Khashayarsha Khazaie, PhD

  • 7841 Citations
  • 46 Scopus h-Index
1984 …2019
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Research Output 1984 2018

  • 7841 Citations
  • 46 Scopus h-Index
  • 92 Article
  • 10 Review article
  • 4 Comment/debate
  • 1 Chapter
2018
35 Citations (Scopus)

Dietary fiber treatment corrects the composition of gut microbiota, promotes SCFA production, and suppresses colon carcinogenesis

Bishehsari, F., Engen, P. A., Preite, N. Z., Tuncil, Y. E., Naqib, A., Shaikh, M., Rossi, M., Wilber, S., Green, S. J., Hamaker, B. R., Khazaie, K., Voigt, R. M., Forsyth, C. B. & Keshavarzian, A., Feb 16 2018, In : Genes. 9, 2, 102.

Research output: Contribution to journalArticle

Volatile Fatty Acids
Dietary Fiber
Colon
Carcinogenesis
Microbiota
1 Citation (Scopus)

Epigenetic therapy: Novel translational implications for arrest of environmental dioxin-Induced disease in females

Khan, Z., Zheng, Y., Jones, T. L., Delaney, A. A., Correa, L. F., Shenoy, C. C., Khazaie, K. & Daftary, G. S., Jan 1 2018, In : Endocrinology. 159, 1, p. 477-489 13 p.

Research output: Contribution to journalArticle

Dioxins
Epigenomics
Histone Acetyltransferases
Endometriosis
Cytochrome P-450 Enzyme System
12 Citations (Scopus)

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner

Saadalla, A. M., Osman, A., Gurish, M. F., Dennis, K. L., Blatner, N. R., Pezeshki, A., McNagny, K. M., Cheroutre, H., Gounari, F. & Khazaie, K., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1588-1592 5 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Mast Cells
Cytokines
Neoplasms
Interleukin-10
5 Citations (Scopus)

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes

Emmanuel, A. O., Arnovitz, S., Haghi, L., Mathur, P. S., Mondal, S., Quandt, J., Okoreeh, M. K., Maienschein-Cline, M., Khazaie, K., Dose, M. & Gounari, F., Dec 1 2018, In : Nature Immunology. 19, 12, p. 1366-1378 13 p.

Research output: Contribution to journalArticle

Thymocytes
Epigenomics
Nucleosomes
Chromatin
Binding Sites
2017
14 Citations (Scopus)

Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation

Principe, D. R., DeCant, B., Staudacher, J., Vitello, D., Mangan, R. J., Wayne, E. A., Mascariñas, E., Diaz, A. M., Bauer, J., McKinney, R. D., Khazaie, K., Pasche, B., Dawson, D. W., Munshi, H. G., Grippo, P. J. & Jung, B., 2017, In : Oncotarget. 8, 3, p. 3826-3839 14 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Inflammation
Neoplasms
Interleukin-8
Colon
21 Citations (Scopus)

Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment

Shaler, C. R., Tun-Abraham, M. E., Skaro, A. I., Khazaie, K., Corbett, A. J., Mele, T., Hernandez-Alejandro, R. & Haeryfar, S. M. M., Aug 10 2017, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-13 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Colorectal Neoplasms
Mucous Membrane
Neoplasm Metastasis
T-Lymphocytes
19 Citations (Scopus)

PD-1 blockade promotes epitope spreading in anticancer CD8+ T cell responses by preventing fratricidal death of subdominant clones to relieve immunodomination

Memarnejadian, A., Meilleur, C. E., Shaler, C. R., Khazaie, K., Bennink, J. R., Schell, T. D. & Haeryfar, S. M. M., Nov 1 2017, In : Journal of Immunology. 199, 9, p. 3348-3359 12 p.

Research output: Contribution to journalArticle

Epitopes
Clone Cells
T-Lymphocytes
Neoplasms
Immunotherapy
4 Citations (Scopus)

Progressive Fibrosis: A Progesterone-and KLF11-Mediated Sexually Dimorphic Female Response

Shenoy, C. C., Khan, Z., Zheng, Y., Jones, T. L., Khazaie, K. & Daftary, G. S., Oct 1 2017, In : Endocrinology. 158, 10, p. 3605-3619 15 p.

