Khashayarsha Khazaie, PhD

  • 8137 Citations
  • 46 Scopus h-Index
1984 …2020

Research output per year

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Research Output

  • 8137 Citations
  • 46 Scopus h-Index
  • 95 Article
  • 10 Review article
  • 4 Comment/debate
  • 1 Chapter
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Article
2020

Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis

Bishehsari, F., Engen, P. A., Voigt, R. M., Swanson, G., Shaikh, M., Wilber, S., Naqib, A., Green, S. J., Shetuni, B., Forsyth, C. B., Saadalla, A., Osman, A., Hamaker, B. R., Keshavarzian, A. & Khazaie, K., 2020, In : CMGH. 9, 2, p. 219-237 19 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer

Saadalla, A., Lima, M. M., Tsai, F., Osman, A., Singh, M. P., Linden, D. R., Dennis, K. L., Haeryfar, S. M. M., Gurish, M. F., Gounari, F. & Khazaie, K., Dec 3 2019, In : Frontiers in immunology. 10, 2777.

Research output: Contribution to journalArticle

Open Access

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures

Sobhani, I., Bergsten, E., Couffin, S., Amiot, A., Nebbad, B., Barau, C., de’Angelis, N., Rabot, S., Canoui-Poitrine, F., Mestivier, D., Pédron, T., Khazaie, K. & Sansonetti, P. J., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24285-24295 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis

Bishehsari, F., Engen, P. A., Preite, N. Z., Tuncil, Y. E., Naqib, A., Shaikh, M., Rossi, M., Wilber, S., Green, S. J., Hamaker, B. R., Khazaie, K., Voigt, R. M., Forsyth, C. B. & Keshavarzian, A., Feb 16 2018, In : Genes. 9, 2, 102.

Research output: Contribution to journalArticle

41 Scopus citations

Epigenetic therapy: Novel translational implications for arrest of environmental dioxin-Induced disease in females

Khan, Z., Zheng, Y., Jones, T. L., Delaney, A. A., Correa, L. F., Shenoy, C. C., Khazaie, K. & Daftary, G. S., Jan 1 2018, In : Endocrinology. 159, 1, p. 477-489 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner

Saadalla, A. M., Osman, A., Gurish, M. F., Dennis, K. L., Blatner, N. R., Pezeshki, A., McNagny, K. M., Cheroutre, H., Gounari, F. & Khazaie, K., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1588-1592 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes

Emmanuel, A. O., Arnovitz, S., Haghi, L., Mathur, P. S., Mondal, S., Quandt, J., Okoreeh, M. K., Maienschein-Cline, M., Khazaie, K., Dose, M. & Gounari, F., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1366-1378 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation

Principe, D. R., DeCant, B., Staudacher, J., Vitello, D., Mangan, R. J., Wayne, E. A., Mascariñas, E., Diaz, A. M., Bauer, J., McKinney, R. D., Khazaie, K., Pasche, B., Dawson, D. W., Munshi, H. G., Grippo, P. J. & Jung, B., Jan 1 2017, In : Oncotarget. 8, 3, p. 3826-3839 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment

Shaler, C. R., Tun-Abraham, M. E., Skaro, A. I., Khazaie, K., Corbett, A. J., Mele, T., Hernandez-Alejandro, R. & Haeryfar, S. M. M., Aug 10 2017, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-13 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Memarnejadian, A., Meilleur, C. E., Shaler, C. R., Khazaie, K., Bennink, J. R., Schell, T. D. & Haeryfar, S. M. M., Nov 1 2017, In : Journal of Immunology. 199, 9, p. 3348-3359 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Progressive Fibrosis: A Progesterone-and KLF11-Mediated Sexually Dimorphic Female Response

Shenoy, C. C., Khan, Z., Zheng, Y., Jones, T. L., Khazaie, K. & Daftary, G. S., Oct 1 2017, In : Endocrinology. 158, 10, p. 3605-3619 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer

Khan, M. W., Saadalla, A., Ewida, A. H., Al-Katranji, K., Al-Saoudi, G., Giaccone, Z. T., Gounari, F., Zhang, M., Frank, D. A. & Khazaie, K., Sep 5 2017, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-11 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2016

KLF10 mediated epigenetic dysregulation of epithelial CD40/CD154 promotes endometriosis

Delaney, A. A., Khan, Z., Zheng, Y., Correa, L. F., Zanfagnin, V., Shenoy, C. C., Schoolmeester, J. K., Saadalla, A. M., El-Nashar, S., Famuyide, A. O., Subramaniam, M., Hawse, J. R., Khazaie, K. & Daftary, G. S., Sep 1 2016, In : Biology of Reproduction. 95, 3, 62.

