Wnt signaling in neuropsychiatric disorders: Ties with adult hippocampal neurogenesis and behavior

Syed Mohammed Qasim Hussaini, Chan Il Choi, Chang Hoon Cho, Hyo Jin Kim, Heechul Jun, Mi Hyeon Jang

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

In an effort to better understand and treat mental disorders, the Wnt pathway and adult hippocampal neurogenesis have received increased attention in recent years. One is a signaling pathway regulating key aspects of embryonic patterning, cell specification and adult tissue homeostasis. The other is the generation of newborn neurons in adulthood that integrate into the neural circuit and function in learning and memory, and mood behavior. In this review, we discuss the growing relationship between Wnt signaling-mediated regulation of adult hippocampal neurogenesis as it applies to neuropsychiatric disorders. Evidence suggests dysfunctional Wnt signaling may aberrantly regulate new neuron development and cognitive function. Indeed, altered expression of key Wnt pathway components are observed in the hippocampus of patients suffering from neuropsychiatric disorders. Clinically-utilized mood stabilizers also proceed through modulation of Wnt signaling in the hippocampus, while Wnt pathway antagonists can regulate the antidepressant response. Here, we review the role of Wnt signaling in disease etiology and pathogenesis, regulation of adult neurogenesis and behavior, and the therapeutic targeting of disease symptoms.

Original languageEnglish (US)
Pages (from-to)369-383
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume47
DOIs
StatePublished - 2014

Keywords

  • Adult neurogenesis
  • Hippocampus
  • Psychiatric disorders
  • Wnt signaling

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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