Research output: Contribution to journalArticle

Progesterone
Fibrosis
Medroxyprogesterone Acetate
Endometriosis
Cicatrix
10 Citations (Scopus)

The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer

Khan, M. W., Saadalla, A., Ewida, A. H., Al-Katranji, K., Al-Saoudi, G., Giaccone, Z. T., Gounari, F., Zhang, M., Frank, D. A. & Khazaie, K., Sep 5 2017, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-11 11 p.

Research output: Contribution to journalArticle

Pyrimethamine
Breast Neoplasms
Neoplasms
Tumor Microenvironment
Transducers
2016
9 Citations (Scopus)

KLF10 mediated epigenetic dysregulation of epithelial CD40/CD154 promotes endometriosis

Delaney, A. A., Khan, Z., Zheng, Y., Correa, L. F., Zanfagnin, V., Shenoy, C. C., Schoolmeester, J. K., Saadalla, A. M., El-Nashar, S., Famuyide, A. O., Subramaniam, M., Hawse, J. R., Khazaie, K. & Daftary, G. S., Sep 1 2016, In : Biology of Reproduction. 95, 3, 62.

Research output: Contribution to journalArticle

Endometriosis
Epigenomics
Phenotype
Fibrosis
Disease Progression
19 Citations (Scopus)

Light/dark shifting promotes alcohol-induced colon carcinogenesis: Possible role of intestinal inflammatory milieu and microbiota

Bishehsari, F., Saadalla, A., Khazaie, K., Engen, P. A., Voigt, R. M., Shetuni, B. B., Forsyth, C., Shaikh, M., Vitaterna, M. H., Turek, F. & Keshavarzian, A., Dec 2 2016, In : International Journal of Molecular Sciences. 17, 12, 2017.

Research output: Contribution to journalArticle

Microbiota
Colon
Carcinogenesis
alcohols
Alcohols
731 Citations (Scopus)

Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., Khazaie, K., Miller, J. D. & Van Deursen, J., Feb 11 2016, In : Nature. 530, 7589, p. 184-189 6 p.

Research output: Contribution to journalArticle

Cell Aging
Transgenes
Adipocytes
Wound Healing
Embryonic Development
2015
10 Citations (Scopus)

Antigen-loaded dendritic cell migration: MR imaging in a pancreatic carcinoma model

Zhang, Z., Li, W., Procissi, D., Li, K., Sheu, A. Y., Gordon, A. C., Guo, Y., Khazaie, K., Huan, Y., Han, G. & Larson, A. C., Jan 1 2015, In : Radiology. 274, 1, p. 192-200 9 p.

Research output: Contribution to journalArticle

Dendritic Cells
Cell Movement
Magnetic Resonance Imaging
Antigens
Lymph Nodes
2 Citations (Scopus)

Erratum: Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis (Journal of Clinical Investigation (2015) 125: 2 (739-751) DOI: 10.1172/JCI74894)

Reissfelder, C., Stamova, S., Gossmann, C., Braun, M., Bonertz, A., Walliczek, U., Grimm, M., Rahbari, N. N., Koch, M., Saadati, M., Benner, A., Büchler, M. W., Jäger, D., Halama, N., Khazaie, K., Weitz, J. & Beckhove, P., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1364 1 p.

Research output: Contribution to journalComment/debate

Methods for the study of mast cells in cancer

Blatner, N. R., Tsai, F. & Khazaie, K., 2015, In : Methods in Molecular Biology. 1220, p. 443-460 18 p.

