@article{e8bbbdcf82bf45aca63cd8e509a41e0e,
title = "White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging",
abstract = "Introduction: The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes. Methods: We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster-derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging. Results: Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive impairment. There was widespread WM degeneration in long association and commissural fibers in the amnestic, dysnomic, and dysexecutive subtypes, and corpus callosum FA accounted for significant variability in global cognition. Discussion: White matter changes likely contribute to cognitive symptoms in incident MCI.",
keywords = "cluster analysis, cognition, diffusion tensor imaging, fractional anisotropy, mild cognitive impairment, white matter hyperintensities",
author = "Machulda, {Mary M.} and Lundt, {Emily S.} and Mester, {Carly T.} and Albertson, {Sabrina M.} and Sheelakumari Raghavan and Reid, {Robert I.} and Schwarz, {Christopher G.} and Jonathan Graff-Radford and Jack, {Clifford R.} and Knopman, {David S.} and Mielke, {Michelle M.} and Kremers, {Walter K.} and Petersen, {Ronald C.} and Bondi, {Mark W.} and Prashanthi Vemuri",
note = "Funding Information: Mary M. Machulda: receives funding from the NIH. Emily S. Lundt, Sabrina M. Albertson, Carly T. Mester, Sheelakumari Raghavan, and Robert I. Reid: no disclosures. Christopher G. Schwarz: receives funding from the NIH. Jonathan Graff‐Radford: receives funding from the NIH. He serves as assistant editor for . Clifford R. Jack Jr: receives funding from the NIH. Has consulted for Biogen, served as a speaker for Eisai and serves on an independent data monitoring board for Roche but receives no personal compensation from any commercial entity. Michelle M. Mielke: receives funding from NIH and DOD. Has consulted for Biogen and Brain Protection Company. Walter K. Kremers: has had research funding from NIH, DOD, Biogen, AstraZeneca, and Roche. David S. Knopman: has served on a data safety monitoring board for the DIAN study. He serves on a data safety monitoring board for a tau therapeutic for Biogen, but receives no personal compensation. He is a site investigator in the Biogen aducanumab trials. He is an investigator in a clinical trials sponsored by Lilly Pharmaceuticals and the University of Southern California. He serves as a consultant for Samus Therapeutics, Third Rock, Roche, and Alzeca Biosciences but receives no personal compensation. He receives research support from the NIH. Ronald C. Petersen: consultant for Roche, Inc., Biogen, Inc., Eisai, Inc.; served on a DSMB for Genentech, Inc.; and receives funding from NIH. Mark W. Bondi: receives funding from the NIH. Receives royalties from Oxford University Press. Prashanthi Vemuri: Receives funding from the NIH. Neurology Funding Information: The authors wish to thank the participants and staff at the Mayo Clinic Study of Aging. This research was made possible by the National Institutes of Health R01 AG49810, R37 AG011378, RO1 AG041851, R01 AG056366, R01 NS097495, U01 AG006786, R01 AG034676, P30 AG062677, Alexander Family Professorship of Alzheimer's Disease Research, The Elsie and Marvin Dekelboum Family Foundation, The GHR Foundation, The Robert Wood Johnson Foundation, and by the Mayo Foundation for Education and Research. Funding Information: The authors wish to thank the participants and staff at the Mayo Clinic Study of Aging. This research was made possible by the National Institutes of Health R01 AG49810, R37 AG011378, RO1 AG041851, R01 AG056366, R01 NS097495, U01 AG006786, R01 AG034676, P30 AG062677, Alexander Family Professorship of Alzheimer's Disease Research, The Elsie and Marvin Dekelboum Family Foundation, The GHR Foundation, The Robert Wood Johnson Foundation, and by the Mayo Foundation for Education and Research. Publisher Copyright: {\textcopyright} 2021 The Authors.",
year = "2021",
doi = "10.1002/dad2.12269",
language = "English (US)",
volume = "13",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "1",
}