Hu Li, PhD

  • 5868 Citations
  • 34 Scopus h-Index
20052021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & Van Deursen, J., Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

6 Scopus citations

Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis

Liu, Z., Che, P., Mercado, J. J., Hackney, J. R., Friedman, G. K., Zhang, C., You, Z., Zhao, X., Ding, Q., Kim, K., Li, H., Liu, X., Markert, J. M., Nabors, B., Gillespie, G. Y., Zhao, R. & Han, X., Jan 30 2019, In : Journal of neuro-oncology. 141, 2, p. 289-301 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Erratum to: ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors (Nature Cell Biology, (2017), 19, 9, (1037-1048), 10.1038/ncb3598)

Skamagki, M., Correia, C., Yeung, P., Baslan, T., Beck, S., Zhang, C., Ross, C. A., Dang, L., Liu, Z., Giunta, S., Chang, T. P., Wang, J., Ananthanarayanan, A., Bohndorf, M., Bosbach, B., Adjaye, J., Funabiki, H., Kim, J., Lowe, S., Collins, J. J. & 4 others, Lu, C. W., Li, H., Zhao, R. & Kim, K., Jan 1 2019, (Accepted/In press) In : Nature Cell Biology.

Research output: Contribution to journalArticle

Microbial Metabolism Modulates Antibiotic Susceptibility within the Murine Gut Microbiome

Cabral, D. J., Penumutchu, S., Reinhart, E. M., Zhang, C., Korry, B. J., Wurster, J. I., Nilson, R., Guang, A., Sano, W. H., Rowan-Nash, A. D., Li, H. & Belenky, P., Oct 1 2019, In : Cell Metabolism. 30, 4, p. 800-823.e7

Research output: Contribution to journalArticle

5 Scopus citations

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

7 Scopus citations

Regulostat Inferelator: a novel network biology platform to uncover molecular devices that predetermine cellular response phenotypes

Ung, C. Y., Ghanat Bari, M., Zhang, C., Liang, J., Correia, C. & Li, H., Aug 22 2019, In : Nucleic acids research. 47, 14, p. e82

Research output: Contribution to journalArticle

Open Access
Open Access
2018

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Kasendra, M., Tovaglieri, A., Sontheimer-Phelps, A., Jalili-Firoozinezhad, S., Bein, A., Chalkiadaki, A., Scholl, W., Zhang, C., Rickner, H., Richmond, C. A., Li, H., Breault, D. T. & Ingber, D. E., Dec 1 2018, In : Scientific Reports. 8, 1, 2871.

Research output: Contribution to journalArticle

90 Scopus citations

Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase

Shrestha, S., Zhang, C., Jerde, C. R., Nie, Q., Li, H., Offer, S. M. & Diasio, R. B., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

7 Scopus citations

Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

Fang, H. T., El Farran, C. A., Xing, Q. R., Zhang, L. F., Li, H., Lim, B. & Loh, Y. H., Dec 1 2018, In : Nature Communications. 9, 1, 1537.

Research output: Contribution to journalArticle

6 Scopus citations

Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

Wang, L., Gao, J., Liu, J., Siedlak, S. L., Torres, S., Fujioka, H., Huntley, M. L., Jiang, Y., Ji, H., Yan, T., Harland, M., Termsarasab, P., Zeng, S., Jiang, Z., Liang, J., Perry, G., Hoppel, C., Zhang, C., Li, H. & Wang, X., Sep 4 2018, In : Cell Metabolism. 28, 3, p. 400-414.e8

Research output: Contribution to journalArticle

12 Scopus citations

Reconstruction of complex single-cell trajectories using CellRouter

Lummertz Da Rocha, E., Rowe, R. G., Lundin, V., Malleshaiah, M., Jha, D. K., Rambo, C. R., Li, H., North, T. E., Collins, J. J. & Daley, G. Q., Dec 1 2018, In : Nature communications. 9, 1, 892.