Research output: Contribution to journalArticle

Mast Cells
Neoplasms
Regulatory T-Lymphocytes
Mastocytosis
T-Lymphocytes
11 Citations (Scopus)

Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer

Phillips, J. D., Knab, L. M., Blatner, N. R., Haghi, L., DeCamp, M. M., Meyerson, S. L., Heiferman, M. J., Heiferman, J. R., Gounari, F., Bentrem, D. J. & Khazaie, K., Sep 21 2015, In : Cancer Immunology, Immunotherapy. 64, 9, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
T-Lymphocytes
Immune System Diseases
Regulatory T-Lymphocytes
20 Citations (Scopus)

T-cell expression of IL10 is essential for tumor immune surveillance in the small intestine

Dennis, K. L., Saadalla, A., Blatner, N. R., Wang, S., Venkateswaran, V., Gounari, F., Cheroutre, H., Weaver, C. T., Roers, A., Egilmez, N. K. & Khazaie, K., Jul 1 2015, In : Cancer immunology research. 3, 7, p. 806-814 9 p.

Research output: Contribution to journalArticle

Interleukin-10
Small Intestine
T-Lymphocytes
Polyps
Neoplasms
26 Citations (Scopus)

The mutant KRAS gene up-regulates BCL-XL protein via STAT3 to confer apoptosis resistance that is reversed by BIM protein induction and BCL-XL antagonism

Zaanan, A., Okamoto, K., Kawakami, H., Khazaie, K., Huang, S. & Sinicrope, F. A., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23838-23849 12 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Up-Regulation
Genes
Apoptosis
Mitogen-Activated Protein Kinase Kinases
65 Citations (Scopus)

Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis

Reissfelder, C., Stamova, S., Gossmann, C., Braun, M., Bonertz, A., Walliczek, U., Grimm, M., Rahbari, N. N., Koch, M., Saadati, M., Benner, A., Büchler, M. W., Jäger, D., Halama, N., Khazaie, K., Weitz, J. & Beckhove, P., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 739-751 13 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Tumor-Infiltrating Lymphocytes
Colorectal Neoplasms
Neoplasm Antigens
T-Lymphocytes
21 Citations (Scopus)

Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation

Gounaris, E., Heiferman, M. J., Heiferman, J. R., Shrivastav, M., Vitello, D., Blatner, N. R., Knab, L. M., Phillips, J. D., Cheon, E. C., Grippo, P. J., Khazaie, K., Munshi, H. G. & Bentrem, D. J., Mar 6 2015, In : PLoS One. 10, 3, e0121402.

Research output: Contribution to journalArticle

zileuton
Intestinal Polyposis
Arachidonate 5-Lipoxygenase
Lipoxygenase Inhibitors
lipoxygenase
2014

Methods for the study of mast cells in cancer

Blatner, N. R., Tsai, F. N. & Khazaie, K., Nov 11 2014, Mast Cells: Methods and Protocols. Springer New York, p. 443-460 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mast Cells
Tumors
T-cells
Neoplasms
Regulatory T-Lymphocytes
5 Citations (Scopus)

MRI-monitored intra-tumoral injection of iron-oxide labeled Clostridium novyi-NT anaerobes in pancreatic carcinoma mouse model

Zheng, L., Zhang, Z., Khazaie, K., Saha, S., Lewandowski, R. J., Zhang, G. & Larson, A. C., Dec 30 2014, In : PLoS One. 9, 12, e116204.

Research output: Contribution to journalArticle

Clostridium novyi
Clostridium
anaerobes
iron oxides
Magnetic resonance
19 Citations (Scopus)

Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells

Chung, A. Y., Li, Q., Blair, S. J., De Jesus, M., Dennis, K. L., Levea, C., Yao, J., Sun, Y., Conway, T. F., Virtuoso, L. P., Battaglia, N. G., Furtado, S., Mathiowitz, E., Mantis, N. J., Khazaie, K. & Egilmez, N. K., Oct 1 2014, In : Cancer Research. 74, 19, p. 5377-5385 9 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Interleukin-10
Homeostasis
Therapeutics
Pathology
64 Citations (Scopus)

β-catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells

Keerthivasan, S., Aghajani, K., Dose, M., Molinero, L., Khan, M. W., Venkateswaran, V., Weber, C., Emmanuel, A. O., Sun, T., Bentrem, D. J., Mulcahy, M., Keshavarzian, A., Ramos, E. M., Blatner, N., Khazaie, K. & Gounari, F., Feb 26 2014, In : Science Translational Medicine. 6, 225, 225ra28.

