Hirohito Kita, MD

  • 13400 E Shea Blvd, Mayo Clinic Arizona, MCCRB Room 2-213

    85259 Scottsdale

    United States

  • 14690 Citations
  • 67 Scopus h-Index
1984 …2020

Research output per year

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Research Output

2020

Expert artificial intelligence-based natural language processing characterises childhood asthma

Seol, H. Y., Rolfes, M. C., Chung, W., Sohn, S., Ryu, E., Park, M. A., Kita, H., Ono, J., Croghan, I., Armasu, S. M., Castro-Rodriguez, J. A., Weston, J. D., Liu, H. & Juhn, Y., Feb 4 2020, In : BMJ Open Respiratory Research. 7, 1, e000524.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Fungal allergen-induced IL-33 secretion involves cholesterol-dependent, VDAC-1-mediated ATP release from the airway epithelium

Srisomboon, Y., Squillace, D. L., Maniak, P. J., Kita, H. & O'Grady, S. M., May 1 2020, In : Journal of Physiology. 598, 10, p. 1829-1845 17 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Image Analysis of Eosinophil Peroxidase Immunohistochemistry for Diagnosis of Eosinophilic Esophagitis

Wright, B. L., Doyle, A. D., Shim, K. P., Pai, R. K., Barshow, S. M., Horsley-Silva, J. L., Luo, H., Rank, M. A., Jacobsen, E. A., Katzka, D. A., Kita, H. & Dellon, E. S., Jan 1 2020, (Accepted/In press) In : Digestive diseases and sciences.

Research output: Contribution to journalArticle

2019

Advances in asthma, asthma-COPD overlap, and related biologics in 2018

Bacharier, L. B., Mori, A. & Kita, H., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 906-919 14 p.

Research output: Contribution to journalArticle

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection

Zhu, B., Zhang, R., Li, C., Jiang, L., Xiang, M., Ye, Z., Kita, H., Melnick, A. M., Dent, A. L. & Sun, J., Jun 11 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 24, p. 11888-11893 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Early life represents a vulnerable time window for IL-33–induced peripheral lung pathology

Drake, L. Y., Squillace, D., Iijima, K., Kobayashi, T., Uchida, M., Kephart, G. M., Britt, R., O’Brien, D. R. & Kita, H., Oct 1 2019, In : Journal of Immunology. 203, 7, p. 1952-1960 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Eosinophil peroxidase, GATA3, and T-bet as tissue biomarkers in chronic rhinosinusitis

Lal, D., Wright, B., Shim, K. P., Zarka, M. A., Lee, J. J., Chang, Y. H., Ochkur, S. I., Divekar, R., Doyle, A. D., Jacobsen, E., Kita, H. & Rank, M. A., Jan 1 2019, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

1 Scopus citations

Therapeutic Antibodies for Nasal Polyposis Treatment: Where Are We Headed?

Agarwal, A., Spath, D., Sherris, D. A., Kita, H. & Ponikau, J. U., Jan 1 2019, In : Clinical Reviews in Allergy and Immunology.

Research output: Contribution to journalReview article

2 Scopus citations

Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults With Eosinophilic Esophagitis

International EEsAI Study Group, Jul 2019, In : Clinical Gastroenterology and Hepatology. 17, 8, p. 1477-1488.e10

Research output: Contribution to journalArticle

2 Scopus citations
2018

Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice

Dolence, J. J., Kobayashi, T., Iijima, K., Krempski, J., Drake, L. Y., Dent, A. L. & Kita, H., Oct 2018, In : Journal of Allergy and Clinical Immunology. 142, 4, p. 1144-1158.e8

Research output: Contribution to journalArticle

14 Scopus citations

Automated chart review utilizing natural language processing algorithm for asthma predictive index

Kaur, H., Sohn, S., Wi, C. I., Ryu, E., Park, M. A., Bachman, K., Kita, H., Croghan, I., Castro-Rodriguez, J. A., Voge, G. A., Liu, H. & Juhn, Y. J., Feb 13 2018, In : BMC Pulmonary Medicine. 18, 1, 34.

