• 6135 Citations
  • 39 Scopus h-Index
1980 …2019

Research output per year

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Research Output

  • 6135 Citations
  • 39 Scopus h-Index
  • 106 Article
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Article
1980

Cholera toxin potentiates the action of competence factors in BALB/c-3T3 cells

Wharton, W., Leof, E. B. & Pledger, W. J., 1980, In : Journal of Cell Biology. 87, 2 II

Research output: Contribution to journalArticle

3 Scopus citations

Cyclic AMP potentiates down regulation of epidermal growth factor receptors by platelet-derived growth factor

Leof, E. B., Olashaw, N. E., Pledger, W. J. & O'Keefe, E. J., Nov 16 1982, In : Biochemical and Biophysical Research Communications. 109, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Elevated intracellular concentrations of cyclic AMP inhibited serum-stimulated, density-arrested BALB/c-3T3 cells in mid G1

Leof, E. B., Wharton, W., O'Keefe, E. & Pledger, W. J., 1982, In : Journal of Cellular Biochemistry. 19, 1, p. 93-103 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells

Leof, E. B., Wharton, W., Van Wyk, J. J. & Pledger, W. J., 1982, In : Experimental Cell Research. 141, 1, p. 107-115 9 p.

Research output: Contribution to journalArticle

231 Scopus citations

Increases in cyclic AMP potentiate competence formation in BALB/c-3T3 cells

Wharton, W., Leof, E. B., Olashaw, N. & Pledger, W. J., 1982, In : Journal of Cellular Physiology. 111, 2, p. 201-206 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
56 Scopus citations

The regulation of cell proliferation by serum growth factors.

Pledger, W. J., Howe, P. H. & Leof, E. B., Dec 10 1982, In : Annals of the New York Academy of Sciences. 397, p. 1-10 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

THE REGULATION OF EPIDERMAL GROWTH FACTOR RECEPTORS BY PLATELET‐DERIVED GROWTH FACTOR

Wharton, W., Leof, E. B., Pledger, W. J. & O'Keefe, E., 1982, In : Annals of the New York Academy of Sciences. 397, 1, p. 325-326 2 p.

Research output: Contribution to journalArticle

1 Scopus citations
1983

Epidermal growth factor (EGF) is required only during the traverse of early G1 in PDGF stimulated density-arrested BALB/c-3T3 cells

Leof, E. B., Van Wyk, J. J., O'Keefe, E. J. & Pledger, W. J., 1983, In : Experimental Cell Research. 147, 1, p. 202-208 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Mitogenic response to epidermal growth factor (EGF) modulated by platelet-derived growth factor in cultured fibroblasts

Wharton, W., Leof, E. B., Olashaw, N., O'Keefe, E. J. & Pledger, W. J., 1983, In : Experimental Cell Research. 147, 2, p. 443-448 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
1984

Differential sensitivity of fibroblasts to epidermal growth factor is related to cyclic AMP concentration

Olashaw, N. E., Leof, E. B., O'Keefe, E. J. & Pledger, W. J., 1984, In : Journal of Cellular Physiology. 118, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
1985

PDGF stimulates transient phosphorylation of 180,000 dalton protein

Harrington, M. A., Estes, J. E., Leof, E. B. & Pledger, W. J., 1985, In : Journal of Cellular Biochemistry. 27, 2, p. 67-81 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
1986

Growth factors and cancer

Leof, E. B., Leof, E. B., Shipley, G. D. & Moses, H. L., 1986, In : Cancer Research. 46, 3, p. 1015-1029 15 p.

Research output: Contribution to journalArticle

764 Scopus citations
384 Scopus citations

Transforming growth factor type β regulation of actin mRNA

Leof, E. B., Proper, J. A., Getz, M. J. & Moses, H. L., 1986, In : Journal of Cellular Physiology. 127, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

65 Scopus citations
1987

Modulation of transforming growth factor type beta action by activated ras and c-myc.

