Research Output

2020

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness

Quan, M. Y., Guo, Q., Liu, J., Yang, R., Bai, J., Wang, W., Cai, Y., Han, R., Lv, Y. Q., Ding, L., Billadeau, D. D., Lou, Z., Bellusci, S., Li, X. & Zhang, J. S., May 7 2020, In : Frontiers in Cell and Developmental Biology. 8, 287.

Research output: Contribution to journalArticle

Open Access

Antitumor activity of Z-endoxifen in aromatase inhibitor-sensitive and aromatase inhibitor-resistant estrogen receptor-positive breast cancer

Jayaraman, S., Hou, X., Kuffel, M. J., Suman, V. J., Hoskin, T. L., Reinicke, K. E., Monroe, D. G., Kalari, K. R., Tang, X., Zeldenrust, M. A., Cheng, J., Bruinsma, E. S., Buhrow, S. A., McGovern, R. M., Safgren, S. L., Walden, C. A., Carter, J. M., Reid, J. M., Ingle, J. N., Ames, M. M. & 2 others, Hawse, J. R. & Goetz, M. P., May 19 2020, In : Breast Cancer Research. 22, 1, 51.

Research output: Contribution to journalArticle

Open Access

Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations

DeLeon, T. T., Almquist, D. R., Kipp, B. R., Langlais, B. T., Mangold, A., Winters, J. L., Kosiorek, H. E., Joseph, R. W., Dronca, R. S., Block, M. S., McWilliams, R. R., Kottschade, L. A., Rumilla, K. M., Voss, J. S., Seetharam, M., Sekulic, A., Markovic, S. N. & Bryce, A. H., Jan 1 2020, In : PloS one. 15, 3, e0230306.

Research output: Contribution to journalArticle

Open Access

CHK2-FOXK axis promotes transcriptional control of autophagy programs

Chen, Y., Wu, J., Liang, G., Geng, G., Zhao, F., Yin, P., Nowsheen, S., Wu, C., Li, Y., Li, L., Kim, W., Zhou, Q., Huang, J., Liu, J., Zhang, C., Guo, G., Deng, M., Tu, X., Gao, X., Liu, Z. & 4 others, Chen, Y., Lou, Z., Luo, K. & Yuan, J., Jan 1 2020, In : Science Advances. 6, 1, eaax5819.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cisplatin-associated neuropathy characteristics compared with those associated with other neurotoxic chemotherapy agents (Alliance A151724)

Albany, C., Dockter, T., Wolfe, E., Le-Rademacher, J., Wagner-Johnston, N., Einhorn, L., Lafky, J. M., Smith, E., Pachman, D., Staff, N. P., Ma, C., Loprinzi, C. L. & Costello, B. A., Jan 1 2020, (Accepted/In press) In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients

Coltro, G., Mangaonkar, A. A., Lasho, T. L., Finke, C. M., Pophali, P., Carr, R., Gangat, N., Binder, M., Pardanani, A., Fernandez-Zapico, M., Robertson, K. D., Bosi, A., Droin, N., Vannucchi, A. M., Tefferi, A., Hunter, A., Padron, E., Solary, E. & Patnaik, M. M., May 1 2020, In : Leukemia. 34, 5, p. 1407-1421 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Complete Surgical Metastasectomy of Renal Cell Carcinoma in the Post-Cytokine Era

Lyon, T. D., Thompson, R. H., Shah, P. H., Lohse, C. M., Boorjian, S. A., Costello, B. A., Cheville, J. C. & Leibovich, B. C., Feb 1 2020, In : The Journal of urology. 203, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

Zhang, L., Sarangi, V., Moon, I., Yu, J., Liu, D., Devarajan, S., Reid, J. M., Kalari, K. R., Wang, L. & Weinshilboum, R., Jan 1 2020, (Accepted/In press) In : Clinical and translational science.

Research output: Contribution to journalArticle

Open Access

Efficacy of Second-Line Chemotherapy in Extrapulmonary Neuroendocrine Carcinoma

McGarrah, P. W., Leventakos, K., Hobday, T. J., Molina, J. R., Finnes, H. D., Westin, G. F. & Halfdanarson, T. R., Apr 1 2020, In : Pancreas. 49, 4, p. 529-533 5 p.

