Eduardo Nunes Chini

2024

Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity

Peclat, T. R., Agorrody, G., Colman, L., Kashyap, S., Zeidler, J. D., Chini, C. C. S., Warner, G. M., Thompson, K. L., Dalvi, P., Beckedorff, F., Ebtehaj, S., Herrmann, J., Schooten, W. V. & Chini, E. N., Feb 1 2024, In: Cardiovascular research. 120, 3, p. 286-300 15 p.

Research output: Contribution to journal › Article › peer-review

NAD metabolism: Role in senescence regulation and aging

Chini, C. C. S., Cordeiro, H. S., Tran, N. L. K. & Chini, E. N., Jan 2024, In: Aging Cell. 23, 1, e13920.

Research output: Contribution to journal › Review article › peer-review

Open Access

2023

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis

Abe, J. I., Imanishi, M., Li, S., Zhang, A., Ko, K. A., Samanthapudi, V. S. K., Lee, L. L., Bojorges, A. P., Gi, Y. J., Hobbs, B. P., Deswal, A., Herrmann, J., Lin, S. H., Chini, E. N., Shen, Y. H., Schadler, K. L., Nguyen, T. H. M., Gupte, A. A., Reyes-Gibby, C., Yeung, S. C. J., & 14 othersAbe, R. J., Olmsted-Davis, E. A., Krishnan, S., Dantzer, R., Palaskas, N. L., Cooke, J. P., Pownall, H. J., Yoshimoto, M., Fujiwara, K., Hamilton, D. J., Burks, J. K., Wang, G., Le, N. T. & Kotla, S., Jun 23 2023, In: Circulation research. 133, 1, p. 25-44 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A stress-induced cilium-to-PML-NB route drives senescence initiation

Ma, X., Zhang, Y., Zhang, Y., Zhang, X., Huang, Y., He, K., Chen, C., Hao, J., Zhao, D., LeBrasseur, N. K., Kirkland, J. L., Chini, E. N., Wei, Q., Ling, K. & Hu, J., Dec 2023, In: Nature communications. 14, 1, 1840.

Research output: Contribution to journal › Article › peer-review

Open Access

Heavy-chain antibody targeting of CD38 NAD⁺ hydrolase ectoenzyme to prevent fibrosis in multiple organs

Shi, B., Amin, A., Dalvi, P., Wang, W., Lukacs, N., Kai, L., Cheresh, P., Peclat, T. R., Chini, C. C., Chini, E. N., van Schooten, W. & Varga, J., Dec 2023, In: Scientific reports. 13, 1, 22085.

Research output: Contribution to journal › Article › peer-review

Open Access

Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma

Bisht, K., Fukao, T., Chiron, M., Richardson, P., Atanackovic, D., Chini, E., Chng, W. J., Van De Velde, H. & Malavasi, F., Oct 2023, In: Cancer medicine. 12, 20, p. 20332-20352 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

p21 induces a senescence program and skeletal muscle dysfunction

Englund, D. A., Jolliffe, A., Aversa, Z., Zhang, X., Sturmlechner, I., Sakamoto, A. E., Zeidler, J. D., Warner, G. M., McNinch, C., White, T. A., Chini, E. N., Baker, D. J., van Deursen, J. M. & LeBrasseur, N. K., Jan 2023, In: Molecular Metabolism. 67, 101652.

Research output: Contribution to journal › Article › peer-review

Open Access

Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights

Jain, A., Casanova, D., Padilla, A. V., Paniagua Bojorges, A., Kotla, S., Ko, K. A., Samanthapudi, V. S. K., Chau, K., Nguyen, M. T. H., Wen, J., Hernandez Gonzalez, S. L., Rodgers, S. P., Olmsted-Davis, E. A., Hamilton, D. J., Reyes-Gibby, C., Yeung, S. C. J., Cooke, J. P., Herrmann, J., Chini, E. N., Xu, X., & 12 othersYusuf, S. W., Yoshimoto, M., Lorenzi, P. L., Hobbs, B., Krishnan, S., Koutroumpakis, E., Palaskas, N. L., Wang, G., Deswal, A., Lin, S. H., Abe, J. I. & Le, N. T., 2023, In: Frontiers in Cardiovascular Medicine. 10, 1212174.

