Research Output per year
Research Output
2019
Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice
Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.Research output: Contribution to journal › Article
Open Access
Erratum to: Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways: Wnt INHIBITS OC DIFFERENTIATION BY CANONICAL/NONCANONICAL PATHWAYS (Journal of Bone and Mineral Research, (2016), 31, 1, (65-75), 10.1002/jbmr.2599)
Weivoda, M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., Jan 1 2019, In : Journal of Bone and Mineral Research.Research output: Contribution to journal › Comment/debate
Open Access
1
Scopus
citations
Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species
Ng, A. Y. H., Li, Z., Jones, M. M., Yang, S., Li, C., Fu, C., Tu, C., Oursler, M. J., Qu, J. & Yang, S., Sep 6 2019, In : eLife. 8Research output: Contribution to journal › Article
Open Access
Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Gαi-ERK Signaling
Li, Z., Liu, T., Gilmore, A., Gómez, N. M., Fu, C., Lim, J., Yang, S., Mitchell, C. H., Li, Y. P., Oursler, M. J. & Yang, S., Jan 1 2019, In : Journal of Bone and Mineral Research.Research output: Contribution to journal › Article
2
Scopus
citations
2017
Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned
Drake, M. M., Clarke, B., Oursler, M. J. & Khosla, S., Aug 1 2017, In : Endocrine Reviews. 38, 4, p. 325-350 26 p.Research output: Contribution to journal › Review article
45
Scopus
citations
Targeting cellular senescence prevents age-related bone loss in mice
Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.Research output: Contribution to journal › Article
171
Scopus
citations
2016
Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling
Carpio, L. R., Bradley, E., McGee-Lawrence, M. E., Weivoda, M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In : Science Signaling. 9, 440, ra79.Research output: Contribution to journal › Article
23
Scopus
citations
Sclerostin expression and functions beyond the osteocyte
Weivoda, M., Youssef, S. J. & Oursler, M. J., Jun 14 2016, (Accepted/In press) In : Bone.Research output: Contribution to journal › Article
20
Scopus
citations
2015
Age Dependence of Estrogen Responsiveness
Judd, J., Kremer, M. & Oursler, M. J., Mar 14 2015, In : Calcified Tissue International. 56, 1, p. S25-S26Research output: Contribution to journal › Article
3
Scopus
citations
Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells
McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., Mc Niven, M. A., Farr, J., Khosla, S., Oursler, M. J. & Westendorf, J. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.Research output: Contribution to journal › Article
27
Scopus
citations
Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation
Weivoda, M., Ruan, M., Pederson, L., Hachfeld, C., Davey, R. A., Zajac, J. D., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.Research output: Contribution to journal › Article
26
Scopus
citations
Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss
Yuan, X., Cao, J., Liu, T., Li, Y. P., Scannapieco, F., He, X., Oursler, M. J., Zhang, X., Vacher, J., Li, C., Olson, D. & Yang, S., Dec 1 2015, In : Cell Death and Differentiation. 22, 12, p. 2046-2057 12 p.Research output: Contribution to journal › Article
17
Scopus
citations
Response to Wnt Signaling Pathways
Oursler, M. J., Westendorf, J. J., Weivoda, M., Ruan, M., Hachfeld, C. M., Howe, A., Davey, R., Zajac, J., Williams, B. O. & Khosla, S., Nov 1 2015, In : Journal of Bone and Mineral Research. 30, 11, p. 2135-2136 2 p.Research output: Contribution to journal › Article
1
Scopus
citations
Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways
Weivoda, M., Ruan, M., Hachfeld, C. M., Pederson, L., Howe, A., Davey, R. A., Zajac, J. D., Kobayashi, Y., Williams, B. O., Westendorf, J. J., Khosla, S. & Oursler, M. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.Research output: Contribution to journal › Article
49
Scopus
citations
2014
Developments in sclerostin biology: Regulation of gene expression, mechanisms of action, and physiological functions
Weivoda, M. M. & Oursler, M. J., Mar 2014, In : Current osteoporosis reports. 12, 1, p. 107-114 8 p.Research output: Contribution to journal › Review article
28
Scopus
citations
2013
MicroRNA functions in osteogenesis and dysfunctions in osteoporosis
Van Wijnen, A. J., Van De Peppel, J., Van Leeuwen, J. P., Lian, J. B., Stein, G. S., Westendorf, J. J., Oursler, M. J., Im, H. J., Taipaleenmäki, H., Hesse, E., Riester, S. & Kakar, S., Jun 1 2013, In : Current osteoporosis reports. 11, 2, p. 72-82 11 p.Research output: Contribution to journal › Article
127
Scopus
citations
Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization
Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Aug 1 2013, In : Journal of cellular biochemistry. 114, 8, p. 1901-1907 7 p.Research output: Contribution to journal › Article
38
Scopus
citations
Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through s1p activation of complementary kinase pathways
Quint, P., Ruan, M., Pederson, L., Kassem, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Feb 22 2013, In : Journal of Biological Chemistry. 288, 8, p. 5398-5406 9 p.Research output: Contribution to journal › Article
39
Scopus
citations
TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts
Ota, K., Quint, P., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3745-3752 8 p.Research output: Contribution to journal › Article
36
Scopus
citations
Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors
Ota, K., Quint, P., Weivoda, M. M., Ruan, M., Pederson, L., Westendorf, J. J., Khosla, S. & Oursler, M. J., Nov 1 2013, In : Bone. 57, 1, p. 68-75 8 p.Research output: Contribution to journal › Article
38
Scopus
citations
2012
Estrogen and the skeleton
Khosla, S., Oursler, M. J. & Monroe, D. G., Nov 1 2012, In : Trends in Endocrinology and Metabolism. 23, 11, p. 576-581 6 p.Research output: Contribution to journal › Review article
234
Scopus
citations
TGF-β mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction
Kumar, A., Ruan, M., Clifton, K., Syed, F., Khosla, S. & Oursler, M. J., Jan 1 2012, In : Endocrinology. 153, 1, p. 254-263 10 p.Research output: Contribution to journal › Article
25
Scopus
citations
Update on Wnt signaling in bone cell biology and bone disease
Monroe, D. G., McGee-Lawrence, M. E., Oursler, M. J. & Westendorf, J. J., Jan 15 2012, In : Gene. 492, 1, p. 1-18 18 p.Research output: Contribution to journal › Review article
264
Scopus
citations
2011
Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women
Mödder, U. I., Roforth, M. M., Hoey, K., McCready, L. K., Peterson, J. M., Monroe, D. G., Oursler, M. J. & Khosla, S., Aug 1 2011, In : Bone. 49, 2, p. 202-207 6 p.Research output: Contribution to journal › Article
56
Scopus
citations
Regulation of circulating sclerostin levels by sex steroids in women and in men
Mödder, U. I., Clowes, J. A., Hoey, K., Peterson, J. M., McCready, L., Oursler, M. J., Riggs, B. L. & Khosla, S., Jan 1 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 27-34 8 p.Research output: Contribution to journal › Article
153
Scopus
citations
TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways
Cicek, M., Vrabel, A., Sturchio, C., Pederson, L., Hawse, J. R., Subramaniam, M., Spelsberg, T. C. & Oursler, M. J., Mar 21 2011, In : PloS one. 6, 3, e17522.Research output: Contribution to journal › Article