Research output: Contribution to journalArticle

9 Scopus citations

Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy

Wright, B., Fernandez-Becker, N. Q., Kambham, N., Purington, N., Tupa, D., Zhang, W., Rank, M. A., Kita, H., Shim, K. P., Bunning, B. J., Doyle, A. D., Jacobsen, E., Boyd, S. D., Tsai, M., Maecker, H., Manohar, M., Galli, S. J., Nadeau, K. C. & Chinthrajah, R. S., Nov 22 2018, In : Frontiers in Immunology. 9, NOV, 02624.

Research output: Contribution to journalArticle

10 Scopus citations

Cellular stress response to varicella-zoster virus infection of human skin includes highly elevated interleukin-6 expression

Jarosinski, K. W., Carpenter, J. E., Buckingham, E. M., Jackson, W., Knudtson, K., Moffat, J. F., Kita, H. & Grose, C., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 6

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis

Kobayashi, T., Noguchi, T., Saito, K., Shirasaki, F., Kita, H., Nagata, M., Okada, H. & Nakamoto, H., Jan 1 2018, In : Contributions to Nephrology. 196, p. 1-4 4 p.

Research output: Contribution to journalArticle

IL-33-responsive group 2 innate lymphoid cells are regulated by female sex hormones in the uterus

Bartemes, K., Chen, C. C., Iijima, K., Drake, L. & Kita, H., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 229-236 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Innate and adaptive immune responses to fungi in the airway

Bartemes, K. R. & Kita, H., Aug 1 2018, In : Journal of Allergy and Clinical Immunology. 142, 2, p. 353-363 11 p.

Research output: Contribution to journalReview article

12 Scopus citations

Innate Immunity Induced by the Major Allergen Alt a 1 From the Fungus Alternaria Is Dependent Upon Toll-Like Receptors 2/4 in Human Lung Epithelial Cells

Hayes, T., Rumore, A., Howard, B., He, X., Luo, M., Wuenschmann, S., Chapman, M., Kale, S., Li, L., Kita, H. & Lawrence, C. B., Jan 1 2018, In : Frontiers in Immunology. 9, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Neonatal hyperoxia promotes asthma-like features through IL-33–dependent ILC2 responses

Cheon, I. S., Son, Y. M., Jiang, L., Goplen, N. P., Kaplan, M. H., Limper, A. H., Kita, H., Paczesny, S., Prakash, Y. S., Tepper, R., Ahlfeld, S. K. & Sun, J., Oct 2018, In : Journal of Allergy and Clinical Immunology. 142, 4, p. 1100-1112 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Airway epithelial anion secretion and barrier function following exposure to fungal aeroallergens: Role of oxidative stress

Zaidman, N. A., O’Grady, K. E., Patil, N., Milavetz, F., Maniak, P. J., Kita, H. & O’Grady, S. M., 2017, In : American Journal of Physiology - Cell Physiology. 313, 1, p. C68-C79

Research output: Contribution to journalArticle

5 Scopus citations

Application of a Natural Language Processing Algorithm to Asthma Ascertainment. An Automated Chart Review

Wi, C. I., Sohn, S., Rolfes, M. C., Seabright, A., Ryu, E., Voge, G., Bachman, K. A., Park, M., Kita, H., Croghan, I. T., Liu, H. D. & Juhn, Y. J., Aug 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 4, p. 430-437 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

279 Scopus citations

Correlation of Symptoms, Clinical Signs, and Biomarkers of Inflammation in Postsurgical Chronic Rhinosinusitis

Racette, S. D., Wijewickrama, R. C., Jayaprakash, V., Sherris, D. A., Santos, C., Kita, H., O'Donnell, F. E. & Ponikau, J. U., Jun 1 2017, In : Annals of Otology, Rhinology and Laryngology. 126, 6, p. 455-462 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Endogenous protease inhibitors in airway epithelial cells contribute to eosinophilic chronic rhinosinusitis

Kouzaki, H., Matsumoto, K., Kikuoka, H., Kato, T., Tojima, I., Shimizu, S., Kita, H. & Shimizu, T., Mar 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 6, p. 737-747 11 p.

Research output: Contribution to journalReview article

27 Scopus citations

Follicular helper T cells mediate IgE antibody response to airborne allergens

Kobayashi, T., Iijima, K., Dent, A. L. & Kita, H., Jan 1 2017, In : Journal of Allergy and Clinical Immunology. 139, 1, p. 300-313.e7

Research output: Contribution to journalArticle

41 Scopus citations

IL-33: biological properties, functions, and roles in airway disease

Drake, L. Y. & Kita, H., Jul 1 2017, In : Immunological Reviews. 278, 1, p. 173-184 12 p.

