Research Output 1990 2019

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2019
2 Citations (Scopus)

53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer

Hurley, R. M., Wahner Hendrickson, A. E., Visscher, D. W., Ansell, P., Harrell, M. I., Wagner, J. M., Negron, V., Goergen, K. M., Maurer, M. J., Oberg, A. L., Meng, X. W., Flatten, K. S., De Jonge, M. J. A., Van Herpen, C. D., Gietema, J. A., Koornstra, R. H. T., Jager, A., den Hollander, M. W., Dudley, M., Shepherd, S. P. & 2 others, Swisher, E. M. & Kaufmann, S. H., Jan 1 2019, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Homologous Recombination
Ovarian Neoplasms
DNA End-Joining Repair
Neoplasms
Gene Deletion

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. M. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms

A novel UCHL 3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair

Song, Z., Tu, X., Zhou, Q., Huang, J., Chen, Y., Liu, J., Lee, S. B., Kim, W., Nowsheen, S., Luo, K., Yuan, J. & Lou, Z., Jun 1 2019, In : Cell Death and Disease. 10, 6, 398.

Research output: Contribution to journalArticle

Open Access
Triple Negative Breast Neoplasms
Double-Stranded DNA Breaks
Homologous Recombination
DNA Damage
Ubiquitination
2 Citations (Scopus)

A phase II study of alisertib in children with recurrent/refractory solid tumors or leukemia: Children's Oncology Group Phase I and pilot Consortium (ADVL0921)

Mosse, Y. P., Fox, E., Teachey, D. T., Reid, J. M., Safgren, S. L., Carol, H., Lock, R. B., Houghton, P. J., Smith, M. A., Hall, D., Barkauskas, D. A., Krailo, M., Voss, S. D., Berg, S. L., Blaney, S. M. & Weigel, B. J., Jun 1 2019, In : Clinical Cancer Research. 25, 11, p. 3229-3238 10 p.

Research output: Contribution to journalArticle

Open Access
Leukemia
Aurora Kinase A
Neoplasms
Pharmacokinetics
Pharmacogenetics
3 Citations (Scopus)

Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia

Lucas, N., Duchmann, M., Rameau, P., Noël, F., Michea, P., Saada, V., Kosmider, O., Pierron, G., Fernandez-Zapico, M. E., Howard, M. T., King, R., Niyongere, S., Diop, M. K., Fenaux, P., Itzykson, R., Willekens, C., Ribrag, V., Fontenay, M., Padron, E., Soumelis, V. & 3 others, Droin, N., Patnaik, M. M. & Solary, E., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Dendritic Cells
Bone Marrow
Protein-Tyrosine Kinases
Flow Cytometry
17 Citations (Scopus)

BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Lin, K. K., Harrell, M. I., Oza, A. M., Oaknin, A., Ray-Coquard, I., Tinker, A. V., Helman, E., Radke, M. R., Say, C., Vo, L. T., Mann, E., Isaacson, J. D., Maloney, L., O'Malley, D. M., Chambers, S. K., Kaufmann, S. H., Scott, C. L., Konecny, G. E., Coleman, R. L., Sun, J. X. & 5 others, Giordano, H., Brenton, J. D., Harding, T. C., McNeish, I. A. & Swisher, E. M., Feb 1 2019, In : Cancer discovery. 9, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

Open Access
Platinum
Carcinoma
Mutation
DNA
Neoplasms
2 Citations (Scopus)

Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine

Vera, J., Paludo, J., Kottschade, L., Brandt, J., Yan, Y., Block, M. S., Mc Williams, R. R., Dronca, R. S., Loprinzi, C. L., Grothey, A. F. & Markovic, S. N., Jan 1 2019, In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Colchicine
Fever
Mitogen-Activated Protein Kinases
Familial Mediterranean Fever
Therapeutics
4 Citations (Scopus)

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation

Maurel, M., Obacz, J., Avril, T., Ding, Y. P., Papadodima, O., Treton, X., Daniel, F., Pilalis, E., Hörberg, J., Hou, W., Beauchamp, M. C., Tourneur-Marsille, J., Cazals-Hatem, D., Sommerova, L., Samali, A., Tavernier, J., Hrstka, R., Dupont, A., Fessart, D., Delom, F. & 9 others, Fernandez-Zapico, M. E., Jansen, G., Eriksson, L. A., Thomas, D. Y., Jerome-Majewska, L., Hupp, T., Chatziioannou, A., Chevet, E. & Ogier-Denis, E., Jun 1 2019, In : EMBO Molecular Medicine. 11, 6, e10120.

