 1 Editorial

Research Output per year

Research Output per year

Search results

• 2020

  Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

  Weivoda, M. M., Chew, C. K., Monroe, D. G., Farr, J. N., Atkinson, E. J., Geske, J. R., Eckhardt, B., Thicke, B., Ruan, M., Tweed, A. J., McCready, L. K., Rizza, R. A., Matveyenko, A., Kassem, M., Andersen, T. L., Vella, A., Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., Dec 1 2020, In: Nature communications. 11, 1, 87.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteoclasts
  • Osteoblasts
  • osteoblasts
  • Energy Metabolism
  • metabolism
  14 Scopus citations

• RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis

  Yuan, G., Yang, S., Ng, A., Fu, C., Oursler, M. J., Xing, L. & Yang, S., Jun 26 2020, In: iScience. 23, 6, 101172.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Allergy and Immunology
  • Orthopedics
  • Arthritis
  1 Scopus citations
• 2019

  Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

  Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E. W., Aug 2 2019, In: Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteoclasts
  • leucine-rich repeat proteins
  • Pleckstrin Homology Domains
  • Protein Phosphatase 1
  • Bone Resorption
  3 Scopus citations

• Erratum to: Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways: Wnt INHIBITS OC DIFFERENTIATION BY CANONICAL/NONCANONICAL PATHWAYS (Journal of Bone and Mineral Research, (2016), 31, 1, (65-75), 10.1002/jbmr.2599)

  Weivoda, M. M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2019, In: Journal of Bone and Mineral Research. 34, 8, p. 1546-1548 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Wnt Signaling Pathway
  • Osteoclasts
  • Minerals
  • Bone and Bones
  • Western Blotting
  2 Scopus citations

• Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species

  Ng, A. Y. H., Li, Z., Jones, M. M., Yang, S., Li, C., Fu, C., Tu, C., Oursler, M. J., Qu, J. & Yang, S., Sep 2019, In: eLife. 8, e42951.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Osteoclasts
  • GTP-Binding Protein Regulators
  • Osteogenesis
  • Reactive Oxygen Species
  • Antioxidants
  5 Scopus citations

• Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling

  Li, Z., Liu, T., Gilmore, A., Gómez, N. M., Fu, C., Lim, J., Yang, S., Mitchell, C. H., Li, Y. P., Oursler, M. J. & Yang, S., Apr 2019, In: Journal of Bone and Mineral Research. 34, 4, p. 752-764 13 p.

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins
  • Calcium Signaling
  • Calcium Channels
  • Osteoblasts
  • mouse RGS12 protein
  5 Scopus citations
• 2017

  Cathepsin K inhibitors for osteoporosis: Biology, potential clinical utility, and lessons learned

  Drake, M. T., Clarke, B. L., Oursler, M. J. & Khosla, S., 2017, In: Endocrine reviews. 38, 4, p. 325-350 26 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cathepsin K
  • Osteoporosis
  • odanacatib
  • Osteoclasts
  • Cathepsins
  72 Scopus citations

• Sclerostin expression and functions beyond the osteocyte

  Weivoda, M. M., Youssef, S. J. & Oursler, M. J., Mar 1 2017, In: Bone. 96, p. 45-50 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteocytes
  • Osteogenesis
  • Rheumatic Diseases
  • Joint Diseases
  • Chondrocytes
  32 Scopus citations

• Targeting cellular senescence prevents age-related bone loss in mice

  Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. T., Pignolo, R. J., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In: Nature Medicine. 23, 9, p. 1072-1079 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cellular Senescence
  • Bone
  • Osteoporosis
  • Janus Kinase Inhibitors
  • Bone and Bones
  257 Scopus citations
• 2016

  Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

  McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., McNiven, M. A., Farr, J. N., Khosla, S., Oursler, M. J. & Westendorf, J. J., Jan 1 2016, In: Journal of Bone and Mineral Research. 31, 1, p. 116-128 13 p.