Research output: Contribution to journalArticle

9 Scopus citations

Light/dark shifting promotes alcohol-induced colon carcinogenesis: Possible role of intestinal inflammatory milieu and microbiota

Bishehsari, F., Saadalla, A., Khazaie, K., Engen, P. A., Voigt, R. M., Shetuni, B. B., Forsyth, C., Shaikh, M., Vitaterna, M. H., Turek, F. & Keshavarzian, A., Dec 2 2016, In : International Journal of Molecular Sciences. 17, 12, 2017.

Research output: Contribution to journalArticle

22 Scopus citations

Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., Khazaie, K., Miller, J. D. & Van Deursen, J., Feb 11 2016, In : Nature. 530, 7589, p. 184-189 6 p.

Research output: Contribution to journalArticle

841 Scopus citations
2015

Antigen-loaded dendritic cell migration: MR imaging in a pancreatic carcinoma model

Zhang, Z., Li, W., Procissi, D., Li, K., Sheu, A. Y., Gordon, A. C., Guo, Y., Khazaie, K., Huan, Y., Han, G. & Larson, A. C., Jan 1 2015, In : Radiology. 274, 1, p. 192-200 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Methods for the study of mast cells in cancer

Blatner, N. R., Tsai, F. & Khazaie, K., 2015, In : Methods in Molecular Biology. 1220, p. 443-460 18 p.

Research output: Contribution to journalArticle

Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer

Phillips, J. D., Knab, L. M., Blatner, N. R., Haghi, L., DeCamp, M. M., Meyerson, S. L., Heiferman, M. J., Heiferman, J. R., Gounari, F., Bentrem, D. J. & Khazaie, K., Sep 21 2015, In : Cancer Immunology, Immunotherapy. 64, 9, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

T-cell expression of IL10 is essential for tumor immune surveillance in the small intestine

Dennis, K. L., Saadalla, A., Blatner, N. R., Wang, S., Venkateswaran, V., Gounari, F., Cheroutre, H., Weaver, C. T., Roers, A., Egilmez, N. K. & Khazaie, K., Jul 1 2015, In : Cancer immunology research. 3, 7, p. 806-814 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

The mutant KRAS gene up-regulates BCL-XL protein via STAT3 to confer apoptosis resistance that is reversed by BIM protein induction and BCL-XL antagonism

Zaanan, A., Okamoto, K., Kawakami, H., Khazaie, K., Huang, S. & Sinicrope, F. A., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23838-23849 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis

Reissfelder, C., Stamova, S., Gossmann, C., Braun, M., Bonertz, A., Walliczek, U., Grimm, M., Rahbari, N. N., Koch, M., Saadati, M., Benner, A., Büchler, M. W., Jäger, D., Halama, N., Khazaie, K., Weitz, J. & Beckhove, P., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 739-751 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation

Gounaris, E., Heiferman, M. J., Heiferman, J. R., Shrivastav, M., Vitello, D., Blatner, N. R., Knab, L. M., Phillips, J. D., Cheon, E. C., Grippo, P. J., Khazaie, K., Munshi, H. G. & Bentrem, D. J., Mar 6 2015, In : PLoS One. 10, 3, e0121402.

Research output: Contribution to journalArticle

23 Scopus citations
2014

MRI-monitored intra-tumoral injection of iron-oxide labeled Clostridium novyi-NT anaerobes in pancreatic carcinoma mouse model

Zheng, L., Zhang, Z., Khazaie, K., Saha, S., Lewandowski, R. J., Zhang, G. & Larson, A. C., Dec 30 2014, In : PloS one. 9, 12, e116204.

Research output: Contribution to journalArticle

6 Scopus citations

Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells

Chung, A. Y., Li, Q., Blair, S. J., De Jesus, M., Dennis, K. L., Levea, C., Yao, J., Sun, Y., Conway, T. F., Virtuoso, L. P., Battaglia, N. G., Furtado, S., Mathiowitz, E., Mantis, N. J., Khazaie, K. & Egilmez, N. K., Oct 1 2014, In : Cancer research. 74, 19, p. 5377-5385 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells

Keerthivasan, S., Aghajani, K., Dose, M., Molinero, L., Khan, M. W., Venkateswaran, V., Weber, C., Emmanuel, A. O., Sun, T., Bentrem, D. J., Mulcahy, M., Keshavarzian, A., Ramos, E. M., Blatner, N., Khazaie, K. & Gounari, F., Feb 26 2014, In : Science translational medicine. 6, 225, 225ra28.