Research output: Contribution to journalArticle

Open Access
Dimerization
Endoplasmic Reticulum
Inflammation
Inflammatory Bowel Diseases
Protein Disulfide-Isomerases
2 Citations (Scopus)

Derivation of adult canine intestinal organoids for translational research in gastroenterology

Chandra, L., Borcherding, D. C., Kingsbury, D., Atherly, T., Ambrosini, Y. M., Bourgois-Mochel, A., Yuan, W., Kimber, M., Qi, Y., Wang, Q., Wannemuehler, M., Ellinwood, N. M., Snella, E., Martin, M., Skala, M., Meyerholz, D., Estes, M., Fernandez-Zapico, M. E., Jergens, A. E., Mochel, J. P. & 1 others, Allenspach, K., Apr 11 2019, In : BMC Biology. 17, 1, 33.

Research output: Contribution to journalArticle

Open Access
Gastroenterology
Organoids
Translational Medical Research
Canidae
Dogs
2 Citations (Scopus)

Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins

Mazzone, A., Gibbons, S. J., Eisenman, S. T., Strege, P. R., Zheng, T., D'Amato, M., Ordog, T., Fernandez-Zapico, M. E. & Farrugia, G., May 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 6632-6642 11 p.

Research output: Contribution to journalArticle

Transcription
Genes
Polymorphism
Hylobates
Kidney

Early integrated telehealth versus in-person palliative care for patients with advanced lung cancer: A study protocol

Chua, I. S., Zachariah, F., Dale, W., Feliciano, J., Hanson, L., Blackhall, L., Quest, T., Curseen, K., Grey, C., Rhodes, R., Shoemaker, L., Silveira, M., Fischer, S., O'Mahony, S., Leventakos, K., Trotter, C., Sereno, I., Kamdar, M., Temel, J. & Greer, J. A., Sep 1 2019, In : Journal of Palliative Medicine. 22, S1, p. S7-S19

Research output: Contribution to journalArticle

Open Access
Telemedicine
Palliative Care
Lung Neoplasms
Quality of Life
Caregivers

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Cytarabine
Daunorubicin
G2 Phase Cell Cycle Checkpoints
In Vitro Techniques

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

Singla, A., Fedoseienko, A., Giridharan, S. S. P., Overlee, B. L., Lopez, A., Jia, D., Song, J., Huff-Hardy, K., Weisman, L., Burstein, E. & Billadeau, D. D., Sep 19 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Recycling
recycling
phosphates
Membrane Proteins
membranes

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

Grant, D. J., Manichaikul, A., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J., Bondy, M., Cote, M. L., Funkhouser, E., Moorman, P. G., Peres, L. C., Peters, E. S., Schwartz, A. G., Terry, P. D., Wang, X. Q., Keku, T. O., Hoyo, C., Berchuck, A., Sandler, D. P., Taylor, J. A., O’Brien, K. M. & 70 others, Velez Edwards, D. R., Edwards, T. L., Beeghly-Fadiel, A., Wentzensen, N., Pearce, C. L., Wu, A. H., Whittemore, A. S., McGuire, V., Sieh, W., Rothstein, J. H., Modugno, F., Ness, R., Moysich, K., Rossing, M. A., Doherty, J. A., Sellers, T. A., Permuth-Way, J. B., Monteiro, A. N., Levine, D. A., Setiawan, V. W., Haiman, C. A., LeMarchand, L., Wilkens, L. R., Karlan, B. Y., Menon, U., Ramus, S., Gayther, S., Gentry-Maharaj, A., Terry, K. L., Cramer, D. W., Goode, E. L., Larson, M. C., Kaufmann, S. H., Cannioto, R., Odunsi, K., Etter, J. L., Huang, R. Y., Bernardini, M. Q., Tone, A. A., May, T., Goodman, M. T., Thompson, P. J., Carney, M. E., Tworoger, S. S., Poole, E. M., Lambrechts, D., Vergote, I., Vanderstichele, A., Van Nieuwenhuysen, E., Anton-Culver, H., Ziogas, A., Brenton, J. D., Bjorge, L., Salvensen, H. B., Kiemeney, L. A., Massuger, L. F. A. G., Pejovic, T., Bruegl, A., Moffitt, M., Cook, L., Le, N. D., Brooks-Wilson, A., Kelemen, L. E., Pharoah, P. D. P., Song, H., Campbell, I., Eccles, D., DeFazio, A., Kennedy, C. J. & Schildkraut, J. M., May 1 2019, In : Cancer medicine. 8, 5, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D
African Americans
Single Nucleotide Polymorphism
Odds Ratio
Confidence Intervals

