Xenopus frizzled-5

A frizzled family member expressed exclusively in the neural retina of the developing eye

Saulius Sumanas, Stephen C Ekker

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalMechanisms of Development
Volume103
Issue number1-2
DOIs
StatePublished - May 2001
Externally publishedYes

Fingerprint

Xenopus
Retina
Wnt Receptors
Xenopus laevis
In Situ Hybridization
Larva

Keywords

  • Ciliary marginal zone
  • Expression
  • Eye
  • Frizzled
  • Neural
  • Retina
  • Wnt
  • Xenopus laevis

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Xenopus frizzled-5 : A frizzled family member expressed exclusively in the neural retina of the developing eye. / Sumanas, Saulius; Ekker, Stephen C.

In: Mechanisms of Development, Vol. 103, No. 1-2, 05.2001, p. 133-136.

Research output: Contribution to journalArticle

@article{1e5669e4d56e469cbe7f7df0dbb2c01e,
title = "Xenopus frizzled-5: A frizzled family member expressed exclusively in the neural retina of the developing eye",
abstract = "We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.",
keywords = "Ciliary marginal zone, Expression, Eye, Frizzled, Neural, Retina, Wnt, Xenopus laevis",
author = "Saulius Sumanas and Ekker, {Stephen C}",
year = "2001",
month = "5",
doi = "10.1016/S0925-4773(01)00327-6",
language = "English (US)",
volume = "103",
pages = "133--136",
journal = "Mechanisms of Development",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Xenopus frizzled-5

T2 - A frizzled family member expressed exclusively in the neural retina of the developing eye

AU - Sumanas, Saulius

AU - Ekker, Stephen C

PY - 2001/5

Y1 - 2001/5

N2 - We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.

AB - We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.

KW - Ciliary marginal zone

KW - Expression

KW - Eye

KW - Frizzled

KW - Neural

KW - Retina

KW - Wnt

KW - Xenopus laevis

UR - http://www.scopus.com/inward/record.url?scp=0034999197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034999197&partnerID=8YFLogxK

U2 - 10.1016/S0925-4773(01)00327-6

DO - 10.1016/S0925-4773(01)00327-6

M3 - Article

VL - 103

SP - 133

EP - 136

JO - Mechanisms of Development

JF - Mechanisms of Development

SN - 0925-4773

IS - 1-2

ER -