Hu Li, PhD

  • 5151 Citations
  • 32 Scopus h-Index
20052021
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Research Output 2005 2019

2019
1 Citation (Scopus)

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & Van Deursen, J., Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

Chromosomal Instability
Cyclins
Liver
Neoplasms
Chromosomes

Erratum to: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors (Nature Cell Biology, (2017), 19, 9, (1037-1048), 10.1038/ncb3598)

Skamagki, M., Correia, C., Yeung, P., Baslan, T., Beck, S., Zhang, C., Ross, C. A., Dang, L., Liu, Z., Giunta, S., Chang, T. P., Wang, J., Ananthanarayanan, A., Bohndorf, M., Bosbach, B., Adjaye, J., Funabiki, H., Kim, J., Lowe, S., Collins, J. J. & 4 others, Lu, C. W., Li, H., Zhao, R. & Kim, K., Jan 1 2019, (Accepted/In press) In : Nature Cell Biology.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Genomic Instability
Cell Biology
Manuscripts
Information Storage and Retrieval

Metabolomics in stem cell biology research

Sun, Z., Zhao, J., Yu, H., Zhang, C., Li, H., Zeng, Z. & Zhang, J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 321-330 10 p. (Methods in Molecular Biology; vol. 1975).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem Cell Research
Metabolomics
Cell Biology
Stem Cells
Metabolic Networks and Pathways
2 Citations (Scopus)

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
2018

Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis

Liu, Z., Che, P., Mercado, J. J., Hackney, J. R., Friedman, G. K., Zhang, C., You, Z., Zhao, X., Ding, Q., Kim, K., Li, H., Liu, X., Markert, J. M., Nabors, B., Gillespie, G. Y., Zhao, R. & Han, X., Jan 1 2018, (Accepted/In press) In : Journal of Neuro-Oncology.

Research output: Contribution to journalArticle

Glioma
Mutation
Clone Cells
Comparative Genomic Hybridization
Transcription Factors
41 Citations (Scopus)

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Kasendra, M., Tovaglieri, A., Sontheimer-Phelps, A., Jalili-Firoozinezhad, S., Bein, A., Chalkiadaki, A., Scholl, W., Zhang, C., Rickner, H., Richmond, C. A., Li, H., Breault, D. T. & Ingber, D. E., Dec 1 2018, In : Scientific Reports. 8, 1, 2871.

Research output: Contribution to journalArticle

Organoids
Small Intestine
Intestines
Biopsy
Epithelial Cells
4 Citations (Scopus)

Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

Shrestha, S., Zhang, C., Jerde, C. R., Nie, Q., Li, H., Offer, S. M. & Diasio, R. B., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Fluorouracil
Alleles
Precision Medicine
Computer Simulation
1 Citation (Scopus)

Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

Fang, H. T., El Farran, C. A., Xing, Q. R., Zhang, L. F., Li, H., Lim, B. & Loh, Y. H., Dec 1 2018, In : Nature Communications. 9, 1, 1537.

Research output: Contribution to journalArticle

Histones
Heterochromatin
Embryonic Stem Cells
cells
Collagen

Lung-resident mesenchymal stromal cells reveal transcriptional dynamics of lung development in preterm infants

Spadafora, R., Lu, J., Khetani, R. S., Zhang, C., Iberg, A., Li, H., Shi, Y. & Lerou, P. H., Oct 1 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 7, p. 961-964 4 p.

Research output: Contribution to journalLetter

Mesenchymal Stromal Cells
Premature Infants
Lung
6 Citations (Scopus)

Metabolism in Pluripotent Stem Cells and Early Mammalian Development

Zhang, J., Zhao, J., Dahan, P., Lu, V., Zhang, C., Li, H. & Teitell, M. A., Feb 6 2018, In : Cell Metabolism. 27, 2, p. 332-338 7 p.

