Fabienne Fiesel, PhD

  • 5565 Citations
  • 24 Scopus h-Index
20082020

Research output per year

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Research Output

  • 5565 Citations
  • 24 Scopus h-Index
  • 32 Article
  • 4 Review article
  • 1 Comment/debate
  • 1 Letter
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Article
2020

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Park, J. H., Burgess, J. D., Faroqi, A. H., Demeo, N. N., Fiesel, F. C., Springer, W., Delenclos, M. & McLean, P. J., Jan 13 2020, In : Molecular neurodegeneration. 15, 1, 5.

Research output: Contribution to journalArticle

Open Access
2019

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F. C., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2018

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Hou, X., Fiesel, F., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff Radford, N. R., Wszolek, Z. K. & 4 others, Ross, O. A., Murray, M. E., Dickson, D. W. & Springer, W., Jan 1 2018, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Rudzińska-Bar, M., Aasly, J. O. & 13 others, Lynch, T., Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A. & Springer, W., Jan 1 2017, In : Brain. 140, 1, p. 98-117 20 p.

Research output: Contribution to journalArticle

52 Scopus citations

Hexokinases link DJ-1 to the PINK1/parkin pathway

Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F. C., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In : Molecular neurodegeneration. 12, 1, 212.

Research output: Contribution to journalArticle

14 Scopus citations

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F., James, E. D., Hudec, R. & Springer, W., Jan 1 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.

Research output: Contribution to journalArticle

9 Scopus citations

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F., Springer, W., Dawson, V. L., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

50 Scopus citations

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F. C., Hudec, R., Caulfield, T. R., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

16 Scopus citations
2016

MiR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

Kim, J., Fiesel, F. C., Belmonte, K. C., Hudec, R., Wang, W. X., Kim, C., Nelson, P. T., Springer, W. & Kim, J., Jul 26 2016, In : Molecular neurodegeneration. 11, 1, 55.

Research output: Contribution to journalArticle

34 Scopus citations
2015

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Fiesel, F., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1114-1130 17 p.

Research output: Contribution to journalArticle

63 Scopus citations

Activation of the E3 ubiquitin ligase Parkin

Caulfield, T., Fiesel, F. & Springer, W., Apr 1 2015, In : Biochemical Society Transactions. 43, p. 269-274 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

Fiesel, F. & Springer, W., Jan 1 2015, In : Autophagy. 11, 11, p. 2125-2126 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

Ogaki, K., Koga, S., Heckman, M. G., Fiesel, F., Ando, M., Labbé, C., Lorenzo-Betancor, O., Moussaud-Lamodière, E. L., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., Uitti, R. J., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K. & 12 others, Puschmann, A., Nishioka, K., Funayama, M., Hattori, N., Parisi, J. E., Petersen, R. C., Graff Radford, N. R., Boeve, B. F., Springer, W., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Dec 8 2015, In : Neurology. 85, 23, p. 2016-2025 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1

Shi, J., Fung, G., Deng, H., Zhang, J., Fiesel, F., Springer, W., Li, X. & Luo, H., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1943.

Research output: Contribution to journalArticle

16 Scopus citations

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

81 Scopus citations

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Fiesel, F., Caulfield, T., Moussaud-Lamodière, E. L., Ogaki, K., Dourado, D. F. A. R., Flores, S. C., Ross, O. A. & Springer, W., Aug 1 2015, In : Human Mutation. 36, 8, p. 774-786 13 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

Fiesel, F. C., Moussaud-Lamodière, E. L., Ando, M. & Springer, W., 2014, In : Journal of cell science. 127, 16, p. 3488-3504 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study

Siuda, J., Jasinska-Myga, B., Boczarska-Jedynak, M., Opala, G., Fiesel, F. C., Moussaud-Lamodière, E. L., Scarffe, L. A., Dawson, V. L., Ross, O. A., Springer, W., Dawson, T. M. & Wszolek, Z. K., Nov 1 2014, In : Parkinsonism and Related Disorders. 20, 11, p. 1274-1278 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

Caulfield, T. R., Fiesel, F. C., Moussaud-Lamodière, E. L., Dourado, D. F. A. R., Flores, S. C. & Springer, W., Nov 1 2014, In : PLoS computational biology. 10, 11

