• 11823 Citations
  • 55 Scopus h-Index
1977 …2019
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Fingerprint Dive into the research topics where Laurence J Miller is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 1 Similar Profiles
Cholecystokinin Receptors Medicine & Life Sciences
Cholecystokinin Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Ligands Medicine & Life Sciences
Secretin Medicine & Life Sciences
Peptides Medicine & Life Sciences
Cholecystokinin A Receptor Medicine & Life Sciences
Labeling Chemical Compounds

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Projects 1983 2016

Ligands
Mutagenesis
G-Protein-Coupled Receptors
GTP-Binding Proteins
Molecular Models

GASTROINTESTINAL FUNCTIONS: NEUROPEPTIDERGIC CONTROL

Miller, L. J., [No Value], V. L. W., Zinsmeister, A. R., La Russo, N. F., Szurszewski, J. H., Kelly, K., Malagelada, J., [No Value], V. L. W., Yaksh, T. & Phillips, S.

National Institutes of Health

9/30/8411/30/90

Project: Research project

GASTROINTESTINAL FUNCTIONS: NEUROPEPTIDERGIC CONTROL

Miller, L. J., [No Value], V. L. W., Zinsmeister, A. R., Kelly, K., Larusso, N., Malagelada, J., Szurszewski, J., [No Value], V. L. W., Yaksh, T., Phillips, S. & La Russo, N. F.

National Institutes of Health

9/30/8411/30/85

Project: Research project

Research Output 1977 2019

Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Tüzmen, Ş., Hostetter, G., Watanabe, A., Ekmekçi, C., Carrigan, P. E., Shechter, I., Kallioniemi, O., Miller, L. J. & Mousses, S., Jan 1 2019, In : Personalized Medicine. 16, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

Transferases
Neoplasms
Cholesterol
Enzymes
Metabolic Networks and Pathways

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., Mar 1 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticle

Cholecystokinin
Structure-Activity Relationship
Cholecystokinin Receptors
Peptides
Structural Models
6 Citations (Scopus)
Metabolic Diseases
G-Protein-Coupled Receptors
Cell Membrane
Membranes
Allosteric Regulation
16 Citations (Scopus)

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Liang, Y. L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., Sep 27 2018, In : Nature. 561, 7724, p. 492-497 6 p.

Research output: Contribution to journalArticle

Calcitonin Receptor-Like Protein
Calcitonin Gene-Related Peptide Receptors
Receptor Activity-Modifying Protein 1
Calcitonin Gene-Related Peptide
G-Protein-Coupled Receptors
10 Citations (Scopus)

Crystal structure of the Frizzled 4 receptor in a ligand-free state

Yang, S., Wu, Y., Xu, T. H., de Waal, P. W., He, Y., Pu, M., Chen, Y., DeBruine, Z. J., Zhang, B., Zaidi, S. A., Popov, P., Guo, Y., Han, G. W., Lu, Y., Suino-Powell, K., Dong, S., Harikumar, K. G., Miller, L. J., Katritch, V., Xu, H. E. & 5 others, Shui, W., Stevens, R. C., Melcher, K., Zhao, S. & Xu, F., Aug 30 2018, In : Nature. 560, 7720, p. 666-670 5 p.

Research output: Contribution to journalLetter

Frizzled Receptors
G-Protein-Coupled Receptors
Ligands
Gatekeeping
Mediator Complex