Khashayarsha Khazaie, PhD

  • 8213 Citations
  • 46 Scopus h-Index
1984 …2020

Research output per year

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Research Output

  • 8213 Citations
  • 46 Scopus h-Index
  • 95 Article
  • 10 Review article
  • 4 Comment/debate
  • 1 Chapter
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Article

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R. & Mohamadzadeh, M., Jun 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10462-10467 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis

Bishehsari, F., Engen, P. A., Voigt, R. M., Swanson, G., Shaikh, M., Wilber, S., Naqib, A., Green, S. J., Shetuni, B., Forsyth, C. B., Saadalla, A., Osman, A., Hamaker, B. R., Keshavarzian, A. & Khazaie, K., 2020, In : CMGH. 9, 2, p. 219-237 19 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias

Miyoshi, K., Shillingford, J. M., Le Provost, F., Gounari, F., Bronson, R., Von Boehmer, H., Taketo, M. M., Cardiff, R. D., Hennighausen, L. & Khazaie, K., Jan 8 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 1, p. 219-224 6 p.

Research output: Contribution to journalArticle

101 Scopus citations

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

159 Scopus citations

Antigen-loaded dendritic cell migration: MR imaging in a pancreatic carcinoma model

Zhang, Z., Li, W., Procissi, D., Li, K., Sheu, A. Y., Gordon, A. C., Guo, Y., Khazaie, K., Huan, Y., Han, G. & Larson, A. C., Jan 1 2015, In : Radiology. 274, 1, p. 192-200 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

Bonertz, A., Weitz, J., Pietsch, D. H. K., Rahbari, N. N., Schlude, C., Ge, Y., Juenger, S., Vlodavsky, I., Khazaie, K., Jaeger, D., Reissfelder, C., Antolovic, D., Aigner, M., Koch, M. & Beckhove, P., Nov 2 2009, In : Journal of Clinical Investigation. 119, 11, p. 3311-3321 11 p.

Research output: Contribution to journalArticle

159 Scopus citations

Cathepsin B is involved in the trafficking of TNF-α-containing vesicles to the plasma membrane in macrophages

Ha, S. D., Martins, A., Khazaie, K., Han, J., Chan, B. M. C. & Kim, S. O., 2008, In : Journal of Immunology. 181, 1, p. 690-697 8 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Cathepsin B is not the processing enzyme for mouse prorenin

Mercure, C., Lacombe, M. J., Khazaie, K. & Reudelhuber, T. L., May 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 5, p. R1212-R1216

Research output: Contribution to journalArticle

13 Scopus citations

Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer

Saadalla, A., Lima, M. M., Tsai, F., Osman, A., Singh, M. P., Linden, D. R., Dennis, K. L., Haeryfar, S. M. M., Gurish, M. F., Gounari, F. & Khazaie, K., Dec 3 2019, In : Frontiers in immunology. 10, 2777.

Research output: Contribution to journalArticle

Open Access

c-Myc mediates pre-TCR-induced proliferation but not developmental progression

Dose, M., Khan, I., Guo, Z., Kovalovsky, D., Krueger, A., Von Boehmer, H., Khazaie, K. & Gounari, F., Oct 15 2006, In : Blood. 108, 8, p. 2669-2677 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures

Sobhani, I., Bergsten, E., Couffin, S., Amiot, A., Nebbad, B., Barau, C., de’Angelis, N., Rabot, S., Canoui-Poitrine, F., Mestivier, D., Pédron, T., Khazaie, K. & Sansonetti, P. J., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24285-24295 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression

Strouch, M. J., Cheon, E. C., Salabat, M. R., Krantz, S. B., Gounaris, E., Melstrom, L. G., Dangi-Garimella, S., Wang, E., Munshi, H. G., Khazaie, K. & Bentrem, D. J., Apr 15 2010, In : Clinical Cancer Research. 16, 8, p. 2257-2265 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe

Chen, W. T., Khazaie, K., Zhang, G., Weissleder, R. & Tung, C. H., Dec 1 2005, In : Molecular Imaging. 4, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice

Marten, K., Bremer, C., Khazaie, K., Sameni, M., Sloane, B., Tung, C. H. & Weissleder, R., Jan 1 2002, In : Gastroenterology. 122, 2, p. 406-414 9 p.

