Zika Vaccine Development: Current Status

Gregory A. Poland, Inna G. Ovsyannikova, Richard B. Kennedy

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Zika virus outbreaks have been explosive and unpredictable and have led to significant adverse health effects—as well as considerable public anxiety. Significant scientific work has resulted in multiple candidate vaccines that are now undergoing further clinical development, with several vaccines now in phase 2 clinical trials. In this review, we survey current vaccine efforts, preclinical and clinical results, and ethical and other concerns that directly bear on vaccine development. It is clear that the world needs safe and effective vaccines to protect against Zika virus infection. Whether such vaccines can be developed through to licensure and public availability absent significant financial investment by countries, and other barriers discussed within this article, remains uncertain.

Original languageEnglish (US)
Pages (from-to)2572-2586
Number of pages15
JournalMayo Clinic proceedings
Volume94
Issue number12
DOIs
StatePublished - Dec 2019

ASJC Scopus subject areas

  • Medicine(all)

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