Research output: Contribution to journalArticle

Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions

Tu, Y., Zhao, L., Billadeau, D. D. & Jia, D., Mar 18 2020, In : Frontiers in Cell and Developmental Biology. 8, 163.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Enzymatic and metabolic regulation of lysine succinylation

Sreedhar, A., Wiese, E. K. & Hitosugi, T., Jun 2020, In : Genes and Diseases. 7, 2, p. 166-171 6 p.

Research output: Contribution to journalReview article

Open Access

Erratum: The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality (Immunity (2019) 51(3) (491–507.e7), (S1074761319303644), (10.1016/j.immuni.2019.08.013))

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., Hitosugi, T. & 1 others, Sun, J., Jan 14 2020, In : Immunity. 52, 1, p. 201-202 2 p.

Research output: Contribution to journalComment/debate

Open Access

Evaluation of the Safety and Efficacy of Immunotherapy Rechallenge in Patients with Renal Cell Carcinoma

Ravi, P., Mantia, C., Su, C., Sorenson, K., Elhag, D., Rathi, N., Bakouny, Z., Agarwal, N., Zakharia, Y., Costello, B. A., McKay, R. R., Narayan, V., Alva, A., McGregor, B. A., Gao, X., McDermott, D. F. & Choueiri, T. K., Jan 1 2020, (Accepted/In press) In : JAMA Oncology.

Research output: Contribution to journalArticle

1 Scopus citations

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Kojima, Y., Machida, Y., Palani, S., Caulfield, T. R., Radisky, E. S., Kaufmann, S. H. & Machida, Y. J., Dec 1 2020, In : Nature communications. 11, 1, 1318.

Research output: Contribution to journalArticle

Open Access

Foundation One Genomic Interrogation of Thyroid Cancers in Patients With Metastatic Disease Requiring Systemic Therapy

Iñiguez-Ariza, N. M., Jasim, S., Ryder, M. M., Chintakuntlawar, A., Morris, J. C., Hilger, C. R., Menefee, M. G., Smallridge, R. C., Karlin, N. J., Alcaino, C. & Bible, K. C., Jul 1 2020, In : The Journal of clinical endocrinology and metabolism. 105, 7

Research output: Contribution to journalArticle

Glycogen synthase kinase-3β: a novel therapeutic target for pancreatic cancer

Ding, L. & Billadeau, D. D., May 3 2020, In : Expert opinion on therapeutic targets. 24, 5, p. 417-426 10 p.

Research output: Contribution to journalReview article

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation

Walpole, G. F. W., Plumb, J. D., Chung, D., Tang, B., Boulay, B., Osborne, D. G., Piotrowski, J. T., Catz, S. D., Billadeau, D. D., Grinstein, S. & Jaumouillé, V., Jun 2 2020, In : Cell reports. 31, 9, 107721.

Research output: Contribution to journalArticle

Open Access

Increased ERBB2 Gene Copy Numbers Reveal a Subset of Salivary Duct Carcinomas with High Densities of Tumor Infiltrating Lymphocytes and PD-L1 Expression

Chatzopoulos, K., Collins, A. R., Sotiriou, S., Keeney, M. G., Visscher, D. W., Rivera, M., Schembri-Wismayer, D. J., Lewis, J. E., Greipp, P. T., Sukov, W. R., Chintakuntlawar, A. V., Price, K. A. & Garcia, J. J., Jan 1 2020, (Accepted/In press) In : Head and Neck Pathology.

Research output: Contribution to journalArticle

Mechanism of cargo recognition by retromerlinked SNX-BAR proteins

Yong, X., Zhao, L., Deng, W., Sun, H., Zhou, X., Mao, L., Hu, W., Shen, X., Sun, Q., Billadeau, D. D., Xue, Y. & Jia, D., Jan 1 2020, In : PLoS biology. 18, 3, e3000631.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Molecular regulation of the plasma membrane-proximal cellular steps involved in NK cell cytolytic function

Phatarpekar, P. V. & Billadeau, D. D., Feb 21 2020, In : Journal of cell science. 133, 5

