Fabienne Fiesel, PhD

  • 5221 Citations
  • 24 Scopus h-Index
20082019
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Research Output 2008 2019

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Article
2019
6 Citations (Scopus)

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Inflammation
Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases
2018
6 Citations (Scopus)

Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease

Hou, X., Fiesel, F., Truban, D., Castanedes Casey, M., Lin, W. L., Soto, A. I., Tacik, P., Rousseau, L. G., Diehl, N. N., Heckman, M. G., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Steele, J. C., Farrer, M. J., Cornejo-Olivas, M., Torres, L., Mata, I. F., Graff Radford, N. R., Wszolek, Z. K. & 4 others, Ross, O. A., Murray, M. E., Dickson, D. W. & Springer, W., Jan 1 2018, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Lewy Body Disease
Ubiquitin
Parkinson Disease
Carbonyl Cyanide m-Chlorophenyl Hydrazone
2017
47 Citations (Scopus)

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

Puschmann, A., Fiesel, F., Caulfield, T., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Aasly, J. O., Lynch, T. & 12 others, Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Wszolek, Z. K. & Ross, O. A., Jan 1 2017, In : Brain : a journal of neurology. 140, p. 98-117 20 p.

Research output: Contribution to journalArticle

Parkinson Disease
Heterozygote
Mutation
Odds Ratio
PTEN-induced putative kinase
12 Citations (Scopus)

Hexokinases link DJ-1 to the PINK1/parkin pathway

Hauser, D. N., Mamais, A., Conti, M. M., Primiani, C. T., Kumaran, R., Dillman, A. A., Langston, R. G., Beilina, A., Garcia, J. H., Diaz-Ruiz, A., Bernier, M., Fiesel, F., Hou, X., Springer, W., Li, Y., De Cabo, R. & Cookson, M. R., Sep 29 2017, In : Molecular Neurodegeneration. 12, 1, 212.

Research output: Contribution to journalArticle

Hexokinase
Parkinson Disease
Mitochondria
Brain
PTEN Phosphohydrolase
8 Citations (Scopus)

Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy

Fiesel, F., James, E. D., Hudec, R. & Springer, W., Jan 1 2017, In : Oncotarget. 8, 63, p. 106233-106248 16 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Autophagy
Mitochondria
Mitochondrial Proteins
Polyubiquitin
40 Citations (Scopus)

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G. E., Kang, H., Ham, S., Kam, T. I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F., Springer, W., Dawson, V. L., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journalArticle

Ubiquitination
Dopaminergic Neurons
Neurons
Phosphorylation
Substantia Nigra
14 Citations (Scopus)

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Ando, M., Fiesel, F., Hudec, R., Caulfield, T., Ogaki, K., Górka-Skoczylas, P., Koziorowski, D., Friedman, A., Chen, L., Dawson, V. L., Dawson, T. M., Bu, G. D., Ross, O. A., Wszolek, Z. K. & Springer, W., Apr 24 2017, In : Molecular Neurodegeneration. 12, 1, 32.

Research output: Contribution to journalArticle

Protein Stability
Ubiquitin
Phosphotransferases
Mutation
Mitochondrial Membranes
2016
29 Citations (Scopus)

MiR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

Kim, J., Fiesel, F., Belmonte, K. C., Hudec, R., Wang, W. X., Kim, C., Nelson, P. T., Springer, W. & Kim, J., Jul 26 2016, In : Molecular Neurodegeneration. 11, 1, 55.

Research output: Contribution to journalArticle

Mitochondria
MicroRNAs
Mitochondrial Degradation
Parkinson Disease
PTEN-induced putative kinase
2015
56 Citations (Scopus)

(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

Fiesel, F., Ando, M., Hudec, R., Hill, A. R., Castanedes-Casey, M., Caulfield, T., Moussaud-Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo-Betancor, O., Ferrer, I., Arbelo, J. M., Siuda, J., Chen, L., Dawson, V. L., Dawson, T. M., Wszolek, Z. K., Ross, O. A., Dickson, D. W. & Springer, W., Sep 1 2015, In : EMBO Reports. 16, 9, p. 1114-1130 17 p.

Research output: Contribution to journalArticle

Phosphorylation
Ubiquitin
Parkinson Disease
Brain
Mitochondria
25 Citations (Scopus)

Activation of the E3 ubiquitin ligase Parkin

Caulfield, T., Fiesel, F. & Springer, W., Apr 1 2015, In : Biochemical Society Transactions. 43, p. 269-274 6 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Phosphorylation
Chemical activation
Autophagy
8 Citations (Scopus)

Disease relevance of phosphorylated ubiquitin (p-S65-Ub)

Fiesel, F. & Springer, W., Jan 1 2015, In : Autophagy. 11, 11, p. 2125-2126 2 p.

