Laurence J Miller, MD

Miller, L. J., [No Value], V. L. W., Zinsmeister, A. R., La Russo, N. F., Szurszewski, J. H., Kelly, K., Malagelada, J., [No Value], V. L. W., Yaksh, T. & Phillips, S.

National Institutes of Health

9/30/84 → 11/30/90

Project: Research project › Center Core Grants

GASTROINTESTINAL FUNCTIONS: NEUROPEPTIDERGIC CONTROL

Miller, L. J., [No Value], V. L. W., Zinsmeister, A. R., Kelly, K., Larusso, N., Malagelada, J., Szurszewski, J., [No Value], V. L. W., Yaksh, T., Phillips, S. & La Russo, N. F.

National Institutes of Health

9/30/84 → 11/30/85

Project: Research project › Center Core Grants

Research Output 1977 2019

11366 Citations
53 h-Index
347 Article
4 Chapter
3 Conference contribution
2 Review article
1 More
- 1 Letter

Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Tüzmen, Ş., Hostetter, G., Watanabe, A., Ekmekçi, C., Carrigan, P. E., Shechter, I., Kallioniemi, O., Miller, L. J. & Mousses, S., Jan 1 2019, In : Personalized Medicine. 16, 1, p. 51-65 15 p.

Research output: Contribution to journal › Article

Transferases

Neoplasms

Cholesterol

Enzymes

Metabolic Networks and Pathways

2 Citations

Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function

Desai, A. J. & Miller, L. J., Nov 1 2018, In : British Journal of Pharmacology. 175, 21, p. 4009-4025 17 p.

Research output: Contribution to journal › Review article

Metabolic Diseases

G-Protein-Coupled Receptors

Cell Membrane

Membranes

Allosteric Regulation

2 Citations

Cryo-EM structure of the active, G_s-protein complexed, human CGRP receptor

Liang, Y. L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., Sep 27 2018, In : Nature. 561, 7724, p. 492-497 6 p.

Research output: Contribution to journal › Article

Calcitonin Receptor-Like Protein

Calcitonin Gene-Related Peptide Receptors

Receptor Activity-Modifying Protein 1

Calcitonin Gene-Related Peptide

G-Protein-Coupled Receptors

2 Citations

Crystal structure of the Frizzled 4 receptor in a ligand-free state

Yang, S., Wu, Y., Xu, T. H., de Waal, P. W., He, Y., Pu, M., Chen, Y., DeBruine, Z. J., Zhang, B., Zaidi, S. A., Popov, P., Guo, Y., Han, G. W., Lu, Y., Suino-Powell, K., Dong, S., Harikumar, K. G., Miller, L. J., Katritch, V., Xu, H. E. & 5 othersShui, W., Stevens, R. C., Melcher, K., Zhao, S. & Xu, F., Aug 30 2018, In : Nature. 560, 7720, p. 666-670 5 p.

Research output: Contribution to journal › Letter

Frizzled Receptors

G-Protein-Coupled Receptors

Ligands

Gatekeeping

Mediator Complex

28 Citations

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., Mar 1 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journal › Article

Glucagon-Like Peptide 1

GTP-Binding Proteins

Peptides

G-Protein-Coupled Receptors

Type 2 Diabetes Mellitus