Research output: Contribution to journalReview article

Open Access

Nivolumab in children and young adults with relapsed or refractory solid tumours or lymphoma (ADVL1412): a multicentre, open-label, single-arm, phase 1–2 trial

Davis, K. L., Fox, E., Merchant, M. S., Reid, J. M., Kudgus, R. A., Liu, X., Minard, C. G., Voss, S., Berg, S. L., Weigel, B. J. & Mackall, C. L., Apr 2020, In : The Lancet Oncology. 21, 4, p. 541-550 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Patients’ Perspectives and Advice on How to Discuss Sexual Orientation, Gender Identity, and Sexual Health in Oncology Clinics

Cathcart-Rake, E., O’Connor, J., Ridgeway, J. L., Breitkopf, C. R., Kaur, J. S., Mitchell, J., Leventakos, K. & Jatoi, A., Jan 1 2020, (Accepted/In press) In : American Journal of Hospice and Palliative Medicine.

Research output: Contribution to journalArticle

Penile cancer with visceral metastasis and p16/human papillomavirus positivity: An unusual case of long-term survival

Mehra, N. S., Ho, T. P., Herrera Hernandez, L., Quevedo, J. F., Costello, B. A. & Pagliaro, L. C., Nov 2020, In : Urology Case Reports. 33, 101278.

Research output: Contribution to journalArticle

Open Access

Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits

Chowdhury, U. R., Kudgus, R. A., Rinkoski, T. A., Holman, B. H., Bahler, C. K., Hann, C. R., Reid, J. M., Dosa, P. I. & Fautsch, M. P., Apr 2020, In : PloS one. 15, 4, e0231841.

Research output: Contribution to journalArticle

Open Access

Phase 1/2 trial of talazoparib in combination with temozolomide in children and adolescents with refractory/recurrent solid tumors including Ewing sarcoma: A Children's Oncology Group Phase 1 Consortium study (ADVL1411)

Schafer, E. S., Rau, R. E., Berg, S. L., Liu, X., Minard, C. G., Bishop, A. J. R., Romero, J. C., Hicks, M. J., Nelson, M. D., Voss, S., Reid, J. M., Fox, E., Weigel, B. J. & Blaney, S. M., Feb 1 2020, In : Pediatric Blood and Cancer. 67, 2, e28073.

Research output: Contribution to journalArticle

Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

McCleary-Wheeler, A. L., Carr, R. M., Palmer, S. R., Smyrk, T. C., Allred, J. B., Almada, L. L., Tolosa, E. J., Lamberti, M. J., Marks, D. L., Borad, M. J., Molina, J. R., Qi, Y., Lingle, W. L., Grothey, A. F., Pitot, H. C., Jatoi, A., Northfelt, D. W., Bryce, A. H., McWilliams, R. R., Okuno, S. H. & 10 others, Haluska, P. R. J., Kim, G. P., Colon-Otero, G., Lowe, V. J., Callstrom, M. R., Ma, W. W., Bekaii-Saab, T., Hung, M. C., Erlichman, C. & Fernandez-Zapico, M. E., Jan 2020, In : Pancreatology. 20, 1, p. 101-109 9 p.

Research output: Contribution to journalArticle

Phase I clinical trial of the WEe1 inhibitor adavosertib (AZD1775) with irinotecan in children with relapsed solid tumors: A COG phase I consortium report (ADVL1312)

Cole, K. A., Pal, S., Kudgus, R. A., Ijaz, H., Liu, X., Minard, C. G., Pawel, B. R., Maris, J. M., Haas-Kogan, D. A., Voss, S. D., Berg, S. L., Reid, J. M., Fox, E. & Weigel, B. J., Mar 15 2020, In : Clinical Cancer Research. 26, 6, p. 1213-1219 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Phase II Trial of Trifluridine/Tipiracil in Patients with Advanced, Refractory Biliary Tract Carcinoma

Chakrabarti, S., Zemla, T. J., Ahn, D. H., Ou, F. S., Fruth, B., Borad, M. J., Hartgers, M. L., Wessling, J., Walkes, R. L., Alberts, S. R., McWilliams, R. R., Liu, M. C., Durgin, L. M., Bekaii-Saab, T. S. & Mahipal, A., May 1 2020, In : Oncologist. 25, 5, p. 380-e763

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Phenotypic correlates and prognostic outcomes of TET2 mutations in myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: A comprehensive study of 504 adult patients

Coltro, G., Antelo, G., Lasho, T. L., Finke, C. M., Pardanani, A., Gangat, N., Carr, R. M., Binder, M., Mangaonkar, A. A., Ketterling, R., Fernandez-Zapico, M. E., Robertson, K. D., Bosi, A., Vannucchi, A. M., Tefferi, A. & Patnaik, M. M., Jan 1 2020, (Accepted/In press) In : American journal of hematology.