Research output: Contribution to journalArticle

Catenins
Regulatory T-Lymphocytes
Colitis
Colonic Neoplasms
T-Lymphocytes
2013
142 Citations (Scopus)

Adenomatous polyps are drivenbymicrobe-instigated focal inflammation and are controlled by IL-10-producing T cells

Dennis, K. L., Wang, Y., Blatner, N. R., Wang, S., Saadalla, A., Trudeau, E., Roers, A., Weaver, C. T., Lee, J. J., Gilbert, J. A., Chang, E. B. & Khazaie, K., Oct 1 2013, In : Cancer Research. 73, 19, p. 5905-5913 9 p.

Research output: Contribution to journalArticle

Adenomatous Polyps
Interleukin-10
Inflammation
T-Lymphocytes
Polyps
102 Citations (Scopus)

Current status of interleukin-10 and regulatory T-cells in cancer

Dennis, K. L., Blatner, N. R., Gounari, F. & Khazaie, K., Nov 2013, In : Current Opinion in Oncology. 25, 6, p. 637-645 9 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Interleukin-10
Neoplasms
Helper-Inducer T-Lymphocytes
Cytokines
22 Citations (Scopus)

Ethanol-Induced Mast Cell-Mediated Inflammation Leads to Increased Susceptibility of Intestinal Tumorigenesis in the APCΔ468 Min Mouse Model of Colon Cancer

Wimberly, A. L., Forsyth, C. B., Khan, M. W., Pemberton, A., Khazaie, K. & Keshavarzian, A., Jan 2013, In : Alcoholism: Clinical and Experimental Research. 37, SUPPL.1

Research output: Contribution to journalArticle

Mast Cells
Colonic Neoplasms
Carcinogenesis
Ethanol
Alcohols
27 Citations (Scopus)

Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis

Gounaris, E., Martin, J., Ishihara, Y., Khan, M. W., Lee, G., Sinh, P., Chen, E. Z., Angarone, M., Weissleder, R., Khazaie, K. & Barrett, T. A., Jun 2013, In : Inflammatory Bowel Diseases. 19, 7, p. 1339-1345 7 p.

Research output: Contribution to journalReview article

Cathepsins
Colitis
Endoscopy
Fluorescence
Colonoscopy
36 Citations (Scopus)

PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer

Khan, M. W., Keshavarzian, A., Gounaris, E., Melson, J. E., Cheon, E. C., Blatner, N. R., Chen, Z. E., Tsai, F. N., Lee, G., Ryu, H., Barrett, T. A., Bentrem, D. J., Beckhove, P. & Khazaie, K., May 1 2013, In : Clinical Cancer Research. 19, 9, p. 2342-2354 13 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Colitis
Mast Cells
Epithelial Cells
Macrophages
4 Citations (Scopus)

Quantitative magnetic resonance imaging in the transgenic APC δ468 mouse model of hereditary colon cancer

Zhang, Z., Li, W., Blatner, N. R., Dennis, K. L., Procissi, D., Khazaie, K. & Larson, A. C., Jan 2013, In : Molecular Imaging. 12, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

Magnetic resonance
Colonic Neoplasms
mice
magnetic resonance
Tumors

Targeted chemo-immunotherapy of leukemia

Khazaie, K., Jul 2013, In : Leukemia and Lymphoma. 54, 7, p. 1353-1354 2 p.

Research output: Contribution to journalComment/debate

Aurora Kinase B
Aurora Kinase A
Acute Myeloid Leukemia
Immunotherapy
Epitopes
8 Citations (Scopus)

The two faces of regulatory t cells in cancer

Blatner, N. R., Gounari, F. & Khazaie, K., May 2013, In : OncoImmunology. 2, 5, e23852.