Research output: Contribution to journal › Review article › peer-review

Open Access

Senescent Cells Accumulate in Systemic Sclerosis Skin

Shi, B., Tsou, P. S., Ma, F., Mariani, M. P., Mattichak, M. N., LeBrasseur, N. K., Chini, E. N., Lafyatis, R., Khanna, D., Whitfield, M. L., Gudjonsson, J. E. & Varga, J., Apr 2023, In: Journal of Investigative Dermatology. 143, 4, p. 661-664.e5

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Benefits in cardiac function by CD38 suppression: Improvement in NAD⁺ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias

Agorrody, G., Peclat, T. R., Peluso, G., Gonano, L. A., Santos, L., van Schooten, W., Chini, C. C. S., Escande, C., Chini, E. N. & Contreras, P., May 2022, In: Journal of Molecular and Cellular Cardiology. 166, p. 11-22 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cancer treatment-induced NAD⁺ depletion in premature senescence and late cardiovascular complications

Banerjee, P., Olmsted-Davis, E. A., Deswal, A., Nguyen, M. T., Koutroumpakis, E., Palaskas, N. L., Lin, S. H., Kotla, S., Reyes-Gibby, C., Yeung, S. C. J., Yusuf, S. W., Yoshimoto, M., Kobayashi, M., Yu, B., Schadler, K., Herrmann, J., Cooke, J. P., Jain, A., Chini, E., Le, N. T., & 1 othersAbe, J. I., Jul 2022, In: Journal of Cardiovascular Aging. 2, 3, 28.

Research output: Contribution to journal › Review article › peer-review

Open Access

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Peclat, T. R., Thompson, K. L., Warner, G. M., Chini, C. C. S., Tarragó, MG., Mazdeh, D. Z., Zhang, C., Zavala-Solorio, J., Kolumam, G., Liang Wong, Y., Cohen, R. L. & Chini, E. N., Apr 2022, In: Aging Cell. 21, 4, e13589.

Research output: Contribution to journal › Article › peer-review

Open Access

CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype

de Zélicourt, A., Fayssoil, A., Dakouane-Giudicelli, M., De Jesus, I., Karoui, A., Zarrouki, F., Lefebvre, F., Mansart, A., Launay, J. M., Piquereau, J., Tarragó, M. G., Bonay, M., Forand, A., Moog, S., Piétri-Rouxel, F., Brisebard, E., Chini, C. C. S., Kashyap, S., Fogarty, M. J., Sieck, G. C., & 5 othersMericskay, M., Chini, E. N., Gomez, A. M., Cancela, J. M. & de la Porte, S., May 9 2022, In: EMBO Molecular Medicine. 14, 5, e12860.

Research output: Contribution to journal › Article › peer-review

Open Access

Dihydronicotinamide Riboside Is a Potent NAD⁺ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages

Chini, C. C. S., Peclat, T. R., Gomez, L. S., Zeidler, J. D., Warner, G. M., Kashyap, S., Mazdeh, D. Z., Hayat, F., Migaud, M. E., Paulus, A., Chanan-Khan, A. A. & Chini, E. N., Feb 25 2022, In: Frontiers in immunology. 13, 840246.

Research output: Contribution to journal › Article › peer-review

Open Access

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

Zeidler, J. D., Chini, C. C. S., Kanamori, K. S., Kashyap, S., Espindola-Netto, J. M., Thompson, K., Warner, G., Cabral, F. S., Peclat, T. R., Gomez, L. S., Lopez, S. A., Wandersee, M. K., Schoon, R. A., Reid, K., Menzies, K., Beckedorff, F., Reid, J. M., Brachs, S., Meyer, R. G., Meyer-Ficca, M. L., & 1 othersChini, E. N., Nov 18 2022, In: iScience. 25, 11, 105431.

Research output: Contribution to journal › Article › peer-review

Open Access

IMPLICATIONS OF THE NADASE CD38 IN COVID PATHOPHYSIOLOGY

Zeidler, J. D., Kashyap, S., Hogan, K. A. & Chini, E. N., Jan 2022, In: Physiological Reviews. 102, 1, p. 339-341 3 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Low NAD⁺ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice

Meyer-Ficca, M. L., Zwerdling, A. E., Swanson, C. A., Tucker, A. G., Lopez, S. A., Wandersee, M. K., Warner, G. M., Thompson, K. L., Chini, C. C. S., Chen, H., Chini, E. N. & Meyer, R. G., May 6 2022, In: Frontiers in Endocrinology. 13, 896356.

Research output: Contribution to journal › Article › peer-review

Open Access

Mitochondrial dysfunction in cell senescence and aging

Miwa, S., Kashyap, S., Chini, E. & von Zglinicki, T., Jul 1 2022, In: Journal of Clinical Investigation. 132, 13, e158447.

