Hirohito Kita, MD

  • 13400 E Shea Blvd, Mayo Clinic Arizona, MCCRB Room 2-213

    85259 Scottsdale

    United States

  • 14965 Citations
  • 68 Scopus h-Index
1984 …2020

Research output per year

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Research Output

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Article
2014

Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice

Drake, L. Y., Iijima, K. & Kita, H., Jan 1 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 10, p. 1300-1307 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure

Iijima, K., Kobayashi, T., Hara, K., Kephart, G. M., Ziegler, S. F., McKenzie, A. N. & Kita, H., Aug 15 2014, In : Journal of Immunology. 193, 4, p. 1549-1559 11 p.

Research output: Contribution to journalArticle

71 Scopus citations

The involvement of glucocorticoids in psychological stress-induced exacerbations of experimental allergic asthma

Okuyama, K., Dobashi, K., Miyasaka, T., Yamazaki, N., Kikuchi, T., Sora, I., Takayanagi, M., Kita, H. & Ohno, I., May 2014, In : International archives of allergy and immunology. 163, 4, p. 297-306 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Alternaria inhibits double-stranded RNA-induced cytokine production through toll-like receptor 3

Wada, K., Kobayashi, T., Matsuwaki, Y., Moriyama, H. & Kita, H., Apr 12 2013, In : International archives of allergy and immunology. 161, p. 75-83 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Analysis of global gene expression changes in human bronchial epithelial cells exposed to spores of the allergenic fungus, Alternaria alternata

Babiceanu, M. C., Howard, B. A., Rumore, A. C., Kita, H. & Lawrence, C. B., 2013, In : Frontiers in Microbiology. 4, JUL

Research output: Contribution to journalArticle

8 Scopus citations

A proposed model to study immunologic changes during chronic rhinosinusitis exacerbations: Data from a pilot study

Rank, M. A., Hagan, J. B., Samant, S. A. & Kita, H., Mar 1 2013, In : American Journal of Rhinology and Allergy. 27, 2, p. 98-101 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Asthma and antibodies to pneumococcal virulence proteins

Zhao, H., Jung, J. A., Briles, D. E., Kita, H., Tsigrelis, C. & Juhn, Y. J., Oct 1 2013, In : Infection. 41, 5, p. 927-934 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

ATP release and Ca2+ signalling by human bronchial epithelial cells following Alternaria aeroallergen exposure

O'Grady, S. M., Patil, N., Melkamu, T., Maniak, P. J., Lancto, C. & Kita, H., Sep 1 2013, In : Journal of Physiology. 591, 18, p. 4595-4609 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Eosinophils: Multifunctional and distinctive properties

Kita, H., Apr 12 2013, In : International archives of allergy and immunology. 161, p. 3-9 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

IL-1 family cytokines drive Th2 and Th17 cells to innocuous airborne antigens

Kobayashi, T., Iijima, K., Checkel, J. L. & Kita, H., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 989-998 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Induction of Malignant Plasma Cell Proliferation by Eosinophils

Wong, T. W., Kita, H., Hanson, C. A., Walters, D. K., Arendt, B. K. & Jelinek, D. F., Jul 22 2013, In : PloS one. 8, 7, e70554.

Research output: Contribution to journalArticle

20 Scopus citations
7 Scopus citations

Systemic reactions to allergen immunotherapy: A role for measuring a PGD2 metabolite?

Rank, M. A., Kita, H., Li, J. T. & Butterfield, J. H., Jan 2013, In : Annals of Allergy, Asthma and Immunology. 110, 1, p. 57-58 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: Clinical correlations and comparison to Lund-Mackay scoring

Pallanch, J. F., Yu, L., Delone, D., Robb, R., Holmes, D. R., Camp, J., Edwards, P., Mccollough, C. H., Ponikau, J., Dearking, A. C., Lane, J., Primak, A., Shinkle, A., Hagan, J., Frigas, E., Ocel, J. J., Tombers, N., Siwani, R., Orme, N. M., Reed, K. B. & 3 others, Jerath, N., Dhillon, R. & Kita, H., Dec 1 2013, In : International Forum of Allergy and Rhinology. 3, 12, p. 963-972 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

TLR3 activation evokes IL-6 secretion, autocrine regulation of Stat3 signaling and TLR2 expression in human bronchial epithelial cells

Melkamu, T., Kita, H. & O'Grady, S. M., Jun 1 2013, In : Journal of Cell Communication and Signaling. 7, 2, p. 109-118 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells

Kouzaki, H., Tojima, I., Kita, H. & Shimizu, T., Nov 1 2013, In : American journal of respiratory cell and molecular biology. 49, 5, p. 741-750 10 p.

