• 1031 Citations
  • 20 Scopus h-Index
20002019
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Research Output 2000 2019

  • 1031 Citations
  • 20 Scopus h-Index
  • 31 Article
  • 1 Chapter
2019

Establishment of TUSMi008-A, an induced pluripotent stem cell (iPSC) line from a 76-year old Alzheimer's disease (AD) patient with PAXIP1 gene mutation

Wang, Y., Zhang, J., Hu, J., Li, G., Lei, Y. & Zhao, J., Apr 1 2019, In : Stem Cell Research. 36, 101391.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Alzheimer Disease
Cell Line
Germ Layers
Mutation
2018
5 Citations (Scopus)

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

He, K., Ma, X., Xu, T., Li, Y., Hodge, A., Zhang, Q., Torline, J., Huang, Y., Zhao, J., Ling, K. & Hu, J., Dec 1 2018, In : Nature Communications. 9, 1, 3310.

Research output: Contribution to journalArticle

Axoneme
Cilia
proteins
effectors
disrupting
2017
2 Citations (Scopus)

EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression

Chen, C., Wang, X., Fang, J., Xue, J., Xiong, X., Huang, Y., Hu, J. & Ling, K., 2017, In : Oncotarget. 8, 26, p. 42621-42637 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Pancreatic Neoplasms
Adenocarcinoma
Phosphotransferases
Phosphorylation
2016
12 Citations (Scopus)

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119

Zhang, Q., Li, Y., Zhang, Y., Torres, V., Harris, P. C., Ling, K. & Hu, J., Apr 22 2016, In : Scientific Reports. 6, 24534.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Guanosine Triphosphate
GTP Phosphohydrolases
Organogenesis
28 Citations (Scopus)

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

Xu, Q., Zhang, Y., Wei, Q., Huang, Y., Hu, J. & Ling, K., Feb 26 2016, In : Nature Communications. 7, 10777.

Research output: Contribution to journalArticle

inositols
Phosphatidylinositol Phosphates
Polyphosphates
phosphatases
Phosphoric Monoester Hydrolases
8 Citations (Scopus)

The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate

Wei, Q., Zhang, Y., Schouteden, C., Zhang, Y., Zhang, Q., Dong, J., Wonesch, V., Ling, K., Dammermann, A. & Hu, J., Aug 18 2016, In : Nature Communications. 7, 12437.

Research output: Contribution to journalArticle

Cilia
proteins
Fibers
Basal Bodies
Axoneme
2015
25 Citations (Scopus)

BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors

Xu, Q., Zhang, Y., Wei, Q., Huang, Y., Li, Y., Ling, K. & Hu, J., Jul 7 2015, In : Scientific Reports. 5, 11855.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Cilia
Lysosomes
Vertebrates
Homeostasis
3 Citations (Scopus)

Small gtpases act as cellular switches in the context of cilia

Li, Y. & Hu, J., Aug 21 2015, The Cytoskeleton in Health and Disease. Springer New York, p. 217-237 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Monomeric GTP-Binding Proteins
Cilia
Switches
27 Citations (Scopus)

The essential roles of transition fibers in the context of cilia

Wei, Q., Ling, K. & Hu, J., Aug 1 2015, In : Current Opinion in Cell Biology. 35, p. 98-105 8 p.

Research output: Contribution to journalArticle

Cilia
Organelles
Vertebrates
Proteins
2014
10 Citations (Scopus)

PIPKIγ targets to the centrosome and restrains centriole duplication

Xu, Q., Zhang, Y., Xiong, X., Huang, Y., Salisbury, J. L., Hu, J. & Ling, K., Mar 2014, In : Journal of Cell Science. 127, 6, p. 1293-1305 13 p.

Research output: Contribution to journalArticle

Centrioles
Centrosome
S Phase
Cell Division
Proteins
16 Citations (Scopus)

Targeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis

Chen, C., Wang, X., Xiong, X., Liu, Q., Huang, Y., Xu, Q., Hu, J., Ge, G. & Ling, K., Dec 8 2014, In : Oncogene. 34, 35, p. 4635-4646 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Phosphotransferases
Breast Neoplasms
Neoplasm Metastasis
Cell Movement
2013
25 Citations (Scopus)

Molecular views of Arf-like small GTPases in cilia and ciliopathies

Zhang, Q., Hu, J. & Ling, K., Sep 10 2013, In : Experimental Cell Research. 319, 15, p. 2316-2322 7 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Inborn Genetic Diseases
Medical Genetics
Eukaryotic Cells
2 Citations (Scopus)

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

Li, Y., Zhang, Q., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Feb 2013, In : Journal of Cell Biology. 200, 3, p. 357 1 p.