Research output: Contribution to journalReview article

43 Scopus citations

Oxidative stress serves as a key checkpoint for IL-33 release by airway epithelium

Uchida, M., Anderson, E. L., Squillace, D. L., Patil, N., Maniak, P. J., Iijima, K., Kita, H. & O'Grady, S. M., 2017, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

31 Scopus citations
2016

Group 2 innate lymphoid cells are increased in nasal polyps in patients with eosinophilic chronic rhinosinusitis

Tojima, I., Kouzaki, H., Shimizu, S., Ogawa, T., Arikata, M., Kita, H. & Shimizu, T., Sep 1 2016, In : Clinical Immunology. 170, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Group 2 innate lymphoid cells promote an early antibody response to a respiratory antigen in mice

Drake, L. Y., Iijima, K., Bartemes, K. & Kita, H., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1335-1342 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs

Chen, C. C., Kobayashi, T., Iijima, K., Hsu, F. C. & Kita, H., Jun 30 2016, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

45 Scopus citations

IL-33 mediates reactive eosinophilopoiesis in response to airborne allergen exposure

Anderson, E. L., Kobayashi, T., Iijima, K., Bartemes, K. R., Chen, C. C. & Kita, H., 2016, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

23 Scopus citations

Influence of HLA-DR polymorphism and allergic sensitization on humoral immune responses to intact pneumococcus in a transgenic mouse model

Sheen, Y. H., Rajagopalan, G., Snapper, C. M., Kita, H., Wi, C. I., Umaretiya, P. J. & Juhn, Y. J., Jul 1 2016, In : HLA. 88, 1-2, p. 25-34 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
13 Scopus citations

Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis

Hagan, J. B., Laidlaw, T. M., Divekar, R., O'Brien, E. K., Kita, H., Volcheck, G. W., Hagan, C. R., Lal, D., Teaford, H. G., Erwin, P. J., Zhang, N. & Rank, M. A., Jun 28 2016, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Accuracy, safety, and tolerability of tissue collection by cytosponge vs endoscopy for evaluation of eosinophilic esophagitis

Katzka, D. A., Geno, D. M., Ravi, A., Smyrk, T. C., Lao-Sirieix, P., Miramedi, A., Debiram, I., O'Donovan, M., Kita, H., Kephart, G. M., Kryzer, L. A., Camilleri, M., Alexander, J. A. & Fitzgerald, R. C., Jan 1 2015, In : Clinical Gastroenterology and Hepatology. 13, 1, p. 77-83.e2

Research output: Contribution to journalArticle

73 Scopus citations

Airway responsiveness in CD38-deficient mice in allergic airway disease: Studies with bone marrow chimeras

Guedes, A. G. P., Jude, J. A., Paulin, J., Rivero-Nava, L., Kita, H., Lund, F. E. & Kannan, M. S., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 5, p. L485-L493

Research output: Contribution to journalArticle

5 Scopus citations

Alternaria inhibits double-stranded RNA-induced cytokines productions through TLR3

Wada, K., Kobayashi, T., Matsuwaki, Y., Moriyama, H. & Kita, H., Jul 1 2015, In : Practica Otologica, Supplement. 143, p. 117-126 10 p.

Research output: Contribution to journalArticle

An immunologic test for chronic rhinosinusitis based on free intranasal eosinophilic major basic protein

Ponikau, J. U., Winter, L. A., Kephart, G. M., Squillace, D. L., Hershcovitch, M. D., Moon, S., Sherris, D. A., Kern, E. B., Gleich, G. J. & Kita, H., Jan 1 2015, In : International Forum of Allergy and Rhinology. 5, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

ATP drives eosinophil effector responses through P2 purinergic receptors

Kobayashi, T., Soma, T., Noguchi, T., Nakagome, K., Nakamoto, H., Kita, H. & Nagata, M., Sep 1 2015, In : Allergology International. 64, p. S30-S36 71.