Research output: Contribution to journalArticle

Ubiquitin
Mitochondria
Mitochondrial Degradation
Ubiquitin-Protein Ligases
Lysosomes
28 Citations (Scopus)

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

Ogaki, K., Koga, S., Heckman, M. G., Fiesel, F., Ando, M., Labbé, C., Lorenzo-Betancor, O., Moussaud-Lamodière, E. L., Soto-Ortolaza, A. I., Walton, R. L., Strongosky, A. J., Uitti, R. J., McCarthy, A., Lynch, T., Siuda, J., Opala, G., Rudzinska, M., Krygowska-Wajs, A., Barcikowska, M., Czyzewski, K. & 12 others, Puschmann, A., Nishioka, K., Funayama, M., Hattori, N., Parisi, J. E., Petersen, R. C., Graff Radford, N. R., Boeve, B. F., Springer, W., Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Dec 8 2015, In : Neurology. 85, 23, p. 2016-2025 10 p.

Research output: Contribution to journalArticle

Lewy Bodies
Lewy Body Disease
Parkinson Disease
Genes
Exons
14 Citations (Scopus)

NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1

Shi, J., Fung, G., Deng, H., Zhang, J., Fiesel, F., Springer, W., Li, X. & Luo, H., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1943.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Proteins
Quality Control
Cluster Analysis
74 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
31 Citations (Scopus)

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Fiesel, F., Caulfield, T., Moussaud-Lamodière, E. L., Ogaki, K., Dourado, D. F. A. R., Flores, S. C., Ross, O. A. & Springer, W., Aug 1 2015, In : Human Mutation. 36, 8, p. 774-786 13 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Parkinson Disease
Mutation
Coenzymes
Missense Mutation
2014
35 Citations (Scopus)

A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently

Fiesel, F., Moussaud-Lamodière, E. L., Ando, M. & Springer, W., 2014, In : Journal of Cell Science. 127, 16, p. 3488-3504 17 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Ubiquitin-Conjugating Enzymes
Mitochondria
Ubiquitin
Cluster Analysis
17 Citations (Scopus)

Early-onset Parkinson's disease due to PINK1 p.Q456X mutation - Clinical and functional study

Siuda, J., Jasinska-Myga, B., Boczarska-Jedynak, M., Opala, G., Fiesel, F., Moussaud-Lamodière, E. L., Scarffe, L. A., Dawson, V. L., Ross, O. A., Springer, W., Dawson, T. M. & Wszolek, Z. K., Nov 1 2014, In : Parkinsonism and Related Disorders. 20, 11, p. 1274-1278 5 p.

Research output: Contribution to journalArticle

Parkinson Disease
Mutation
Dystonic Disorders
Ubiquitination
Gait
53 Citations (Scopus)

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

Caulfield, T., Fiesel, F., Moussaud-Lamodière, E. L., Dourado, D. F. A. R., Flores, S. C. & Springer, W., Nov 1 2014, In : PLoS Computational Biology. 10, 11

Research output: Contribution to journalArticle

ubiquitin-protein ligase
Phosphorylation
Ubiquitin-Protein Ligases
Conformation
Conformations
13 Citations (Scopus)

Three families with Perry syndrome from distinct parts of the world

Tacik, P., Fiesel, F., Fujioka, S., Ross, O. A., Pretelt, F., Castañeda Cardona, C., Kidd, A., Hlavac, M., Raizis, A., Okun, M. S., Traynor, S., Strongosky, A. J., Springer, W. & Wszolek, Z. K., 2014, In : Parkinsonism and Related Disorders. 20, 8, p. 884-888 5 p.

Research output: Contribution to journalArticle

Respiratory Insufficiency
Parkinsonian Disorders
New Zealand
Mutation
Early Diagnosis
31 Citations (Scopus)

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase y regulate TDP-43 protein ubiquitination

Hans, F., Fiesel, F., Strong, J. C., Jackel, S., Rasse, T. M., Geisler, S., Springer, W., Schulz, J. B., Voigt, A. & Kahle, P. J., Jul 4 2014, In : Journal of Biological Chemistry. 289, 27, p. 19164-19179 16 p.

Research output: Contribution to journalArticle

Ubiquitin-Conjugating Enzymes
Ubiquitination
Neurodegenerative diseases
Ubiquitin
Cell culture
2012
62 Citations (Scopus)

Suppression of dynamin GTPase decreases -synuclein uptake by neuronal and oligodendroglial cells: A potent therapeutic target for synucleinopathy

Konno, M., Hasegawa, T., Baba, T., Miura, E., Sugeno, N., Kikuchi, A., Fiesel, F., Sasaki, T., Aoki, M., Itoyama, Y. & Takeda, A., Aug 17 2012, In : Molecular neurodegeneration. 7, 1, 38.

