Which factors affect survival in patients with upper limb osteosarcoma?

David J. Restrepo, Maria T. Huayllani, Daniel Boczar, Andrea Sisti, Aaron C. Spaulding, Rickey E. Carter, Steven L. Moran, Alexander S. Parker, Galen Perdikis, Antonio Jorge Forte

Research output: Contribution to journalArticle

Abstract

Aim: The purpose of this study was to identify patient-, facility-, disease-, and treatment-specific characteristics that increase mortality in patients with upper limb osteosarcoma. Patients and Methods: The National Cancer Data Base (NCDB) was queried for bone cancer. With Cox regression, the demographic, facility, tumor-specific and treatment characteristics were analyzed to identify factors that increased mortality. Results: Cox regression model showed that patients older than 40 years had a significantly higher likelihood of dying from upper limb osteosarcoma than those aged 0-14 years [hazard ratio (HR)=4.12, 95% confidence interval (CI)=2.261-7.508]. Patients with an income of $38,000-47,999 (HR=3.335, 95%CI=1.694-657) or less than $38,000 (HR=2.41, 95%CI=1.098-5.288) were also at greater risk of dying from their tumor. Patients who received radiation therapy (HR=2.457, 95%CI=1.056-5.717) had a higher likelihood of dying than patients who did not undergo this therapy. Conclusion: Age, gender, income, education, stage at diagnosis, radiation therapy and type of surgery seem to increase mortality from upper limb osteosarcoma.

Original languageEnglish (US)
Pages (from-to)5027-5031
Number of pages5
JournalAnticancer research
Volume39
Issue number9
DOIs
StatePublished - 2019

Keywords

  • Osteosarcoma
  • Survival
  • Survivors
  • Treatment
  • Upper limb

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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