Research output: Contribution to journalReview article

Pluripotent Stem Cells
Gene Expression
Histone Code
Embryonic Structures
Cell Differentiation
8 Citations (Scopus)

Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

Wang, L., Gao, J., Liu, J., Siedlak, S. L., Torres, S., Fujioka, H., Huntley, M. L., Jiang, Y., Ji, H., Yan, T., Harland, M., Termsarasab, P., Zeng, S., Jiang, Z., Liang, J., Perry, G., Hoppel, C., Zhang, C., Li, H. & Wang, X., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Axonal Transport
Synapses
Skeletal Muscle
Sarcopenia
Amyotrophic Lateral Sclerosis
12 Citations (Scopus)

Reconstruction of complex single-cell trajectories using CellRouter

Lummertz Da Rocha, E., Rowe, R. G., Lundin, V., Malleshaiah, M., Jha, D. K., Rambo, C. R., Li, H., North, T. E., Collins, J. J. & Daley, G. Q., Dec 1 2018, In : Nature Communications. 9, 1, 892.

Research output: Contribution to journalArticle

Cell engineering
Ecosystems
Trajectories
trajectories
cells
32 Citations (Scopus)

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Apicco, D. J., Ash, P. E. A., Maziuk, B., Leblang, C., Medalla, M., Al Abdullatif, A., Ferragud, A., Botelho, E., Ballance, H. I., Dhawan, U., Boudeau, S., Cruz, A. L., Kashy, D., Wong, A., Goldberg, L. R., Yazdani, N., Zhang, C., Ung, C. Y., Tripodis, Y., Kanaan, N. M. & 7 others, Ikezu, T., Cottone, P., Leszyk, J., Li, H., Luebke, J., Bryant, C. D. & Wolozin, B., Jan 1 2018, In : Nature Neuroscience. 21, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
T-Lymphocytes
Antigens
Neurofibrillary Tangles
Pathology
8 Citations (Scopus)

RNA binding proteins co-localize with small tau inclusions in tauopathy

Maziuk, B. F., Apicco, D. J., Cruz, A. L., Jiang, L., Ash, P. E. A., da Rocha, E. L., Zhang, C., Yu, W. H., Leszyk, J., Abisambra, J. F., Li, H. & Wolozin, B., Aug 1 2018, In : Acta neuropathologica communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Tauopathies
RNA-Binding Proteins
Pathology
tau Proteins
Neurofibrillary Tangles
13 Citations (Scopus)

Senescent cells: A therapeutic target for cardiovascular disease

Childs, B. G., Li, H. & Van Deursen, J., Apr 2 2018, In : Journal of Clinical Investigation. 128, 4, p. 1217-1228 12 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Cell Aging
Therapeutics
Cardiovascular System
Morbidity
1 Citation (Scopus)

Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm

Lu, J., Baccei, A., Lummertz da Rocha, E., Guillermier, C., McManus, S., Finney, L. A., Zhang, C., Steinhauser, M. L., Li, H. & Lerou, P. H., Apr 1 2018, In : Stem Cell Research. 28, p. 48-55 8 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Endoderm
Metallothionein
Pluripotent Stem Cells
Fluorescence Microscopy
1 Citation (Scopus)

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L. M., Li, H. & Weinshilboum, R. M., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Single Nucleotide Polymorphism
Estrogens
Transcription Factors
RNA Sequence Analysis
2017
7 Citations (Scopus)

Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells

Zhang, C., Skamagki, M., Liu, Z., Ananthanarayanan, A., Zhao, R., Li, H. & Kim, K., Nov 21 2017, In : Cell Reports. 21, 8, p. 2058-2065 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Facilitative Glucose Transport Proteins
Oxidative Phosphorylation
Acetylation
Stem cells
5 Citations (Scopus)

Canonical microRNAs Enable Differentiation, Protect Against DNA Damage, and Promote Cholesterol Biosynthesis in Neural Stem Cells

Liu, Z., Zhang, C., Khodadadi-Jamayran, A., Dang, L., Han, X., Kim, K., Li, H. & Zhao, R., Feb 1 2017, In : Stem Cells and Development. 26, 3, p. 177-188 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
MicroRNAs
DNA Damage
Cholesterol
Oligodendroglia
7 Citations (Scopus)

Combining hiPSCs and Human Genetics: Major Applications in Drug Development

Zhang, J., Li, H., Trounson, A., Wu, J. C. & Nioi, P., Aug 3 2017, In : Cell Stem Cell. 21, 2, p. 161-165 5 p.

