Which endoneurial microvessel histologic measurements are least influenced by vasomotor tone?

Angelo E. Schenone, Peter James Dyck

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The thickness and area of rat sciatic endoneurial microvessel components (endothelial cells, basement membranes and wall) were assessed to test whether collapse or vasoconstriction was typical of immersion (I) as compared to perfusion (P) or in situ (S) fixation and to determine whether area, but not thickness, would be unaffected by collapse of vasoconstriction. In S and in P fixation there was no apparent collapse or vasoconstriction; in fact, none of the measurements were significantly different between themselves except for index of circularity (IC), which was a little lower in S than in P fixation. By contrast to S or P, in I fixation, the lumen was much smaller and more irregular and the wall was thicker. Area of wall (and of its components) was not significantly different among I, P or S fixation, but thickness was significantly greater in I than in P or S fixation. For comparison to such properties of vessels as permeability, thickness may be the appropriate measurement, but for other purposes, such as determining the amount of basement membrane in diabetes mellitus, area may be a better measurement as it is less affected by collapse or vasoconstriction.

Original languageEnglish (US)
Pages (from-to)151-154
Number of pages4
JournalBrain Research
Volume402
Issue number1
DOIs
StatePublished - Jan 27 1987

Keywords

  • Basement membrane
  • Endoneurial microvessel
  • Endothelial cell
  • Fixation
  • Histologic measurement
  • Ultrastructure
  • Vasomotor tone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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