Research output: Contribution to journalArticle

185 Scopus citations

Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis

Bishehsari, F., Engen, P. A., Preite, N. Z., Tuncil, Y. E., Naqib, A., Shaikh, M., Rossi, M., Wilber, S., Green, S. J., Hamaker, B. R., Khazaie, K., Voigt, R. M., Forsyth, C. B. & Keshavarzian, A., Feb 16 2018, In : Genes. 9, 2, 102.

Research output: Contribution to journalArticle

41 Scopus citations

Differential expression of human globin genes introduced in K562 cells.

Kioussis, D., Wilson, F., Khazaie, K. & Grosveld, F., Apr 1985, In : The EMBO journal. 4, 4, p. 927-931 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Direct Presentation of Antigen by Lymph Node Stromal Cells Protects Against CD8 T-Cell-Mediated Intestinal Autoimmunity

Magnusson, F. C., Liblau, R. S., von Boehmer, H., Pittet, M. J., Lee, J. W., Turley, S. J. & Khazaie, K., Apr 2008, In : Gastroenterology. 134, 4, p. 1028-1037 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

EblacZ tumor dormancy in bone marrow and lymph nodes: Active control of proliferating tumor cells by CD8+ immune T cells

Müller, M., Gounari, F., Prifti, S., Hacker, H. J., Schirrmacher, V. & Khazaie, K., Dec 1 1998, In : Cancer research. 58, 23, p. 5439-5446 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector

Fuerstenberg, S., Beug, H., Introna, M., Khazaie, K., Munoz, A., Ness, S., Nordstrom, K., Sap, J., Stanley, I., Zenke, M. & Vennstrom, B., 1990, In : Journal of virology. 64, 12, p. 5891-5902 12 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

EGF promotes in vivo tumorigenic growth of primary chicken embryo fibroblasts expressing v-myc and enhances in vitro transformation by the v-erbA oncogene

Khazaie, K., Panayotou, G., Aguzzi, A., Samarut, J., Gazzolo, L. & Jurdic, P., Feb 7 1991, In : Oncogene. 6, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

EGF receptor in neoplasia and metastasis

Khazaie, K., Schirrmacher, V. & Lichtner, R. B., Sep 1993, In : Cancer and Metastasis Reviews. 12, 3-4, p. 255-274 20 p.

Research output: Contribution to journalArticle

261 Scopus citations

Epigenetic therapy: Novel translational implications for arrest of environmental dioxin-Induced disease in females

Khan, Z., Zheng, Y., Jones, T. L., Delaney, A. A., Correa, L. F., Shenoy, C. C., Khazaie, K. & Daftary, G. S., Jan 1 2018, In : Endocrinology. 159, 1, p. 477-489 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ethanol-Induced Mast Cell-Mediated Inflammation Leads to Increased Susceptibility of Intestinal Tumorigenesis in the APCΔ468 Min Mouse Model of Colon Cancer

Wimberly, A. L., Forsyth, C. B., Khan, M. W., Pemberton, A., Khazaie, K. & Keshavarzian, A., Jan 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, SUPPL.1, p. E199-E208

Research output: Contribution to journalArticle

25 Scopus citations

Expression of epidermal growth factor receptor correlates with metastatic potential of 13762NF rat mammary adenocarcinoma cells

Kaufmann, A. M., Khazaie, K., Wiedemuth, M., Rohde-Schulz, B., Ullrich, A., Schirrmacher, V. & Lichtner, R. B., 1994, In : International journal of oncology. 4, 6, p. 1149-1155 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., Halverson, A. L., Stryker, S. J., Boller, A. M., Singal, A., Sneed, R. K., Sarraj, B., Ansari, M. J., Oft, M., Iwakura, Y., Zhou, L. & 4 others, Bonertz, A., Beckhove, P., Gounari, F. & Khazaie, K., Dec 12 2012, In : Science translational medicine. 4, 164

Research output: Contribution to journalArticle

116 Scopus citations

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

Cabarrocas, J., Cassan, C., Magnusson, F., Piaggio, E., Mars, L., Derbinski, J., Kyewski, B., Gross, D. A., Salomon, B. L., Khazaie, K., Saoudi, A. & Liblau, R. S., May 30 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 22, p. 8453-8458 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Ganciclovir uptake in human mammary carcinoma cells expressing herpes simplex virus thymidine kinase

Haberkorn, U., Khazaie, K., Morr, I., Altmann, A., Müller, M. & Van Kaick, G., May 1 1998, In : Nuclear Medicine and Biology. 25, 4, p. 367-373 7 p.

