Christopher Jon Klein, MD, MS

  • 5123 Citations
  • 40 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2020

Collapsin Response-Mediator Protein 5–Associated Retinitis, Vitritis, and Optic Disc Edema

Cohen, D. A., Bhatti, M. T., Pulido, J. S., Lennon, V. A., Dubey, D., Flanagan, E. P., Pittock, S. J., Klein, C. J. & Chen, J. J., Feb 2020, In : Ophthalmology. 127, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

2019

Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome

Dubey, D., Jitprapaikulsan, J., Bi, H., Do Campo, R. V., McKeon, A., Pittock, S. J., Engelstad, J. K., Mills, J. R. & Klein, C. J., Nov 12 2019, In : Neurology. 93, 20, p. e1873-e1880

Research output: Contribution to journalArticle

Autoimmune gait disturbance accompanying adaptor protein-3B2-IgG

Honorat, J. A., Lopez-Chiriboga, A. S., Kryzer, T. J., Komorowski, L., Scharf, M., Hinson, S. R., Lennon, V. A., Pittock, S. J., Klein, C. J. & McKeon, A., Sep 3 2019, In : Neurology. 93, 10, p. e954-e963

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

DNA methylation patterns in human iPSC-derived sensory neuronal differentiation

Ankam, S., Rovini, A., Baheti, S., Hrstka, R., Wu, Y., Schmidt, K., Wang, H., Madigan, N., Koenig, L. S., Stelzig, K., Resch, Z., Klein, C. J., Sun, Z. & Staff, N. P., Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

Embolized Spinal Dural AV Fistula Repairs Syringomyelia and Polyradiculopathy

Pinto, M. V., Cloft, H. & Klein, C. J., Sep 2019, In : Mayo Clinic proceedings. 94, 9, p. 1904-1906 3 p.

Research output: Contribution to journalLetter

Open Access

Fatal TTR amyloidosis with neuropathy from domino liver p.Val71Ala transplant

Puffer, R. C., Spinner, R. J., Bi, H., Sharma, R., Wang, Y., Theis, J. D., McPhail, E. D., Poterucha, J. J., Niu, Z. & Klein, C. J., Jan 1 2019, In : Neurology: Genetics. 5, 5, e351.

Research output: Contribution to journalReview article

Open Access

Mitochondrial cerebellar ataxia, renal failure, neuropathy, and encephalopathy (MCARNE)

Ng, P. S., Pinto, M. V., Neff, J. L., Hasadsri, L., Highsmith, W. E. J., Fidler, M. E., Gavrilova, R. M. & Klein, C. J., Apr 1 2019, In : Neurology: Genetics. 5, 2, e314.

Research output: Contribution to journalArticle

Open Access

Onion-bulb patterns predict acquired or inherited demyelinating polyneuropathy

Tracy, J. A., Dyck, P. J., Klein, C. J., Engelstad, J. N. K., Meyer, J. E. & Dyck, P. J. B., Jan 1 2019, In : Muscle and Nerve.

Research output: Contribution to journalArticle

Phenotypic presentations of paraneoplastic neuropathies associated with MAP1B-IgG

Jitprapaikulsan, J., Klein, C. J., Pittock, S. J., Gadoth, A., Mckeon, A., Mills, J. R. & Dubey, D., Jan 1 2019, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalLetter

Open Access

Plantar Ulcers and Neuropathic Arthropathies: Associated Diseases, Polyneuropathy Correlates, and Risk Covariates

Andrews, K. L., Dyck, P. J., Kavros, S. J., Vella, A., Kazamel, M., Clark, V., Litchy, W. J., Dyck, P. J. B., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Klein, C. J., Apr 1 2019, In : Advances in skin & wound care. 32, 4, p. 168-175 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Polyneuropathies and chronic inflammatory demyelinating polyradiculoneuropathy in multiple sclerosis

Suanprasert, N., Taylor, B. V., Klein, C. J., Roforth, M. M., Karam, C., Keegan, B. M. & Dyck, P. J. B., May 1 2019, In : Multiple Sclerosis and Related Disorders. 30, p. 284-290 7 p.