Research output: Contribution to journalArticle

63 Scopus citations
2012

Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2

Matsuwaki, Y., Wada, K., White, T., Moriyama, H. & Kita, H., May 1 2012, In : International archives of allergy and immunology. 158, SUPPL. 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Asthma outcomes: Biomarkers

Szefler, S. J., Wenzel, S., Brown, R., Erzurum, S. C., Fahy, J. V., Hamilton, R. G., Hunt, J. F., Kita, H., Liu, A. H., Panettieri, R. A., Schleimer, R. P. & Minnicozzi, M., Mar 1 2012, In : Journal of Allergy and Clinical Immunology. 129, 3 SUPPL., p. S9-S23

Research output: Contribution to journalArticle

252 Scopus citations

Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with kimura disease

Hosoki, K., Hirayama, M., Kephart, G. M., Kita, H., Nagao, M., Uchizono, H., Toyoda, H., Senba, Y., Imai, Y., Komada, Y., Ihara, T. & Fujisawa, T., May 1 2012, In : International archives of allergy and immunology. 158, SUPPL. 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Eosinophil granular proteins damage bronchial epithelial cells infected with respiratory syncytial virus

Kato, M., Ishioka, T., Kita, H., Kozawa, K., Hayashi, Y. & Kimura, H., May 1 2012, In : International archives of allergy and immunology. 158, SUPPL. 1, p. 11-18 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases

Plager, D. A., Torres, S. M. F., Koch, S. N. & Kita, H., Sep 15 2012, In : Veterinary Immunology and Immunopathology. 149, 1-2, p. 136-142 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

IL-33-responsive lineage -CD25 +CD44 hi lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs

Bartemes, K. R., Iijima, K., Kobayashi, T., Kephart, G. M., McKenzie, A. N. & Kita, H., Feb 1 2012, In : Journal of Immunology. 188, 3, p. 1503-1513 11 p.

Research output: Contribution to journalArticle

333 Scopus citations

Improving the detection of fungi in eosinophilic mucin: Seeing what we could not see before

Guo, C., Ghadersohi, S., Kephart, G. M., Laine, R. A., Sherris, D. A., Kita, H. & Ponikau, J. U., Nov 1 2012, In : Otolaryngology - Head and Neck Surgery (United States). 147, 5, p. 943-949 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia

Sridhara, S., Ravi, K., Smyrk, T. C., Kita, H., Kephart, G. M., Weiler, C. R. & Katzka, D. A., Jul 1 2012, In : Clinical Gastroenterology and Hepatology. 10, 7, p. 735-741 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Swallowed Fluticasone Improves Histologic but Not Symptomatic Response of Adults With Eosinophilic Esophagitis

Alexander, J. A., Jung, K. W., Arora, A. S., Enders, F., Katzka, D. A., Kephardt, G. M., Kita, H., Kryzer, L. A., Romero, Y., Smyrk, T. C. & Talley, N. J., Jul 2012, In : Clinical Gastroenterology and Hepatology. 10, 7, p. 742-749.e1

Research output: Contribution to journalArticle

195 Scopus citations
2011

An 8-year-old boy with hypereosinophilic syndrome

Hosoki, K., Nagao, M., Iguchi, K., Ihara, T., Yamada, Y., Higashigawa, M., Kephart, G. M., Kita, H. & Fujisawa, T., Jun 1 2011, In : International archives of allergy and immunology. 155, SUPPL. 1, p. 117-122 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Analysis of fluticasone propionate in induced sputum by mass spectrometry

Hagan, J. B., Taylor, R. L., Kita, H. & Singh, R. J., Jul 1 2011, In : Allergy and Asthma Proceedings. 32, 4, p. e18-e21

Research output: Contribution to journalArticle

3 Scopus citations

Antigen-specific IgG and IgA, but not IgE, activate the effector functions of eosinophils in the presence of antigen

Muraki, M., Gleich, G. J. & Kita, H., Jan 1 2011, In : International archives of allergy and immunology. 154, 2, p. 119-127 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cockroach induces inflammatory responses through protease-dependent pathways

Wada, K., Matsuwaki, Y., Moriyama, H. & Kita, H., Jun 1 2011, In : International archives of allergy and immunology. 155, SUPPL. 1, p. 135-141 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549).

Ishioka, T., Kimura, H., Kita, H., Obuchi, M., Hoshino, H., Noda, M., Nishina, A., Kozawa, K. & Kato, M., May 1 2011, In : Cell biology international. 35, 5, p. 467-474 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Eosinophil degranulation is more important than Eosinophilia in identifying asthma in chronic cough

Kim, C. K., Callaway, Z., Kim, D. W. & Kita, H., Dec 1 2011, In : Journal of Asthma. 48, 10, p. 994-1000 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophils: Multifaceted biological properties and roles in health and disease

Kita, H., Jul 1 2011, In : Immunological Reviews. 242, 1, p. 161-177 17 p.