Research output: Contribution to journalArticle

23 Scopus citations

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo

Apicco, D. J., Ash, P. E. A., Maziuk, B., Leblang, C., Medalla, M., Al Abdullatif, A., Ferragud, A., Botelho, E., Ballance, H. I., Dhawan, U., Boudeau, S., Cruz, A. L., Kashy, D., Wong, A., Goldberg, L. R., Yazdani, N., Zhang, C., Ung, C. Y., Tripodis, Y., Kanaan, N. M. & 7 others, Ikezu, T., Cottone, P., Leszyk, J., Li, H., Luebke, J., Bryant, C. D. & Wolozin, B., Jan 1 2018, In : Nature Neuroscience. 21, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

RNA binding proteins co-localize with small tau inclusions in tauopathy

Maziuk, B. F., Apicco, D. J., Cruz, A. L., Jiang, L., Ash, P. E. A., da Rocha, E. L., Zhang, C., Yu, W. H., Leszyk, J., Abisambra, J. F., Li, H. & Wolozin, B., Aug 1 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

23 Scopus citations

Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm

Lu, J., Baccei, A., Lummertz da Rocha, E., Guillermier, C., McManus, S., Finney, L. A., Zhang, C., Steinhauser, M. L., Li, H. & Lerou, P. H., Apr 1 2018, In : Stem Cell Research. 28, p. 48-55 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L., Li, H. & Weinshilboum, R. M., Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Biological Significance of the Suppression of Oxidative Phosphorylation in Induced Pluripotent Stem Cells

Zhang, C., Skamagki, M., Liu, Z., Ananthanarayanan, A., Zhao, R., Li, H. & Kim, K., Nov 21 2017, In : Cell Reports. 21, 8, p. 2058-2065 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Canonical microRNAs Enable Differentiation, Protect Against DNA Damage, and Promote Cholesterol Biosynthesis in Neural Stem Cells

Liu, Z., Zhang, C., Khodadadi-Jamayran, A., Dang, L., Han, X., Kim, K., Li, H. & Zhao, R., Feb 1 2017, In : Stem Cells and Development. 26, 3, p. 177-188 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling

Chandrasekaran, S., Zhang, J., Sun, Z., Zhang, L., Ross, C. A., Huang, Y. C., Asara, J. M., Li, H., Daley, G. Q. & Collins, J. J., Dec 5 2017, In : Cell reports. 21, 10, p. 2965-2977 13 p.

Research output: Contribution to journalArticle

15 Scopus citations

Conserved DNA methylation combined with differential frontal cortex and cerebellar expression distinguishes C9orf72-associated and sporadic ALS, and implicates SERPINA1 in disease

Ebbert, M. T. W., Ross, C. A., Pregent, L. J., Lank, R. J., Zhang, C., Katzman, R. B., Jansen-West, K., Song, Y., da Rocha, E. L., Palmucci, C., Desaro, P., Robertson, A. E., Caputo, A. M., Dickson, D. W., Boylan, K. B., Rademakers, R. V., Ordog, T., Li, H. & Belzil, V., Aug 14 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-14 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Zhang, X., Dong, Z., Zhang, C., Ung, C. Y., He, S., Tao, T., Oliveira, A. M., Meves, A., Ji, B. D., Look, A. T., Li, H., Neel, B. G. & Zhu, S., Mar 21 2017, In : Cell Reports. 18, 12, p. 2932-2942 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells

Liu, Z., Zhang, C., Skamagki, M., Khodadadi-Jamayran, A., Zhang, W., Kong, D., Chang, C. W., Feng, J., Han, X., Townes, T. M., Li, H., Kim, K. & Zhao, R., Nov 14 2017, In : Stem Cell Reports. 9, 5, p. 1604-1617 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A. C., Oldridge, D., Ung, C. Y., van Ree, J. H., Khan, A., Salazar, B. M., Lummertz da Rocha, E., Zimmerman, M. W., Guo, F., Cao, H., Hou, X., Weroha, S. J. & 8 others, Perez-Atayde, A. R., Neuberg, D. S., Meves, A., McNiven, M. A., van Deursen, J. M., Li, H., Maris, J. M. & Look, A. T., Sep 11 2017, In : Cancer cell. 32, 3, p. 310-323.e5