First Line Androgen Deprivation Therapy vs. Chemotherapy for Patients With Androgen Receptor Positive Recurrent or Metastatic Salivary Gland Carcinoma—A Retrospective Study

Viscuse, P. V., Price, K. A., Garcia, J. J., Schembri-Wismayer, D. J. & Chintakuntlawar, A. V., Aug 2 2019, In : Frontiers in Oncology. 9, 701.

Research output: Contribution to journalArticle

Open Access
Androgen Receptors
Salivary Glands
Androgens
Retrospective Studies
Drug Therapy
1 Citation (Scopus)

Genes associated with bowel metastases in ovarian cancer

Mariani, A., Wang, C., Oberg, A. L., Riska, S. M., Torres, M., Kumka, J., Multinu, F., Sagar, G., Roy, D., Jung, DB. B., Zhang, Q., Grassi, T., Visscher, D. W., Patel, V. P., Jin, L., Staub, J. K., Cliby, W. A., Weroha, S. J., Kalli, K. R., Hartmann, L. C. & 3 others, Kaufmann, S. H., Goode, E. L. & Shridhar, V., Jan 1 2019, In : Gynecologic oncology.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Neoplasm Metastasis
Genes
Neoplasms
Immunohistochemistry

Glioblastoma with bilateral extraocular muscle infiltration preceded by evidence of vascular tropism

Ruff, M. W. & Kizilbash, S., Mar 1 2019, In : Journal of Clinical Neuroscience. 61, p. 277-278 2 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Trigeminal Nerve
Tropism
Glioblastoma
Blood Vessels

Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to chemotherapy by abrogating the ToPBP1/ATR-mediated DNA damage response

Ding, L., Madamsetty, V. S., Kiers, S., Alekhina, O., Ugolkov, A., Dube, J., Zhang, Y., Zhang, J. S., Wang, E., Dutta, S. K., Schmitt, D. M., Giles, F. J., Kozikowski, A. P., Mazar, A. P., Mukhopadhyay, D. & Billadeau, D. D., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6452-6462 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
gemcitabine
Pancreatic Neoplasms
DNA Damage
Drug Therapy
1 Citation (Scopus)

Glypican-1 and glycoprotein 2 bearing extracellular vesicles do not discern pancreatic cancer from benign pancreatic diseases

Lucien, F., Lac, V., Billadeau, D. D., Borgida, A., Gallinger, S. & Leong, H. S., Feb 1 2019, In : Oncotarget. 10, 10, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

Glypicans
Pancreatic Diseases
Pancreatic Neoplasms
Glycoproteins
Adenocarcinoma
5 Citations (Scopus)

MRE11 UFMylation promotes ATM activation

Wang, Z., Gong, Y., Peng, B., Shi, R., Fan, D., Zhao, H., Zhu, M., Zhang, H., Lou, Z., Zhou, J., Zhu, W. G., Cong, Y. S. & Xu, X., Jan 1 2019, In : Nucleic acids research. 47, 8, p. 4124-4135 12 p.

Research output: Contribution to journalArticle

Open Access
DNA Damage
Ubiquitins
Genome
Endometrioid Carcinoma
Recombinational DNA Repair
3 Citations (Scopus)

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis

Yadav, S., Xie, H., Bin-Riaz, I., Sharma, P., Durani, U., Goyal, G., Borah, B. J., Borad, M. J., Smoot, R., Roberts, L. R., Go, R. S., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Propensity Score
Cholangiocarcinoma
Adjuvant Chemotherapy
Drug Therapy
Survival

NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity

Wilton, K. M., Overlee, B. L. & Billadeau, D. D., Jul 18 2019, In : Journal of cell science. 133, 5

Research output: Contribution to journalArticle

Open Access
Natural Killer Cells
Synapses
Actins
Integrins
NK Cell Lectin-Like Receptor Subfamily K

Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma

Huffman, B. M., Jin, Z., Yadav, S., Patel, S., Nagorney, D. M., Truty, M., Mc Williams, R. R., Halfdanarson, T. R. & Mahipal, A., Jan 1 2019, In : Clinical colorectal cancer.