Research output: Contribution to journalArticle

Colonic Neoplasms
Retinoids
Regulatory T-Lymphocytes
Neoplasms
Inflammation
69 Citations (Scopus)

Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells

Hix, L. M., Karavitis, J., Khan, M. W., Shi, Y. H., Khazaie, K. & Zhang, M., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 11676-11688 13 p.

Research output: Contribution to journalArticle

STAT1 Transcription Factor
Tumors
Transcription Factors
Breast Neoplasms
Growth
2012
88 Citations (Scopus)

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

Khazaie, K., Zadeh, M., Khan, M. W., Bere, P., Gounari, F., Dennis, K., Blatner, N. R., Owen, J. L., Klaenhammer, T. R. & Mohamadzadeh, M., Jun 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. 10462-10467 6 p.

Research output: Contribution to journalArticle

Lactobacillus acidophilus
Colonic Neoplasms
Colonic Polyps
Inflammation
Bacteria
111 Citations (Scopus)

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., Halverson, A. L., Stryker, S. J., Boller, A. M., Singal, A., Sneed, R. K., Sarraj, B., Ansari, M. J., Oft, M., Iwakura, Y., Zhou, L. & 4 others, Bonertz, A., Beckhove, P., Gounari, F. & Khazaie, K., Dec 12 2012, In : Science Translational Medicine. 4, 164, 164ra159.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Polyps
Colonic Neoplasms
Interleukin-17
46 Citations (Scopus)

Regulation of COX2 Expression in Mouse Mammary Tumor Cells Controls Bone Metastasis and PGE2-Induction of Regulatory T Cell Migration

Karavitis, J., Hix, L. M., Shi, Y. H., Schultz, R. F., Khazaie, K. & Zhang, M., Sep 28 2012, In : PLoS One. 7, 9, e46342.

Research output: Contribution to journalArticle

T-cells
mammary neoplasms (animal)
prostaglandin synthase
Regulatory T-Lymphocytes
Cyclooxygenase 2
36 Citations (Scopus)

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

Serebrennikova, O. B., Tsatsanis, C., Mao, C., Gounaris, E., Ren, W., Siracusa, L. D., Eliopoulos, A. G., Khazaie, K. & Tsichlis, P. N., May 1 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 18

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Interleukin-10
Carcinogenesis
Inflammation
Polyps
2011
55 Citations (Scopus)

Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APC Δ468 mice

Cheon, E. C., Khazaie, K., Khan, M. W., Strouch, M. J., Krantz, S. B., Phillips, J., Blatner, N. R., Hix, L. M., Zhang, M., Dennis, K. L., Salabat, M. R., Heiferman, M., Grippo, P. J., Munshi, H. G., Gounaris, E. & Bentrem, D. J., Mar 1 2011, In : Cancer Research. 71, 5, p. 1627-1636 10 p.

Research output: Contribution to journalArticle

Intestinal Polyposis
Arachidonate 5-Lipoxygenase
Mast Cells
Colon
Arginase
124 Citations (Scopus)

The significant role of mast cells in cancer

Khazaie, K., Blatner, N. R., Khan, M. W., Gounari, F., Gounaris, E., Dennis, K., Bonertz, A., Tsai, F. N., Strouch, M. J., Cheon, E., Phillips, J. D., Beckhove, P. & Bentrem, D. J., Mar 2011, In : Cancer and Metastasis Reviews. 30, 1, p. 45-60 16 p.

Research output: Contribution to journalArticle

Mast Cells
Neoplasms
Adaptive Immunity
Viral Tumor Antigens
Antigen-Presenting Cells
2010
13 Citations (Scopus)

Cathepsin B is not the processing enzyme for mouse prorenin

Mercure, C., Lacombe, M. J., Khazaie, K. & Reudelhuber, T. L., May 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 5

Research output: Contribution to journalArticle

Cathepsin B
Renin
Kidney
Renin-Angiotensin System
prorenin processing enzyme
108 Citations (Scopus)

Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression

Strouch, M. J., Cheon, E. C., Salabat, M. R., Krantz, S. B., Gounaris, E., Melstrom, L. G., Dangi-Garimella, S., Wang, E., Munshi, H. G., Khazaie, K. & Bentrem, D. J., Apr 15 2010, In : Clinical Cancer Research. 16, 8, p. 2257-2265 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mast Cells
Neoplasms
Conditioned Culture Medium
Tryptases
40 Citations (Scopus)

HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death

Chlichlia, K. & Khazaie, K., Nov 2010, In : Chemico-Biological Interactions. 188, 2, p. 359-365 7 p.

