Christopher Jon Klein, MD, MS

  • 5123 Citations
  • 40 Scopus h-Index
1991 …2020

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2020

Collapsin Response-Mediator Protein 5–Associated Retinitis, Vitritis, and Optic Disc Edema

Cohen, D. A., Bhatti, M. T., Pulido, J. S., Lennon, V. A., Dubey, D., Flanagan, E. P., Pittock, S. J., Klein, C. J. & Chen, J. J., Feb 2020, In : Ophthalmology. 127, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

2019

Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome

Dubey, D., Jitprapaikulsan, J., Bi, H., Do Campo, R. V., McKeon, A., Pittock, S. J., Engelstad, J. K., Mills, J. R. & Klein, C. J., Nov 12 2019, In : Neurology. 93, 20, p. e1873-e1880

Research output: Contribution to journalArticle

Autoimmune gait disturbance accompanying adaptor protein-3B2-IgG

Honorat, J. A., Lopez-Chiriboga, A. S., Kryzer, T. J., Komorowski, L., Scharf, M., Hinson, S. R., Lennon, V. A., Pittock, S. J., Klein, C. J. & McKeon, A., Sep 3 2019, In : Neurology. 93, 10, p. e954-e963

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

DNA methylation patterns in human iPSC-derived sensory neuronal differentiation

Ankam, S., Rovini, A., Baheti, S., Hrstka, R., Wu, Y., Schmidt, K., Wang, H., Madigan, N., Koenig, L. S., Stelzig, K., Resch, Z., Klein, C. J., Sun, Z. & Staff, N. P., Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

Mitochondrial cerebellar ataxia, renal failure, neuropathy, and encephalopathy (MCARNE)

Ng, P. S., Pinto, M. V., Neff, J. L., Hasadsri, L., Highsmith, W. E. J., Fidler, M. E., Gavrilova, R. M. & Klein, C. J., Apr 1 2019, In : Neurology: Genetics. 5, 2, e314.

Research output: Contribution to journalArticle

Open Access

Onion-bulb patterns predict acquired or inherited demyelinating polyneuropathy

Tracy, J. A., Dyck, P. J., Klein, C. J., Engelstad, J. N. K., Meyer, J. E. & Dyck, P. J. B., Jan 1 2019, In : Muscle and Nerve.

Research output: Contribution to journalArticle

Plantar Ulcers and Neuropathic Arthropathies: Associated Diseases, Polyneuropathy Correlates, and Risk Covariates

Andrews, K. L., Dyck, P. J., Kavros, S. J., Vella, A., Kazamel, M., Clark, V., Litchy, W. J., Dyck, P. J. B., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Klein, C. J., Apr 1 2019, In : Advances in skin & wound care. 32, 4, p. 168-175 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Polyneuropathies and chronic inflammatory demyelinating polyradiculoneuropathy in multiple sclerosis

Suanprasert, N., Taylor, B. V., Klein, C. J., Roforth, M. M., Karam, C., Keegan, B. M. & Dyck, P. J. B., May 1 2019, In : Multiple Sclerosis and Related Disorders. 30, p. 284-290 7 p.

Research output: Contribution to journalArticle

Targeted gene approach with biochemical assay confirms ABCD1 mutation of X-linked adrenoleukodystrophy in a 62-year-old man with gait imbalance

Mauermann, M. M., Niu, Z., Renaud, D. L., Kemppainen, J. L., Schultz, M. J. & Klein, C. J., Jan 1 2019, (Accepted/In press) In : Neuromuscular Disorders.

Research output: Contribution to journalArticle

2018

Antiepileptic drug therapy in autoimmune epilepsy associated with antibodies targeting the leucine-rich glioma-inactivated protein 1

Feyissa, A., Lamb, C., Pittock, S. J., Gadoth, A., McKeon, A., Klein, C. J. & Britton, J. W., Sep 1 2018, In : Epilepsia Open. 3, 3, p. 348-356 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases

Dubey, D., Lennon, V. A., Gadoth, A., Pittock, S. J., Flanagan, E., Schmeling, J. E., McKeon, A. & Klein, C. J., Jan 9 2018, In : Neurology. 90, 2, p. e103-e110

Research output: Contribution to journalArticle

13 Scopus citations

Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis

Dubey, D., Pittock, S. J., Kelly, C. R., McKeon, A., Lopez-Chiriboga, A. S., Lennon, V. A., Gadoth, A., Smith, C. Y., Bryant, S. C., Klein, C. J., Aksamit, A. J., Toledano, M., Boeve, B. F., Tillema, J-M. & Flanagan, E., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 166-177 12 p.