Research output: Contribution to journalArticle

Adenocarcinoma
Survival
Adjuvant Chemotherapy
Monocytes
Neoplasms
11 Citations (Scopus)

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

Konstantinopoulos, P. A., Barry, W. T., Birrer, M., Westin, S. N., Cadoo, K. A., Shapiro, G. I., Mayer, E. L., O'Cearbhaill, R. E., Coleman, R. L., Kochupurakkal, B., Whalen, C., Curtis, J., Farooq, S., Luo, W., Eismann, J., Buss, M. K., Aghajanian, C., Mills, G. B., Palakurthi, S., Kirschmeier, P. & 8 others, Liu, J., Cantley, L. C., Kaufmann, S. H., Swisher, E. M., D'Andrea, A. D., Winer, E., Wulf, G. M. & Matulonis, U. A., Apr 1 2019, In : The Lancet Oncology. 20, 4, p. 570-580 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Histology
Ovarian Neoplasms
Recombinational DNA Repair
3 Citations (Scopus)

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

Tu, X., Qin, B., Zhang, Y., Zhang, C., Kahila, M., Nowsheen, S., Yin, P., Yuan, J., Pei, H., Li, H., Yu, J., Song, Z., Zhou, Q., Zhao, F., Liu, J., Zhang, C., Dong, H. M., Mutter, R. & Lou, Z., Jun 20 2019, In : Molecular Cell. 74, 6, p. 1215-1226.e4

Research output: Contribution to journalArticle

Exosome Multienzyme Ribonuclease Complex
DNA Damage
Radiation
Drug Therapy
Genetic Therapy
16 Citations (Scopus)

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study

Meric-Bernstam, F., Hurwitz, H., Raghav, K. P. S., Mc Williams, R. R., Fakih, M., VanderWalde, A., Swanton, C., Kurzrock, R., Burris, H., Sweeney, C., Bose, R., Spigel, D. R., Beattie, M. S., Blotner, S., Stone, A., Schulze, K., Cuchelkar, V. & Hainsworth, J., Apr 1 2019, In : The Lancet Oncology. 20, 4, p. 518-530 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Therapeutics
Trastuzumab
pertuzumab
Chills
2 Citations (Scopus)

Pharmacogenomic next-generation DNA sequencing: Lessons from the identification and functional characterization of variants of unknown significance in CYP2C9 and CYP2C19

Devarajan, S., Moon, I., Ho, M. F., Larson, N., Neavin, D. R., Moyer, A., Black, J. L., Bielinski, S. J., Scherer, S. E., Wang, L. M., Weinshilboum, R. M. & Reid, J. M., Apr 1 2019, In : Drug Metabolism and Disposition. 47, 4, p. 425-435 11 p.

Research output: Contribution to journalArticle

Pharmacogenetics
DNA Sequence Analysis
Cytochrome P-450 Enzyme System
Oxidoreductases
Proteins

Pharmacogenomics of cytochrome p450 of nimodipine metabolism after aneurysmal subarachnoid hemorrhage

Peacock, S. H., James, C., Turnbull, M. T., Cowart, J. B., Reid, J. M. & Freeman, W. D., Oct 1 2019, In : Journal of Neuroscience Nursing. 51, 5, p. 238-242 5 p.