Research output: Contribution to journal › Review article › peer-review

Open Access

Radiation therapy induces immunosenescence mediated by p90RSK

Imanishi, M., Cheng, H., Kotla, S., Deswal, A., Le, N. T., Chini, E., Ko, K. A., Samanthapudi, V. S. K., Lee, L. L., Herrmann, J., Xu, X., Reyes-Gibby, C., Yeung, S. C. J., Schadler, K. L., Yusuf, S. W., Liao, Z., Nurieva, R., Amir, E. A. D., Burks, J. K., Palaskas, N. L., & 5 othersCooke, J. P., Lin, S. H., Kobayashi, M., Yoshimoto, M. & Abe, J. I., Nov 7 2022, In: Frontiers in Cardiovascular Medicine. 9, 988713.

Research output: Contribution to journal › Article › peer-review

Open Access

The CD38 glycohydrolase and the NAD sink: Implications for pathological conditions

Zeidler, J. D., Hogan, K. A., Agorrody, G., Peclat, T. R., Kashyap, S., Kanamori, K. S., Gomez, L. S., Mazdeh, D. Z., Warner, G. M., Thompson, K. L., Chini, C. C. S. & Chini, E. N., Mar 2022, In: American Journal of Physiology - Cell Physiology. 322, 3, p. C521-C545

Research output: Contribution to journal › Review article › peer-review

Open Access

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

Ugamraj, H. S., Dang, K., Ouisse, L. H., Buelow, B., Chini, E. N., Castello, G., Allison, J., Clarke, S. C., Davison, L. M., Buelow, R., Deng, R., Iyer, S., Schellenberger, U., Manika, S. N., Bijpuria, S., Musnier, A., Poupon, A., Cuturi, M. C., van Schooten, W. & Dalvi, P., 2022, In: mAbs. 14, 1, 2095949.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A methionine-Mettl3-N⁶-methyladenosine axis promotes polycystic kidney disease

Ramalingam, H., Kashyap, S., Cobo-Stark, P., Flaten, A., Chang, C. M., Hajarnis, S., Hein, K. Z., Lika, J., Warner, G. M., Espindola-Netto, J. M., Kumar, A., Kanchwala, M., Xing, C., Chini, E. N. & Patel, V., Jun 1 2021, In: Cell Metabolism. 33, 6, p. 1234-1247.e7

Research output: Contribution to journal › Article › peer-review

Open Access

Critical role of astrocyte nad+ glycohydrolase in myelin injury and regeneration

Langley, M. R., Choi, C. I., Peclat, T. R., Guo, Y., Simon, W. L., Yoon, H., Kleppe, L., Lucchinetti, C. F., Chini, C. C. S., Chini, E. N. & Scarisbrick, I. A., Oct 13 2021, In: Journal of Neuroscience. 41, 41, p. 8644-8667 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Evolving concepts in NAD⁺ metabolism

Chini, C. C. S., Zeidler, J. D., Kashyap, S., Warner, G. & Chini, E. N., Jun 1 2021, In: Cell Metabolism. 33, 6, p. 1076-1087 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue

Zhang, Y., Hao, J., Tarrago, M. G., Warner, G. M., Giorgadze, N., Wei, Q., Huang, Y., He, K., Chen, C., Peclat, T. R., White, T. A., Ling, K., Tchkonia, T., Kirkland, J. L., Chini, E. N. & Hu, J., Aug 3 2021, In: Cell reports. 36, 5, 109481.

Research output: Contribution to journal › Article › peer-review

Open Access

Surface color spectrophotometry in a murine model of steatosis: an accurate technique with potential applicability in liver procurement

Kanamori, K. S., Tarragó, M. G., Jones, A., Cheek, E. H., Warner, G. M., Jenkins, S. M., Povero, D., Graham, R. P., Mounajjed, T., Chedid, M. F., Sabat, B. D., Torbenson, M. S., Heimbach, J. K., Chini, E. N. & Moreira, R. K., Aug 2021, In: Laboratory Investigation. 101, 8, p. 1098-1109 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting CD38-dependent NAD⁺ metabolism to mitigate multiple organ fibrosis

Shi, B., Wang, W., Korman, B., Kai, L., Wang, Q., Wei, J., Bale, S., Marangoni, R. G., Bhattacharyya, S., Miller, S., Xu, D., Akbarpour, M., Cheresh, P., Proccissi, D., Gursel, D., Espindola-Netto, J. M., Chini, C. C. S., de Oliveira, G. C., Gudjonsson, J. E., Chini, E. N., & 1 othersVarga, J., Jan 22 2021, In: iScience. 24, 1, 101902.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging

Hayashi, Y., Asuzu, D. T., Bardsley, M. R., Gajdos, G. B., Kvasha, S. M., Linden, D. R., Nagy, R. A., Saravanaperumal, S. A., Syed, S. A., Toyomasu, Y., Yan, H., Chini, E. N., Gibbons, S. J., Kellogg, T. A., Khazaie, K., Kuro-o, M., Machado Espindola Netto, J., Singh, M. P., Tidball, J. G., Wehling-Henricks, M., & 2 othersFarrugia, G. & Ordog, T., Jan 2021, In: CMGH. 11, 1, p. 117-145 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD⁺ and NMN levels

Chini, C. C. S., Peclat, T. R., Warner, G. M., Kashyap, S., Espindola-Netto, J. M., de Oliveira, G. C., Gomez, L. S., Hogan, K. A., Tarragó, M. G., Puranik, A. S., Agorrody, G., Thompson, K. L., Dang, K., Clarke, S., Childs, B. G., Kanamori, K. S., Witte, M. A., Vidal, P., Kirkland, A. L., De Cecco, M., & 12 othersChellappa, K., McReynolds, M. R., Jankowski, C., Tchkonia, T., Kirkland, J. L., Sedivy, J. M., van Deursen, J. M., Baker, D. J., van Schooten, W., Rabinowitz, J. D., Baur, J. A. & Chini, E. N., Nov 2020, In: Nature Metabolism. 2, 11, p. 1284-1304 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Implications of the PAPP-A-IGFBP-IGF-1 pathway in the pathogenesis and treatment of polycystic kidney disease

Kashyap, S., Zeidler, J. D., Chini, C. C. S. & Chini, E. N., Sep 2020, In: Cellular Signalling. 73, 109698.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Metalloproteinase PAPP - A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Kashyap, S., Hein, K. Z., Chini, C. C. S., Lika, J., Warner, G. M., Bale, L. K., Torres, V. E., Harris, P. C., Oxvig, C., Conover, C. A. & Chini, E. N., Feb 27 2020, In: JCI Insight. 5, 4, e135700.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Of Mice and Men: NAD⁺ Boosting with Niacin Provides Hope for Mitochondrial Myopathy Patients

Chini, E. N., Jun 2 2020, In: Cell Metabolism. 31, 6, p. 1041-1043 3 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

1 Scopus citations

Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD8¹ T-cell responses

Manna, A., Kellett, T., Aulakh, S., Lewis-Tuffin, L. J., Dutta, N., Knutson, K., Chini, E., Pinilla-Ibarz, J., Lamanna, N., Manochakian, R., Malavasi, F., Sher, T., Chanan-Khan, A. A., Ailawadhi, S. & Paulus, A., May 26 2020, In: Blood Advances. 4, 10, p. 2143-2157 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

The NADase enzyme CD38: An emerging pharmacological target for systemic sclerosis, systemic lupus erythematosus and rheumatoid arthritis

Peclat, T. R., Shi, B., Varga, J. & Chini, E. N., Nov 1 2020, In: Current opinion in rheumatology. 32, 6, p. 488-496 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Tissue-resident CD8⁺ T cells drive age-associated chronic lung sequelae after viral pneumonia

Goplen, N. P., Wu, Y., Son, Y. M., Li, C., Wang, Z., Cheon, I. S., Jiang, L., Zhu, B., Ayasoufi, K., Chini, E. N., Johnson, A. J., Vassallo, R., Limper, A. H., Zhang, N. & Sun, J., Nov 6 2020, In: Science Immunology. 5, 53, eabc4557.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2019

A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo

Santos, L., Colman, L., Contreras, P., Chini, C. C., Carlomagno, A., Leyva, A., Bresque, M., Marmisolle, I., Quijano, C., Durán, R., Irigoín, F., Prieto-Echagüe, V., Vendelbo, M. H., Sotelo-Silveira, J. R., Chini, E. N., Badano, J. L., Calliari, A. J. & Escande, C., Dec 1 2019, In: Scientific reports. 9, 1, 14381.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Targeting CD38 enhances the antileukemic activity of ibrutinib in chronic lymphocytic leukemia

