Abstract
We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-136 |
| Number of pages | 4 |
| Journal | Mechanisms of Development |
| Volume | 103 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 2001 |
Keywords
- Ciliary marginal zone
- Expression
- Eye
- Frizzled
- Neural
- Retina
- Wnt
- Xenopus laevis
ASJC Scopus subject areas
- Embryology
- Developmental Biology