What comes first: Translational repression or mRNA degradation? the deepening mystery of microRNA function

Wengian Hu, Jeff Coller

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

While many mechanisms have been proposed for microRNAs (miRNAs) function, most ultimately cause message degradation. A view has emerged that miRNAs silence gene expression by promoting the association of mRNA decay factors. Recent research results, however, suggest that in both zebrafish and fruit fly, translational inhibition is the initiating event of miRNA-mediated gene silencing.

Original languageEnglish (US)
Pages (from-to)1322-1324
Number of pages3
JournalCell Research
Volume22
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

RNA Stability
MicroRNAs
Gene Silencing
Zebrafish
Diptera
Fruit
Gene Expression
Research

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

What comes first : Translational repression or mRNA degradation? the deepening mystery of microRNA function. / Hu, Wengian; Coller, Jeff.

In: Cell Research, Vol. 22, No. 9, 09.2012, p. 1322-1324.

Research output: Contribution to journalArticle

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