Leof, E. B., Proper, J. A. & Moses, H. L., Jul 1987, In : Molecular and Cellular Biology. 7, 7, p. 2649-2652 4 p.

Research output: Contribution to journalArticle

35 Scopus citations

Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells

Coffey, R. J., Leof, E. B., Shipley, G. D. & Moses, H. L., 1987, In : Journal of Cellular Physiology. 132, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

325 Scopus citations

Transforming growth factors and control of neoplastic cell growth

Keski-Oja, J., Leof, E. B., Lyons, R. M., Coffey, R. J. & Moses, H. L., 1987, In : Journal of Cellular Biochemistry. 33, 2, p. 95-107 13 p.

Research output: Contribution to journalArticle

94 Scopus citations

Transforming growth factor type β can act as a potent competence factor for AKR-2B cells

Goustin, A. S., Nuttall, G. A., Leof, E. B., Ranganathan, G. & Moses, H. L., 1987, In : Experimental Cell Research. 172, 2, p. 293-303 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transforming growth factor β regulation of cell proliferation

Moses, H. L., Coffey, R. J., Leof, E. B., Lyons, R. M. & Keski-Oja, J., 1987, In : Journal of Cellular Physiology. 133, SUPPL. 5, p. 1-7 7 p.

Research output: Contribution to journalArticle

128 Scopus citations
1988

Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-β

Keski-Oja, J., Blasi, F., Leof, E. B. & Moses, H. L., 1988, In : Journal of Cell Biology. 106, 2, p. 451-459 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
1989

Interferon α/β modulation of growth-factor-stimulated mitogenicity in AKR-2B fibroblasts

Pietenpol, J. A., Howe, P. H., Cunningham, M. R. & Leof, E. B., 1989, In : Journal of Cellular Physiology. 141, 3, p. 453-460 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mid-G1 arrest and epidermal growth factor independence of ras-transfected mouse cells

Leof, E. B., Lyons, R. M., Cunningham, M. R. & O'Sullivan, D., 1989, In : Cancer Research. 49, 9, p. 2356-2361 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Regulation of transforming growth factor β1 action by multiple transducing pathways: Evidence for both G protein-dependent and -independent signaling

Howe, P. H., Bascom, C. C., Cunningham, M. R. & Leof, E. B., 1989, In : Cancer Research. 49, 21, p. 6024-6031 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Transforming growth factor β1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s)

Howe, P. H. & Leof, E. B., 1989, In : Biochemical Journal. 261, 3, p. 879-886 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
1990

Distinct pathways regulate transforming growth factor β1-stimulated proto-oncogene and extracellular matrix gene expression

Howe, P. H., Cunningham, M. R. & Leof, E. B., 1990, In : Journal of Cellular Physiology. 142, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Inhibition of mink lung epithelial cell proliferation by transforming growth factor-β is coupled through a pertussis-toxin-sensitive substrate

Howe, P. H., Cunningham, M. R. & Leof, E. B., 1990, In : Biochemical Journal. 266, 2, p. 537-543 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
1991
161 Scopus citations
1994

Cell cycle-dependent inhibition of p34(cdc2) synthesis by transforming growth factor β1 in cycling epithelial cells

Eblen, S. T., Fautsch, M. P., Burnette, R. J., Joshi, P. & Leof, E. B., 1994, In : Cell Growth and Differentiation. 5, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
1995

Conditional binding to and cell cycle-regulated inhibition of cyclin- dependent kinase complexes by p27(Kip1)

Eblen, S. T., Fautsch, M. P., Anders, R. A. & Leof, E. B., 1995, In : Cell Growth and Differentiation. 6, 8, p. 915-925 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Differential regulation of p34(cdc2) and p33(cdk2) by transforming growth factor-β1 in murine mammary epithelial cells

Fautsch, M. P., Eblen, S. T., Anders, R. A., Burnette, R. J. & Leof, E. B., 1995, In : Journal of Cellular Biochemistry. 58, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Dissociation of p34cdc2 complex formation from phosphorylation and histone H1 kinase activity