Research output: Contribution to journalLetter

Open Access

Querying Patients With Cancer About Sexual Health and Sexual and Gender Minority Status: A Qualitative Study of Health-Care Providers

Cathcart-Rake, E., O’Connor, J. M., Ridgeway, J. L., Breitkopf, C. R., Guire, L. J. M., Olson, E. A., Kaur, J. S., Leventakos, K. & Jatoi, A., Jun 1 2020, In : American Journal of Hospice and Palliative Medicine. 37, 6, p. 418-423 6 p.

Research output: Contribution to journalArticle

Rare BRIP1 missense alleles confer risk for ovarian and breast cancer

Moyer, C. L., Ivanovich, J., Gillespie, J. L., Doberstein, R., Radke, M. R., Richardson, M. E., Kaufmann, S. H., Swisher, E. M. & Goodfellow, P. J., Feb 15 2020, In : Cancer research. 80, 4, p. 857-867 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Reductive amination of α-Ketoglutarate in metabolite extracts results in glutamate overestimation

Wiese, E. K., Hitosugi, S., Buhrow, S. A., Loa, S. T., Sreedhar, A., Reid, J. M., Gonsalves, W. I. & Hitosugi, T., Jan 1 2020, (Accepted/In press) In : Journal of Chromatography A. 461169.

Research output: Contribution to journalArticle

Regulation of sister chromatid cohesion by nuclear PD-L1

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Tu, X., Dong, H., Boughey, J. C., Goetz, M. P., Weinshilboum, R., Lou, Z. & Wang, L., Jan 1 2020, (Accepted/In press) In : Cell Research.

Research output: Contribution to journalArticle

Open Access

Reply by Authors

Lyon, T. D., Thompson, R. H., Shah, P. H., Lohse, C. M., Boorjian, S. A., Costello, B. A., Cheville, J. C. & Leibovich, B. C., Feb 1 2020, In : The Journal of urology. 203, 2, 1 p.

Research output: Contribution to journalComment/debate

Response to erythropoiesis-stimulating agents in patients with WHO-defined myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)

Antelo, G., Mangaonkar, A. A., Coltro, G., Buradkar, A., Lasho, T. L., Finke, C., Carr, R., Binder, M., Gangat, N., Al-Kali, A., Elliott, M. A., King, R. L., Howard, M., Melody, M. E., Hogan, W., Litzow, M. R., Tefferi, A., Fernandez-Zapico, M. E., Komrokji, R. & Patnaik, M. M., Jan 1 2020, (Accepted/In press) In : British journal of haematology.

Research output: Contribution to journalLetter

Open Access

Selective Inhibition of BFL1: It's All about Finding the Right Partner

Dai, H., Meng, X. W. & Kaufmann, S. H., Jun 18 2020, In : Cell Chemical Biology. 27, 6, p. 639-642 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Stromal deactivation by CSF1: a new feature of the aggressive pancreatic cancer microenvironment

Vera, R. E. & Fernandez-Zapico, M. E., May 6 2020, In : EMBO Reports. 21, 5, e50468.

Research output: Contribution to journalArticle

Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain

Liu, D., Yang, F., Liu, Z., Wang, J., Huang, W., Meng, W., Billadeau, D. D., Sun, Q., Mo, X. & Jia, D., May 1 2020, In : PLoS biology. 18, 5, e3000746.