Research output: Contribution to journalArticle

46 Scopus citations

Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants.

Gounari, F., Banks, G. R., Khazaie, K., Jeggo, P. A. & Holliday, R., Nov 1987, In : Genes & development. 1, 9, p. 899-912 14 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Gene transfer and genetic modification of embryonic stem cells by Cre- and Cre-PR-expressing MESV-based retroviral vectors

Psarras, S., Karagianni, N., Kellendonk, C., Tronche, F., Cosset, F. L., Stocking, C., Schirrmacher, V., von Boehmer, H. & Khazaie, K., Jan 1 2004, In : Journal of Gene Medicine. 6, 1, p. 32-42 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human T cell leukemia virus-I (HTLV-I) tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state

Los, M., Khazaie, K., Schulze-Osthoff, K., Baeuerle, P. A., Schirrmacher, V. & Chlichlia, K., Sep 15 1998, In : Journal of Immunology. 161, 6, p. 3050-3055 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Human T cell leukemia virus type I tax enhances IL-4 gene expression in T cells

Li-Weber, M., Giaisi, M., Chlichlia, K., Khazaie, K. & Krammer, P. H., Oct 8 2001, In : European Journal of Immunology. 31, 9, p. 2623-2632 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

ICE-proteases mediate HTLV-I tax-induced apoptotic T-cell death

Chlichlia, K., Busslinger, M., Peter, M. E., Walczak, H., Krammer, P. H., Schirrmacher, V. & Khazaie, K., Jan 1 1997, In : Oncogene. 14, 19, p. 2265-2272 8 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis

Chlichlia, K., Moldenhauer, G., Daniel, P. T., Busslinger, M., Gazzolo, L., Schirrmacher, V. & Khazaie, K., Jan 1 1995, In : Oncogene. 10, 2, p. 269-277 9 p.

Research output: Contribution to journalArticle

83 Scopus citations

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

Blatner, N. R., Bonertz, A., Beckhove, P., Cheon, E. C., Krantz, S. B., Strouch, M., Weitz, J., Koch, M., Halverson, A. L., Bentrem, D. J. & Khazaie, K., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6430-6435 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Inducing and expanding regulatory T cell populations by foreign antigen

Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C. & von Boehmer, H., Dec 1 2005, In : Nature immunology. 6, 12, p. 1219-1227 9 p.

Research output: Contribution to journalArticle

951 Scopus citations

Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis

Kaufmann, A. M., Lichtner, R. B., Schirrmacher, V. & Khazaie, K., 1996, In : Oncogene. 13, 11, p. 2349-2358 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

Klein, L., Khazaie, K. & Von Boehmer, H., Jul 22 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 15, p. 8886-8891 6 p.

Research output: Contribution to journalArticle

337 Scopus citations

KLF10 mediated epigenetic dysregulation of epithelial CD40/CD154 promotes endometriosis

Delaney, A. A., Khan, Z., Zheng, Y., Correa, L. F., Zanfagnin, V., Shenoy, C. C., Schoolmeester, J. K., Saadalla, A. M., El-Nashar, S., Famuyide, A. O., Subramaniam, M., Hawse, J. R., Khazaie, K. & Daftary, G. S., Sep 1 2016, In : Biology of Reproduction. 95, 3, 62.