Research output: Contribution to journalComment/debate

Genetic Research
Medical Genetics
Research
Pharmaceutical Preparations
11 Citations (Scopus)

Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling

Chandrasekaran, S., Zhang, J., Sun, Z., Zhang, L., Ross, C. A., Huang, Y. C., Asara, J. M., Li, H., Daley, G. Q. & Collins, J. J., Dec 5 2017, In : Cell Reports. 21, 10, p. 2965-2977 13 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Metabolism
Metabolomics
Genes
5 Citations (Scopus)

Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease

Ebbert, M. T. W., Ross, C. A., Pregent, L. J., Lank, R. J., Zhang, C., Katzman, R. B., Jansen-West, K., Song, Y., da Rocha, E. L., Palmucci, C., Desaro, P., Robertson, A. E., Caputo, A. M., Dickson, D. W., Boylan, K. B., Rademakers, R. V., Ordog, T., Li, H. & Belzil, V., Aug 14 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-14 14 p.

Research output: Contribution to journalArticle

Frontal Lobe
DNA Methylation
Brain
Transcriptome
Epigenomics
4 Citations (Scopus)

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Zhang, X., Dong, Z., Zhang, C., Ung, C. Y., He, S., Tao, T., Oliveira, A. M., Meves, A., Ji, B. D., Look, A. T., Li, H., Neel, B. G. & Zhu, S., Mar 21 2017, In : Cell Reports. 18, 12, p. 2932-2942 11 p.

Research output: Contribution to journalArticle

Neuroblastoma
Tumors
Fish
SH2 Domain-Containing Protein Tyrosine Phosphatases
Penetrance
3 Citations (Scopus)

Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells

Liu, Z., Zhang, C., Skamagki, M., Khodadadi-Jamayran, A., Zhang, W., Kong, D., Chang, C. W., Feng, J., Han, X., Townes, T. M., Li, H., Kim, K. & Zhao, R., Nov 14 2017, In : Stem Cell Reports. 9, 5, p. 1604-1617 14 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Embryonic Stem Cells
Stem cells
MicroRNAs
Polyomavirus Transforming Antigens
19 Citations (Scopus)

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A. C., Oldridge, D., Ung, C. Y., van Ree, J. H., Khan, A., Salazar, B. M., Lummertz da Rocha, E., Zimmerman, M. W., Guo, F., Cao, H., Hou, X., Weroha, S. J. & 8 others, Perez-Atayde, A. R., Neuberg, D. S., Meves, A., Mc Niven, M. A., Van Deursen, J., Li, H., Maris, J. M. & Look, A. T., Sep 11 2017, In : Cancer Cell. 32, 3, p. 310-323.e5

Research output: Contribution to journalArticle

Neuroblastoma
Neoplasm Metastasis
Zebrafish
Oncogenes
Extracellular Matrix
6 Citations (Scopus)

Machine Learning-Assisted Network Inference Approach to Identify a New Class of Genes that Coordinate the Functionality of Cancer Networks

Ghanat Bari, M., Ung, C. Y., Zhang, C., Zhu, S. & Li, H., Dec 1 2017, In : Scientific Reports. 7, 1, 6993.

Research output: Contribution to journalArticle

Neoplasm Genes
MHC Class II Genes
Genes
Neoplasms
MHC Class I Genes
2 Citations (Scopus)

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells

Skamagki, M., Zhang, C., Ross, C. A., Ananthanarayanan, A., Liu, Z., Mu, Q., Basu, U., Wang, J., Zhao, R., Li, H. & Kim, K., Oct 10 2017, In : Stem Cell Reports. 9, 4, p. 1053-1061 9 p.

