• 12377 Citations
  • 56 Scopus h-Index
1977 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., Jan 16 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Structural basis for allosteric modulation of class b g protein-coupled receptors

Wootten, D. & Miller, L. J., Jan 6 2020, In : Annual Review of Pharmacology and Toxicology. 60, p. 89-107 19 p.

Research output: Contribution to journalReview article

3 Scopus citations
2019

Characterization of farnesyl diphosphate farnesyl transferase 1 expression in cancer

Tüzmen, Ş., Hostetter, G., Watanabe, A., Ekmekçi, C., Carrigan, P. E., Shechter, I., Kallioniemi, O., Miller, L. J. & Mousses, S., Jan 1 2019, In : Personalized Medicine. 16, 1, p. 51-65 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., Mar 1 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticle

2018
7 Scopus citations

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Liang, Y. L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., Sep 27 2018, In : Nature. 561, 7724, p. 492-497 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Crystal structure of the Frizzled 4 receptor in a ligand-free state

Yang, S., Wu, Y., Xu, T. H., de Waal, P. W., He, Y., Pu, M., Chen, Y., DeBruine, Z. J., Zhang, B., Zaidi, S. A., Popov, P., Guo, Y., Han, G. W., Lu, Y., Suino-Powell, K., Dong, S., Harikumar, K. G., Miller, L. J., Katritch, V., Xu, H. E. & 5 others, Shui, W., Stevens, R. C., Melcher, K., Zhao, S. & Xu, F., Aug 30 2018, In : Nature. 560, 7720, p. 666-670 5 p.

Research output: Contribution to journalLetter

19 Scopus citations

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., Mar 1 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticle

92 Scopus citations
2017

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., Jan 11 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview article

37 Scopus citations

Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype

Desai, A. J., Dong, M., Langlais, B. T., Dueck, A. & Miller, L. J., Aug 1 2017, In : American Journal of Clinical Nutrition. 106, 2, p. 447-456 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Coexpressed class B G protein-coupled secretin and GLP-1 receptors self-and cross-associate: Impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., Jun 1 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticle

5 Scopus citations

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites

Yan, Y., Xu, T. H., Harikumar, K. G., Miller, L. J., Melcher, K. & Xu, H. E., Sep 22 2017, In : Journal of Biological Chemistry. 292, 38, p. 15826-15837 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Liang, Y. L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D. M., Furness, S. G. B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L. J., Christopoulos, A., Kobilka, B. K., Wootten, D., Skiniotis, G. & Sexton, P. M., Jun 1 2017, In : Nature. 546, 7656, p. 118-123 6 p.

Research output: Contribution to journalArticle

199 Scopus citations

Secretin receptor dimerization. Prototypic of class B GPCR behavior

Harikumar, K. G. & Miller, L. J., Jan 1 2017, Receptors. Humana Press Inc., p. 273-287 15 p. (Receptors; vol. 33).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor

Ward, R. J., Pediani, J. D., Harikumar, K. G., Miller, L. J. & Milligan, G., Jun 1 2017, In : Biochemical Journal. 474, 11, p. 1879-1895 17 p.

Research output: Contribution to journalArticle

12 Scopus citations

Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells

Ramil, C. P., Dong, M., An, P., Lewandowski, T. M., Yu, Z., Miller, L. J. & Lin, Q., Sep 27 2017, In : Journal of the American Chemical Society. 139, 38, p. 13376-13386 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

CGTP Collaborators, Dec 1 2017, In : British Journal of Pharmacology. 174, p. S1-S16

Research output: Contribution to journalArticle

149 Scopus citations

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

DeBruine, Z. J., Ke, J., Harikumar, K. G., Gu, X., Borowsky, P., Williams, B. O., Xu, W., Miller, L. J., Xu, H. E. & Melcher, K., 2017, In : Genes and Development. 31, 9, p. 916-926 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2016

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: Lessons from class B crystal structuress

Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., Mar 1 2016, In : Molecular Pharmacology. 89, 3, p. 335-347 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Glucagon-like peptide-1 and its class B G protein-coupled receptors: A long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J. M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M. W., Oct 1 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticle

65 Scopus citations

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., Oct 15 2016, In : Biochemical Pharmacology. 118, p. 68-87 20 p.

Research output: Contribution to journalArticle

18 Scopus citations

Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target

Miller, L. J. & Desai, A. J., 2016, (Accepted/In press) In : Trends in Endocrinology and Metabolism.

Research output: Contribution to journalArticle

12 Scopus citations

Signaling modification by GPCR heteromer and its implication on X-linked nephrogenic diabetes insipidus

Ng, H. K. H., Harikumar, K. G., Miller, L. J. & Chow, B. K. C., Sep 1 2016, In : PLoS One. 11, 9, e0163086.