  Research output: Contribution to journal › Article › peer-review

  • histone deacetylase 3
  • Adiposity
  • Glucocorticoids
  • Bone Marrow
  • Lipids
  37 Scopus citations

• Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

  Carpio, L. R., Bradley, E. W., McGee-Lawrence, M. E., Weivoda, M. M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., Van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In: Science Signaling. 9, 440, ra79.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • histone deacetylase 3
  • Chondrocytes
  • Bone
  • Genes
  36 Scopus citations

• Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation

  Weivoda, M. M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., Jan 1 2016, In: Journal of Bone and Mineral Research. 31, 1, p. 76-85 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Bone Resorption
  • Osteogenesis
  • Osteoblasts
  • Wnt1 Protein
  35 Scopus citations

• Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

  Weivoda, M. M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., Jan 1 2016, In: Journal of Bone and Mineral Research. 31, 1, p. 65-75 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclic AMP-Dependent Protein Kinases
  • Osteoclasts
  • Cyclic AMP
  • Catenins
  • procathepsin K
  64 Scopus citations
• 2015

  Age Dependence of Estrogen Responsiveness

  Judd, J., Kremer, M. & Oursler, M. J., Mar 14 2015, In: Calcified Tissue International. 56, 1, p. S25-S26

  Research output: Contribution to journal › Article › peer-review
  3 Scopus citations

• Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss

  Yuan, X., Cao, J., Liu, T., Li, Y. P., Scannapieco, F., He, X., Oursler, M. J., Zhang, X., Vacher, J., Li, C., Olson, D. & Yang, S., Dec 1 2015, In: Cell Death and Differentiation. 22, 12, p. 2046-2057 12 p.

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators
  • Osteoclasts
  • Bone Remodeling
  • Osteogenesis
  • Bone and Bones
  21 Scopus citations

• Response to Wnt Signaling Pathways

  Oursler, M. J., Westendorf, J. J., Weivoda, M., Ruan, M., Hachfeld, C. M., Howe, A., Davey, R., Zajac, J., Williams, B. O. & Khosla, S., Nov 1 2015, In: Journal of Bone and Mineral Research. 30, 11, p. 2135-2136 2 p.

  Research output: Contribution to journal › Article › peer-review
  1 Scopus citations
• 2014

  Developments in sclerostin biology: Regulation of gene expression, mechanisms of action, and physiological functions

  Weivoda, M. M. & Oursler, M. J., Mar 2014, In: Current osteoporosis reports. 12, 1, p. 107-114 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Gene expression
  • Gene Expression Regulation
  • Sclerosteosis
  • Low Density Lipoprotein Receptor-Related Protein-6
  • Low Density Lipoprotein Receptor-Related Protein-5
  29 Scopus citations
• 2013

  MicroRNA functions in osteogenesis and dysfunctions in osteoporosis

  Van Wijnen, A. J., Van De Peppel, J., Van Leeuwen, J. P., Lian, J. B., Stein, G. S., Westendorf, J. J., Oursler, M. J., Im, H. J., Taipaleenmäki, H., Hesse, E., Riester, S. & Kakar, S., Jun 2013, In: Current osteoporosis reports. 11, 2, p. 72-82 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoporosis
  • Osteogenesis
  • MicroRNAs
  • Bone
  • Osteoclasts
  138 Scopus citations

• Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

  Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 2013, In: Journal of cellular biochemistry. 114, 8, p. 1901-1907 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Bone
  • Conditioned Culture Medium
  • Osteogenesis
  • Osteoblasts
  42 Scopus citations

• Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways

  Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In: Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Lysosphingolipid Receptors
  • Bone
  • Chemical activation
  • Osteogenesis
  • sphingosine 1-phosphate
  46 Scopus citations

• TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts

  Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In: Endocrinology. 154, 10, p. 3745-3752 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Osteoblasts
  • Bone Morphogenetic Protein 6
  • Mitogen-Activated Protein Kinase Kinases
  • Bone Remodeling
  42 Scopus citations

• Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

  Ota, K., Quint, P., Weivoda, M. M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 2013, In: Bone. 57, 1, p. 68-75 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Leukemia Inhibitory Factor
  • Osteoclasts
  • Osteoblasts
  • Transforming Growth Factor beta
  • Bone Resorption
  46 Scopus citations
• 2012

  Estrogen and the skeleton

  Khosla, S., Oursler, M. J. & Monroe, D. G., Nov 2012, In: Trends in Endocrinology and Metabolism. 23, 11, p. 576-581 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Skeleton
  • Estrogens
  • Bone Resorption
  • Osteogenesis
  • Osteocytes
  287 Scopus citations

• TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction

  Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 2012, In: Endocrinology. 153, 1, p. 254-263 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Connective Tissue Growth Factor
  • Adipogenesis
  • Adipocytes
  • Estradiol
  • Osteoblasts
  27 Scopus citations

• Update on Wnt signaling in bone cell biology and bone disease

  Monroe, D. G., McGee-Lawrence, M. E., Oursler, M. J. & Westendorf, J. J., Jan 15 2012, In: Gene. 492, 1, p. 1-18 18 p.

  Research output: Contribution to journal › Review article › peer-review

  • Wnt Signaling Pathway
  • Bone Diseases
  • Cell Biology
  • Bone and Bones
  • Bone Development
  276 Scopus citations
• 2011

  Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

  Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 2011, In: Bone. 49, 2, p. 202-207 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogens
  • Bone Marrow
  • Cytokines
  • Bone and Bones
  • Adiponectin
  59 Scopus citations

• Regulation of circulating sclerostin levels by sex steroids in women and in men

  Mödder, U. I., Clowes, J. A., Hoey, K., Peterson, J. M., McCready, L., Oursler, M. J., Riggs, B. L. & Khosla, S., Jan 2011, In: Journal of Bone and Mineral Research. 26, 1, p. 27-34 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Steroids
  • Bone Resorption
  • Elderly
  • Bone Remodeling
  • Collagen Type I
  161 Scopus citations

• TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways

  Cicek, M., Vrabel, A., Sturchio, C., Pederson, L., Hawse, J. R., Subramaniam, M., Spelsberg, T. C. & Oursler, M. J., 2011, In: PloS one. 6, 3, e17522.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • osteoclasts
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinase Kinases
  • mitogen-activated protein kinase
  38 Scopus citations

• TIEG1/KLF10 modulates runx2 expression and activity in osteoblasts

  Hawse, J. R., Cicek, M., Grygo, S. B., Bruinsma, E. S., Rajamannan, N. M., van Wijnen, A. J., Lian, J. B., Stein, G. S., Oursler, M. J., Subramaniam, M. & Spelsberg, T. C., 2011, In: PloS one. 6, 4, e19429.

  Research output: Contribution to journal › Article › peer-review

  • Osteoblasts
  • osteoblasts
  • Bone
  • Knockout Mice
  • bones
  28 Scopus citations

• Wnt10b activates the wnt, notch, and NFIκB pathways in u2os osteosarcoma cells

  Mödder, U. I., Oursler, M. J., Khosla, S. & Monroe, D. G., May 2011, In: Journal of cellular biochemistry. 112, 5, p. 1392-1402 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Wnt Signaling Pathway
  • Osteosarcoma
  • Genes
  • Chemical activation
  • Microarrays
  40 Scopus citations
• 2010

  Effects of chronic estrogen treatment on modulating age-related bone loss in female mice

  Syed, F. A., Mödder, U. I., Roforth, M., Hensen, I., Fraser, D. G., Peterson, J. M., Oursler, M. J. & Khosla, S., Nov 2010, In: Journal of Bone and Mineral Research. 25, 11, p. 2438-2446 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoporosis
  • Estrogens
  • Spine
  • Differentiation Antigens
  • Cortical Bone
  35 Scopus citations