Research output: Contribution to journalArticle

Sumoylation
Monomeric GTP-Binding Proteins
Sensory Receptor Cells
44 Citations (Scopus)

Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

Wei, Q., Xu, Q., Zhang, Y., Li, Y., Zhang, Q., Hu, Z., Harris, P. C., Torres, V., Ling, K. & Hu, J., Nov 15 2013, In : Nature Communications. 4, 3750.

Research output: Contribution to journalArticle

Cilia
entry
proteins
fibers
Fibers
2012
30 Citations (Scopus)

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

Xiong, X., Xu, Q., Huang, Y., Singh, R. D., Anderson, R., Leof, E. B., Hu, J. & Ling, K., Jan 1 2012, In : Molecular Biology of the Cell. 23, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

Cadherins
Cluster Analysis
Phosphotransferases
Adherens Junctions
Cell Membrane
23 Citations (Scopus)

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

Li, Y., Zhang, Q., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Nov 2012, In : Journal of Cell Biology. 199, 4, p. 589-598 10 p.

Research output: Contribution to journalArticle

Sumoylation
Monomeric GTP-Binding Proteins
Sensory Receptor Cells
Autosomal Dominant Polycystic Kidney
Cilia
111 Citations (Scopus)

The BBSome controls IFT assembly and turnaround in cilia

Wei, Q., Zhang, Y., Li, Y., Zhang, Q., Ling, K. & Hu, J., Sep 2012, In : Nature Cell Biology. 14, 9, p. 950-957 8 p.

Research output: Contribution to journalArticle

Cilia
Bardet-Biedl Syndrome
Caenorhabditis elegans
Recycling
Mutagenesis
22 Citations (Scopus)

The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Li, Y., Ling, K. & Hu, J., Jul 2012, In : Journal of Cellular Biochemistry. 113, 7, p. 2201-2207 7 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Mountings
Body Patterning
Organelles
2011

Erratum to: Small GTPases and cilia (Protein Cell, (2011), 1, 1 (13-25), 10.1007/s13238-011-1004-7)

Li, Y. & Hu, J., 2011, In : Protein and Cell. 2, 3, p. 259 1 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Proteins
21 Citations (Scopus)

Small GTPases and cilia

Li, Y. & Hu, J., 2011, In : Protein and Cell. 2, 1, p. 13-25 13 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Guanosine Triphosphate
Cytoskeleton
Mountings
2010
204 Citations (Scopus)

Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy

Otto, E. A., Hurd, T. W., Airik, R., Chaki, M., Zhou, W., Stoetzel, C., Patil, S. B., Levy, S., Ghosh, A. K., Murga-Zamalloa, C. A., Van Reeuwijk, J., Letteboer, S. J. F., Sang, L., Giles, R. H., Liu, Q., Coene, K. L. M., Estrada-Cuzcano, A., Collin, R. W. J., McLaughlin, H. M., Held, S. & 35 others, Kasanuki, J. M., Ramaswami, G., Conte, J., Lopez, I., Washburn, J., MacDonald, J., Hu, J., Yamashita, Y., Maher, E. R., Guay-Woodford, L. M., Neumann, H. P. H., Obermüller, N., Koenekoop, R. K., Bergmann, C., Bei, X., Lewis, R. A., Katsanis, N., Lopes, V., Williams, D. S., Lyons, R. H., Dang, C. V., Brito, D. A., Dias, M. B., Zhang, X., Cavalcoli, J. D., Nürnberg, G., Nürnberg, P., Pierce, E. A., Jackson, P. K., Antignac, C., Saunier, S., Roepman, R., Dollfus, H., Khanna, H. & Hildebrandt, F., Oct 2010, In : Nature Genetics. 42, 10, p. 840-850 11 p.