Research output: Contribution to journalArticle

70 Scopus citations
2013

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

153 Scopus citations

Ethanol-Induced Mast Cell-Mediated Inflammation Leads to Increased Susceptibility of Intestinal Tumorigenesis in the APCΔ468 Min Mouse Model of Colon Cancer

Wimberly, A. L., Forsyth, C. B., Khan, M. W., Pemberton, A., Khazaie, K. & Keshavarzian, A., Jan 1 2013, In : Alcoholism: Clinical and Experimental Research. 37, SUPPL.1, p. E199-E208

Research output: Contribution to journalArticle

25 Scopus citations

PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer

Khan, M. W., Keshavarzian, A., Gounaris, E., Melson, J. E., Cheon, E. C., Blatner, N. R., Chen, Z. E., Tsai, F. N., Lee, G., Ryu, H., Barrett, T. A., Bentrem, D. J., Beckhove, P. & Khazaie, K., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2342-2354 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Quantitative magnetic resonance imaging in the transgenic APC δ468 mouse model of hereditary colon cancer

Zhang, Z., Li, W., Blatner, N. R., Dennis, K. L., Procissi, D., Khazaie, K. & Larson, A. C., Jan 1 2013, In : Molecular Imaging. 12, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The two faces of regulatory t cells in cancer

Blatner, N. R., Gounari, F. & Khazaie, K., May 1 2013, In : OncoImmunology. 2, 5, e23852.

Research output: Contribution to journalArticle

8 Scopus citations

Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells

Hix, L. M., Karavitis, J., Khan, M. W., Shi, Y. H., Khazaie, K. & Zhang, M., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11676-11688 13 p.

Research output: Contribution to journalArticle

75 Scopus citations
2012

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R. & Mohamadzadeh, M., Jun 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10462-10467 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., Halverson, A. L., Stryker, S. J., Boller, A. M., Singal, A., Sneed, R. K., Sarraj, B., Ansari, M. J., Oft, M., Iwakura, Y., Zhou, L. & 4 others, Bonertz, A., Beckhove, P., Gounari, F. & Khazaie, K., Dec 12 2012, In : Science translational medicine. 4, 164

Research output: Contribution to journalArticle

114 Scopus citations

Regulation of COX2 Expression in Mouse Mammary Tumor Cells Controls Bone Metastasis and PGE2-Induction of Regulatory T Cell Migration

Karavitis, J., Hix, L. M., Shi, Y. H., Schultz, R. F., Khazaie, K. & Zhang, M., Sep 28 2012, In : PloS one. 7, 9, e46342.

Research output: Contribution to journalArticle

50 Scopus citations

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

Serebrennikova, O. B., Tsatsanis, C., Mao, C., Gounaris, E., Ren, W., Siracusa, L. D., Eliopoulos, A. G., Khazaie, K. & Tsichlis, P. N., May 1 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 18, p. E1082-E1091

Research output: Contribution to journalArticle

36 Scopus citations
2011

Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APC Δ468 mice

Cheon, E. C., Khazaie, K., Khan, M. W., Strouch, M. J., Krantz, S. B., Phillips, J., Blatner, N. R., Hix, L. M., Zhang, M., Dennis, K. L., Salabat, M. R., Heiferman, M., Grippo, P. J., Munshi, H. G., Gounaris, E. & Bentrem, D. J., Mar 1 2011, In : Cancer research. 71, 5, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

The significant role of mast cells in cancer

Khazaie, K., Blatner, N. R., Khan, M. W., Gounari, F., Gounaris, E., Dennis, K., Bonertz, A., Tsai, F. N., Strouch, M. J., Cheon, E., Phillips, J. D., Beckhove, P. & Bentrem, D. J., Mar 2011, In : Cancer and Metastasis Reviews. 30, 1, p. 45-60 16 p.