Research output: Contribution to journalArticle

Open Access

The association of anxiety and depression with perioperative and oncologic outcomes among patients with clear cell renal cell carcinoma undergoing nephrectomy

Packiam, V. T., Tyson, M. D., Tsivian, M., Lohse, C. M., Boorjian, S. A., Cheville, J. C., Costello, B. A., Leibovich, B. C. & Thompson, R. H., Feb 2020, In : Urologic Oncology: Seminars and Original Investigations. 38, 2, p. 41.e19-41.e27

Research output: Contribution to journalArticle

The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair

Zhou, Q., Huang, J., Zhang, C., Zhao, F., Kim, W., Tu, X., Zhang, Y., Nowsheen, S., Zhu, Q., Deng, M., Chen, Y., Qin, B., Luo, K., Liu, B., Lou, Z., Mutter, R. W. & Yuan, J., Dec 1 2020, In : Nature communications. 11, 1, 2639.

Research output: Contribution to journalArticle

Open Access

The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoterlooping GLI1-STAT3 transcriptional complex

Carr, R. M., Duran, P. A. R., Tolosa, E. J., Ma, C., Oseini, A. M., Moser, C. D., Banini, B. A., Huang, J., Asumda, F., Dhanasekaran, R., Graham, R. P., Toruner, M. D., Safgren, S. L., Almada, L. L., Wang, S., Patnaik, M. M., Roberts, L. R. & Fernandez-Zapico, M. E., Feb 28 2020, In : Journal of Biological Chemistry. 295, 9, p. 2698-2712 15 p.

Research output: Contribution to journalArticle

The necessity for standardization of glioma stem cell culture: A systematic review

Zhang, L., Yu, H., Yuan, Y., Yu, J. S., Lou, Z., Xue, Y. & Liu, Y., Feb 26 2020, In : Stem Cell Research and Therapy. 11, 1, 84.

Research output: Contribution to journalReview article

Open Access

Therapeutic options for mucinous ovarian carcinoma

Gorringe, K. L., Cheasley, D., Wakefield, M. J., Ryland, G. L., Allan, P. E., Alsop, K., Amarasinghe, K. C., Ananda, S., Bowtell, D. D. L., Christie, M., Chiew, Y. E., Churchman, M., DeFazio, A., Fereday, S., Gilks, C. B., Gourley, C., Hadley, A. M., Hendley, J., Hunter, S. M., Kaufmann, S. H. & 20 others, Kennedy, C. J., Köbel, M., Le Page, C., Li, J., Lupat, R., McNally, O. M., McAlpine, J. N., Pyman, J., Rowley, S. M., Salazar, C., Saunders, H., Semple, T., Stephens, A. N., Thio, N., Torres, M. C., Traficante, N., Zethoven, M., Antill, Y. C., Campbell, I. G. & Scott, C. L., Mar 2020, In : Gynecologic oncology. 156, 3, p. 552-560 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53

Hu, C., Zhang, M., Moses, N., Hu, C. L., Polin, L., Chen, W., Jang, H., Heyza, J., Malysa, A., Caruso, J. A., Xiang, S., Patrick, S., Stemmer, P., Lou, Z., Bai, W., Wang, C., Bepler, G. & Zhang, X. M., May 1 2020, In : Cell Death and Disease. 11, 5, 328.

Research output: Contribution to journalArticle

Open Access

The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy

Guo, Q., Quan, M., Dong, J., Bai, J., Wang, J., Han, R., Wang, W., Cai, Y., Lv, Y., Chen, Q., Xu, H., Lyu, H., Deng, L., Zhou, D., Xiao, X., de Langhe, S., Billadeau, D. D., Lou, Z. & Zhang, J. S., Jan 1 2020, In : Theranostics. 10, 10, p. 4422-4436 15 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

Yu, J., Qin, B. & Lou, Z., Feb 11 2020, In : Cell and Bioscience. 10, 1, 13.

Research output: Contribution to journalReview article

Open Access

ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells

Liu, M., Zhang, Y., Yang, J., Cui, X., Zhou, Z., Zhan, H., Ding, K., Tian, X., Yang, Z., Fung, K. M. A., Edil, B. H., Postier, R. G., Bronze, M. S., Fernandez-Zapico, M. E., Stemmler, M. P., Brabletz, T., Li, Y. P., Houchen, C. W. & Li, M., Feb 2020, In : Gastroenterology. 158, 3, p. 679-692.e1

Research output: Contribution to journalArticle

1 Scopus citations