Research output: Contribution to journalArticle

Exome
Kidney
Mutation
Orofaciodigital Syndromes
Centrioles
92 Citations (Scopus)

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

Li, Y., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Jun 14 2010, In : Journal of Cell Biology. 189, 6, p. 1039-1051 13 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Guanosine
Caenorhabditis elegans
Adenosine Diphosphate
2007
41 Citations (Scopus)

STAM and Hrs down-regulate ciliary TRP receptors

Hu, J., Wittekind, S. G. & Barr, M. M., Sep 2007, In : Molecular Biology of the Cell. 18, 9, p. 3277-3289 13 p.

Research output: Contribution to journalArticle

Cilia
Down-Regulation
TRPP Cation Channels
Caenorhabditis elegans
Growth Factor Receptors
2006
46 Citations (Scopus)

Casein kinase II and calcineurin modulate TRPP function and ciliary localization

Hu, J., Bae, Y. K., Knobel, K. M. & Barr, M. M., May 2006, In : Molecular Biology of the Cell. 17, 5, p. 2200-2211 12 p.

Research output: Contribution to journalArticle

TRPP Cation Channels
Casein Kinase II
Cilia
Calcineurin
Transient Receptor Potential Channels
69 Citations (Scopus)

General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia

Bae, Y. K., Qin, H., Knobel, K. M., Hu, J., Rosenbaum, J. L. & Barr, M. M., Oct 2006, In : Development. 133, 19, p. 3859-3870 12 p.

Research output: Contribution to journalArticle

Cilia
Dendrites
Adaptor Protein Complex 1
Sensory Receptor Cells
Neurons
2005
41 Citations (Scopus)

ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling

Hu, J. & Barr, M. M., Feb 2005, In : Molecular Biology of the Cell. 16, 2, p. 458-469 12 p.

Research output: Contribution to journalArticle

TRPP Cation Channels
Lipoxygenase
Caenorhabditis elegans
Autosomal Dominant Polycystic Kidney
Adenosine Triphosphate
5 Citations (Scopus)

Identification and characterization of a novel splice variant of β3 subunit of GABA A receptor in rat testis and spermatozoa

Li, S. F., Hu, J., Yan, Y. C., Chen, Y. G., Koide, S. S. & Li, Y. P., Feb 2005, In : International Journal of Biochemistry and Cell Biology. 37, 2, p. 350-360 11 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Spermatozoa
Testis
Rats
Protein Isoforms
2002
28 Citations (Scopus)

Biphasic effect of GABA on rat sperm acrosome reaction: Involvement of GABAa and GABAb receptors

Hu, J., He, X. B., Wu, Q., Yan, Y. C. & Koide, S. S., 2002, In : Archives of Andrology. 48, 5, p. 369-378 10 p.

Research output: Contribution to journalArticle

Acrosome Reaction
gamma-Aminobutyric Acid
Spermatozoa
GABA-A Receptors
Yin-Yang
12 Citations (Scopus)

Identification of γ1 subunit of GABAA receptor in rat testis

Hu, J. & Yan, Y. C., Mar 2002, In : Cell Research. 12, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Testis
Spermatozoa
Reverse Transcription
Acrosome Reaction
23 Citations (Scopus)

Subunit composition and function of GABAA receptors of rat spermatozoa

Hu, J., He, X. B., Wu, Q., Yan, Y. C. & Koide, S. S., 2002, In : Neurochemical Research. 27, 3, p. 195-199 5 p.

Research output: Contribution to journalArticle

Acrosome Reaction
GABA-A Receptors
GABA-A Receptor Agonists
GABA-A Receptor Antagonists
Spermatozoa
2001
34 Citations (Scopus)

Identification of GABAB receptor in rat testis and sperm

He, X. B., Hu, J., Wu, Q., Yan, Y. C. & Koide, S. S., 2001, In : Biochemical and Biophysical Research Communications. 283, 1, p. 243-247 5 p.

Research output: Contribution to journalArticle

Spermatozoa
Testis
Rats
Complementary DNA
Aminobutyrates
2000
22 Citations (Scopus)

Identification of γ-aminobutyric acid transporter (GAT1) on the rat sperm

Hu, J., He, X. B. & Yan, Y. C., Mar 2000, In : Cell Research. 10, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

GABA Plasma Membrane Transport Proteins
Aminobutyrates
Spermatozoa
Acrosome Reaction
Testis