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
Pluripotent Stem Cells
Stem cells
Oxidation-Reduction
RNA
11 Citations (Scopus)

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

Skamagki, M., Correia, C., Yeung, P., Baslan, T., Beck, S., Zhang, C., Ross, C. A., Dang, L., Liu, Z., Giunta, S., Chang, T. P., Wang, J., Ananthanarayanan, A., Bohndorf, M., Bosbach, B., Adjaye, J., Funabiki, H., Kim, J., Lowe, S., Collins, J. J. & 4 others, Lu, C. W., Li, H., Zhao, R. & Kim, K., Sep 1 2017, In : Nature Cell Biology. 19, 9, p. 1037-1048 12 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Genomic Instability
Tissue Donors
DNA Damage
Glutathione
2016
2 Citations (Scopus)

A network-based phenotype mapping approach to identify genes that modulate drug response phenotypes

Cairns, J., Ung, C. Y., Da Rocha, E. L., Zhang, C., Correia, C., Weinshilboum, R. M., Wang, L. M. & Li, H., Nov 14 2016, In : Scientific Reports. 6, 37003.

Research output: Contribution to journalArticle

Phenotype
Pharmaceutical Preparations
Genes
Triple Negative Breast Neoplasms
Cell Line
20 Citations (Scopus)

A role for the bacterial GATC methylome in antibiotic stress survival

Cohen, N. R., Ross, C. A., Jain, S., Shapiro, R. S., Gutierrez, A., Belenky, P., Li, H. & Collins, J. J., May 1 2016, In : Nature Genetics. 48, 5, p. 581-586 6 p.

Research output: Contribution to journalArticle

Anti-Bacterial Agents
Adenine
Methylation
Pharmaceutical Preparations
Escherichia coli
201 Citations (Scopus)
Microbiota
Inflammation
Peristalsis
Epithelial Cells
Ileus
4 Citations (Scopus)

Influence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells

Lu, J., Li, H., Baccei, A., Sasaki, T., Gilbert, D. M. & Lerou, P. H., May 1 2016, In : Stem Cells and Development. 25, 9, p. 740-747 8 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
DNA Damage
Genome
Therapeutic Human Experimentation
Genomic Instability
65 Citations (Scopus)

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Vanderweyde, T., Apicco, D. J., Youmans-Kidder, K., Ash, P. E. A., Cook, C., Lummertz da Rocha, E., Jansen-West, K., Frame, A. A., Citro, A., Leszyk, J. D., Ivanov, P., Abisambra, J. F., Steffen, M., Li, H., Petrucelli, L. & Wolozin, B., May 17 2016, In : Cell Reports. 15, 7, p. 1455-1466 12 p.

Research output: Contribution to journalArticle

Tauopathies
RNA-Binding Proteins
Toxicity
Brain
Microtubule-Associated Proteins
76 Citations (Scopus)

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

Zhang, J., Ratanasirintrawoot, S., Chandrasekaran, S., Wu, Z., Ficarro, S. B., Yu, C., Ross, C. A., Cacchiarelli, D., Xia, Q., Seligson, M., Shinoda, G., Xie, W., Cahan, P., Wang, L., Ng, S. C., Tintara, S., Trapnell, C., Onder, T., Loh, Y. H., Mikkelsen, T. & 7 others, Sliz, P., Teitell, M. A., Asara, J. M., Marto, J. A., Li, H., Collins, J. J. & Daley, G. Q., Jul 1 2016, In : Cell Stem Cell. 19, 1, p. 66-80 15 p.

Research output: Contribution to journalArticle

Stem Cells
Induced Pluripotent Stem Cells
Metabolomics
RNA-Binding Proteins
Oxidative Phosphorylation
6 Citations (Scopus)

NetDecoder: A network biology platform that decodes context-specific biological networks and gene activities

Da Rocha, E. L., Ung, C. Y., Mcgehee, C. D., Correia, C. & Li, H., Jun 2 2016, In : Nucleic Acids Research. 44, 10, e100.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
Research Personnel
Breast Diseases
Dyslipidemias
8 Citations (Scopus)

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

Cheng, H., Ang, H. Y. K., El Farran, C. A., Li, P., Fang, H. T., Liu, T. M., Kong, S. L., Chin, M. L., Ling, W. Y., Lim, E. K. H., Li, H., Huber, T., Loh, K. M., Loh, Y. H. & Lim, B., Nov 21 2016, In : Nature Communications. 7, 13396.