37
Scopus
citations
TIEG1/KLF10 modulates runx2 expression and activity in osteoblasts
Hawse, J. R., Cicek, M., Grygo, S. B., Bruinsma, E. S., Rajamannan, N. M., van Wijnen, A. J., Lian, J. B., Stein, G. S., Oursler, M. J., Subramaniam, M. & Spelsberg, T. C., May 13 2011, In : PloS one. 6, 4, e19429.Research output: Contribution to journal › Article
26
Scopus
citations
Wnt10b activates the wnt, notch, and NFIκB pathways in u2os osteosarcoma cells
Mödder, U. I., Oursler, M. J., Khosla, S. & Monroe, D. G., May 1 2011, In : Journal of cellular biochemistry. 112, 5, p. 1392-1402 11 p.Research output: Contribution to journal › Article
40
Scopus
citations
2010
Effects of chronic estrogen treatment on modulating age-related bone loss in female mice
Syed, F. A., Mödder, U. I., Roforth, M., Hensen, I., Fraser, D. G., Peterson, J. M., Oursler, M. J. & Khosla, S., Nov 1 2010, In : Journal of Bone and Mineral Research. 25, 11, p. 2438-2446 9 p.Research output: Contribution to journal › Article
33
Scopus
citations
Recent advances in understanding the mechanisms of osteoclast precursor fusion
Oursler, M. J., Aug 1 2010, In : Journal of cellular biochemistry. 110, 5, p. 1058-1062 5 p.Research output: Contribution to journal › Review article
35
Scopus
citations
TGFβ inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts
Subramaniam, M., Hawse, J. R., Bruinsma, E. S., Grygo, S. B., Cicek, M., Oursler, M. J. & Spelsberg, T. C., Jan 29 2010, In : Biochemical and Biophysical Research Communications. 392, 1, p. 72-76 5 p.Research output: Contribution to journal › Article
22
Scopus
citations
Transforming growth factor-β coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis
Ruan, M., Pederson, L., Bradley, E. W., Bamberger, A. M. & Oursler, M. J., Apr 1 2010, In : Endocrinology. 151, 4, p. 1713-1722 10 p.Research output: Contribution to journal › Article
28
Scopus
citations
2009
Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo
Clowes, J. A., Eghbali-Fatourechi, G. Z., McCready, L., Oursler, M. J., Khosla, S. & Riggs, B. L., May 1 2009, In : Osteoporosis International. 20, 5, p. 761-769 9 p.Research output: Contribution to journal › Article
15
Scopus
citations
2008
Building bone to reverse osteoporosis and repair fractures
Khosla, S., Westendorf, J. J. & Oursler, M. J., Feb 1 2008, In : Journal of Clinical Investigation. 118, 2, p. 421-428 8 p.Research output: Contribution to journal › Review article
273
Scopus
citations
Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women
Syed, F. A., Oursler, M. J., Hefferanm, T. E., Peterson, J. M., Riggs, B. L. & Khosla, S., Sep 1 2008, In : Osteoporosis International. 19, 9, p. 1323-1330 8 p.Research output: Contribution to journal › Article
118
Scopus
citations
Estrogen receptor β isoform-specific induction of transforming growth factor β-inducible early gene-1 in human osteoblast cells: An essential role for the activation function 1 domain
Hawse, J. R., Subramaniam, M., Monroe, D. G., Hemmingsen, A. H., Ingle, J. N., Khosla, S., Oursler, M. J. & Spelsberg, T. C., Jul 1 2008, In : Molecular Endocrinology. 22, 7, p. 1579-1595 17 p.Research output: Contribution to journal › Article
37
Scopus
citations
Estrogen-TGFβ cross-talk in bone and other cell types: Role of TIEG, Runx2, and other transcription factors
Hawse, J. R., Subramaniam, M., Ingle, J. N., Oursler, M. J., Rajamannan, N. M. & Spelsberg, T. C., Feb 1 2008, In : Journal of cellular biochemistry. 103, 2, p. 383-392 10 p.Research output: Contribution to journal › Article
36
Scopus
citations
Loss of ERE binding activity by estrogen receptor-α alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells
Rudnik, V., Sanyal, A., Syed, F. A., Monroe, D. G., Spelsberg, T. C., Oursler, M. J. & Khosla, S., Feb 15 2008, In : Journal of cellular biochemistry. 103, 3, p. 896-907 12 p.Research output: Contribution to journal › Article
15
Scopus
citations
Novel pro-survival functions of the kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway
Bradley, E. W., Ruan, M. M. & Oursler, M. J., Mar 21 2008, In : Journal of Biological Chemistry. 283, 12, p. 8055-8064 10 p.Research output: Contribution to journal › Article
34
Scopus
citations
Osteoclast culture and resorption assays
Bradley, E. W. & Oursler, M. J., 2008, Methods in Molecular Biology. Vol. 455. p. 19-35 17 p. (Methods in Molecular Biology; vol. 455).Research output: Chapter in Book/Report/Conference proceeding › Chapter
Osteoclast culture and resorption assays
Bradley, E. & Oursler, M. J., 2008, Methods in Molecular Biology. Humana Press, Vol. 455. p. 19-35 17 p. (Methods in Molecular Biology; vol. 455).Research output: Chapter in Book/Report/Conference proceeding › Chapter
37
Scopus
citations
PAK1 is a novel MEK-independent Raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival
Bradley, E. W., Ruan, M. M. & Oursler, M. J., Dec 1 2008, In : Journal of Cellular Physiology. 217, 3, p. 752-758 7 p.Research output: Contribution to journal › Article
12
Scopus
citations
Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival
Bradley, E. W., Ruan, M. M., Vrable, A. & Oursler, M. J., Jul 1 2008, In : Journal of cellular biochemistry. 104, 4, p. 1439-1451 13 p.Research output: Contribution to journal › Article
36
Scopus
citations
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S. & Oursler, M. J., Dec 30 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 52, p. 20764-20769 6 p.Research output: Contribution to journal › Article
317
Scopus
citations
Regulation of bone turnover by sex steroids in men
Sanyal, A., Hoey, K. A., Mödder, U. I., Lamsam, J. L., McCready, L. K., Peterson, J. M., Achenbach, S. J., Oursler, M. J. & Khosla, S., May 1 2008, In : Journal of Bone and Mineral Research. 23, 5, p. 705-714 10 p.Research output: Contribution to journal › Article
22
Scopus
citations
TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival
Gingery, A., Bradley, E. W., Pederson, L., Ruan, M., Horwood, N. J. & Oursler, M. J., Sep 10 2008, In : Experimental Cell Research. 314, 15, p. 2725-2738 14 p.Research output: Contribution to journal › Article
122
Scopus
citations
TIEG-null mice display an osteopenic gender-specific phenotype
Hawse, J. R., Iwaniec, U. T., Bensamoun, S. F., Monroe, D. G., Peters, K. D., Ilharreborde, B., Rajamannan, N. M., Oursler, M. J., Turner, R. T., Spelsberg, T. C. & Subramaniam, M., Jun 1 2008, In : Bone. 42, 6, p. 1025-1031 7 p.Research output: Contribution to journal › Article
40
Scopus
citations
2007
2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo
Cicek, M., Iwaniec, U. T., Goblirsch, M. J., Vrabel, A., Ruan, M., Clohisy, D. R., Turner, R. R. & Oursler, M. J., Nov 1 2007, In : Cancer research. 67, 21, p. 10106-10111 6 p.Research output: Contribution to journal › Article
34
Scopus
citations
2006
2-Methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts
Maran, A., Corny, G., Oursler, M. J., Zhang, M., Shogren, K. L., Yaszemski, M. J. & Turner, R. T., Oct 1 2006, In : Journal of cellular biochemistry. 99, 2, p. 425-434 10 p.Research output: Contribution to journal › Article
19
Scopus
citations
Breast cancer bone metastasis and current small therapeutics
Cicek, M. & Oursler, M. J., Dec 1 2006, In : Cancer and Metastasis Reviews. 25, 4, p. 635-644 10 p.Research output: Contribution to journal › Review article
43
Scopus
citations