Research output: Contribution to journalReview article

Human T-lymphotropic virus 1
T-cells
Cell death
Taxation
DNA Damage
89 Citations (Scopus)

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction

Blatner, N. R., Bonertz, A., Beckhove, P., Cheon, E. C., Krantz, S. B., Strouch, M., Weitz, J., Koch, M., Halverson, A. L., Bentrem, D. J. & Khazaie, K., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6430-6435 6 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Mast Cells
Colorectal Neoplasms
Interleukin-6
Polyps

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction (Proceedings of the National Academy of Sciences of the United States of America (2010) 107 (6430-6435))

Blatner, N. R., Bonertz, A., Beckhove, P., Cheon, E. C., Krantz, S., Strouch, M., Weitz, J., Koch, M., Halverson, A. L., Bentrem, D. J. & Khazaie, K., Jul 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 27, p. 12405 1 p.

Research output: Contribution to journalComment/debate

53 Citations (Scopus)

Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis

Brown, J. B., Lee, G., Managlia, E., Grimm, G. R., Dirisina, R., Goretsky, T., Cheresh, P., Blatner, N. R., Khazaie, K., Yang, G. Y., Li, L. & Barrett, T. A., Feb 2010, In : Gastroenterology. 138, 2

Research output: Contribution to journalArticle

Mesalamine
Catenins
Ulcerative Colitis
Colitis
Interleukin-10
2009
154 Citations (Scopus)

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

Bonertz, A., Weitz, J., Pietsch, D. H. K., Rahbari, N. N., Schlude, C., Ge, Y., Juenger, S., Vlodavsky, I., Khazaie, K., Jaeger, D., Reissfelder, C., Antolovic, D., Aigner, M., Koch, M. & Beckhove, P., Nov 2 2009, In : Journal of Clinical Investigation. 119, 11, p. 3311-3321 11 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Colorectal Neoplasms
T-Lymphocytes
Antigens
Neoplasms
22 Citations (Scopus)

Current developments with peptide-based human tumor vaccines

Khazaie, K., Bonertz, A. & Beckhove, P., Nov 2009, In : Current Opinion in Oncology. 21, 6, p. 524-530 7 p.

Research output: Contribution to journalReview article

Cancer Vaccines
Peptides
Neoplasms
Subunit Vaccines
Immunotherapy
193 Citations (Scopus)

Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation

Maltby, S., Khazaie, K. & McNagny, K. M., Aug 2009, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1796, 1, p. 19-26 8 p.

Research output: Contribution to journalReview article

Mast Cells
Growth
Neoplasms
Vascular Tissue Neoplasms
Tumor Microenvironment
126 Citations (Scopus)

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis

Gounaris, E., Blatner, N. R., Dennis, K., Magnusson, F., Gurish, M. F., Strom, T. B., Beckhove, P., Gounari, F. & Khazaie, K., Jul 1 2009, In : Cancer Research. 69, 13, p. 5490-5497 8 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Anti-Inflammatory Agents
Phenotype
Interleukin-10
Neoplasms
2008
67 Citations (Scopus)

Cathepsin B is involved in the trafficking of TNF-α-containing vesicles to the plasma membrane in macrophages

Ha, S. D., Martins, A., Khazaie, K., Han, J., Chan, B. M. C. & Kim, S. O., 2008, In : Journal of Immunology. 181, 1, p. 690-697 8 p.

Research output: Contribution to journalArticle

Cathepsin B
Macrophages
Cell Membrane
Cysteine Proteases
Cellular Structures