Research output: Contribution to journalArticle

54 Scopus citations

Three families with Perry syndrome from distinct parts of the world

Tacik, P., Fiesel, F. C., Fujioka, S., Ross, O. A., Pretelt, F., Castañeda Cardona, C., Kidd, A., Hlavac, M., Raizis, A., Okun, M. S., Traynor, S., Strongosky, A. J., Springer, W. & Wszolek, Z. K., Aug 2014, In : Parkinsonism and Related Disorders. 20, 8, p. 884-888 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase y regulate TDP-43 protein ubiquitination

Hans, F., Fiesel, F. C., Strong, J. C., Jackel, S., Rasse, T. M., Geisler, S., Springer, W., Schulz, J. B., Voigt, A. & Kahle, P. J., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 19164-19179 16 p.

Research output: Contribution to journalArticle

32 Scopus citations
2012

Suppression of dynamin GTPase decreases -synuclein uptake by neuronal and oligodendroglial cells: A potent therapeutic target for synucleinopathy

Konno, M., Hasegawa, T., Baba, T., Miura, E., Sugeno, N., Kikuchi, A., Fiesel, F. C., Sasaki, T., Aoki, M., Itoyama, Y. & Takeda, A., Aug 17 2012, In : Molecular neurodegeneration. 7, 1, 38.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR

Fiesel, F. C., Weber, S. S., Supper, J., Zell, A. & Kahle, P. J., Mar 1 2012, In : Nucleic acids research. 40, 6, p. 2668-2682 15 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations
2011

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

Fiesel, F. C., Schurr, C., Weber, S. S. & Kahle, P. J., Sep 1 2011, In : Molecular neurodegeneration. 6, 1, 64.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
2010

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

Fiesel, F. C., Voigt, A., Weber, S. S., Van Den Haute, C., Waldenmaier, A., Görner, K., Walter, M., Marlene, A. L., Kern, J. V., Rasse, T. M., Schmidt, T., Springer, W., Kirchner, R., Bonin, M., Neumann, M., Baekelandt, V., Alunni-Fabbroni, M., Schulz, J. B. & Kahle, P. J., Jan 6 2010, In : EMBO Journal. 29, 1, p. 209-221 13 p.

Research output: Contribution to journalArticle

163 Scopus citations

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

Kieper, N., Holmström, K. M., Ciceri, D., Fiesel, F. C., Wolburg, H., Ziviani, E., Whitworth, A. J., Martins, L. M., Kahle, P. J. & Krüger, R., Apr 2010, In : Experimental Cell Research. 316, 7, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F. C., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W. & Kahle, P. J., May 2010, In : Journal of Neural Transmission. 117, 5, p. 599-604 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)

Kraemer, B. F., Borst, O., Gehring, E. M., Schoenberger, T., Urban, B., Ninci, E., Seizer, P., Schmidt, C., Bigalke, B., Koch, M., Martinovic, I., Daub, K., Merz, T., Schwanitz, L., Stellos, K., Fiesel, F., Schaller, M., Lang, F., Gawaz, M. & Lindemann, S., Dec 1 2010, In : Journal of Molecular Medicine. 88, 12, p. 1277-1288 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J. & Springer, W., Feb 2010, In : Nature Cell Biology. 12, 2, p. 119-131 13 p.

Research output: Contribution to journalArticle

1515 Scopus citations

TDP-43-mediated neuron loss In Vivo requires RNA-binding activity

Voigt, A., Herholz, D., Fiesel, F. C., Kaur, K., Müller, D., Karsten, P., Weber, S. S., Kahle, P. J., Marquardt, T. & Schulz, J. B., Oct 20 2010, In : PloS one. 5, 8, e12247.

Research output: Contribution to journalArticle

Open Access
122 Scopus citations

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

Geisler, S., Holmström, K. M., Treis, A., Skujat, D., Weber, S. S., Fiesel, F. C., Kahle, P. J. & Springer, W., Oct 1 2010, In : Autophagy. 6, 7, p. 871-878 8 p.

Research output: Contribution to journalArticle

174 Scopus citations
2008

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways

Hasegawa, T., Treis, A., Patenge, N., Fiesel, F. C., Springer, W. & Kahle, P. J., Jun 2008, In : Journal of neurochemistry. 105, 5, p. 1700-1715 16 p.

Research output: Contribution to journalArticle

60 Scopus citations