Research output: Contribution to journalArticle

Targeted gene approach with biochemical assay confirms ABCD1 mutation of X-linked adrenoleukodystrophy in a 62-year-old man with gait imbalance

Mauermann, M. M., Niu, Z., Renaud, D. L., Kemppainen, J. L., Schultz, M. J. & Klein, C. J., Jan 1 2019, (Accepted/In press) In : Neuromuscular Disorders.

Research output: Contribution to journalArticle

The Classification of Autosomal Recessive Cerebellar Ataxias: a Consensus Statement from the Society for Research on the Cerebellum and Ataxias Task Force

Beaudin, M., Matilla-Dueñas, A., Soong, B. W., Pedroso, J. L., Barsottini, O. G., Mitoma, H., Tsuji, S., Schmahmann, J. D., Manto, M., Rouleau, G. A., Klein, C. & Dupre, N., Jan 1 2019, (Accepted/In press) In : Cerebellum.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
2018

Antiepileptic drug therapy in autoimmune epilepsy associated with antibodies targeting the leucine-rich glioma-inactivated protein 1

Feyissa, A., Lamb, C., Pittock, S. J., Gadoth, A., McKeon, A., Klein, C. J. & Britton, J. W., Sep 1 2018, In : Epilepsia Open. 3, 3, p. 348-356 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases

Dubey, D., Lennon, V. A., Gadoth, A., Pittock, S. J., Flanagan, E., Schmeling, J. E., McKeon, A. & Klein, C. J., Jan 9 2018, In : Neurology. 90, 2, p. e103-e110

Research output: Contribution to journalArticle

13 Scopus citations

Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis

Dubey, D., Pittock, S. J., Kelly, C. R., McKeon, A., Lopez-Chiriboga, A. S., Lennon, V. A., Gadoth, A., Smith, C. Y., Bryant, S. C., Klein, C. J., Aksamit, A. J., Toledano, M., Boeve, B. F., Tillema, J-M. & Flanagan, E., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 166-177 12 p.

Research output: Contribution to journalArticle

86 Scopus citations

Composite ganglioside autoantibodies and immune treatment response in MMN and MADSAM

Martinez-Thompson, J., Snyder, M. R., Ettore, M., McKeon, A., Pittock, S. J., Roforth, M. M., Mandrekar, J., Mauermann, M. M., Taylor, B. V., Dyck, P. J., Windebank, A. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

1 Scopus citations

Elevated LGI1-IgG CSF index predicts worse neurological outcome

Gadoth, A., Zekeridou, A., Klein, C. J., Thoreson, C. J., Majed, M., Dubey, D., Flanagan, E., McKeon, A., Jenkins, S. M., Lennon, V. A. & Pittock, S. J., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

4 Scopus citations

Expanded teased nerve fibre pathological conditions in disease association

Xu, M., Pinto, M., Sun, C., Engelstad, J. K., Dyck, P. J. B., Dyck, P. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations
21 Scopus citations

Inherited neuropathy precision classification: What's in a name?

Klein, C. J., Mar 6 2018, In : Neurology. 90, 10, p. 445-446 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes

Binks, S. N. M., Klein, C. J., Waters, P., Pittock, S. J. & Irani, S. R., May 1 2018, In : Journal of neurology, neurosurgery, and psychiatry. 89, 5, p. 526-534 9 p.

Research output: Contribution to journalReview article

Open Access
33 Scopus citations

LGI1 and CASPR2 neurological autoimmunity in children

López-Chiriboga, A. S., Klein, C. J., Zekeridou, A., McKeon, A., Dubey, D., Flanagan, E., Lennon, V. A., Tillema, J-M., Wirrell, E. C., Patterson, M. C., Gadoth, A., Aaen, J. G., Brenton, J. N., Bui, J. D., Moen, A., Otten, C., Piquet, A. & Pittock, S. J., Sep 1 2018, In : Annals of Neurology. 84, 3, p. 473-480 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Novel hemizygous nonsense mutation in DRP2 is associated with inherited neuropathy

Roda, R. H., McCray, B. A., Klein, C. J. & Hoke, A., Feb 1 2018, In : Neurology: Genetics. 4, 1, e220.

