Christopher Jon Klein, MD, MS

  • 5372 Citations
  • 41 Scopus h-Index
1991 …2020

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2020

Association of intraneural perineurioma with neurofibromatosis type 2

Pendleton, C., Spinner, R. J., Dyck, P. J. B., Mauermann, M. L., Ladak, A., Restrepo, C. E., Baheti, S. & Klein, C. J., Aug 1 2020, In : Acta Neurochirurgica. 162, 8, p. 1891-1897 7 p.

Research output: Contribution to journalArticle

CASPR2-IgG–Associated Autoimmune Encephalitis: Unusual Cause of Delirium

Sun, Q., Davidson, T., Sween, J. K., Klein, C., McLeod, T. & Rummans, T. A., 2020, (Accepted/In press) In : Psychosomatics.

Research output: Contribution to journalArticle

Collapsin Response-Mediator Protein 5–Associated Retinitis, Vitritis, and Optic Disc Edema

Cohen, D. A., Bhatti, M. T., Pulido, J. S., Lennon, V. A., Dubey, D., Flanagan, E. P., Pittock, S. J., Klein, C. J. & Chen, J. J., Feb 2020, In : Ophthalmology. 127, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

Contactin-1 autoimmunity: Serologic, neurologic, and pathologic correlates

Dubey, D., Honorat, J. A., Shelly, S., Klein, C. J., Komorowski, L., Mills, J. R., Brakopp, S., Probst, C., Lennon, V. A., Pittock, S. J. & McKeon, A., Jul 1 2020, In : Neurology(R) neuroimmunology & neuroinflammation. 7, 4

Research output: Contribution to journalArticle

Open Access

GFAP IgG associated inflammatory polyneuropathy

Paul, P., McKeon, A., Pittock, S. J., Klein, C. J., Shah, S., Toledano, M., Mills, J. R. & Dubey, D., Jun 15 2020, In : Journal of neuroimmunology. 343, 577233.

Research output: Contribution to journalArticle

Phrenic neuropathy water immersion dyspnea: Clinical findings and need for patient counseling

Vazquez Do Campo, R., Shelly, S., Boon, A. J., Mandrekar, J., Vassallo, R. & Klein, C. J., Mar 24 2020, In : Neurology. 94, 12, p. e1314-e1319

Research output: Contribution to journalArticle

2019

Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome

Dubey, D., Jitprapaikulsan, J., Bi, H., Campo, R. V. D., McKeon, A., Pittock, S. J., Engelstad, J. K., Mills, J. R. & Klein, C. J., Nov 12 2019, In : Neurology. 93, 20, p. E1873-E1880

Research output: Contribution to journalArticle

1 Scopus citations

Autoimmune gait disturbance accompanying adaptor protein-3B2-IgG

Honorat, J. A., Lopez-Chiriboga, A. S., Kryzer, T. J., Komorowski, L., Scharf, M., Hinson, S. R., Lennon, V. A., Pittock, S. J., Klein, C. J. & McKeon, A., Sep 3 2019, In : Neurology. 93, 10, p. e954-e963

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

DNA methylation patterns in human iPSC-derived sensory neuronal differentiation

Ankam, S., Rovini, A., Baheti, S., Hrstka, R., Wu, Y., Schmidt, K., Wang, H., Madigan, N., Koenig, L. S., Stelzig, K., Resch, Z., Klein, C. J., Sun, Z. & Staff, N. P., Sep 2 2019, In : Epigenetics. 14, 9, p. 927-937 11 p.

Research output: Contribution to journalArticle

Mitochondrial cerebellar ataxia, renal failure, neuropathy, and encephalopathy (MCARNE)

Ng, P. S., Pinto, M. V., Neff, J. L., Hasadsri, L., Highsmith, E. W., Fidler, M. E., Gavrilova, R. H. & Klein, C. J., Apr 1 2019, In : Neurology: Genetics. 5, 2, e314.

Research output: Contribution to journalArticle

Open Access

Onion-bulb patterns predict acquired or inherited demyelinating polyneuropathy

Tracy, J. A., Dyck, P. J., Klein, C. J., Engelstad, J. N. K., Meyer, J. E. & Dyck, P. J. B., Jan 1 2019, In : Muscle and Nerve.