Manna, A., Aulakh, S., Jani, P., Ahmed, S., Akhtar, S., Coignet, M., Heckman, M., Meghji, Z., Bhatia, K., Sharma, A., Sher, T., Alegria, V., Malavasi, F., Chini, E. N., Chanan-Khan, A., Ailawadhi, S. & Paulus, A., 2019, In: Clinical Cancer Research. 25, 13, p. 3974-3985 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A., Stout, M. B., & 13 othersSchafer, M. J., White, T. A., Hickson, L. T. J., Demaria, M., Garovic, V., Grande, J., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 2019, In: Aging Cell. 18, 3, e12950.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

The Multi-faceted Ecto-enzyme CD38: Roles in immunomodulation, cancer, aging, and metabolic diseases

Hogan, K. A., Chini, C. C. S. & Chini, E. N., 2019, In: Frontiers in immunology. 10, MAY, 1187.

Research output: Contribution to journal › Review article › peer-review

Open Access

54 Scopus citations

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD⁺ decline

Chini, C., Hogan, K. A., Warner, G. M., Tarragó, M. G., Peclat, T. R., Tchkonia, T., Kirkland, J. L. & Chini, E., May 28 2019, In: Biochemical and Biophysical Research Communications. 513, 2, p. 486-493 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2018

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD⁺ Decline

Tarragó, M. G., Chini, C. C. S., Kanamori, K. S., Warner, G. M., Caride, A., de Oliveira, G. C., Rud, M., Samani, A., Hein, K. Z., Huang, R., Jurk, D., Cho, D. S., Boslett, J. J., Miller, J. D., Zweier, J. L., Passos, J. F., Doles, J. D., Becherer, D. J. & Chini, E. N., May 1 2018, In: Cell Metabolism. 27, 5, p. 1081-1095.e10

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

Boslett, J., Helal, M., Chini, E. & Zweier, J. L., May 2018, In: Journal of Molecular and Cellular Cardiology. 118, p. 81-94 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Rho GTPase effectors and NAD metabolism in cancer immune suppression

Chaker, M., Minden, A., Chen, S., Weiss, R. H., Chini, E. N., Mahipal, A. & Azmi, A. S., Jan 2 2018, In: Expert opinion on therapeutic targets. 22, 1, p. 9-17 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Scopus citations

The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

Chini, E. N., Chini, C. C. S., Espindola Netto, J. M., de Oliveira, G. C. & van Schooten, W., Apr 2018, In: Trends in Pharmacological Sciences. 39, 4, p. 424-436 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

59 Scopus citations

2017

NAD and the aging process: Role in life, death and everything in between

Chini, C. C. S., Tarragó, M. G. & Chini, E. N., Nov 5 2017, In: Molecular and Cellular Endocrinology. 455, p. 62-74 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer

Espindola-Netto, J. M., Chini, C. C. S., Tarragó, M., Wang, E., Dutta, S., Pal, K., Mukhopadhyay, D., Sola-Penna, M. & Chini, E. N., Oct 17 2017, In: Oncotarget. 8, 49, p. 85054-85067 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism

Matalonga, J., Glaria, E., Bresque, M., Escande, C., Carbó, J. M., Kiefer, K., Vicente, R., León, T. E., Beceiro, S., Pascual-García, M., Serret, J., Sanjurjo, L., Morón-Ros, S., Riera, A., Paytubi, S., Juarez, A., Sotillo, F., Lindbom, L., Caelles, C., Sarrias, M. R., & 4 othersSancho, J., Castrillo, A., Chini, E. N. & Valledor, A. F., Jan 31 2017, In: Cell reports. 18, 5, p. 1241-1255 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2016

A high dose of isoniazid disturbs endobiotic homeostasis in mouse liver

Li, F., Wang, P., Liu, K., Tarrago, M. G., Lu, J., Chini, E. N. & Ma, X., Nov 2016, In: Drug Metabolism and Disposition. 44, 11, p. 1742-1751 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A. & Chini, E. N., Jun 14 2016, In: Cell Metabolism. 23, 6, p. 1127-1139 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

234 Scopus citations

Erratum: SIRT1 Activity is linked to its brain region-specific phosphorylation and is impaired in huntington's disease mice (PLoS ONE (2016) 11:1 (e0145425) DOI: 10.1371/journal.pone.0145425)

Tulino, R., Benjamin, A. C., Jolinon, N., Smith, D. L., Chini, E. N., Carnemolla, A. & Bates, G. P., Feb 2016, In: PloS one. 11, 2, e0150682.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

4 Scopus citations

Eduardo Nunes Chini, MD, PhD

Research output

Search results