Research output: Contribution to journalArticle

28 Scopus citations

Machine Learning-Assisted Network Inference Approach to Identify a New Class of Genes that Coordinate the Functionality of Cancer Networks

Ghanat Bari, M., Ung, C. Y., Zhang, C., Zhu, S. & Li, H., Dec 1 2017, In : Scientific Reports. 7, 1, 6993.

Research output: Contribution to journalArticle

9 Scopus citations

RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells

Skamagki, M., Zhang, C., Ross, C. A., Ananthanarayanan, A., Liu, Z., Mu, Q., Basu, U., Wang, J., Zhao, R., Li, H. & Kim, K., Oct 10 2017, In : Stem Cell Reports. 9, 4, p. 1053-1061 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors

Skamagki, M., Correia, C., Yeung, P., Baslan, T., Beck, S., Zhang, C., Ross, C. A., Dang, L., Liu, Z., Giunta, S., Chang, T. P., Wang, J., Ananthanarayanan, A., Bohndorf, M., Bosbach, B., Adjaye, J., Funabiki, H., Kim, J., Lowe, S., Collins, J. J. & 4 others, Lu, C. W., Li, H., Zhao, R. & Kim, K., Sep 1 2017, In : Nature Cell Biology. 19, 9, p. 1037-1048 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

A network-based phenotype mapping approach to identify genes that modulate drug response phenotypes

Cairns, J., Ung, C. Y., Da Rocha, E. L., Zhang, C., Correia, C., Weinshilboum, R. M., Wang, L. M. & Li, H., Nov 14 2016, In : Scientific Reports. 6, 37003.

Research output: Contribution to journalArticle

3 Scopus citations

A role for the bacterial GATC methylome in antibiotic stress survival

Cohen, N. R., Ross, C. A., Jain, S., Shapiro, R. S., Gutierrez, A., Belenky, P., Li, H. & Collins, J. J., May 1 2016, In : Nature Genetics. 48, 5, p. 581-586 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
251 Scopus citations

Influence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells

Lu, J., Li, H., Baccei, A., Sasaki, T., Gilbert, D. M. & Lerou, P. H., May 1 2016, In : Stem Cells and Development. 25, 9, p. 740-747 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Vanderweyde, T., Apicco, D. J., Youmans-Kidder, K., Ash, P. E. A., Cook, C., Lummertz da Rocha, E., Jansen-West, K., Frame, A. A., Citro, A., Leszyk, J. D., Ivanov, P., Abisambra, J. F., Steffen, M., Li, H., Petrucelli, L. & Wolozin, B., May 17 2016, In : Cell reports. 15, 7, p. 1455-1466 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

Zhang, J., Ratanasirintrawoot, S., Chandrasekaran, S., Wu, Z., Ficarro, S. B., Yu, C., Ross, C. A., Cacchiarelli, D., Xia, Q., Seligson, M., Shinoda, G., Xie, W., Cahan, P., Wang, L., Ng, S. C., Tintara, S., Trapnell, C., Onder, T., Loh, Y. H., Mikkelsen, T. & 7 others, Sliz, P., Teitell, M. A., Asara, J. M., Marto, J. A., Li, H., Collins, J. J. & Daley, G. Q., Jul 1 2016, In : Cell Stem Cell. 19, 1, p. 66-80 15 p.