Research output: Contribution to journalArticle

86 Scopus citations

Composite ganglioside autoantibodies and immune treatment response in MMN and MADSAM

Martinez-Thompson, J., Snyder, M. R., Ettore, M., McKeon, A., Pittock, S. J., Roforth, M. M., Mandrekar, J., Mauermann, M. M., Taylor, B. V., Dyck, P. J., Windebank, A. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

1 Scopus citations

Elevated LGI1-IgG CSF index predicts worse neurological outcome

Gadoth, A., Zekeridou, A., Klein, C. J., Thoreson, C. J., Majed, M., Dubey, D., Flanagan, E., McKeon, A., Jenkins, S. M., Lennon, V. A. & Pittock, S. J., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

4 Scopus citations

Expanded teased nerve fibre pathological conditions in disease association

Xu, M., Pinto, M., Sun, C., Engelstad, J. K., Dyck, P. J. B., Dyck, P. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations
21 Scopus citations

LGI1 and CASPR2 neurological autoimmunity in children

López-Chiriboga, A. S., Klein, C. J., Zekeridou, A., McKeon, A., Dubey, D., Flanagan, E., Lennon, V. A., Tillema, J-M., Wirrell, E. C., Patterson, M. C., Gadoth, A., Aaen, J. G., Brenton, J. N., Bui, J. D., Moen, A., Otten, C., Piquet, A. & Pittock, S. J., Sep 1 2018, In : Annals of Neurology. 84, 3, p. 473-480 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Novel hemizygous nonsense mutation in DRP2 is associated with inherited neuropathy

Roda, R. H., McCray, B. A., Klein, C. J. & Hoke, A., Feb 1 2018, In : Neurology: Genetics. 4, 1, e220.

Research output: Contribution to journalArticle

Pain and the immune system: Emerging concepts of IgG-mediated autoimmune pain and immunotherapies

Xu, M., Bennett, D. L. H., Querol, L. A., Wu, L., Irani, S. R., Watson, J., Pittock, S. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

3 Scopus citations

Predictors of neural-specific autoantibodies and immunotherapy response in patients with cognitive dysfunction

Dubey, D., Kothapalli, N., McKeon, A., Flanagan, E., Lennon, V. A., Klein, C. J., Britton, J. W., So, E., Boeve, B. F., Tillema, J-M., Sadjadi, R. & Pittock, S. J., Oct 15 2018, In : Journal of Neuroimmunology. 323, p. 62-72 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Recurrent Genomic Alterations in Soft Tissue Perineuriomas

Carter, J., Wu, Y., Blessing, M. M., Folpe, A. L., Thorland, E. C., Spinner, R. J., Jentoft, M. E., Wang, C., Baheti, S., Niu, Z., Mauermann, M. M. & Klein, C. J., Dec 1 2018, In : American Journal of Surgical Pathology. 42, 12, p. 1708-1714 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Somatotopic heat pain thresholds and intraepidermal nerve fibers in health

Davies, J. L., Engelstad, J. K., E. Gove, L., Linbo, L. K., Carter, R. E., Lynch, C., Staff, N. P., Klein, C. J., Dyck, P. J. B., Herrmann, D. N. & Dyck, P. J., Oct 1 2018, In : Muscle and Nerve. 58, 4, p. 509-516 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Teaching Video NeuroImages: Acquired focal neuromyotonia in LGI-1 autoimmunity

López Chiriboga, A. S., Matsumoto, J., Sorenson, E., Klein, C. J. & McKeon, A., May 1 2018, In : Neurology. 90, 18, p. e1636-e1637

