Eduardo Nunes Chini, MD, PhD

  • 3705 Citations
  • 36 Scopus h-Index
1990 …2019
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  • 1 Similar Profiles
Cyclic ADP-Ribose Medicine & Life Sciences
NAD Medicine & Life Sciences
ADP-ribosyl Cyclase Medicine & Life Sciences
NAD+ Nucleosidase Medicine & Life Sciences
Second Messenger Systems Medicine & Life Sciences
Mesangial Cells Medicine & Life Sciences
Rats Chemical Compounds
Metabolism Chemical Compounds

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Projects 2003 2019

Mayo Clinic SPORE in Pancreatic Cancer

Cohen, P. A., Urrutia, R. A., De Andrade, M., Chari, S. T., Lingle, W. L., Billadeau, D. D., Petersen, G. M., Couch, F. J., Mukhopadhyay, D., Chini, E. N., Smyrk, T. C., Oberg, A. L., Gendler, S. J., Couch, F. J., Mukherjee, P., Mukherjee, P., Andrade, M., Fernandez-Zapico, M. E. & Billadeau, D. D.

National Institutes of Health

9/29/038/31/19

Project: Research project

Pancreatic Neoplasms
Research
Biostatistics
Glycogen Synthase Kinase 3
Neoplasms
Fatty Liver
Liver Diseases
Breast Neoplasms
Proteins
Adenylate Kinase
Health
Insulin-Like Growth Factor I
Transgenic Mice
Assisted Reproductive Techniques
Protein Isoforms

Research Output 1990 2019

  • 3705 Citations
  • 36 Scopus h-Index
  • 109 Article
  • 2 Review article
1 Citation (Scopus)

Targeting CD38 enhances the antileukemic activity of ibrutinib in chronic lymphocytic leukemia

Manna, A., Aulakh, S., Jani, P., Ahmed, S., Akhtar, S., Coignet, M., Heckman, M., Meghji, Z., Bhatia, K., Sharma, A., Sher, T., Alegria, V., Malavasi, F., Chini, E. N., Chanan Khan, A. A., Ailawadhi, S. & Paulus, A., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Heterografts
B-Lymphocytes
Antibody-Dependent Cell Cytotoxicity
PCI 32765
4 Citations (Scopus)

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A. V., Stout, M. B. & 13 others, Schafer, M. J., White, T. A., Hickson, L., Demaria, M., Garovic, V. D., Grande, J. P., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 1 2019, In : Aging Cell. 18, 3, e12950.

Research output: Contribution to journalArticle

Open Access
Obesity
Adipose Tissue
Obese Mice
Insulin Resistance
p16 Genes

The Multi-faceted Ecto-enzyme CD38: Roles in immunomodulation, cancer, aging, and metabolic diseases

Hogan, K. A., Chini, C. C. S. & Chini, E. N., Jan 1 2019, In : Frontiers in immunology. 10, MAY, 1187.

Research output: Contribution to journalReview article

Open Access
Immunomodulation
Metabolic Diseases
NAD
Enzymes
Neoplasms
3 Citations (Scopus)

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD + decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L. & Chini, E. N., May 28 2019, In : Biochemical and Biophysical Research Communications. 513, 2, p. 486-493 8 p.

Research output: Contribution to journalArticle

Open Access
NAD+ Nucleosidase
NAD
Cell Aging
Aging of materials
Phenotype
24 Citations (Scopus)

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Tarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., Jurk, D., Cho, D. S., Boslett, J. J., Miller, J. D., Zweier, J. L., Passos, J. F., Doles, J., Becherer, D. J. & Chini, E. N., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

NAD
NAD+ Nucleosidase
Telomere
DNA Damage
Sirtuins