Research output: Contribution to journalArticle

129 Scopus citations
2010

Cathepsin B is not the processing enzyme for mouse prorenin

Mercure, C., Lacombe, M. J., Khazaie, K. & Reudelhuber, T. L., May 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 5, p. R1212-R1216

Research output: Contribution to journalArticle

13 Scopus citations

Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression

Strouch, M. J., Cheon, E. C., Salabat, M. R., Krantz, S. B., Gounaris, E., Melstrom, L. G., Dangi-Garimella, S., Wang, E., Munshi, H. G., Khazaie, K. & Bentrem, D. J., Apr 15 2010, In : Clinical Cancer Research. 16, 8, p. 2257-2265 9 p.

Research output: Contribution to journalArticle

111 Scopus citations

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

Blatner, N. R., Bonertz, A., Beckhove, P., Cheon, E. C., Krantz, S. B., Strouch, M., Weitz, J., Koch, M., Halverson, A. L., Bentrem, D. J. & Khazaie, K., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6430-6435 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis

Brown, J. B., Lee, G., Managlia, E., Grimm, G. R., Dirisina, R., Goretsky, T., Cheresh, P., Blatner, N. R., Khazaie, K., Yang, G. Y., Li, L. & Barrett, T. A., Feb 2010, In : Gastroenterology. 138, 2, p. 595-605.e3

Research output: Contribution to journalArticle

53 Scopus citations
2009

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

Bonertz, A., Weitz, J., Pietsch, D. H. K., Rahbari, N. N., Schlude, C., Ge, Y., Juenger, S., Vlodavsky, I., Khazaie, K., Jaeger, D., Reissfelder, C., Antolovic, D., Aigner, M., Koch, M. & Beckhove, P., Nov 2 2009, In : Journal of Clinical Investigation. 119, 11, p. 3311-3321 11 p.

Research output: Contribution to journalArticle

157 Scopus citations

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis

Gounaris, E., Blatner, N. R., Dennis, K., Magnusson, F., Gurish, M. F., Strom, T. B., Beckhove, P., Gounari, F. & Khazaie, K., Jul 1 2009, In : Cancer research. 69, 13, p. 5490-5497 8 p.

Research output: Contribution to journalArticle

130 Scopus citations
2008

Cathepsin B is involved in the trafficking of TNF-α-containing vesicles to the plasma membrane in macrophages

Ha, S. D., Martins, A., Khazaie, K., Han, J., Chan, B. M. C. & Kim, S. O., Dec 1 2008, In : Journal of Immunology. 181, 1, p. 690-697 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Direct Presentation of Antigen by Lymph Node Stromal Cells Protects Against CD8 T-Cell-Mediated Intestinal Autoimmunity

Magnusson, F. C., Liblau, R. S., von Boehmer, H., Pittet, M. J., Lee, J. W., Turley, S. J. & Khazaie, K., Apr 2008, In : Gastroenterology. 134, 4, p. 1028-1037 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth

Gounaris, E., Tung, C. H., Restaino, C., Maehr, R., Kohler, R., Joyce, J. A., Plough, H. L., Barrett, T. A., Weissleder, R. & Khazaie, K., Aug 13 2008, In : PloS one. 3, 8, e2916.

Research output: Contribution to journalArticle

84 Scopus citations

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

Li, X., Gounari, F., Protopopov, A., Khazaie, K. & Von Boehmer, H., Nov 12 2008, In : Journal of Experimental Medicine. 205, 12, p. 2851-2861 11 p.

Research output: Contribution to journalArticle

70 Scopus citations
2007

Mast cells are an essential hematopoietic component for polyp development

Gounaris, E., Erdman, S. E., Restaino, C., Gurish, M. F., Friend, D. S., Gounari, F., Lee, D. M., Zhang, G., Glickman, J. N., Shin, K., Rao, V. P., Poutahidis, T., Weissleder, R., McNagny, K. M. & Khazaie, K., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 19977-19982 6 p.

Research output: Contribution to journalArticle

189 Scopus citations

β-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation

Guo, Z., Dose, M., Kovalovsky, D., Chang, R., O'Neil, J., Look, A. T., Von Boehmer, H., Khazaie, K. & Gounari, F., Jun 15 2007, In : Blood. 109, 12, p. 5463-5472 10 p.

Research output: Contribution to journalArticle

87 Scopus citations
2006

c-Myc mediates pre-TCR-induced proliferation but not developmental progression

Dose, M., Khan, I., Guo, Z., Kovalovsky, D., Krueger, A., Von Boehmer, H., Khazaie, K. & Gounari, F., Oct 15 2006, In : Blood. 108, 8, p. 2669-2677 9 p.

Research output: Contribution to journalArticle

70 Scopus citations