Claudia F Lucchinetti, MD

  • 34638 Citations
  • 84 Scopus h-Index
1988 …2020

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2020

Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology

Reichard, R. R., Kashani, K. B., Boire, N. A., Constantopoulos, E., Guo, Y. & Lucchinetti, C. F., Jul 1 2020, In : Acta neuropathologica. 140, 1

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody

Höftberger, R., Guo, Y., Flanagan, E. P., Lopez-Chiriboga, A. S., Endmayr, V., Hochmeister, S., Joldic, D., Pittock, S. J., Tillema, J. M., Gorman, M., Lassmann, H. & Lucchinetti, C. F., May 1 2020, In : Acta neuropathologica. 139, 5, p. 875-892 18 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2019

Exercise and metformin counteract altered mitochondrial function in the insulinresistant brain

Ruegsegger, G. N., Vanderboom, P. M., Dasari, S., Klaus, K. A., Kabiraj, P., McCarthy, C. B., Lucchinetti, C. F. & Nair, K. S., Sep 19 2019, In : JCI Insight. 4, 18, e130681.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Pathological findings in central nervous system demyelination associated with infliximab

Kalinowska-Lyszczarz, A., Fereidan-Esfahani, M., Guo, Y., Lucchinetti, C. F. & Tobin, W. O., Jan 1 2019, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

1 Scopus citations

Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity

Zekeridou, A., Kryzer, T., Guo, Y., Hassan, A., Lennon, V., Lucchinetti, C. F., Pittock, S. & McKeon, A., Aug 20 2019, In : Neurology. 93, 8, p. e815-e822

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Using germline variants to estimate glioma and subtype risks

Eckel-Passow, J. E., Decker, P. A., Kosel, M. L., Kollmeyer, T. M., Molinaro, A. M., Rice, T., Caron, A. A., Drucker, K. L., Praska, C. E., Pekmezci, M., Hansen, H. M., Mccoy, L. S., Bracci, P. M., Erickson, B. J., Lucchinetti, C. F., Wiemels, J. L., Wiencke, J. K., Bondy, M. L., Melin, B., Burns, T. C. & 4 others, Giannini, C., Lachance, D. H., Wrensch, M. R. & Jenkins, R. B., Mar 18 2019, In : Neuro-oncology. 21, 4, p. 451-461 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Autoantibody Status Predict Outcome of Recurrent Optic Neuritis

Jitprapaikulsan, J., Chen, J., Flanagan, E., Tobin, W. O., Fryer, J. P., Weinshenker, B. G., McKeon, A., Lennon, V. A., Leavitt, J. A., Tillema, J-M., Lucchinetti, C. F., Keegan, B. M., Kantarci, O. H., Khanna, C., Jenkins, S. M., Spears, G. M., Sagan, J. & Pittock, S. J., Jan 1 2018, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticle

28 Scopus citations

Association of MOG-IgG Serostatus with Relapse after Acute Disseminated Encephalomyelitis and Proposed Diagnostic Criteria for MOG-IgG-Associated Disorders

López-Chiriboga, A. S., Majed, M., Fryer, J., Dubey, D., McKeon, A., Flanagan, E., Jitprapaikulsan, J., Kothapalli, N., Tillema, J-M., Chen, J., Weinshenker, B. G., Wingerchuk, D. M., Sagen, J., Gadoth, A., Lennon, V. A., Keegan, B. M., Lucchinetti, C. F. & Pittock, S. J., Nov 1 2018, In : JAMA Neurology. 75, 11, p. 1355-1363 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Clinical, Radiologic, and Prognostic Features of Myelitis Associated with Myelin Oligodendrocyte Glycoprotein Autoantibody

Dubey, D., Pittock, S. J., Krecke, K. N., Morris, P. P., Sechi, E., Zalewski, N. L., Weinshenker, B. G., Shosha, E., Lucchinetti, C. F., Fryer, J. P., Lopez-Chiriboga, A. S., Chen, J. C., Jitprapaikulsan, J., McKeon, A., Gadoth, A., Keegan, B. M., Tillema, J. M., Naddaf, E., Patterson, M. C., Messacar, K. & 2 others, Tyler, K. L. & Flanagan, E. P., Jan 1 2018, (Accepted/In press) In : JAMA Neurology.