Research output: Contribution to journalArticle

fibroblasts
Fibroblasts
mice
Transcription Factors
Blood
18 Citations (Scopus)

RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming

Toh, C. X. D., Chan, J. W., Chong, Z. S., Wang, H. F., Guo, H. C., Satapathy, S., Ma, D., Goh, G. Y. L., Khattar, E., Yang, L., Tergaonkar, V., Chang, Y. T., Collins, J. J., Daley, G. Q., Wee, K. B., Farran, C. A. E. L., Li, H., Lim, Y. P., Bard, F. A. & Loh, Y. H., Jun 21 2016, In : Cell Reports. 15, 12, p. 2597-2607 11 p.

Research output: Contribution to journalArticle

RNA Interference
Chromatin
Genes
Ubiquitination
GTP-Binding Proteins
12 Citations (Scopus)

TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors

Gao, X., Lee, H. Y., Da Rocha, E. L., Zhang, C., Lu, Y. F., Li, D., Feng, Y., Ezike, J., Elmes, R. R., Inmaculada Barrasa, M., Cahan, P., Li, H., Daley, G. Q. & Lodish, H. F., Dec 8 2016, In : Blood. 128, 23, p. 2637-2641 5 p.

Research output: Contribution to journalArticle

Erythroid Precursor Cells
Transforming Growth Factors
Blood
Erythrocytes
Cells
74 Citations (Scopus)

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

Wang, W., Wang, L., Lu, J., Siedlak, S. L., Fujioka, H., Liang, J., Jiang, S., Ma, X., Jiang, Z., Da Rocha, E. L., Sheng, M., Choi, H., Lerou, P. H., Li, H. & Wang, X., Aug 1 2016, In : Nature Medicine. 22, 8, p. 869-878 10 p.

Research output: Contribution to journalArticle

Mitochondria
Amyotrophic Lateral Sclerosis
Toxicity
Neurons
Neurodegenerative diseases
2015
12 Citations (Scopus)

Case-only exome sequencing and complex disease susceptibility gene discovery: Study design considerations

Wu, L., Schaid, D. J., Sicotte, H., Wieben, E. D., Li, H. & Petersen, G. M., 2015, In : Journal of Medical Genetics. 52, 1, p. 10-16 7 p.

Research output: Contribution to journalReview article

Exome
Disease Susceptibility
Genetic Association Studies
Gene Frequency
Genes
126 Citations (Scopus)

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

Prudencio, M., Belzil, V., Batra, R., Ross, C. A., Gendron, T. D., Pregent, L. J., Murray, M. E., Overstreet, K. K., Piazza-Johnston, A. E., Desaro, P., Bieniek, K. F., Deture, M., Lee, W. C., Biendarra, S. M., Davis, M. D., Baker, M. C., Perkerson, R. B., Van Blitterswijk, M., Stetler, C. T., Rademakers, R. V. & 5 others, Link, C. D., Dickson, D. W., Boylan, K. B., Li, H. & Petrucelli, L., Aug 30 2015, In : Nature Neuroscience. 18, 8, p. 1175-1182 8 p.

Research output: Contribution to journalArticle

Alternative Splicing
Transcriptome
Polyadenylation
Amyotrophic Lateral Sclerosis
Brain

Erratum: Deconstructing transcriptional heterogeneity in pluripotent stem cells (Nature (2014) 516 (5661) DOI:10.1038/nature13920)

Kumar, R. M., Cahan, P., Shalek, A. K., Satija, R., DaleyKeyser, A. J., Li, H., Zhang, J., Pardee, K., Gennert, D., Trombetta, J. J., Ferrante, T. C., Regev, A., Daley, G. Q. & Collins, J. J., Mar 5 2015, In : Nature. 519, 7541, p. 118 1 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

