Which endoneurial microvessel histologic measurements are least influenced by vasomotor tone?

Angelo E. Schenone, Peter J Dyck

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The thickness and area of rat sciatic endoneurial microvessel components (endothelial cells, basement membranes and wall) were assessed to test whether collapse or vasoconstriction was typical of immersion (I) as compared to perfusion (P) or in situ (S) fixation and to determine whether area, but not thickness, would be unaffected by collapse of vasoconstriction. In S and in P fixation there was no apparent collapse or vasoconstriction; in fact, none of the measurements were significantly different between themselves except for index of circularity (IC), which was a little lower in S than in P fixation. By contrast to S or P, in I fixation, the lumen was much smaller and more irregular and the wall was thicker. Area of wall (and of its components) was not significantly different among I, P or S fixation, but thickness was significantly greater in I than in P or S fixation. For comparison to such properties of vessels as permeability, thickness may be the appropriate measurement, but for other purposes, such as determining the amount of basement membrane in diabetes mellitus, area may be a better measurement as it is less affected by collapse or vasoconstriction.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalBrain Research
Volume402
Issue number1
DOIs
StatePublished - Jan 27 1987

Fingerprint

Microvessels
Vasoconstriction
Basement Membrane
Immersion
Cell Wall
Permeability
Diabetes Mellitus
Endothelial Cells
Perfusion
Cell Membrane

Keywords

  • Basement membrane
  • Endoneurial microvessel
  • Endothelial cell
  • Fixation
  • Histologic measurement
  • Ultrastructure
  • Vasomotor tone

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Which endoneurial microvessel histologic measurements are least influenced by vasomotor tone? / Schenone, Angelo E.; Dyck, Peter J.

In: Brain Research, Vol. 402, No. 1, 27.01.1987, p. 151-154.

Research output: Contribution to journalArticle

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