• 6135 Citations
  • 39 Scopus h-Index
1980 …2019

Research output per year

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Research Output

  • 6135 Citations
  • 39 Scopus h-Index
  • 106 Article
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Article
2019

B7-1 drives TGF-β stimulated pancreatic carcinoma cell migration and expression of EMT target genes

Kang, J. H., Jung, M. Y. & Leof, E. B., Jan 1 2019, In : PloS one. 14, 9, e0222083.

Research output: Contribution to journalArticle

Open Access
2018

Fatty acid synthase is required for profibrotic TGF-b signaling

Jung, M. Y., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., Gonzalez-Guerrico, A., Limper, A. H., Lupu, R. & Leof, E. B., Jul 1 2018, In : FASEB Journal. 32, 7, p. 3803-3815 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Basolateral delivery of the type i transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif

Yin, X., Kang, J. H., Andrianifahanana, M., Wang, Y., Jung, M. Y., Hernandez, D. M. & Leof, E. B., Oct 1 2017, In : Molecular Biology of the Cell. 28, 20, p. 2701-2711 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling

Kang, J. H., Jung, M. Y., Yin, X., Andrianifahanana, M., Hernandez, D. M. & Leof, E. B., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2541-2554 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia

Yang, B., Kilari, S., Brahmbhatt, A., McCall, D. L., Torres, E. N., Leof, E. B., Mukhopadhyay, D. & Misra, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14298.

Research output: Contribution to journalArticle

3 Scopus citations
2016
1 Scopus citations

Patterns of Müllerian inhibiting substance type II and candidate type I receptors in epithelial ovarian cancer

Basal, E., Ayeni, T., Zhang, Q., Langstraat, C., Donahoe, P. K., Pepin, D., Yin, X., Leof, E. B. & Cliby, W. A., Mar 1 2016, In : Current Molecular Medicine. 16, 3, p. 222-231 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways

Andrianifahanana, M., Hernandez, D. M., Yin, X., Kang, J. H., Jung, M. Y., Wang, Y., Yi, E. S., Roden, A., Limper, A. H. & Leof, E. B., Nov 1 2016, In : FASEB Journal. 30, 11, p. 3733-3744 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tracking and therapeutic value of human adipose tissue-derived mesenchymal stem cell transplantation in reducing venous neointimal hyperplasia associated with arteriovenous fistula

Yang, B., Brahmbhatt, A., Torres, E. N., Thielen, B., McCall, D. L., Engel, S., Bansal, A., Pandey, M., Dietz, A. B., Leof, E. B., DeGrado, T. R., Mukhopadhyay, D. & Misra, S., May 1 2016, In : Radiology. 279, 2, p. 513-522 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis

Wang, Y., Cao, Y., Yamada, S., Thirunavukkarasu, M., Nin, V., Joshi, M., Rishi, M. T., Bhattacharya, S., Camacho-Pereira, J., Sharma, A. K., Shameer, K., Kocher, J-P., Sanchez, J. A., Wang, E., Hoeppner, L. H., Dutta, S. K., Leof, E. B., Shah, V., Claffey, K. P., Chini, E. N. & 4 others, Simons, M., Terzic, A., Maulik, N. & Mukhopadhyay, D., Jun 27 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula

Torres, E. C. N., Yang, B., Janardhanan, R., Brahmbhatt, A., Leof, E. B., Mukhopadhyay, D. & Misra, S., 2014, In : PLoS One. 9, 4, p. e94510

Research output: Contribution to journalArticle

15 Scopus citations

Adventitial transduction of lentivirus-shRNA-VEGF-A in arteriovenous fistula reduces venous stenosis formation

Yang, B., Janardhanan, R., Vohra, P., Greene, E. L., Bhattacharya, S., Withers, S., Roy, B., Nieves Torres, E. C., Mandrekar, J., Leof, E. B., Mukhopadhyay, D. & Misra, S., Feb 2014, In : Kidney International. 85, 2, p. 289-306 18 p.

