Whole genome approaches in ischemic stroke

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background and Purpose - The field of ischemic stroke genetics is moving beyond candidate gene studies into the realm of genomewide association studies. Such studies have resulted in discoveries in diverse, complex disorders. Methods - The author conducted an informal qualitative review of peer-reviewed medical literature. Results - The power of genomewide association studies to confirm prior associations and establish new ones is illustrated by recent work focusing on type 2 diabetes mellitus. A pilot genomewide association study of ischemic stroke failed to identify a single gene of major effect. Conclusions - Follow-up studies with substantially greater statistical power are essential and are being planned by the Wellcome Trust and others.

Original languageEnglish (US)
Pages (from-to)S61-S63
JournalStroke
Volume40
Issue number3 SUPPL. 1
DOIs
StatePublished - Mar 2009

Keywords

  • Consesus data elements
  • Ischemia
  • Whole genome

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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