Research output: Contribution to journalArticle

107 Scopus citations

NetDecoder: A network biology platform that decodes context-specific biological networks and gene activities

Da Rocha, E. L., Ung, C. Y., Mcgehee, C. D., Correia, C. & Li, H., Jun 2 2016, In : Nucleic Acids Research. 44, 10, e100.

Research output: Contribution to journalArticle

8 Scopus citations

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

Cheng, H., Ang, H. Y. K., El Farran, C. A., Li, P., Fang, H. T., Liu, T. M., Kong, S. L., Chin, M. L., Ling, W. Y., Lim, E. K. H., Li, H., Huber, T., Loh, K. M., Loh, Y. H. & Lim, B., Nov 21 2016, In : Nature Communications. 7, 13396.

Research output: Contribution to journalArticle

15 Scopus citations

RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming

Toh, C. X. D., Chan, J. W., Chong, Z. S., Wang, H. F., Guo, H. C., Satapathy, S., Ma, D., Goh, G. Y. L., Khattar, E., Yang, L., Tergaonkar, V., Chang, Y. T., Collins, J. J., Daley, G. Q., Wee, K. B., Farran, C. A. E. L., Li, H., Lim, Y. P., Bard, F. A. & Loh, Y. H., Jun 21 2016, In : Cell reports. 15, 12, p. 2597-2607 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors

Gao, X., Lee, H. Y., Da Rocha, E. L., Zhang, C., Lu, Y. F., Li, D., Feng, Y., Ezike, J., Elmes, R. R., Inmaculada Barrasa, M., Cahan, P., Li, H., Daley, G. Q. & Lodish, H. F., Dec 8 2016, In : Blood. 128, 23, p. 2637-2641 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

Wang, W., Wang, L., Lu, J., Siedlak, S. L., Fujioka, H., Liang, J., Jiang, S., Ma, X., Jiang, Z., Da Rocha, E. L., Sheng, M., Choi, H., Lerou, P. H., Li, H. & Wang, X., Aug 1 2016, In : Nature Medicine. 22, 8, p. 869-878 10 p.

Research output: Contribution to journalArticle

97 Scopus citations
2015

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

Prudencio, M., Belzil, V., Batra, R., Ross, C. A., Gendron, T. D., Pregent, L. J., Murray, M. E., Overstreet, K. K., Piazza-Johnston, A. E., Desaro, P., Bieniek, K. F., Deture, M., Lee, W. C., Biendarra, S. M., Davis, M. D., Baker, M. C., Perkerson, R. B., Van Blitterswijk, M., Stetler, C. T., Rademakers, R. V. & 5 others, Link, C. D., Dickson, D. W., Boylan, K. B., Li, H. & Petrucelli, L., Aug 30 2015, In : Nature Neuroscience. 18, 8, p. 1175-1182 8 p.

Research output: Contribution to journalArticle

145 Scopus citations

PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal

Lee, H. Y., Gao, X., Barrasa, M. I., Li, H., Elmes, R. R., Peters, L. L. & Lodish, H. F., Jun 25 2015, In : Nature. 522, 7557, p. 474-477 4 p.

Research output: Contribution to journalArticle

53 Scopus citations

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

Yang, B. X., El Farran, C. A., Guo, H. C., Yu, T., Fang, H. T., Wang, H. F., Schlesinger, S., Seah, Y. F. S., Goh, G. Y. L., Neo, S. P., Li, Y., Lorincz, M. C., Tergaonkar, V., Lim, T. M., Chen, L., Gunaratne, J., Collins, J. J., Goff, S. P., Daley, G. Q., Li, H. & 2 others, Bard, F. A. & Loh, Y. H., Sep 24 2015, In : Cell. 163, 1, p. 230-245 16 p.