Research output: Contribution to journalArticle

Structure and function of Cross-class complexes of G Protein-Coupled secretin and angiotensin 1a receptors

Harikumar, K. G., Augustine, M. L., Lee, L. T. O., Chow, B. K. C. & Miller, L. J., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 17332-17344 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Koole, C., Savage, E. E., Pabreja, K., Simms, J., Sridhar, R., Furness, S. G. B., Liu, M., Thompson, P. E., Miller, L. J., Christopoulos, A. & Sexton, P. M., Jun 16 2016, In : Cell. 165, 7, p. 1632-1643 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Use of cysteine trapping to map spatial approximations between residues contributing to the helix N-capping motif of secretin and distinct residues within each of the extracellular loops of its receptor

Dong, M., Lam, P. C. H., Orry, A., Sexton, P. M., Christopoulos, A., Abagyan, R. & Miller, L. J., Mar 4 2016, In : Journal of Biological Chemistry. 291, 10, p. 5172-5184 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol

Desai, A. J., Dong, M. & Miller, L. J., Sep 10 2015, (Accepted/In press) In : Clinical Nutrition.

Research output: Contribution to journalArticle

9 Scopus citations

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Dong, M., Vattelana, A. M., Lam, P. C. H., Orry, A. J., Abagyan, R., Christopoulos, A., Sexton, P. M., Haines, D. R. & Miller, L. J., Jan 1 2015, In : Molecular Pharmacology. 87, 1, p. 130-140 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allosterys

Koole, C., Wootten, D., Simms, J., Miller, L. J., Christopoulos, A. & Sexton, P. M., Apr 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
7 Scopus citations
7 Scopus citations

Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex

Desai, A. J., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P. M. & Miller, L. J., Dec 24 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9562-9577 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

The Concise Guide to PHARMACOLOGY 2015/16: Overview

CGTP Collaborators, Dec 1 2015, In : British Journal of Pharmacology. 172, 24, p. 5729-5743 15 p.

Research output: Contribution to journalReview article

Open Access
148 Scopus citations

Use of fluorescence indicators in receptor ligands

Harikumar, K. G. & Miller, L. J., 2015, In : Methods in Molecular Biology. 1335, p. 115-130 16 p.

Research output: Contribution to journalArticle

2014

A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment

Desai, A. J., Harikumar, K. G. & Miller, L. J., Jun 27 2014, In : Journal of Biological Chemistry. 289, 26, p. 18314-18326 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs

Dong, M., Koole, C., Wootten, D., Sexton, P. M. & Miller, L. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1085-1101 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex

Lee, L. T. O., Ng, S. Y. L., Chu, J. Y. S., Sekar, R., Harikumar, K. G., Miller, L. J. & Chow, B. K. C., 2014, In : FASEB Journal. 28, 6, p. 2632-2644 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013
3 Scopus citations

Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity

Dong, M., Pinon, D. I. & Miller, L. J., Jan 2013, In : Regulatory Peptides. 180, 1, p. 5-11 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young

Lomberk, G., Grzenda, A., Mathison, A., Escande, C., Zhang, J. S., Calvo, E., Miller, L. J., Iovanna, J., Chini, E. N., Fernandez-Zapico, M. E. & Urrutia, R., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17745-17758 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: Use of cell lines with elevated cholesterol

Harikumar, K. G., Potter, R. M., Patil, A., Echeveste, V. & Miller, L. J., Mar 2013, In : Lipids. 48, 3, p. 231-244 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: Implications for drug discovery

Koole, C., Savage, E. E., Christopoulos, A., Miller, L. J., Sexton, P. M. & Wootten, D., Aug 1 2013, In : Molecular Endocrinology. 27, 8, p. 1234-1244 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B. R., Abagyan, R., Christopoulos, A., Sexton, P. M. & Miller, L. J., Jul 19 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082-21095 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular basis of peptide activation of the GLP-1 receptor

Miller, L. J., Apr 2013, In : Molecular Metabolism. 2, 2, p. 60-61 2 p.

Research output: Contribution to journalArticle

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Wootten, D., Simms, J., Miller, L. J., Christopoulos, A. & Sexton, P. M., Mar 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 13, p. 5211-5216 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

Koole, C., Pabreja, K., Savage, E. E., Wootten, D., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., Feb 2013, In : Biochemical Society Transactions. 41, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT(a) function

Qi, T., Dong, M., Watkins, H. A., Wootten, D., Miller, L. J. & Hay, D. L., Feb 2013, In : British Journal of Pharmacology. 168, 3, p. 644-657 14 p.

Research output: Contribution to journalArticle

23 Scopus citations

Secretin

Miller, L. J., 2013, Handbook of Biologically Active Peptides. Elsevier Inc., p. 1314-1319 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

Ke, J., Harikumar, K. G., Erice, C., Chen, C., Gu, X., Wang, L., Parker, N., Cheng, Z., Xu, W., Williams, B. O., Melcher, K., Miller, L. J. & Eric Xu, H., Nov 1 2013, In : Genes and Development. 27, 21, p. 2305-2319 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor

Miller, L. J. & Dong, M., Feb 2013, In : Biochemical Society Transactions. 41, 1, p. 154-158 5 p.

Research output: Contribution to journalArticle

3 Scopus citations