• Recent advances in understanding the mechanisms of osteoclast precursor fusion

  Oursler, M. J., Aug 1 2010, In: Journal of cellular biochemistry. 110, 5, p. 1058-1062 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Osteoclasts
  • Macrophages
  • Fusion reactions
  • Bone
  • Membrane Glycoproteins
  36 Scopus citations

• TGFβ inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts

  Subramaniam, M., Hawse, J. R., Bruinsma, E. S., Grygo, S. B., Cicek, M., Oursler, M. J. & Spelsberg, T. C., Jan 29 2010, In: Biochemical and Biophysical Research Communications. 392, 1, p. 72-76 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoblasts
  • Osteoprotegerin
  • Genes
  • Gene Knockout Techniques
  • Genetic Promoter Regions
  23 Scopus citations

• Transforming growth factor-β coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis

  Ruan, M., Pederson, L., Bradley, E. W., Bamberger, A. M. & Oursler, M. J., Apr 2010, In: Endocrinology. 151, 4, p. 1713-1722 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Leukemia Inhibitory Factor
  • Transforming Growth Factors
  • Osteoclasts
  • Cytokines
  • Apoptosis
  30 Scopus citations
• 2009

  Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo

  Clowes, J. A., Eghbali-Fatourechi, G. Z., McCready, L., Oursler, M. J., Khosla, S. & Riggs, B. L., May 2009, In: Osteoporosis International. 20, 5, p. 761-769 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Receptors, Tumor Necrosis Factor, Type II
  • Estrogens
  • Bone Marrow Cells
  • Bone Marrow
  16 Scopus citations
• 2008

  Building bone to reverse osteoporosis and repair fractures

  Khosla, S., Westendorf, J. J. & Oursler, M. J., Feb 1 2008, In: Journal of Clinical Investigation. 118, 2, p. 421-428 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Osteoporosis
  • Fracture Healing
  • Bone and Bones
  • Spinal Fractures
  • Bone Morphogenetic Protein 2
  292 Scopus citations

• Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women

  Syed, F. A., Oursler, M. J., Hefferanm, T. E., Peterson, J. M., Riggs, B. L. & Khosla, S., Sep 2008, In: Osteoporosis International. 19, 9, p. 1323-1330 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Adipocytes
  • Estrogens
  • Bone Marrow
  • Placebos
  • Therapeutics
  124 Scopus citations

• Estrogen receptor β isoform-specific induction of transforming growth factor β-inducible early gene-1 in human osteoblast cells: An essential role for the activation function 1 domain

  Hawse, J. R., Subramaniam, M., Monroe, D. G., Hemmingsen, A. H., Ingle, J. N., Khosla, S., Oursler, M. J. & Spelsberg, T. C., Jul 2008, In: Molecular Endocrinology. 22, 7, p. 1579-1595 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Transforming Growth Factors
  • Osteoblasts
  • Estrogen Receptors
  • Protein Isoforms
  • Genes
  39 Scopus citations

• Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors

  Hawse, J. R., Subramaniam, M., Ingle, J. N., Oursler, M. J., Rajamannan, N. M. & Spelsberg, T. C., Feb 1 2008, In: Journal of cellular biochemistry. 103, 2, p. 383-392 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone
  • Estrogens
  • Transcription Factors
  • Bone and Bones
  • Tissue
  38 Scopus citations

• Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells

  Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In: Journal of cellular biochemistry. 103, 3, p. 896-907 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene expression
  • Response Elements
  • Bone
  • Estrogen Receptors
  • Estrogens
  17 Scopus citations

• Novel pro-survival functions of the kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway

  Bradley, E. W., Ruan, M. M. & Oursler, M. J., Mar 21 2008, In: Journal of Biological Chemistry. 283, 12, p. 8055-8064 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Kruppel-Like Transcription Factors
  • Macrophage Colony-Stimulating Factor
  • MAP Kinase Signaling System
  • Mitogen-Activated Protein Kinase Kinases
  35 Scopus citations