Research output: Contribution to journalArticle

Pain and the immune system: Emerging concepts of IgG-mediated autoimmune pain and immunotherapies

Xu, M., Bennett, D. L. H., Querol, L. A., Wu, L., Irani, S. R., Watson, J., Pittock, S. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

3 Scopus citations

Predictors of neural-specific autoantibodies and immunotherapy response in patients with cognitive dysfunction

Dubey, D., Kothapalli, N., McKeon, A., Flanagan, E., Lennon, V. A., Klein, C. J., Britton, J. W., So, E., Boeve, B. F., Tillema, J-M., Sadjadi, R. & Pittock, S. J., Oct 15 2018, In : Journal of Neuroimmunology. 323, p. 62-72 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Recurrent Genomic Alterations in Soft Tissue Perineuriomas

Carter, J., Wu, Y., Blessing, M. M., Folpe, A. L., Thorland, E. C., Spinner, R. J., Jentoft, M. E., Wang, C., Baheti, S., Niu, Z., Mauermann, M. M. & Klein, C. J., Dec 1 2018, In : American Journal of Surgical Pathology. 42, 12, p. 1708-1714 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Somatotopic heat pain thresholds and intraepidermal nerve fibers in health

Davies, J. L., Engelstad, J. K., E. Gove, L., Linbo, L. K., Carter, R. E., Lynch, C., Staff, N. P., Klein, C. J., Dyck, P. J. B., Herrmann, D. N. & Dyck, P. J., Oct 1 2018, In : Muscle and Nerve. 58, 4, p. 509-516 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Teaching Video NeuroImages: Acquired focal neuromyotonia in LGI-1 autoimmunity

López Chiriboga, A. S., Matsumoto, J., Sorenson, E., Klein, C. J. & McKeon, A., May 1 2018, In : Neurology. 90, 18, p. e1636-e1637

Research output: Contribution to journalArticle

Open Access
2017

Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial

Dyck, P. J., Kincaid, J. C., Dyck, P. J. B., Chaudhry, V., Goyal, N. A., Alves, C., Salhi, H., Wiesman, J. F., Labeyrie, C., Robinson-Papp, J., Cardoso, M., Laura, M., Ruzhansky, K., Cortese, A., Brannagan, T. H., Khoury, J., Khella, S., Waddington-cruz, M., Ferreira, J., Wang, A. K. & 24 others, Pinto, M. V., Ayache, S. S., Benson, M. D., Berk, J. L., Coelho, T., Polydefkis, M., Gorevic, P., Adams, D. H., Plante-Bordeneuve, V., Whelan, C., Merlini, G., Heitner, S., Drachman, B. M., Conceição, I., Klein, C. J., Gertz, M., Ackermann, E. J., Hughes, S. G., Mauermann, M. M., Bergemann, R., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Litchy, W. J., 2017, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

23 Scopus citations
31 Scopus citations
1 Scopus citations

Clinical, physiological and pathological characterisation of the sensory predominant peripheral neuropathy in copper deficiency

Taylor, S. W., Laughlin, R. S., Kumar, N., Goodman, B., Klein, C. J., Dyck, P. J. & Dyck, P. J. B., Oct 1 2017, In : Journal of neurology, neurosurgery, and psychiatry. 88, 10, p. 839-845 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Clinical-pathologic correlations in voltage-gated Kv1 potassium channel complex-subtyped autoimmune painful polyneuropathy

Lahoria, R., Pittock, S. J., Gadoth, A., Engelstad, J. K., Lennon, V. A. & Klein, C. J., Apr 1 2017, In : Muscle and Nerve. 55, 4, p. 520-525 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG–positive patients

Gadoth, A., Pittock, S. J., Dubey, D., McKeon, A., Britton, J. W., Schmeling, J. E., Smith, A., Kotsenas, A. L., Watson, R. E., Lachance, D. H., Flanagan, E., Lennon, V. A. & Klein, C. J., Jul 1 2017, In : Annals of Neurology. 82, 1, p. 79-92 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas

Klein, C. J., Wu, Y., Jentoft, M. E., Mer, G., Spinner, R. J., Dyck, P. J. B., Dyck, P. J. & Mauermann, M. M., Feb 1 2017, In : Annals of Neurology. 81, 2, p. 316-321 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N., Mcdonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., Macinnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., 2017, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

2 Scopus citations

Guillain-Barré Syndrome

Wijdicks, E. F. M. & Klein, C. J., Mar 1 2017, In : Mayo Clinic Proceedings. 92, 3, p. 467-479 13 p.

Research output: Contribution to journalReview article

45 Scopus citations

Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies

Kao, J. C., Liao, B., Markovic, S. N., Klein, C. J., Naddaf, E., Staff, N. P., Liewluck, T., Hammack, J. E., Sandroni, P., Finnes, H. & Mauermann, M. M., Oct 1 2017, In : JAMA Neurology. 74, 10, p. 1216-1222 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Neurology Individualized Medicine: When to Use Next-Generation Sequencing Panels

Klein, C. J. & Foroud, T. M., Feb 1 2017, In : Mayo Clinic Proceedings. 92, 2, p. 292-305 14 p.

Research output: Contribution to journalReview article

18 Scopus citations

Radiation-induced spinal nerve root cavernous malformations as a rare cause of radiculopathy

Rastogi, K., Klein, C. J., O'Toole, J. E., Jhaveri, M. D. & Malik, R., Jan 1 2017, In : Neurology. 89, 22, p. 2299-2300 2 p.

Research output: Contribution to journalArticle

Subacute demyelinating polyradiculoneuropathy complicating Epstein-Barr virus infection in GATA2 haploinsufficiency

Kazamel, M., Klein, C. J., Benarroch, E. E., Patnaik, M. M. & Tracy, J. A., 2017, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

3 Scopus citations

Systematic review of autosomal recessive ataxias and proposal for a classification

Beaudin, M., Klein, C. J., Rouleau, G. A. & Dupré, N., Feb 23 2017, In : Cerebellum and Ataxias. 4, 1, 3.

Research output: Contribution to journalReview article

Open Access
24 Scopus citations

Wild-type TTR neuropathy with cardiomyopathy presenting with burning feet

Visser, A. C. & Klein, C. J., Mar 14 2017, In : Neurology. 88, 11, p. 1101-1102 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2016

Autoimmune-mediated peripheral neuropathies and autoimmune pain

Klein, C. J., 2016, Autoimmune Neurology, 2016. Elsevier, Vol. 133. p. 417-446 30 p. (Handbook of Clinical Neurology; vol. 133).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Bilateral facial and trigeminal nerve hypertrophy in a patient with polyneuropathy

Frisch, C. D., Klein, C. J. & Carlson, M. L., Nov 28 2016, In : Otology and Neurotology. 37, 10, p. e404-e406

Research output: Contribution to journalShort survey

1 Scopus citations

Blink reflex role in algorithmic genetic testing of inherited polyneuropathies

Wang, W., Litchy, W. J., Mandrekar, J., Dyck, P. J. & Klein, C. J., 2016, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

2 Scopus citations

Copy number analysis reveals a novel multiexon deletion of the colq gene in congenital myasthenia

Wang, W., Wu, Y., Wang, C., Jiao, J. & Klein, C. J., Jan 1 2016, In : Neurology: Genetics. 2, 6, e117.

Research output: Contribution to journalShort survey

1 Scopus citations
31 Scopus citations

Pediatric Nerve Biopsy Diagnostic and Treatment Utility in Tertiary Care Referral

Ida, C. M., Dyck, P. J., Dyck, P. J. B., Engelstad, J. K., Wang, W., Selcen, D., Bodensteiner, J. B., Mauermann, M. M. & Klein, C. J., May 1 2016, In : Pediatric Neurology. 58, p. 3-11 9 p.

Research output: Contribution to journalArticle

3 Scopus citations