White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging

Mary M. Machulda; Emily S. Lundt; Carly T. Mester; Sabrina M. Albertson; Sheelakumari Raghavan; Robert I. Reid; Christopher G. Schwarz; Jonathan Graff-Radford; Clifford R. Jack; David S. Knopman; Michelle M. Mielke; Walter K. Kremers; Ronald C. Petersen; Mark W. Bondi; Prashanthi Vemuri

doi:10.1002/dad2.12269

White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging

Mary M. Machulda, Emily S. Lundt, Carly T. Mester, Sabrina M. Albertson, Sheelakumari Raghavan, Robert I. Reid, Christopher G. Schwarz, Jonathan Graff-Radford, Clifford R. Jack, David S. Knopman, Michelle M. Mielke, Walter K. Kremers, Ronald C. Petersen, Mark W. Bondi, Prashanthi Vemuri

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes. Methods: We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster-derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging. Results: Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive impairment. There was widespread WM degeneration in long association and commissural fibers in the amnestic, dysnomic, and dysexecutive subtypes, and corpus callosum FA accounted for significant variability in global cognition. Discussion: White matter changes likely contribute to cognitive symptoms in incident MCI.

Original language	English (US)
Article number	e12269
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12269
State	Published - 2021

Keywords

cluster analysis
cognition
diffusion tensor imaging
fractional anisotropy
mild cognitive impairment
white matter hyperintensities

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1002/dad2.12269

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Machulda, M. M., Lundt, E. S., Mester, C. T., Albertson, S. M., Raghavan, S., Reid, R. I., Schwarz, C. G., Graff-Radford, J., Jack, C. R., Knopman, D. S., Mielke, M. M., Kremers, W. K., Petersen, R. C., Bondi, M. W., & Vemuri, P. (2021). White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article e12269. https://doi.org/10.1002/dad2.12269

Machulda, MM, Lundt, ES, Mester, CT, Albertson, SM, Raghavan, S, Reid, RI, Schwarz, CG , Graff-Radford, J , Jack, CR , Knopman, DS, Mielke, MM, Kremers, WK , Petersen, RC, Bondi, MW & Vemuri, P 2021, 'White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 13, no. 1, e12269. https://doi.org/10.1002/dad2.12269

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abstract = "Introduction: The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes. Methods: We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster-derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging. Results: Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive impairment. There was widespread WM degeneration in long association and commissural fibers in the amnestic, dysnomic, and dysexecutive subtypes, and corpus callosum FA accounted for significant variability in global cognition. Discussion: White matter changes likely contribute to cognitive symptoms in incident MCI.",

keywords = "cluster analysis, cognition, diffusion tensor imaging, fractional anisotropy, mild cognitive impairment, white matter hyperintensities",

author = "Machulda, {Mary M.} and Lundt, {Emily S.} and Mester, {Carly T.} and Albertson, {Sabrina M.} and Sheelakumari Raghavan and Reid, {Robert I.} and Schwarz, {Christopher G.} and Jonathan Graff-Radford and Jack, {Clifford R.} and Knopman, {David S.} and Mielke, {Michelle M.} and Kremers, {Walter K.} and Petersen, {Ronald C.} and Bondi, {Mark W.} and Prashanthi Vemuri",

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year = "2021",

doi = "10.1002/dad2.12269",

language = "English (US)",

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AU - Machulda, Mary M.

AU - Lundt, Emily S.

AU - Mester, Carly T.

AU - Albertson, Sabrina M.

AU - Raghavan, Sheelakumari

AU - Reid, Robert I.

AU - Schwarz, Christopher G.

AU - Graff-Radford, Jonathan

AU - Jack, Clifford R.

AU - Knopman, David S.

AU - Mielke, Michelle M.

AU - Kremers, Walter K.

AU - Petersen, Ronald C.

AU - Bondi, Mark W.

AU - Vemuri, Prashanthi

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N2 - Introduction: The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes. Methods: We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster-derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging. Results: Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive impairment. There was widespread WM degeneration in long association and commissural fibers in the amnestic, dysnomic, and dysexecutive subtypes, and corpus callosum FA accounted for significant variability in global cognition. Discussion: White matter changes likely contribute to cognitive symptoms in incident MCI.

AB - Introduction: The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes. Methods: We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster-derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging. Results: Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive impairment. There was widespread WM degeneration in long association and commissural fibers in the amnestic, dysnomic, and dysexecutive subtypes, and corpus callosum FA accounted for significant variability in global cognition. Discussion: White matter changes likely contribute to cognitive symptoms in incident MCI.

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White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging

Abstract

Keywords

ASJC Scopus subject areas

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