Research output: Contribution to journalArticle

Plantar Ulcers and Neuropathic Arthropathies: Associated Diseases, Polyneuropathy Correlates, and Risk Covariates

Andrews, K. L., Dyck, P. J., Kavros, S. J., Vella, A., Kazamel, M., Clark, V., Litchy, W. J., Dyck, P. J. B., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Klein, C. J., Apr 1 2019, In : Advances in skin & wound care. 32, 4, p. 168-175 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Polyneuropathies and chronic inflammatory demyelinating polyradiculoneuropathy in multiple sclerosis

Suanprasert, N., Taylor, B. V., Klein, C. J., Roforth, M. M., Karam, C., Keegan, B. M. & Dyck, P. J. B., May 1 2019, In : Multiple Sclerosis and Related Disorders. 30, p. 284-290 7 p.

Research output: Contribution to journalArticle

Targeted gene approach with biochemical assay confirms ABCD1 mutation of X-linked adrenoleukodystrophy in a 62-year-old man with gait imbalance

Mauermann, M. L., Niu, Z., Renaud, D. L., Kemppainen, J. L., Schultz, M. J. & Klein, C. J., Feb 2019, In : Neuromuscular Disorders. 29, 2, p. 146-149 4 p.

Research output: Contribution to journalArticle

The Classification of Autosomal Recessive Cerebellar Ataxias: a Consensus Statement from the Society for Research on the Cerebellum and Ataxias Task Force

Beaudin, M., Matilla-Dueñas, A., Soong, B. W., Pedroso, J. L., Barsottini, O. G., Mitoma, H., Tsuji, S., Schmahmann, J. D., Manto, M., Rouleau, G. A., Klein, C. & Dupre, N., Dec 1 2019, In : Cerebellum. 18, 6, p. 1098-1125 28 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2018

Antiepileptic drug therapy in autoimmune epilepsy associated with antibodies targeting the leucine-rich glioma-inactivated protein 1

Feyissa, A. M., Lamb, C., Pittock, S. J., Gadoth, A., McKeon, A., Klein, C. J. & Britton, J. W., Sep 1 2018, In : Epilepsia Open. 3, 3, p. 348-356 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases

Dubey, D., Lennon, V. A., Gadoth, A., Pittock, S. J., Flanagan, E., Schmeling, J. E., McKeon, A. & Klein, C. J., Jan 9 2018, In : Neurology. 90, 2, p. e103-e110

Research output: Contribution to journalArticle

14 Scopus citations

Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis

Dubey, D., Pittock, S. J., Kelly, C. R., McKeon, A., Lopez-Chiriboga, A. S., Lennon, V. A., Gadoth, A., Smith, C. Y., Bryant, S. C., Klein, C. J., Aksamit, A. J., Toledano, M., Boeve, B. F., Tillema, J-M. & Flanagan, E., Jan 1 2018, In : Annals of Neurology. 83, 1, p. 166-177 12 p.

Research output: Contribution to journalArticle

112 Scopus citations

Composite ganglioside autoantibodies and immune treatment response in MMN and MADSAM

Martinez-Thompson, J., Snyder, M. R., Ettore, M., McKeon, A., Pittock, S. J., Roforth, M. M., Mandrekar, J., Mauermann, M. M., Taylor, B. V., Dyck, P. J., Windebank, A. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

1 Scopus citations

Elevated LGI1-IgG CSF index predicts worse neurological outcome

Gadoth, A., Zekeridou, A., Klein, C. J., Thoreson, C. J., Majed, M., Dubey, D., Flanagan, E., McKeon, A., Jenkins, S. M., Lennon, V. A. & Pittock, S. J., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

4 Scopus citations

Expanded teased nerve fibre pathological conditions in disease association

Xu, M., Pinto, M., Sun, C., Engelstad, J. K., Dyck, P. J. B., Dyck, P. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

1 Scopus citations
22 Scopus citations

LGI1 and CASPR2 neurological autoimmunity in children

López-Chiriboga, A. S., Klein, C., Zekeridou, A., McKeon, A., Dubey, D., Flanagan, E. P., Lennon, V. A., Tillema, J. M., Wirrell, E. C., Patterson, M. C., Gadoth, A., Aaen, J. G., Brenton, J. N., Bui, J. D., Moen, A., Otten, C., Piquet, A. & Pittock, S. J., Sep 2018, In : Annals of neurology. 84, 3, p. 473-480 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Novel hemizygous nonsense mutation in DRP2 is associated with inherited neuropathy

Roda, R. H., McCray, B. A., Klein, C. J. & Hoke, A., Feb 1 2018, In : Neurology: Genetics. 4, 1, e220.