Research output: Contribution to journalArticle

Nimodipine
Pharmacogenetics
Subarachnoid Hemorrhage
Cytochrome P-450 Enzyme System
Brain Ischemia
4 Citations (Scopus)

Phase II Evaluation of Aggressive Dose De-Escalation for Adjuvant Chemoradiotherapy in Human Papillomavirus-Associated Oropharynx Squamous Cell Carcinoma

Ma, D. J., Price, K. A., Moore, E. J., Patel, S. H., Hinni, M. L., Garcia, J. J., Graner, D. E., Foster, N. R., Ginos, B., Neben-Wittich, M., Garces, Y. I., Chintakuntlawar, A., Price, D. L., Olsen, K. D., Van Abel, K. M., Kasperbauer, J., Janus, J. R., Waddle, M., Miller, R., Shiraishi, S. & 1 others, Foote, R. L., Aug 1 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 22, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

Adjuvant Chemoradiotherapy
Oropharynx
Squamous Cell Carcinoma
Radiotherapy
Deglutition

Phase II trial of the glycoprotein non-metastatic B-targeted antibody–drug conjugate, glembatumumab vedotin (CDX-011), in recurrent osteosarcoma AOST1521: A report from the Children's Oncology Group

Kopp, L. M., Malempati, S., Krailo, M., Gao, Y., Buxton, A., Weigel, B. J., Hawthorne, T., Crowley, E., Moscow, J. A., Reid, J. M., Villalobos, V., Randall, R. L., Gorlick, R. & Janeway, K. A., Nov 2019, In : European Journal of Cancer. 121, p. 177-183 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Glycoproteins
glembatumumab vedotin
Exanthema
Microtubules
2 Citations (Scopus)

Prediction of the Renal Elimination of Drugs With Cystatin C vs Creatinine: A Systematic Review

Barreto, E. F., Rule, A. D., Murad, M. H., Kashani, K. B., Lieske, J. C., Erwin, P. J., Steckelberg, J. M., Gajic, O., Reid, J. M. & Kane-Gill, S. L., Jan 1 2019, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

Cystatin C
Creatinine
Pharmaceutical Preparations
Kidney
Acute Kidney Injury

Querying Patients With Cancer About Sexual Health and Sexual and Gender Minority Status: A Qualitative Study of Health-Care Providers

Cathcart-Rake, E., O’Connor, J. M., Ridgeway, J. L., Breitkopf, C. R., Guire, L. J. M., Olson, E. A., Kaur, J. S., Leventakos, K. & Jatoi, A., Jan 1 2019, (Accepted/In press) In : American Journal of Hospice and Palliative Medicine.

Research output: Contribution to journalArticle

Reproductive Health
Health Personnel
Taboo
Neoplasms
Radiation Oncology
1 Citation (Scopus)

Risk of Different Cancers Among First-degree Relatives of Pancreatic Cancer Patients: Influence of Probands' Susceptibility Gene Mutation Status

Antwi, S., Fagan, S. E., Chaffee, K. G., Bamlet, W. R., Hu, C., Polley, E., Hart, S., Shimelis, H., Lilyquist, J., Gnanaolivu, R. D., Mc Williams, R. R., Oberg, A. L., Couch, F. J. & Petersen, G. M., Mar 1 2019, In : Journal of the National Cancer Institute. 111, 3, p. 264-271 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Mutation
Genes
Confidence Intervals
Neoplasms
2 Citations (Scopus)

Sex Differences in Tolerability to Anti-Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non-Small Cell Lung Cancer: Are We All Equal?

Duma, N., Abdel-Ghani, A., Yadav, S., Hoversten, K. P., Reed, C. T., Sitek, A. N., Enninga, E. A. L., Paludo, J., Aguilera, J. V., Leventakos, K., Lou, Y., Kottschade, L. A., Dong, H. M., Mansfield, A., Manochakian, R., Adjei, A. & Dronca, R. S., Jan 1 2019, In : Oncologist.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Non-Small Cell Lung Carcinoma
Sex Characteristics
Melanoma
Therapeutics

Shared and unique genomic structural variants of different histological components within testicular germ cell tumours identified with mate pair sequencing

Bryce, A. H., Egan, J. B., Smadbeck, J., Johnson, S. H., Murphy, S. J., Harris, F. R., Halling, G. C., Terra, S. B. S. P., Cheville, J., Pagliaro, L., Leibovich, B., Costello, B. & Vasmatzis, G., Dec 1 2019, In : Scientific reports. 9, 1, 3586.