Research output: Contribution to journalArticle

65 Scopus citations
2014

Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells

Lu, Y., Loh, Y. H., Li, H., Cesana, M., Ficarro, S. B., Parikh, J. R., Salomonis, N., Toh, C. X. D., Andreadis, S. T., Luckey, C. J., Collins, J. J., Daley, G. Q. & Marto, J. A., Jul 3 2014, In : Cell Stem Cell. 15, 1, p. 92-101 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Dusonchet, J., Li, H., Guillily, M., Liu, M., Stafa, K., Derada Troletti, C., Boon, J. Y., Saha, S., Glauser, L., Mamais, A., Citro, A., Youmans, K. L., Liu, L. Q., Schneider, B. L., Aebischer, P., Yue, Z., Bandopadhyay, R., Glicksman, M. A., Moore, D. J., Collins, J. J. & 1 others, Wolozin, B., Sep 2014, In : Human molecular genetics. 23, 18, p. 4887-4905 19 p., ddu202.

Research output: Contribution to journalArticle

30 Scopus citations

CellNet: Network biology applied to stem cell engineering

Cahan, P., Li, H., Morris, S. A., Lummertz Da Rocha, E., Daley, G. Q. & Collins, J. J., Aug 14 2014, In : Cell. 158, 4, p. 903-915 13 p.

Research output: Contribution to journalArticle

259 Scopus citations

Central role for RNase YbeY in Hfq-dependent and Hfq-independent small-RNA regulation in bacteria

Pandey, S. P., Winkler, J. A., Li, H., Camacho, D. M., Collins, J. J. & Walker, G. C., Feb 11 2014, In : BMC genomics. 15, 1, 121.

Research output: Contribution to journalArticle

35 Scopus citations

Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy

Jasuja, R., Costello, J. C., Singh, R., Gupta, V., Spina, C. S., Toraldo, G., Jang, H., Li, H., Serra, C., Guo, W., Chauhan, P., Narula, N. S., Guarneri, T., Ergun, A., Travison, T. G., Collins, J. J. & Bhasin, S., Apr 2014, In : Aging Cell. 13, 2, p. 303-310 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Deconstructing transcriptional heterogeneity in pluripotent stem cells

Kumar, R. M., Cahan, P., Shalek, A. K., Satija, R., Keyser, A. D., Li, H., Zhang, J., Pardee, K., Gennert, D., Trombetta, J. J., Ferrante, T. C., Regev, A., Daley, G. Q. & Collins, J. J., Dec 4 2014, In : Nature. 516, 729, p. 56-61 6 p.

Research output: Contribution to journalArticle

191 Scopus citations

Dissecting engineered cell types and enhancing cell fate conversion via Cellnet

Morris, S. A., Cahan, P., Li, H., Zhao, A. M., San Roman, A. K., Shivdasani, R. A., Collins, J. J. & Daley, G. Q., Aug 14 2014, In : Cell. 158, 4, p. 889-902 14 p.

Research output: Contribution to journalArticle

134 Scopus citations

Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes

Lang, A. H., Li, H., Collins, J. J. & Mehta, P., Aug 14 2014, In : PLoS computational biology. 10, 8, e1003734.

Research output: Contribution to journalArticle

52 Scopus citations

Gene networks of fully connected triads with complete auto-activation enable multistability and stepwise stochastic transitions

Faucon, P. C., Pardee, K., Kumar, R. M., Li, H., Loh, Y. H. & Wang, X., Jul 24 2014, In : PloS one. 9, 7, e102873.

Research output: Contribution to journalArticle

22 Scopus citations

Hsp70-Bag3 interactions regulate cancer-related signaling networks

Colvin, T. A., Gabai, V. L., Gong, J., Calderwood, S. K., Li, H., Gummuluru, S., Matchuk, O. N., Smirnova, S. G., Orlova, N. V., Zamulaeva, I. A., Garcia-Marcos, M., Li, X., Young, Z. T., Rauch, J. N., Gestwicki, J. E., Takayama, S. & Sherman, M. Y., Sep 1 2014, In : Cancer research. 74, 17, p. 4731-4740 10 p.

Research output: Contribution to journalArticle

71 Scopus citations