Research output: Contribution to journalArticle

36 Scopus citations

Dark rims: Novel sequence enhances diagnostic specificity in multiple sclerosis

Tillema, J-M., Weigand, S. D., Dayan, M., Shu, Y., Kantarci, O. H., Lucchinetti, C. F. & Port, J. D., Jun 1 2018, In : American Journal of Neuroradiology. 39, 6, p. 1052-1058 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Differences in the reponses to apheresis therapy of patients with 3 histopathologically classified immunopathological patterns of multiple sclerosis

Stork, L., Ellenberger, D., Beißbarth, T., Friede, T., Lucchinetti, C. F., Brück, W. & Metz, I., Apr 1 2018, In : JAMA Neurology. 75, 4, p. 428-435 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Myelin Oligodendrocyte Glycoprotein Antibody–Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome

Chen, J., Flanagan, E., Jitprapaikulsan, J., López-Chiriboga, A. S. S., Fryer, J. P., Leavitt, J. A., Weinshenker, B. G., McKeon, A., Tillema, J-M., Lennon, V. A., Tobin, W. O., Keegan, B. M., Lucchinetti, C. F., Kantarci, O. H., McClelland, C. M., Lee, M. S., Bennett, J. L., Pelak, V. S., Chen, Y., VanStavern, G. & 7 others, Adesina, O. O. O., Eggenberger, E. R., Acierno, M. D., Wingerchuk, D. M., Brazis, P. W., Sagen, J. & Pittock, S. J., Nov 1 2018, In : American Journal of Ophthalmology. 195, p. 8-15 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Neuromyelitis Optica and Herpes Simplex Virus 2

Vanessa Marin Collazo, I., Howe, C. L., Lucchinetti, C. F. & Tobin, W., Jan 1 2018, In : Neurologist. 23, 3, p. 92-93 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

Paraneoplastic neuronal intermediate filament autoimmunity

Basal, E., Zalewski, N., Kryzer, T. J., Hinson, S. R., Guo, Y., Dubey, D., Benarroch, E. E., Lucchinetti, C. F., Pittock, S. J., Lennon, V. A. & McKeon, A., Oct 30 2018, In : Neurology. 91, 18, p. e1677-e1689

Research output: Contribution to journalArticle

7 Scopus citations
2 Scopus citations
2017

Clinical–radiological–pathological spectrum of central nervous system–idiopathic inflammatory demyelinating disease in the elderly

Tobin, W., Costanzi, C., Guo, Y., Parisi, J. E., Weigand, S. D. & Lucchinetti, C. F., Jan 1 2017, In : Multiple Sclerosis Journal. 23, 9, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)

Tobin, W. O., Guo, Y., Krecke, K. N., Parisi, J. E., Lucchinetti, C. F., Pittock, S. J., Mandrekar, J., Dubey, D., Debruyne, J. & Keegan, B. M., Sep 1 2017, In : Brain. 140, 9, p. 2415-2425 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

In vivo detection of connectivity between cortical and white matter lesions in early MS

Tillema, J. M., Weigand, S. D., Mandrekar, J., Shu, Y., Lucchinetti, C. F., Pirko, I. & Port, J. D., Jun 1 2017, In : Multiple Sclerosis. 23, 7, p. 973-981 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Guo, Y., Weigand, S. D., Popescu, B. F., Lennon, V. A., Parisi, J. E., Pittock, S. J., Parks, N. E., Clardy, S. L., Howe, C. L. & Lucchinetti, C. F., Feb 9 2017, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions

Popescu, B. F., Frischer, J. M., Webb, S. M., Tham, M., Adiele, R. C., Robinson, C. A., Fitz-Gibbon, P. D., Weigand, S. D., Metz, I., Nehzati, S., George, G. N., Pickering, I. J., Brück, W., Hametner, S., Lassmann, H., Parisi, J. E., Yong, G. & Lucchinetti, C. F., Jul 1 2017, In : Acta neuropathologica. 134, 1, p. 45-64 20 p.

Research output: Contribution to journalArticle

30 Scopus citations
2 Scopus citations
2016

Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome

Pohl, D., Alper, G., Van Haren, K., Kornberg, A. J., Lucchinetti, C. F., Tenembaum, S. & Belman, A. L., Aug 30 2016, In : Neurology. 87, 9, p. S38-S45

Research output: Contribution to journalArticle

103 Scopus citations

Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum

Flanagan, E., Cabre, P., Weinshenker, B. G., St. Sauver, J., Jacobson, D. J., Majed, M., Lennon, V. A., Lucchinetti, C. F., McKeon, A., Matiello, M., Kale, N., Wingerchuk, D. M., Mandrekar, J., Sagen, J. A., Fryer, J. P., Robinson, A. B. & Pittock, S. J., May 1 2016, In : Annals of Neurology. 79, 5, p. 775-783 9 p.

Research output: Contribution to journalArticle

99 Scopus citations

LRP1 expression in microglia is protective during CNS autoimmunity

Chuang, T. Y., Guo, Y., Seki, S. M., Rosen, A. M., Johanson, D. M., Mandell, J. W., Lucchinetti, C. F. & Gaultier, A., Jul 11 2016, In : Acta Neuropathologica Communications. 4, 1, 1 p.