Research output: Contribution to journalArticle

Open Access
Synucleins
Dynamins
GTP Phosphohydrolases
Inclusion Bodies
Genetic Suppression
51 Citations (Scopus)

TDP-43 regulates global translational yield by splicing of exon junction complex component SKAR

Fiesel, F., Weber, S. S., Supper, J., Zell, A. & Kahle, P. J., Mar 1 2012, In : Nucleic acids research. 40, 6, p. 2668-2682 15 p.

Research output: Contribution to journalArticle

Open Access
Ribosomal Protein S6 Kinases
Exons
Ribonucleoproteins
RNA Precursors
Alternative Splicing
2011
37 Citations (Scopus)

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6

Fiesel, F., Schurr, C., Weber, S. S. & Kahle, P. J., Sep 1 2011, In : Molecular neurodegeneration. 6, 1, 64.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
DNA-Binding Proteins
Tretinoin
Neuronal Outgrowth
Protein Deficiency
2010
161 Citations (Scopus)

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

Fiesel, F., Voigt, A., Weber, S. S., Van Den Haute, C., Waldenmaier, A., Görner, K., Walter, M., Marlene, A. L., Kern, J. V., Rasse, T. M., Schmidt, T., Springer, W., Kirchner, R., Bonin, M., Neumann, M., Baekelandt, V., Alunni-Fabbroni, M., Schulz, J. B. & Kahle, P. J., Jan 6 2010, In : EMBO Journal. 29, 1, p. 209-221 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
DNA-Binding Proteins
Down-Regulation
Messenger RNA
RNA
44 Citations (Scopus)

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

Kieper, N., Holmström, K. M., Ciceri, D., Fiesel, F., Wolburg, H., Ziviani, E., Whitworth, A. J., Martins, L. M., Kahle, P. J. & Krüger, R., Jan 1 2010, In : Experimental Cell Research. 316, 7, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Dynamics
Serine Proteases
Mitochondrial Membrane Potential
Huntington Disease
HeLa Cells
20 Citations (Scopus)

Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans

Cornejo Castro, E. M., Waak, J., Weber, S. S., Fiesel, F., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W. & Kahle, P. J., May 2010, In : Journal of Neural Transmission. 117, 5, p. 599-604 6 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Innate Immunity
Parkinson Disease
p38 Mitogen-Activated Protein Kinases
Gram-Negative Bacteria
50 Citations (Scopus)

PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1)

Kraemer, B. F., Borst, O., Gehring, E. M., Schoenberger, T., Urban, B., Ninci, E., Seizer, P., Schmidt, C., Bigalke, B., Koch, M., Martinovic, I., Daub, K., Merz, T., Schwanitz, L., Stellos, K., Fiesel, F., Schaller, M., Lang, F., Gawaz, M. & Lindemann, S., Dec 1 2010, In : Journal of Molecular Medicine. 88, 12, p. 1277-1288 12 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
Phosphotransferases
Blood Platelets
Blood Vessels
Wiskott-Aldrich Syndrome Protein
1469 Citations (Scopus)

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F., Rothfuss, O. C., Kahle, P. J. & Springer, W., Feb 2010, In : Nature Cell Biology. 12, 2, p. 119-131 13 p.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 1
Mitochondrial Degradation
Ubiquitination
Parkinson Disease
Mitochondria
118 Citations (Scopus)

TDP-43-mediated neuron loss In Vivo requires RNA-binding activity

Voigt, A., Herholz, D., Fiesel, F., Kaur, K., Müller, D., Karsten, P., Weber, S. S., Kahle, P. J., Marquardt, T. & Schulz, J. B., Oct 20 2010, In : PloS one. 5, 8, e12247.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Amyotrophic Lateral Sclerosis
Neurons
neurons
RNA
169 Citations (Scopus)

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

Geisler, S., Holmström, K. M., Treis, A., Skujat, D., Weber, S. S., Fiesel, F., Kahle, P. J. & Springer, W., Oct 1 2010, In : Autophagy. 6, 7, p. 871-878 8 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Parkinson Disease
Mitochondria
Mutation
Autophagy
2008
58 Citations (Scopus)

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways

Hasegawa, T., Treis, A., Patenge, N., Fiesel, F., Springer, W. & Kahle, P. J., Jun 2008, In : Journal of Neurochemistry. 105, 5, p. 1700-1715 16 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Heat-Shock Proteins
Protein Kinases
Parkinson Disease
Dopamine