Research output: Contribution to journalArticle

Open Access
2017

Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial

Dyck, P. J., Kincaid, J. C., Dyck, P. J. B., Chaudhry, V., Goyal, N. A., Alves, C., Salhi, H., Wiesman, J. F., Labeyrie, C., Robinson-Papp, J., Cardoso, M., Laura, M., Ruzhansky, K., Cortese, A., Brannagan, T. H., Khoury, J., Khella, S., Waddington-cruz, M., Ferreira, J., Wang, A. K. & 24 others, Pinto, M. V., Ayache, S. S., Benson, M. D., Berk, J. L., Coelho, T., Polydefkis, M., Gorevic, P., Adams, D. H., Plante-Bordeneuve, V., Whelan, C., Merlini, G., Heitner, S., Drachman, B. M., Conceição, I., Klein, C. J., Gertz, M., Ackermann, E. J., Hughes, S. G., Mauermann, M. M., Bergemann, R., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Litchy, W. J., 2017, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

23 Scopus citations
31 Scopus citations
1 Scopus citations

Clinical, physiological and pathological characterisation of the sensory predominant peripheral neuropathy in copper deficiency

Taylor, S. W., Laughlin, R. S., Kumar, N., Goodman, B., Klein, C. J., Dyck, P. J. & Dyck, P. J. B., Oct 1 2017, In : Journal of neurology, neurosurgery, and psychiatry. 88, 10, p. 839-845 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Clinical-pathologic correlations in voltage-gated Kv1 potassium channel complex-subtyped autoimmune painful polyneuropathy

Lahoria, R., Pittock, S. J., Gadoth, A., Engelstad, J. K., Lennon, V. A. & Klein, C. J., Apr 1 2017, In : Muscle and Nerve. 55, 4, p. 520-525 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG–positive patients

Gadoth, A., Pittock, S. J., Dubey, D., McKeon, A., Britton, J. W., Schmeling, J. E., Smith, A., Kotsenas, A. L., Watson, R. E., Lachance, D. H., Flanagan, E., Lennon, V. A. & Klein, C. J., Jul 1 2017, In : Annals of Neurology. 82, 1, p. 79-92 14 p.

Research output: Contribution to journalArticle

52 Scopus citations

Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas

Klein, C. J., Wu, Y., Jentoft, M. E., Mer, G., Spinner, R. J., Dyck, P. J. B., Dyck, P. J. & Mauermann, M. M., Feb 1 2017, In : Annals of Neurology. 81, 2, p. 316-321 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N., Mcdonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., Macinnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., 2017, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

2 Scopus citations

Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies

Kao, J. C., Liao, B., Markovic, S. N., Klein, C. J., Naddaf, E., Staff, N. P., Liewluck, T., Hammack, J. E., Sandroni, P., Finnes, H. & Mauermann, M. M., Oct 1 2017, In : JAMA Neurology. 74, 10, p. 1216-1222 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Radiation-induced spinal nerve root cavernous malformations as a rare cause of radiculopathy

Rastogi, K., Klein, C. J., O'Toole, J. E., Jhaveri, M. D. & Malik, R., Jan 1 2017, In : Neurology. 89, 22, p. 2299-2300 2 p.

Research output: Contribution to journalArticle

Subacute demyelinating polyradiculoneuropathy complicating Epstein-Barr virus infection in GATA2 haploinsufficiency

Kazamel, M., Klein, C. J., Benarroch, E. E., Patnaik, M. M. & Tracy, J. A., 2017, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Blink reflex role in algorithmic genetic testing of inherited polyneuropathies

Wang, W., Litchy, W. J., Mandrekar, J., Dyck, P. J. & Klein, C. J., 2016, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

2 Scopus citations
31 Scopus citations

Pediatric Nerve Biopsy Diagnostic and Treatment Utility in Tertiary Care Referral

Ida, C. M., Dyck, P. J., Dyck, P. J. B., Engelstad, J. K., Wang, W., Selcen, D., Bodensteiner, J. B., Mauermann, M. M. & Klein, C. J., May 1 2016, In : Pediatric Neurology. 58, p. 3-11 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Larson, N., McDonnell, S., Albright, L. C., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J., Cussenot, O., Cancel-Tassin, G., Giles, G., MacInnis, R., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., Sep 1 2016, In : Genetic Epidemiology. 40, 6, p. 461-469 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Target-enrichment sequencing and copy number evaluation in inherited polyneuropathy