Research output: Contribution to journalArticle

20 Scopus citations

Meningeal mast cell-T cell crosstalk regulates T cell encephalitogenicity

Russi, A. E., Walker-Caulfield, M. E., Guo, Y., Lucchinetti, C. F. & Brown, M. A., Sep 1 2016, In : Journal of Autoimmunity. 73, p. 100-110 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Multiple sclerosis masquerading as Alzheimer-type dementia: Clinical, radiological and pathological findings

Tobin, W., Popescu, B. F., Lowe, V., Pirko, I., Parisi, J. E., Kantarci, K. M., Fields, J. A., Bruns, M. B., Boeve, B. F. & Lucchinetti, C. F., Apr 1 2016, In : Multiple Sclerosis. 22, 5, p. 698-704 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D., 2016, In : Journal of cell science. 129, 20, p. 3911-3921 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ring-enhancing spinal cord lesions in neuromyelitis optica spectrum disorders

Zalewski, N. L., Morris, P. P., Weinshenker, B. G., Lucchinetti, C. F., Guo, Y., Pittock, S. J., Krecke, K. N., Kaufmann, T. J., Wingerchuk, D. M., Kumar, N. & Flanagan, E., Dec 2 2016, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

19 Scopus citations
2015

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

Frischer, J. M., Weigand, S. D., Guo, Y., Kale, N., Parisi, J. E., Pirko, I., Mandrekar, J., Bramow, S., Metz, I., Brück, W., Lassmann, H. & Lucchinetti, C. F., Nov 1 2015, In : Annals of Neurology. 78, 5, p. 710-721 12 p.

Research output: Contribution to journalArticle

169 Scopus citations

Corrigendum: Multiple sclerosis - A quiet revolution

Ransohoff, R. M., Hafler, D. A. & Lucchinetti, C. F., May 11 2015, In : Nature Reviews Neurology. 11, 5, p. 246 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

Diagnostic utility of aquaporin-4 in the analysis of active demyelinating lesions

Popescu, B. F. G., Guo, Y., Jentoft, M. E., Parisi, J. E., Lennon, V. A., Pittock, S. J., Weinshenker, B. G., Wingerchuk, D. M., Giannini, C., Metz, I., Brück, W., Shuster, E. A., Carter, J., Boyd, C. D., Clardy, S. L., Cohen, B. A. & Lucchinetti, C. F., 2015, In : Neurology. 84, 2, p. 148-158 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

Extensive acute axonal damage in pediatric multiple sclerosis lesions

Pfeifenbring, S., Bunyan, R. F., Metz, I., Röver, C., Huppke, P., Gärtner, J., Lucchinetti, C. F. & Brück, W., Apr 1 2015, In : Annals of neurology. 77, 4, p. 655-667 13 p.

Research output: Contribution to journalArticle

41 Scopus citations
70 Scopus citations

NFΚB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

Walker-Caulfield, M. E., Guo, Y., Johnson, R. K., McCarthy, C. B., Fitz-Gibbon, P. D., Lucchinetti, C. F. & Howe, C. L., Sep 30 2015, In : Journal of Neuroinflammation. 12, 1, 185.

Research output: Contribution to journalArticle

12 Scopus citations

Poor early relapse recovery affects onset of progressive disease course in multiple sclerosis

Novotna, M., Paz Soldán, M. M., Zeid, N. A., Kale, N., Tutuncu, M., Crusan, D. J., Atkinson, E. J., Siva, A., Keegan, B. M., Pirko, I., Pittock, S. J., Lucchinetti, C. F., Noseworthy, J. H., Weinshenker, B. G., Rodriguez, M. & Kantarci, O. H., Aug 25 2015, In : Neurology. 85, 8, p. 722-729 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Relapses and disability accumulation in progressive multiple sclerosis

Soldán, M. M. P., Novotna, M., Zeid, N. A., Kale, N., Tutuncu, M., Crusan, D. J., Atkinson, E. J., Siva, A., Keegan, B. M., Pirko, I., Pittock, S. J., Lucchinetti, C. F., Weinshenker, B. G., Rodriguez, M. & Kantarci, O. H., 2015, In : Neurology. 84, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Short myelitis lesions in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders

Flanagan, E. P., Weinshenker, B. G., Krecke, K. N., Lennon, V. A., Lucchinetti, C. F., McKeon, A., Wingerchuk, D. M., Shuster, E. A., Jiao, Y., Horta, E. S. & Pittock, S. J., Jan 1 2015, In : JAMA neurology. 72, 1, p. 81-87 7 p.