Research output: Contribution to journalArticle

Open Access
Genomic Structural Variation
Exome
Histology
Neoplasms
Protein Isoforms

Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH

Huang, W., Liu, Z., Yang, F., Zhou, H., Yong, X., Yang, X., Zhou, Y., Xue, L., Zhang, Y., Liu, D., Meng, W., Zhang, W., Zhang, X., Shen, X., Sun, Q., Li, L., Ma, C., Wei, Y., Billadeau, D. D., Mo, X. & 1 others, Jia, D., Nov 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 45, p. 22598-22608 11 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositols
trans-Golgi Network
Mutation
Pons
Endosomes

Survival and prognostic factors in patients with pancreatic squamous cell carcinoma

Tella, S. H., Kommalapati, A., Yadav, S., Bergquist, J. R., Truty, M., Durgin, L., Ma, W. W., Cleary, S. P., Mc Williams, R. R. & Mahipal, A., Jan 1 2019, In : European Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Survival
Neoplasms
Drug Therapy
Survival Analysis
1 Citation (Scopus)

Targeting glycogen synthase kinase 3 for therapeutic benefit in lymphoma

Wu, X., Stenson, M., Abeykoon, J., Nowakowski, K., Zhang, L., Lawson, J., Wellik, L., Li, Y., Krull, J., Wenzl, K., Novak, A. J., Ansell, S. M., Bishop, G. A., Billadeau, D. D., Peng, K. W., Giles, F., Schmitt, D. M. & Witzig, T. E., Jul 25 2019, In : Blood. 134, 4, p. 363-373 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Lymphoma
Therapeutics
B-Lymphocytes
Clustered Regularly Interspaced Short Palindromic Repeats
2 Citations (Scopus)

The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome

Lee, S. B., Kim, J. J., Han, S. A., Fan, Y., Guo, L. S., Aziz, K., Nowsheen, S., Kim, S. S., Park, S. Y., Luo, Q., Chung, J. O., Choi, S. I., Aziz, A., Yin, P., Tong, S. Y., Fiesel, F., Springer, W., Zhang, J. S. & Lou, Z., Aug 1 2019, In : Nature Cell Biology. 21, 8, p. 940-951 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Inflammation
Receptor-Interacting Protein Serine-Threonine Kinases
AMP-Activated Protein Kinases
Ubiquitin-Protein Ligases

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jäckstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., Dekker, D., Kloosterhuis, N., van Dijk, T. H., Billadeau, D. D., Kuipers, F., Klumperman, J., von Eckardstein, A., Kuivenhoven, J. A. & van de Sluis, B., Jun 6 2019, In : JCI Insight. 4, 11, :e126462 .

Research output: Contribution to journalArticle

Open Access
Wiskott-Aldrich Syndrome Protein
LDL Cholesterol
HDL Cholesterol
LDL Receptors
Liver
1 Citation (Scopus)

The molecular origin and taxonomy of mucinous ovarian carcinoma

Cheasley, D., Wakefield, M. J., Ryland, G. L., Allan, P. E., Alsop, K., Amarasinghe, K. C., Ananda, S., Anglesio, M. S., Au-Yeung, G., Böhm, M., Bowtell, D. D. L., Brand, A., Chenevix-Trench, G., Christie, M., Chiew, Y. E., Churchman, M., DeFazio, A., Demeo, R., Dudley, R., Fairweather, N. & 44 others, Fedele, C. G., Fereday, S., Fox, S. B., Gilks, C. B., Gourley, C., Hacker, N. F., Hadley, A. M., Hendley, J., Ho, G. Y., Hughes, S., Hunstman, D. G., Hunter, S. M., Jobling, T. W., Kalli, K. R., Kaufmann, S. H., Kennedy, C. J., Köbel, M., Le Page, C., Li, J., Lupat, R., McNally, O. M., McAlpine, J. N., Mes-Masson, A. M., Mileshkin, L., Provencher, D. M., Pyman, J., Rahimi, K., Rowley, S. M., Salazar, C., Samimi, G., Saunders, H., Semple, T., Sharma, R., Sharpe, A. J., Stephens, A. N., Thio, N., Torres, M. C., Traficante, N., Xing, Z., Zethoven, M., Antill, Y. C., Scott, C. L., Campbell, I. G. & Gorringe, K. L., Dec 1 2019, In : Nature communications. 10, 1, 3935.