Research output: Contribution to journalArticle

9 Scopus citations

Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation

Lichtner, R. B., Wiedemuth, M., Kittmann, A., Ullrich, A., Schirrmacher, V. & Khazaie, K., Jan 1 1992, In : Journal of Biological Chemistry. 267, 17, p. 11872-11880 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells

Lichtner, R. B., Kaufmann, A. M., Kittmann, A., Rohde-Schulz, B., Walter, J., Williams, L., Ullrich, A., Schirrmacher, V. & Khazaie, K., 1995, In : Oncogene. 10, 9, p. 1823-1832 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Light/dark shifting promotes alcohol-induced colon carcinogenesis: Possible role of intestinal inflammatory milieu and microbiota

Bishehsari, F., Saadalla, A., Khazaie, K., Engen, P. A., Voigt, R. M., Shetuni, B. B., Forsyth, C., Shaikh, M., Vitaterna, M. H., Turek, F. & Keshavarzian, A., Dec 2 2016, In : International journal of molecular sciences. 17, 12, 2017.

Research output: Contribution to journalArticle

23 Scopus citations

Lines of Murine Oligodendroglial Precursor Cells Immortalized by an Activated neu Tyrosine Kinase Show Distinct Degrees of Interaction with Axons In Vitro and In Vivo

Jung, M., Krämer, E., Grzenkowski, M., Tang, K., Blakemore, W., Aguzzi, A., Khazaie, K., Chlichlia, K., von Blankenfeld, G., Kettenmann, H. & Trotter, J., Jun 1995, In : European Journal of Neuroscience. 7, 6, p. 1245-1265 21 p.

Research output: Contribution to journalArticle

183 Scopus citations

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth

Gounaris, E., Tung, C. H., Restaino, C., Maehr, R., Kohler, R., Joyce, J. A., Plough, H. L., Barrett, T. A., Weissleder, R. & Khazaie, K., Aug 13 2008, In : PloS one. 3, 8, e2916.

Research output: Contribution to journalArticle

85 Scopus citations

Loss of adenomatous polyposis coli gene function disrupts thymic development

Gounari, F., Chang, R., Cowan, J., Guo, Z., Dose, M., Gounaris, E. & Khazaie, K., Aug 1 2005, In : Nature immunology. 6, 8, p. 800-809 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation

Principe, D. R., DeCant, B., Staudacher, J., Vitello, D., Mangan, R. J., Wayne, E. A., Mascariñas, E., Diaz, A. M., Bauer, J., McKinney, R. D., Khazaie, K., Pasche, B., Dawson, D. W., Munshi, H. G., Grippo, P. J. & Jung, B., 2017, In : Oncotarget. 8, 3, p. 3826-3839 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APC Δ468 mice

Cheon, E. C., Khazaie, K., Khan, M. W., Strouch, M. J., Krantz, S. B., Phillips, J., Blatner, N. R., Hix, L. M., Zhang, M., Dennis, K. L., Salabat, M. R., Heiferman, M., Grippo, P. J., Munshi, H. G., Gounaris, E. & Bentrem, D. J., Mar 1 2011, In : Cancer research. 71, 5, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Mast cells are an essential hematopoietic component for polyp development

Gounaris, E., Erdman, S. E., Restaino, C., Gurish, M. F., Friend, D. S., Gounari, F., Lee, D. M., Zhang, G., Glickman, J. N., Shin, K., Rao, V. P., Poutahidis, T., Weissleder, R., McNagny, K. M. & Khazaie, K., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19977-19982 6 p.

Research output: Contribution to journalArticle

189 Scopus citations

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner

Saadalla, A. M., Osman, A., Gurish, M. F., Dennis, K. L., Blatner, N. R., Pezeshki, A., McNagny, K. M., Cheroutre, H., Gounari, F. & Khazaie, K., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1588-1592 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis

Brown, J. B., Lee, G., Managlia, E., Grimm, G. R., Dirisina, R., Goretsky, T., Cheresh, P., Blatner, N. R., Khazaie, K., Yang, G. Y., Li, L. & Barrett, T. A., Feb 2010, In : Gastroenterology. 138, 2, p. 595-605.e3

Research output: Contribution to journalArticle

53 Scopus citations

Methods for the study of mast cells in cancer

Blatner, N. R., Tsai, F. & Khazaie, K., 2015, In : Methods in Molecular Biology. 1220, p. 443-460 18 p.

Research output: Contribution to journalArticle