Research output: Contribution to journalArticle

112 Scopus citations
2014

AQP4 autoantibody assay performance in clinical laboratory service

Fryer, J. P., Lennon, V. A., Pittock, S. J., Jenkins, S. M., Fallier-Becker, P., Clardy, S. L., Horta, E., Jedynak, E. A., Lucchinetti, C. F., Shuster, E. A., Weinshenker, B. G., Wingerchuk, D. M. & McKeon, A., Apr 24 2014, In : Neurology: Neuroimmunology and NeuroInflammation. 1, 1, 11.

Research output: Contribution to journalArticle

48 Scopus citations

Aquaporin 4 IgG serostatus and outcome in recurrent longitudinally extensive transverse myelitis

Jiao, Y., Fryer, J. P., Lennon, V. A., McKeon, A., Jenkins, S. M., Smith, C. Y., Quek, A. M. L., Weinshenker, B. G., Wingerchuk, D. M., Shuster, E. A., Lucchinetti, C. F. & Pittock, S. J., Jan 2014, In : JAMA neurology. 71, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Autoimmune aquaporin-4 myopathy in neuromyelitis optica spectrum

Guo, Y., Lennon, V. A., Bogdan, B. F., Grouse, C. K., Topel, J., Milone, M., Lassmann, H., Parisi, J. E., Pittock, S. J., Stefoski, D., Balabanov, R. & Lucchinetti, C. F., Aug 2014, In : JAMA neurology. 71, 8, p. 1025-1029 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Clinical/scientific notes

Clardy, S. L., Lucchinetti, C. F., Krecke, K. N., Lennon, V. A., O'Toole, O., Weinshenker, B. G., Boyd, C. D., Krieger, S., McGraw, C., Guo, Y. & Pittock, S. J., May 20 2014, In : Neurology. 82, 20, p. 1841-1843 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

DPPX potassium channel antibody: Frequency, clinical accompaniments, and outcomes in 20 patients

Tobin, W. O., Lennon, V. A., Komorowski, L., Probst, C., Clardy, S. L., Aksamit, A. J., Appendino, J. P., Lucchinetti, C. F., Matsumoto, J. Y., Pittock, S. J., Sandroni, P., Tippmann-Peikert, M., Wirrell, E. C. & McKeon, A., Nov 1 2014, In : Neurology. 83, 20, p. 1797-1803 7 p.

Research output: Contribution to journalArticle

105 Scopus citations

Early and widespread injury of astrocytes in the absence of demyelination in acute haemorrhagic leukoencephalitis

Robinson, C. A., Adiele, R. C., Tham, M., Lucchinetti, C. F. & Popescu, B. FG., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 52.

Research output: Contribution to journalArticle

12 Scopus citations

Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: A comparative study

Brickshawana, A., Hinson, S. R., Romero, M. F., Lucchinetti, C. F., Guo, Y., Buttmann, M., McKeon, A., Pittock, S. J., Chang, M. H., Chen, A. P., Kryzer, T. J., Fryer, J. P., Jenkins, S. M., Cabre, P. & Lennon, V. A., Aug 2014, In : The Lancet Neurology. 13, 8, p. 795-806 12 p.

Research output: Contribution to journalArticle

59 Scopus citations

Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

Howe, C. L., Kaptzan, T., Magaña, S. M., Ayers-Ringler, J. R., Lafrance-Corey, R. G. & Lucchinetti, C. F., May 2014, In : Glia. 62, 5, p. 692-708 17 p.

Research output: Contribution to journalArticle

30 Scopus citations

Paraneoplastic neuromyelitis optica spectrum disorder associated with metastatic carcinoid expressing aquaporin-4

Figueroa, M., Guo, Y., Tselis, A., Pittock, S. J., Lennon, V. A., Lucchinetti, C. F. & Lisak, R. P., Apr 2014, In : JAMA neurology. 71, 4, p. 495-498 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Pathologic heterogeneity persists in early active multiple sclerosis lesions

Metz, I., Weigand, S. D., Popescu, B. F. G., Frischer, J. M., Parisi, J. E., Guo, Y., Lassmann, H., Brück, W. & Lucchinetti, C. F., May 2014, In : Annals of neurology. 75, 5, p. 728-738 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

The pathology of an autoimmune astrocytopathy: Lessons learned from neuromyelitis optica

Lucchinetti, C. F., Guo, Y., Popescu, B. F. G., Fujihara, K., Itoyama, Y. & Misu, T., Jan 1 2014, In : Brain Pathology. 24, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

142 Scopus citations
2013
230 Scopus citations

Evidence of aquaporin involvement in human central pontine myelinolysis

Popescu, B. F. G., Bunyan, R. F., Guo, Y., Parisi, J. E., Lennon, V. A. & Lucchinetti, C. F., 2013, In : Acta neuropathologica communications. 1, 1, p. 40 1 p.

Research output: Contribution to journalArticle

19 Scopus citations