Lee, H. Y., Gao, X., Barrasa, M. I., Li, H., Elmes, R. R., Peters, L. L. & Lodish, H. F., Jun 25 2015, In : Nature. 522, 7557, p. 474-477 4 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Glucocorticoid Receptors
Erythroid Precursor Cells
Erythropoietin
Anemia
56 Citations (Scopus)

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

Yang, B. X., El Farran, C. A., Guo, H. C., Yu, T., Fang, H. T., Wang, H. F., Schlesinger, S., Seah, Y. F. S., Goh, G. Y. L., Neo, S. P., Li, Y., Lorincz, M. C., Tergaonkar, V., Lim, T. M., Chen, L., Gunaratne, J., Collins, J. J., Goff, S. P., Daley, G. Q., Li, H. & 2 others, Bard, F. A. & Loh, Y. H., Sep 24 2015, In : Cell. 163, 1, p. 230-245 16 p.

Research output: Contribution to journalArticle

Proviruses
Embryonic Stem Cells
Sumoylation
Stem cells
Endogenous Retroviruses
2014
54 Citations (Scopus)

Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells

Lu, Y., Loh, Y. H., Li, H., Cesana, M., Ficarro, S. B., Parikh, J. R., Salomonis, N., Toh, C. X. D., Andreadis, S. T., Luckey, C. J., Collins, J. J., Daley, G. Q. & Marto, J. A., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Alternative Splicing
Proteome
Protein Isoforms
Chromatin Assembly and Disassembly
28 Citations (Scopus)

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Dusonchet, J., Li, H., Guillily, M., Liu, M., Stafa, K., Derada Troletti, C., Boon, J. Y., Saha, S., Glauser, L., Mamais, A., Citro, A., Youmans, K. L., Liu, L., Schneider, B. L., Aebischer, P., Yue, Z., Bandopadhyay, R., Glicksman, M. A., Moore, D. J., Collins, J. J. & 1 others, Wolozin, B., 2014, In : Human Molecular Genetics. 23, 18, p. 4887-4905 19 p., ddu202.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Parkinson Disease
GTP Phosphohydrolases
Mutation
GTPase-Activating Proteins
236 Citations (Scopus)

CellNet: Network biology applied to stem cell engineering

Cahan, P., Li, H., Morris, S. A., Lummertz Da Rocha, E., Daley, G. Q. & Collins, J. J., Aug 14 2014, In : Cell. 158, 4, p. 903-915 13 p.

Research output: Contribution to journalArticle

Cell engineering
Cell Engineering
Stem cells
Stem Cells
Genes
32 Citations (Scopus)

Central role for RNase YbeY in Hfq-dependent and Hfq-independent small-RNA regulation in bacteria

Pandey, S. P., Winkler, J. A., Li, H., Camacho, D. M., Collins, J. J. & Walker, G. C., Feb 11 2014, In : BMC Genomics. 15, 1, 121.

Research output: Contribution to journalArticle

Ribonucleases
RNA
Hydroxyurea
Bacteria
Messenger RNA
10 Citations (Scopus)

Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy

Jasuja, R., Costello, J. C., Singh, R., Gupta, V., Spina, C. S., Toraldo, G., Jang, H., Li, H., Serra, C., Guo, W., Chauhan, P., Narula, N. S., Guarneri, T., Ergun, A., Travison, T. G., Collins, J. J. & Bhasin, S., 2014, In : Aging Cell. 13, 2, p. 303-310 8 p.

Research output: Contribution to journalArticle

Follistatin
Testosterone
Prostate
Muscles
Therapeutics
167 Citations (Scopus)

Deconstructing transcriptional heterogeneity in pluripotent stem cells

Kumar, R. M., Cahan, P., Shalek, A. K., Satija, R., Keyser, A. D., Li, H., Zhang, J., Pardee, K., Gennert, D., Trombetta, J. J., Ferrante, T. C., Regev, A., Daley, G. Q. & Collins, J. J., Dec 4 2014, In : Nature. 516, 729, p. 56-61 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
MicroRNAs
Chromatin
Population Characteristics
Cell Division