White blood cell telomerase activity and incident respiratory illness among community-dwelling elderly vaccinated against seasonal influenza

P. V. Targonski, C. R. Caldwell, M. Strausbauch, P. Wettstein, G. A. Poland, E. G. Tangalos

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Immune cell telomerase activity may impact vaccine response in the elderly. Fifty persons aged 60-100 years were tested for post-influenza vaccination telomerase RNA expression (TERT) in peripheral blood mononuclear cells to assess for an association with influenza antibody levels and influenza-like illness or incident respiratory infection (IRI) in the year following vaccination. High rates of seroprotective influenza antibody (≥1:40 titers) were observed post-vaccination (86-92% to vaccine viral strains), with no association to TERT. No IRI occurred among persons in the top quartile of TERT expression, whereas the IRI rate was 33% in the lower three quartiles (Kaplan-Meier P=0.028). TERT expression was also IRI significantly higher in those who did not experience IRI than those who did in the follow-up period (0.845 vs. 0.301, P=0.024). These data suggest that telomerase expression may correlate with immune capacity for vaccine response in the elderly and could represent a target for recognizing risk for vaccine failure.

Original languageEnglish (US)
Pages (from-to)694-699
Number of pages6
JournalClinical pharmacology and therapeutics
Volume82
Issue number6
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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