Research output: Contribution to journalArticle

14 Scopus citations

B cells play key roles in Th2-type airway immune responses in mice exposed to natural airborne allergens

Drake, L. Y., Iijima, K., Hara, K., Kobayashi, T., Kephart, G. M. & Kita, H., Mar 24 2015, In : PloS one. 10, 3, e0121660.

Research output: Contribution to journalArticle

11 Scopus citations

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Yarova, P. L., Stewart, A. L., Sathish, V., Britt, R. D., Thompson, M. A., Lowe, A. P. P., Freeman, M., Aravamudan, B., Kita, H., Brennan, S. C., Schepelmann, M., Davies, T., Yung, S., Cholisoh, Z., Kidd, E. J., Ford, W. R., Broadley, K. J., Rietdorf, K., Chang, W., Bin Khayat, M. E. & 7 others, Ward, D. T., Corrigan, C. J., Ward, J. P. T., Kemp, P. J., Pabelick, C. M., Prakash, Y. S. & Riccardi, D., Apr 22 2015, In : Science translational medicine. 7, 284, p. 284ra58

Research output: Contribution to journalArticle

66 Scopus citations

Combinatorial immunoprofiling in latent tuberculosis infection: Toward better risk stratification

Escalante, P., Peikert, T. D., Van Keulen, V. P., Erskine, C. L., Bornhorst, C. L., Andrist, B. R., McCoy, K., Pease, L. R., Abraham, R. S., Knutson, K. L., Kita, H., Schrum, A. G. & Limper, A. H., Sep 1 2015, In : American Journal of Respiratory and Critical Care Medicine. 192, 5, p. 605-617 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Diagnostic Utility of Urinary LTE4 in Asthma, Allergic Rhinitis, Chronic Rhinosinusitis, Nasal Polyps, and Aspirin Sensitivity

Divekar, R., Hagan, J., Rank, M. A., Park, M., Volcheck, G., O'Brien, E., Meeusen, J., Kita, H. & Butterfield, J., Oct 6 2015, (Accepted/In press) In : Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticle

27 Scopus citations

ILC2s and fungal allergy

Kita, H., Jul 1 2015, In : Allergology International. 64, 3, p. 219-226 8 p., 66.

Research output: Contribution to journalArticle

16 Scopus citations

Immunological profiling in chronic rhinosinusitis with nasal polyps reveals distinct VEGF and GM-CSF signatures during symptomatic exacerbations

Divekar, R. D., Samant, S., Rank, M. A., Hagan, J., Lal, D., O'Brien, E. K. & Kita, H., Apr 1 2015, In : Clinical and Experimental Allergy. 45, 4, p. 767-778 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
106 Scopus citations

Symptom-Based Clustering in Chronic Rhinosinusitis Relates to History of Aspirin Sensitivity and Postsurgical Outcomes

Divekar, R., Patel, N., Jin, J., Hagan, J., Rank, M. A., Lal, D., Kita, H. & O'Brien, E., Nov 1 2015, In : Journal of Allergy and Clinical Immunology: In Practice. 3, 6, p. 934-940.e3

Research output: Contribution to journalArticle

16 Scopus citations

The FACT score in predicting pneumococcal antibody levels in asthmatics

Podjasek, J. C., Jung, J. A., Kita, H., Park, M. & Juhn, Y. J., May 1 2015, In : Journal of Asthma. 52, 4, p. 370-375 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory Mucosa

Hara, K., Iijima, K., Elias, M. K., Seno, S., Tojima, I., Kobayashi, T., Kephart, G. M., Kurabayashi, M. & Kita, H., May 1 2014, In : Journal of Immunology. 192, 9, p. 4032-4042 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Calcitonin gene-related peptide and vascular endothelial growth factor are expressed in lesional but not uninvolved skin in chronic spontaneous urticaria

Kay, A. B., Ying, S., Ardelean, E., Mlynek, A., Kita, H., Clark, P. & Maurer, M., Aug 2014, In : Clinical and Experimental Allergy. 44, 8, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Computed tomography scans as an objective measure of disease severity in chronic rhinosinusitis

Likness, M. M., Pallanch, J. F., Sherris, D. A., Kita, H., Mashtare, T. L. & Ponikau, J. U., Feb 1 2014, In : Otolaryngology - Head and Neck Surgery (United States). 150, 2, p. 305-311 7 p.

Research output: Contribution to journalArticle

21 Scopus citations