Wang, W., Wang, C., Brian Dawson, D., Thorland, E. C., Lundquist, P. A., Eckloff, B. W., Wu, Y., Baheti, S., Evans, J. M., Scherer, S. S., Dyck, P. J. B. & Klein, C. J., May 10 2016, In : Neurology. 86, 19, p. 1762-1771 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Thirty Years Later, Case Closed: A Case of PMP22 Triplication from Anticipation

Martinez-Thompson, J. & Klein, C. J., May 1 2016, In : Mayo Clinic Proceedings. 91, 5, p. 687-688 2 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic Seizures

Flanagan, E., Kotsenas, A. L., Britton, J. W., McKeon, A., Watson, R. E., Klein, C. J., Boeve, B. F., Lowe, V., Ahlskog, J. E., Shin, C., Boes, C. J., Crum, B. A., Laughlin, R. S. & Pittock, S. J., 2015, In : Neurology. 2, 6, e161.

Research output: Contribution to journalArticle

62 Scopus citations

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders

Baets, J., Duan, X., Wu, Y., Smith, G., Seeley, W. W., Mademan, I., McGrath, N. M., Beadell, N. C., Khoury, J., Botuyan, M. V., Mer, G., Worrell, G. A., Hojo, K., DeLeon, J., Laura, M., Liu, Y. T., Senderek, J., Weis, J., Van Den Bergh, P., Merrill, S. L. & 7 others, Reilly, M. M., Houlden, H., Grossman, M., Scherer, S. S., De Jonghe, P., Dyck, P. J. & Klein, C. J., Apr 1 2015, In : Brain. 138, 4, p. 845-861 17 p.

Research output: Contribution to journalArticle

43 Scopus citations

Impairments and comorbidities of polyneuropathy revealed by population-based analyses

Hoffman, E. M., Staff, N. P., Robb, J. M., St. Sauver, J., Dyck, P. J. & Klein, C. J., Apr 21 2015, In : Neurology. 84, 16, p. 1644-1651 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Office immunotherapy in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy

Dyck, P. J., Taylor, B. V., Davies, J. L., Mauermann, M. L., Litchy, W. J., Klein, C. J. & Dyck, P. J. B., Oct 1 2015, In : Muscle and Nerve. 52, 4, p. 488-497 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Polyneuropathy improvement following autologous stem cell transplantation for POEMS syndrome

Karam, C., Klein, C. J., Dispenzieri, A., Dyck, P. J. B., Mandrekar, J., D'Souza, A. & Mauermann, M. M., May 12 2015, In : Neurology. 84, 19, p. 1981-1987 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Psychiatric Autoimmunity: N-Methyl-d-Aspartate Receptor IgG and Beyond

Kruse, J. L., Lapid, M. I., Lennon, V. A., Klein, C. J., Toole, O. O., Pittock, S. J., Strand, E. A., Frye, M. A. & McKeon, A. B., May 1 2015, In : Psychosomatics. 56, 3, p. 227-241 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Solving the riddle of the sphinx may provide new insights into diabetes and polyneuropathy

Klein, C. J., Mar 1 2015, In : Diabetes. 64, 3, p. 706-708 3 p.

Research output: Contribution to journalArticle

2014

Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E

Sun, Z. D., Wu, Y., Ordog, T., Baheti, S., Nie, J., Duan, X., Hojo, K., Kocher, J-P., Dyck, P. J. & Klein, C. J., Jul 7 2014, In : Epigenetics. 9, 8, p. 1184-1193 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Analysis of the clinical phenotypes of Charcot-Marie-Tooth disease type 2A2 patients with mitofusin2 mutation

Duan, X., Gu, W., Klein, C. J., Hao, Y., Wang, G., Wang, R. & Fan, D., 2014, In : Chinese Journal of Neurology. 47, 2, p. 77-83 7 p.

Research output: Contribution to journalArticle