Research output: Contribution to journalArticle

Open Access
taxonomy
Mucinous Adenocarcinoma
Taxonomies
Tumors
cancer
1 Citation (Scopus)

The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., Hitosugi, T. & 1 others, Sun, J., Sep 17 2019, In : Immunity. 51, 3, p. 491-507.e7

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Transcription Factors
T-Lymphocytes
Epigenomics
Immunotherapy
2 Citations (Scopus)

Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells

Generous, A. R., Harrison, O. J., Troyanovsky, R. B., Mateo, M., Navaratnarajah, C. K., Donohue, R. C., Pfaller, C. K., Alekhina, O., Sergeeva, A. P., Indra, I., Thornburg, T., Kochetkova, I., Billadeau, D. D., Taylor, M. P., Troyanovsky, S. M., Honig, B., Shapiro, L. & Cattaneo, R., Aug 23 2019, In : Journal of cell science. 132, 16

Research output: Contribution to journalArticle

Open Access
Endocytosis
Measles virus
nectins
Cytoplasm
Epithelial Cells
26 Citations (Scopus)

Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis

Wang, Y., Zhou, S., Yang, F., Qi, X., Wang, X., Guan, X., Shen, C., Duma, N., Vera Aguilera, J., Chintakuntlawar, A., Price, K. A., Molina, J. R., Pagliaro, L. C., Halfdanarson, T. R., Grothey, A. F., Markovic, S. N., Nowakowski, G. S., Ansell, S. M. & Wang, M. L., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

CD274 Antigen
Meta-Analysis
Clinical Trials
Incidence
Odds Ratio
6 Citations (Scopus)

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
ataxia
Ataxia Telangiectasia
Ligases
Histones
Chemical activation

Using Genomics to Differentiate Multiple Primaries From Metastatic Lung Cancer

Murphy, S. J., Harris, F. R., Kosari, F., Barreto Siqueira Parrilha Terra, S., Nasir, A., Johnson, S. H., Serla, V., Smadbeck, J., Halling, G. C., Karagouga, G., Sukov, W. R., Leventakos, K., Yang, P., Peikert, T. D., Mansfield, A., Wigle, D. A., Yi, E. S., Kipp, B. R., Vasmatzis, G. & Aubry, M. C., Jan 1 2019, In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Open Access
Genomics
Lung Neoplasms
Neoplasms
DNA
Histology
2 Citations (Scopus)

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

Wu, J., Chen, Y., Geng, G., Li, L., Yin, P., Nowsheen, S., Li, Y., Wu, C., Liu, J., Zhao, F., Kim, W., Zhou, Q., Huang, J., Guo, G., Zhang, C., Tu, X., Gao, X., Lou, Z., Luo, K., Qiao, H. & 1 others, Yuan, J., May 1 2019, In : Cancer Letters. 449, p. 114-124 11 p.

Research output: Contribution to journalArticle

Checkpoint Kinase 2
DNA Damage
Radiation
Apoptosis
Protein-Serine-Threonine Kinases

WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis

Tsarouhas, V., Liu, D., Tsikala, G., Fedoseienko, A., Zinn, K., Matsuda, R., Billadeau, D. D. & Samakovlis, C., Dec 1 2019, In : Nature communications. 10, 1, 2193.

Research output: Contribution to journalArticle

Open Access
phosphorylation
Phosphorylation
Morphogenesis
integrity
Actins
3 Citations (Scopus)

WASH regulates glucose homeostasis by facilitating Glut2 receptor recycling in pancreatic β-cells

Ding, L., Han, L., Dube, J. & Billadeau, D. D., Feb 1 2019, In : Diabetes. 68, 2, p. 377-386 10 p.

Research output: Contribution to journalArticle

Homeostasis
Glucose
Pancreas
Wiskott-Aldrich Syndrome Protein
Actin-Related Protein 2-3 Complex

X-Linked Lymphoproliferative Syndrome Presenting as Adult-Onset Multi-Infarct Dementia

Blackburn, P. R., Lin, W. L., Miller, D. A., Lorenzo-Betancor, O., Edwards, E. S., Zimmermann, M. T., Farrugia, L. P., Freeman, W. D., Soto, A. I., Walton, R. L., Klee, E. W., Atwal, P. S., Abraham, R. S., Billadeau, D. D., Ross, O. A., Dickson, D. W. & Meschia, J. F., May 1 2019, In : Journal of neuropathology and experimental neurology. 78, 5, p. 460-466 7 p.

Research output: Contribution to journalArticle

Multi-Infarct Dementia
Lymphoproliferative Disorders
Siblings
Central Nervous System Vasculitis
Exome