Research output: Contribution to journalArticle

32 Scopus citations

Erratum to Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro [Clin Exp Rheumatol, 30, 2 Suppl. 71, (2012) S86-S96]

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. B. & Varga, J., 2014, In : Clinical and Experimental Rheumatology. 32, 1, p. 150 1 p.

Research output: Contribution to journalArticle

2013

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver

Liu, C., Billadeau, D. D., Abdelhakim, H., Leof, E. B., Kaibuchi, K., Bernabeu, C., Bloom, G. S., Yang, L., Boardman, L. A., Shah, V. & Kang, N., Mar 1 2013, In : Journal of Clinical Investigation. 123, 3, p. 1138-1156 19 p.

Research output: Contribution to journalArticle

51 Scopus citations

Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases

Andrianifahanana, M., Wilkes, M. C., Gupta, S. K., Rahimi, R. A., Repellin, C. E., Edens, M., Wittenberger, J., Yin, X., Maidl, E., Becker, J. & Leof, E. B., Nov 2013, In : FASEB Journal. 27, 11, p. 4444-4454 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Retromer maintains basolateral distribution of the type II TGF-β receptor via the recycling endosome

Yin, X., Murphy, S. J., Wilkes, M. C., Ji, Y. & Leof, E. B., Jul 15 2013, In : Molecular Biology of the Cell. 24, 14, p. 2285-2298 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
38 Scopus citations
2012

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

Xiong, X., Xu, Q., Huang, Y., Singh, R. D., Anderson, R., Leof, E. B., Hu, J. & Ling, K., Jan 1 2012, In : Molecular Biology of the Cell. 23, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Imatinib mesylate causes genome-wide transcriptional changes in systemic sclerosis fibroblasts in vitro

Hinchcliff, M., Huang, C. C., Ishida, W., Fang, F., Lee, J., Jafari, N., Wilkes, M., Bhattacharyya, S., Leof, E. B. & Varga, J., May 2012, In : Clinical and Experimental Rheumatology. 30, SUPPL.71

Research output: Contribution to journalArticle

7 Scopus citations
2011

Fibrosis, regeneration, and aging: Playing chess with evolution

Torres, V. & Leof, E. B., 2011, In : Journal of the American Society of Nephrology. 22, 8, p. 1393-1395 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase

Hong, M., Wilkes, M. C., Penheiter, S. G., Gupta, S. K., Edens, M. & Leof, E. B., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 17841-17850 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

ERBB receptor activation is required for profibrotic responses to transforming growth factor β

Andrianifahanana, M., Wilkes, M. C., Repellin, C. E., Edens, M., Kottom, T. J., Rahimi, R. A. & Leof, E. B., Oct 1 2010, In : Cancer Research. 70, 19, p. 7421-7430 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
35 Scopus citations

Neuropilin-1 mediates divergent R-smad signaling and the myofibroblast phenotype

Cao, Y., Szabolcs, A., Dutta, S. K., Yaqoob, U., Jagavelu, K., Wang, L., Leof, E. B., Urrutia, R. A., Shah, V. & Mukhopadhyay, D., Oct 8 2010, In : Journal of Biological Chemistry. 285, 41, p. 31840-31848 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
99 Scopus citations

Noncanonical TGF-β pathways, mTORC1 and Abl, in renal interstitial fibrogenesis

Wang, S., Wilkes, M. C., Leof, E. B. & Hirschberg, R., Jan 2010, In : American Journal of Physiology - Renal Physiology. 298, 1

Research output: Contribution to journalArticle

93 Scopus citations

Type II transforming growth factor-β receptor recycling is dependent upon the clathrin adaptor protein Dab2

Penheiter, S. G., Singh, R. D., Repellin, C. E., Wilkes, M. C., Edens, M., Howe, P. H., Pagano, R. E. & Leof, E. B., Nov 15 2010, In : Molecular Biology of the Cell. 21, 22, p. 4009-4019 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2009

A non-Smad mechanism of fibroblast activation by transforming growth factor-β via c-Abl and Egr-1: Selective modulation by imatinib mesylate