Research output: Contribution to journalArticle

176 Scopus citations

HLA-DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation

Rajagopalan, G., Tilahun, A. Y., Iijima, K., David, C. S., Kita, H. & Juhn, Y. J., Jun 1 2011, In : Tissue Antigens. 77, 6, p. 589-592 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human eosinophil innate response to Alternaria fungus through protease-activated receptor-2

Matsuwaki, Y., Wada, K., Moriyama, H. & Kita, H., Jun 1 2011, In : International archives of allergy and immunology. 155, SUPPL. 1, p. 123-128 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Lineage -Sca1 +c-Kit -CD25 + cells are IL-33-responsive type 2 innate cells in the mouse bone marrow

Brickshawana, A., Shapiro, V. S., Kita, H. & Pease, L. R., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 5795-5804 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Neuropeptide levels in nasal secretions from patients with and without chronic cough

Lim, K. G., Rank, M. A., Kita, H., Patel, A. & Moore, E., Oct 1 2011, In : Annals of Allergy, Asthma and Immunology. 107, 4, p. 360-363 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Serum 25-hydroxyvitamin D is associated with enhanced pneumococcal antibody levels in individuals with asthma

Lee, J., Zhao, H., Fenta, Y., Kita, H., Kumar, R. & Juhn, Y. J., Nov 1 2011, In : Allergy and Asthma Proceedings. 32, 6, p. 445-452 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses

Kouzaki, H., Iijima, K., Kobayashi, T., O'Grady, S. M. & Kita, H., Apr 1 2011, In : Journal of Immunology. 186, 7, p. 4375-4387 13 p.

Research output: Contribution to journalArticle

284 Scopus citations

The role of IL-17 in the association between pneumococcal pneumonia and allergic sensitization

Zhao, H., Kang, C. I., Rouse, M. S., Patel, R., Kita, H. & Juhn, Y. J., 2011, In : International Journal of Microbiology. 709509.

Research output: Contribution to journalArticle

4 Scopus citations
2010

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: A randomised, placebo-controlled, double-blind trial

Straumann, A., Conus, S., Grzonka, P., Kita, H., Kephart, G., Bussmann, C., Beglinger, C., Smith, D. A., Patel, J., Byrne, M. & Simon, H. U., Jan 1 2010, In : Gut. 59, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

346 Scopus citations

Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis

Plager, D. A., Kahl, J. C., Asmann, Y. W., Nilson, A. E., Pallanch, J. F., Friedman, O. & Kita, H., 2010, In : PloS one. 5, 7, e11450.

Research output: Contribution to journalArticle

39 Scopus citations

Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the ras-ERK pathway when compared with blood eosinophils

Bates, M. E., Sedgwick, J. B., Zhu, Y., Liu, L. Y., Heuser, R. G., Jarjour, N. N., Kita, H. & Bertics, P. J., Jun 15 2010, In : Journal of Immunology. 184, 12, p. 7125-7133 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP

Kobayashi, T., Kouzaki, H. & Kita, H., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6350-6358 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma

Jung, J. A., Kita, H., Yawn, B. P., Boyce, T. G., Yoo, K. H., McGree, M. E., Weaver, A. L., Wollan, P., Jacobson, R. M. & Juhn, Y. J., Jan 1 2010, In : Journal of Allergy and Clinical Immunology. 125, 1-3, p. 217-221 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Increases in airway eosinophilia and a th1 cytokine during the chronic asymptomatic phase of asthma

Kim, C. K., Choi, J., Callaway, Z., Iijima, K., Volcheck, G. & Kita, H., Oct 1 2010, In : Respiratory Medicine. 104, 10, p. 1436-1443 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis

Kephart, G. M., Alexander, J. A., Arora, A. S., Romero, Y., Smyrk, T. C., Talley, N. J. & Kita, H., Feb 1 2010, In : American Journal of Gastroenterology. 105, 2, p. 298-307 10 p.

Research output: Contribution to journalArticle

74 Scopus citations
4 Scopus citations

The roles of a Th2 cytokine and CC chemokine in children with stable asthma: Potential implication in eosinophil degranulation

Kim, C. K., Kita, H., Callaway, Z., Kim, H. B., Choi, J., Fujisawa, T., Shin, B. M. & Koh, Y. Y., Jun 1 2010, In : Pediatric Allergy and Immunology. 21, 4 PART2, p. e697-e704

Research output: Contribution to journalArticle

10 Scopus citations
2009
15 Scopus citations

Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent TH2 adjuvant activity

Kobayashi, T., Iijima, K., Radhakrishnan, S., Mehta, V., Vassallo, R., Lawrence, C. B., Cyong, J. C., Pease, L. R., Oguchi, K. & Kita, H., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 2502-2510 9 p.

Research output: Contribution to journalArticle

75 Scopus citations