Whole genome sequencing–based copy number variations reveal novel pathways and targets in Alzheimer's disease

Chen Ming, Minghui Wang, Qian Wang, Ryan Neff, Erming Wang, Qi Shen, Joseph S. Reddy, Xue Wang, Mariet Allen, Nilüfer Ertekin-Taner, Philip L. De Jager, David A. Bennett, Vahram Haroutunian, Eric Schadt, Bin Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: A few copy number variations (CNVs) have been reported for Alzheimer's disease (AD). However, there is a lack of a systematic investigation of CNVs in AD based on whole genome sequencing (WGS) data. Methods: We used four methods to identify consensus CNVs from the WGS data of 1,411 individuals and further investigated their functional roles in AD using the matched transcriptomic and clinicopathological data. Results: We identified 3,012 rare AD-specific CNVs whose residing genes are enriched for cellular glucuronidation and neuron projection pathways. Genes whose mRNA expressions are significantly correlated with common CNVs are involved in major histocompatibility complex class II receptor activity. Integration of CNVs, gene expression, and clinical and pathological traits further pinpoints a key CNV that potentially regulates immune response in AD. Discussion: We identify CNVs as potential genetic regulators of immune response in AD. The identified CNVs and their downstream gene networks reveal novel pathways and targets for AD.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2021

Keywords

  • Alzheimer's disease
  • copy number variation
  • correlation network
  • immune response
  • late-onset Alzheimer's disease
  • multi-omics integration
  • regulation of response to external stimulus
  • whole genomic sequencing

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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