• Osteoclast culture and resorption assays

  Bradley, E. W. & Oursler, M. J., 2008, Osteoporosis: Methods and Protocols. Humana Press, p. 19-35 17 p. (Methods in Molecular Biology; vol. 455).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Osteoclasts
  • Bone and Bones
  • Bone Remodeling
  • Osteolysis
  • Macrophage Colony-Stimulating Factor
  41 Scopus citations

• Osteoclast culture and resorption assays

  Bradley, E. W. & Oursler, M. J., 2008, Methods in Molecular Biology. Vol. 455. p. 19-35 17 p. (Methods in Molecular Biology; vol. 455).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Osteoclasts
  • Bone and Bones
  • Bone Remodeling
  • Osteolysis
  • Macrophage Colony-Stimulating Factor

• PAK1 is a novel MEK-independent Raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival

  Bradley, E. W., Ruan, M. M. & Oursler, M. J., Dec 2008, In: Journal of Cellular Physiology. 217, 3, p. 752-758 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Macrophage Colony-Stimulating Factor
  • Survivin
  • Mitogen-Activated Protein Kinase Kinases
  • Chemical activation
  14 Scopus citations

• Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

  Bradley, E. W., Ruan, M. M., Vrable, A. & Oursler, M. J., Jul 1 2008, In: Journal of cellular biochemistry. 104, 4, p. 1439-1451 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Osteoclasts
  • Macrophage Colony-Stimulating Factor
  • Crosstalk
  • Mitogen-Activated Protein Kinase Kinases
  • Phosphatidylinositol 3-Kinases
  37 Scopus citations

• Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

  Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Dec 30 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20764-20769 6 p.

  Research output: Contribution to journal › Article › peer-review

  • sphingosine 1-phosphate
  • Osteoclasts
  • Chemokines
  • Osteogenesis
  • Osteoblasts
  342 Scopus citations

• Regulation of bone turnover by sex steroids in men

  Sanyal, A., Hoey, K. A., Mödder, U. I., Lamsam, J. L., McCready, L. K., Peterson, J. M., Achenbach, S. J., Oursler, M. J. & Khosla, S., May 2008, In: Journal of Bone and Mineral Research. 23, 5, p. 705-714 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Remodeling
  • Bone Resorption
  • Steroids
  • Follicle Stimulating Hormone
  • Gonadotropin-Releasing Hormone
  23 Scopus citations

• TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

  Gingery, A., Bradley, E. W., Pederson, L., Ruan, M., Horwood, N. J. & Oursler, M. J., Sep 10 2008, In: Experimental Cell Research. 314, 15, p. 2725-2738 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-Activated Protein Kinase Kinases
  • Osteoclasts
  • Phosphotransferases
  • MAP Kinase Kinase Kinases
  • Apoptosis
  135 Scopus citations

• TIEG-null mice display an osteopenic gender-specific phenotype

  Hawse, J. R., Iwaniec, U. T., Bensamoun, S. F., Monroe, D. G., Peters, K. D., Ilharreborde, B., Rajamannan, N. M., Oursler, M. J., Turner, R. T., Spelsberg, T. C. & Subramaniam, M., Jun 2008, In: Bone. 42, 6, p. 1025-1031 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Phenotype
  • Genes
  • Femur
  • Osteoblasts
  • Bone Density
  40 Scopus citations
• 2007

  2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo

  Cicek, M., Iwaniec, U. T., Goblirsch, M. J., Vrabel, A., Ruan, M., Clohisy, D. R., Turner, R. R. & Oursler, M. J., Nov 1 2007, In: Cancer research. 67, 21, p. 10106-10111 6 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-Methoxyestradiol
  • Breast Neoplasms
  • Osteoclasts
  • Bone and Bones
  • Neoplasms
  34 Scopus citations