Bhattacharyya, S., Ishida, W., Wu, M., Wilkes, M., Mori, Y., Hinchcliff, M., Leof, E. B. & Varga, J., Mar 12 2009, In : Oncogene. 28, 10, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-β

Rahimi, R. A., Andrianifahanana, M., Wilkes, M. C., Edens, M., Kottom, T. J., Blenis, J. & Leof, E. B., Jan 1 2009, In : Cancer Research. 69, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

66 Scopus citations

Erbin and the NF2 Tumor Suppressor Merlin Cooperatively Regulate Cell-Type-Specific Activation of PAK2 by TGF-β

Wilkes, M. C., Repellin, C. E., Hong, M., Bracamonte, M., Penheiter, S. G., Borg, J. P. & Leof, E. B., Mar 17 2009, In : Developmental Cell. 16, 3, p. 433-444 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
2008
7 Scopus citations

Platelet-Derived Growth Factor Signaling Through Ephrin-B2 Regulates Hepatic Vascular Structure and Function

Semela, D., Das, A., Langer, D., Kang, N., Leof, E. B. & Shah, V., Aug 2008, In : Gastroenterology. 135, 2

Research output: Contribution to journalArticle

99 Scopus citations
2007

A unique element in the cytoplasmic tail of the type II transforming growth factor-β receptor controls basolateral delivery

Murphy, S. J., Shapira, K. E., Henis, Y. I. & Leof, E. B., Oct 2007, In : Molecular Biology of the Cell. 18, 10, p. 3788-3799 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Phase I trial of sirolimus combined with radiation and cisplatin in non-small cell lung cancer

Sarkaria, J. N., Schwingler, P., Schild, S. E., Grogan, P. T., Mladek, A. C., Mandrekar, S. J., Tan, A. D., Kobayashi, T., Marks, R. S., Kita, H., Miller, R. C., Limper, A. H. & Leof, E. B., Aug 2007, In : Journal of Thoracic Oncology. 2, 8, p. 751-757 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor β-induced downregulation of cyclin A in vascular smooth muscle cells

Kamiya, K., Sakakibara, K., Ryer, E. J., Hom, R. P., Leof, E. B., Kent, K. C. & Liu, B., May 2007, In : Molecular and Cellular Biology. 27, 9, p. 3489-3498 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
289 Scopus citations
41 Scopus citations
2005

Transforming growth factor-β activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2

Wilkes, M. C., Mitchell, H., Penheiter, S. G., Doré, J. J., Suzuki, K., Edens, M., Sharma, D. K., Pagano, R. E. & Leof, E. B., Nov 15 2005, In : Cancer Research. 65, 22, p. 10431-10440 10 p.

Research output: Contribution to journalArticle

137 Scopus citations
2004

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

Daniels, C. E., Wilkes, M. C., Edens, M., Kottom, T. J., Murphy, S. J., Limper, A. H. & Leof, E. B., Nov 2004, In : Journal of Clinical Investigation. 114, 9, p. 1308-1316 9 p.

Research output: Contribution to journalArticle

459 Scopus citations
141 Scopus citations
2003

Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3

Wilkes, M. C., Murphy, S. J., Garamszegi, N. & Leof, E. B., Dec 2003, In : Molecular and Cellular Biology. 23, 23, p. 8878-8889 12 p.

Research output: Contribution to journalArticle

102 Scopus citations
2002

Internalization-dependent and -independent requirements for transforming growth factor β receptor signaling via the Smad pathway

Penheiter, S. G., Mitchell, H., Garamszegi, N., Edens, M., Doré, J. J. E. & Leof, E. B., 2002, In : Molecular and Cellular Biology. 22, 13, p. 4750-4759 10 p.

Research output: Contribution to journalArticle

150 Scopus citations

Transforming growth factor-β receptors interact with AP2 by direct binding to β2 subunit

Yao, D., Ehrlich, M., Henis, Y. I. & Leof, E. B., Nov 1 2002, In : Molecular Biology of the Cell. 13, 11, p. 4001-4012 12 p.

Research output: Contribution to journalArticle

94 Scopus citations