Eblen, S. T., Fautsch, M. P., Fautsch, M. P., Snyder, M. & Leof, E. B., May 1 1995, In : Cancer Research. 55, 9, p. 1994-2000 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
1996
43 Scopus citations

Identification of a cell division cycle (cdc2) homologue in Pneumocystis carinii

Thomas, C. F., Gustafson, M., Vuk-Pavlovic, Z., Leof, E. B. & Limper, A. H., Sep 1996, In : Journal of Eukaryotic Microbiology. 43, 5

Research output: Contribution to journalArticle

6 Scopus citations
5 Scopus citations

The Pneumocystis carinii cdc2 cell division cycle homologue exhibits characteristic protein kinase acttvity

Thomas, C. F., Gustafson, M., Leof, E. B. & Limper, A. H., Oct 1996, In : Chest. 110, 4 SUPPL.

Research output: Contribution to journalArticle

1997

Characterization of the Pneumocystis carinii cyclin-dependent kinase life cycle regulatory system

Limper, A. H., Thomas C.F., J., Mubarak, K. K., Gustafson, M., Kottom, T. J. & Leof, E. B., Nov 1997, In : Journal of Eukaryotic Microbiology. 44, 6

Research output: Contribution to journalArticle

3 Scopus citations

Distinct endocytic responses of heteromeric and homomeric transforming growth factor β receptors

Anders, R. A., Arline, S. L., Doré, J. J. E. & Leof, E. B., 1997, In : Molecular Biology of the Cell. 8, 11, p. 2133-2143 11 p.

Research output: Contribution to journalArticle

55 Scopus citations

Interactions of parasite and host epithelial cell cycle regulation during Pneumocystis carinii pneumonia

Limper, A. H., Thomas, C. F., Anders, R. A. & Leof, E. B., Aug 1997, In : Journal of Laboratory and Clinical Medicine. 130, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

37 Scopus citations
1998
24 Scopus citations

Cloning and characterization of the suc1 cell cycle control gene from Pneumocystis carinii

Mubarak, K. K., Thomas, C. F., Leof, E. B. & Limper, A. H., Oct 1998, In : Chest. 114, 4 SUPPL.

Research output: Contribution to journalArticle

Differential requirement for type I and type II transforming growth factor β receptor kinase activity in ligand-mediated receptor endocytosis

Anders, R. A., Doré, J. J. E., Arline, S. L., Garamszegi, N. & Leof, E. B., Sep 4 1998, In : Journal of Biological Chemistry. 273, 36, p. 23118-23125 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Pneumocystis carinii contains a functional cell-division-cycle Cdc2 homologue

Thomas, C. F., Anders, R. A., Gustafson, M., Leof, E. B. & Limper, A. H., 1998, In : American Journal of Respiratory Cell and Molecular Biology. 18, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Pneumocystis carinii inhibits cyclin-dependent kinase activity in lung epithelial cells

Limper, A. H., Edens, M., Anders, R. A. & Leof, E. B., Mar 1 1998, In : Journal of Clinical Investigation. 101, 5, p. 1148-1155 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
1999

Analysis of Pneumocystis carinii introns

Thomas, C. F., Leof, E. B. & Limper, A. H., Nov 1999, In : Infection and Immunity. 67, 11, p. 6157-6160 4 p.

Research output: Contribution to journalArticle

20 Scopus citations
1 Scopus citations

Heteromeric and homomeric transforming growth factor-β receptors show distinct signaling and endocytic responses in epithelial cells

Dore, J. J. J. E., Edens, M., Garamszegi, N. & Leof, E. B., Nov 27 1999, In : Journal of Biological Chemistry. 273, 48, p. 31770-31777 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2000

FKBP12 is a negative regulator of transforming growth factor-β receptor internalization

Yao, D., Dore, J. J. J. E. & Leof, E. B., Apr 28 2000, In : Journal of Biological Chemistry. 275, 17, p. 13149-13154 6 p.

Research output: Contribution to journalArticle

49 Scopus citations