Research output: Contribution to journalArticle

Predictors of neural-specific autoantibodies and immunotherapy response in patients with cognitive dysfunction

Dubey, D., Kothapalli, N., McKeon, A., Flanagan, E., Lennon, V. A., Klein, C. J., Britton, J. W., So, E., Boeve, B. F., Tillema, J-M., Sadjadi, R. & Pittock, S. J., Oct 15 2018, In : Journal of Neuroimmunology. 323, p. 62-72 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Recurrent Genomic Alterations in Soft Tissue Perineuriomas

Carter, J. M., Wu, Y., Blessing, M. M., Folpe, A. L., Thorland, E. C., Spinner, R., Jentoft, M. E., Wang, C., Baheti, S., Niu, Z., Mauermann, M. L. & Klein, C. J., Dec 1 2018, In : American Journal of Surgical Pathology. 42, 12, p. 1708-1714 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Somatotopic heat pain thresholds and intraepidermal nerve fibers in health

Davies, J. L., Engelstad, J. K., E. Gove, L., Linbo, L. K., Carter, R. E., Lynch, C., Staff, N. P., Klein, C. J., Dyck, P. J. B., Herrmann, D. N. & Dyck, P. J., Oct 1 2018, In : Muscle and Nerve. 58, 4, p. 509-516 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Teaching Video NeuroImages: Acquired focal neuromyotonia in LGI-1 autoimmunity

López Chiriboga, A. S., Matsumoto, J., Sorenson, E., Klein, C. J. & McKeon, A., May 1 2018, In : Neurology. 90, 18, p. e1636-e1637

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Assessing mNIS+7Ionis and international neurologists' proficiency in a familial amyloidotic polyneuropathy trial

Dyck, P. J., Kincaid, J. C., Dyck, P. J. B., Chaudhry, V., Goyal, N. A., Alves, C., Salhi, H., Wiesman, J. F., Labeyrie, C., Robinson-Papp, J., Cardoso, M., Laura, M., Ruzhansky, K., Cortese, A., Brannagan, T. H., Khoury, J., Khella, S., Waddington-Cruz, M., Ferreira, J., Wang, A. K. & 24 others, Pinto, M. V., Ayache, S. S., Benson, M. D., Berk, J. L., Coelho, T., Polydefkis, M., Gorevic, P., Adams, D. H., Plante-Bordeneuve, V., Whelan, C., Merlini, G., Heitner, S., Drachman, B. M., Conceição, I., Klein, C. J., Gertz, M. A., Ackermann, E. J., Hughes, S. G., Mauermann, M. L., Bergemann, R., Lodermeier, K. A., Davies, J. L., Carter, R. E. & Litchy, W. J., Nov 2017, In : Muscle and Nerve. 56, 5, p. 901-911 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
36 Scopus citations
1 Scopus citations

Clinical, physiological and pathological characterisation of the sensory predominant peripheral neuropathy in copper deficiency

Taylor, S. W., Laughlin, R. S., Kumar, N., Goodman, B., Klein, C. J., Dyck, P. J. & Dyck, P. J. B., Oct 1 2017, In : Journal of neurology, neurosurgery, and psychiatry. 88, 10, p. 839-845 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Clinical-pathologic correlations in voltage-gated Kv1 potassium channel complex-subtyped autoimmune painful polyneuropathy

Lahoria, R., Pittock, S. J., Gadoth, A., Engelstad, J. K., Lennon, V. A. & Klein, C. J., Apr 1 2017, In : Muscle and Nerve. 55, 4, p. 520-525 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG–positive patients

Gadoth, A., Pittock, S. J., Dubey, D., McKeon, A., Britton, J. W., Schmeling, J. E., Smith, A., Kotsenas, A. L., Watson, R. E., Lachance, D. H., Flanagan, E., Lennon, V. A. & Klein, C. J., Jul 1 2017, In : Annals of Neurology. 82, 1, p. 79-92 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

Genomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas

Klein, C. J., Wu, Y., Jentoft, M. E., Mer, G., Spinner, R. J., Dyck, P. J. B., Dyck, P. J. & Mauermann, M. M., Feb 1 2017, In : Annals of Neurology. 81, 2, p. 316-321 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N. B., McDonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., MacInnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., May 2017, In : Genetic epidemiology. 41, 4, p. 297-308 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies

