Xenopus frizzled-5: A frizzled family member expressed exclusively in the neural retina of the developing eye

Saulius Sumanas, Stephen C Ekker

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalMechanisms of Development
Volume103
Issue number1-2
DOIs
StatePublished - May 2001
Externally publishedYes

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Keywords

  • Ciliary marginal zone
  • Expression
  • Eye
  • Frizzled
  • Neural
  • Retina
  • Wnt
  • Xenopus laevis

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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