Kao, J. C., Liao, B., Markovic, S. N., Klein, C. J., Naddaf, E., Staff, N. P., Liewluck, T., Hammack, J. E., Sandroni, P., Finnes, H. & Mauermann, M. M., Oct 1 2017, In : JAMA Neurology. 74, 10, p. 1216-1222 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Radiation-induced spinal nerve root cavernous malformations as a rare cause of radiculopathy

Rastogi, K., Klein, C. J., O'Toole, J. E., Jhaveri, M. D. & Malik, R., Jan 1 2017, In : Neurology. 89, 22, p. 2299-2300 2 p.

Research output: Contribution to journalArticle

Subacute demyelinating polyradiculoneuropathy complicating Epstein-Barr virus infection in GATA2 haploinsufficiency

Kazamel, M., Klein, C. J., Benarroch, E. E., Patnaik, M. M. & Tracy, J. A., 2017, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Blink reflex role in algorithmic genetic testing of inherited polyneuropathies

Wang, W., Litchy, W. J., Mandrekar, J., Dyck, P. J. & Klein, C. J., 2016, (Accepted/In press) In : Muscle and Nerve.

Research output: Contribution to journalArticle

2 Scopus citations

CSF herpes virus and autoantibody profiles in the evaluation of encephalitis

Linnoila, J. J., Binnicker, M. J., Majed, M., Klein, C. J. & McKeon, A., 2016, In : Neurology: Neuroimmunology and NeuroInflammation. 3, 4, e245.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
32 Scopus citations

Pediatric Nerve Biopsy Diagnostic and Treatment Utility in Tertiary Care Referral

Ida, C. M., Dyck, P. J., Dyck, P. J. B., Engelstad, J. K., Wang, W., Selcen, D., Bodensteiner, J. B., Mauermann, M. M. & Klein, C. J., May 1 2016, In : Pediatric Neurology. 58, p. 3-11 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Larson, N. B., McDonnell, S., Albright, L. C., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J., Cussenot, O., Cancel-Tassin, G., Giles, G., MacInnis, R., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., Sep 1 2016, In : Genetic epidemiology. 40, 6, p. 461-469 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Target-enrichment sequencing and copy number evaluation in inherited polyneuropathy

Wang, W., Wang, C., Brian Dawson, D., Thorland, E. C., Lundquist, P. A., Eckloff, B. W., Wu, Y., Baheti, S., Evans, J. M., Scherer, S. S., Dyck, P. J. B. & Klein, C. J., May 10 2016, In : Neurology. 86, 19, p. 1762-1771 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Thirty Years Later, Case Closed: A Case of PMP22 Triplication from Anticipation

Martinez-Thompson, J. & Klein, C. J., May 1 2016, In : Mayo Clinic Proceedings. 91, 5, p. 687-688 2 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic Seizures

Flanagan, E. P., Kotsenas, A. L., Britton, J. W., McKeon, A., Watson, R. E., Klein, C. J., Boeve, B. F., Lowe, V., Ahlskog, J. E., Shin, C., Boes, C. J., Crum, B. A., Laughlin, R. S. & Pittock, S. J., 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 6, e161.

Research output: Contribution to journalArticle

70 Scopus citations

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders

Baets, J., Duan, X., Wu, Y., Smith, G., Seeley, W. W., Mademan, I., McGrath, N. M., Beadell, N. C., Khoury, J., Botuyan, M. V., Mer, G., Worrell, G. A., Hojo, K., DeLeon, J., Laura, M., Liu, Y. T., Senderek, J., Weis, J., Van Den Bergh, P., Merrill, S. L. & 7 others, Reilly, M. M., Houlden, H., Grossman, M., Scherer, S. S., De Jonghe, P., Dyck, P. J. & Klein, C. J., Apr 1 2015, In : Brain. 138, 4, p. 845-861 17 p.

Research output: Contribution to journalArticle

44 Scopus citations

Impairments and comorbidities of polyneuropathy revealed by population-based analyses

Hoffman, E. M., Staff, N. P., Robb, J. M., St. Sauver, J., Dyck, P. J. & Klein, C. J., Apr 21 2015, In : Neurology. 84, 16, p. 1644-1651 8 p.

Research output: Contribution to journalArticle

38 Scopus citations