TY - JOUR
T1 - Weight, Height, and Body Mass Index and Risk for Ovarian Cancer in a Cohort Study
AU - Lacey, James V.
AU - Leitzmann, Michael
AU - Brinton, Louise A.
AU - Lubin, Jay H.
AU - Sherman, Mark E.
AU - Schatzkin, Arthur
AU - Schairer, Catherine
N1 - Funding Information:
Supported by National Cancer Institute intramural funds.
PY - 2006/12
Y1 - 2006/12
N2 - Purpose: Reported associations between ovarian cancer and body size are inconsistent. We assessed ovarian cancer and anthropometry in the Breast Cancer Detection Demonstration Project Follow-Up Study. Methods: The 46,026 participants completed a baseline interview and mailed questionnaires between 1979 and 1998. By using multiple sources, we identified 346 incident ovarian cancers during follow-up. We calculated rate ratios (RRs) and 95% confidence intervals (CIs) to estimate relative risks for developing ovarian cancer associated with height and weight (measured 1973 to 1980) and self-reported current and usual adult weight (collected during follow-up). Results: Neither taller height (≥66 versus <62 inches; RR, 0.90; 95% CI, 0.64-1.26) nor greater weight (≥161 versus ≤120 lbs; RR, 1.09; 95% CI, 0.77-1.55) was associated with ovarian cancer. Compared with normal weight (body mass index [BMI], 18.5 to 24.9 kg/m2), overweight (BMI, 25 to 29.9 kg/m2; RR, 1.00; 95% CI, 0.78-1.29) and obesity (BMI, 30 to 34.9 kg/m2; RR, 0.94; 95% CI, 0.59-1.48) were not associated with ovarian cancer. Severe obesity (BMI ≥ 35 kg/m2) produced a nonsignificantly elevated RR (1.55; 95% CI, 0.84-2.84). Associations with histologic types and statistical interactions with menopausal status and hormone therapy use were null. Conclusions: Based on height and weight measured before baseline, overweight and obesity were not significantly associated with ovarian cancer in this cohort.
AB - Purpose: Reported associations between ovarian cancer and body size are inconsistent. We assessed ovarian cancer and anthropometry in the Breast Cancer Detection Demonstration Project Follow-Up Study. Methods: The 46,026 participants completed a baseline interview and mailed questionnaires between 1979 and 1998. By using multiple sources, we identified 346 incident ovarian cancers during follow-up. We calculated rate ratios (RRs) and 95% confidence intervals (CIs) to estimate relative risks for developing ovarian cancer associated with height and weight (measured 1973 to 1980) and self-reported current and usual adult weight (collected during follow-up). Results: Neither taller height (≥66 versus <62 inches; RR, 0.90; 95% CI, 0.64-1.26) nor greater weight (≥161 versus ≤120 lbs; RR, 1.09; 95% CI, 0.77-1.55) was associated with ovarian cancer. Compared with normal weight (body mass index [BMI], 18.5 to 24.9 kg/m2), overweight (BMI, 25 to 29.9 kg/m2; RR, 1.00; 95% CI, 0.78-1.29) and obesity (BMI, 30 to 34.9 kg/m2; RR, 0.94; 95% CI, 0.59-1.48) were not associated with ovarian cancer. Severe obesity (BMI ≥ 35 kg/m2) produced a nonsignificantly elevated RR (1.55; 95% CI, 0.84-2.84). Associations with histologic types and statistical interactions with menopausal status and hormone therapy use were null. Conclusions: Based on height and weight measured before baseline, overweight and obesity were not significantly associated with ovarian cancer in this cohort.
KW - Anthropometry
KW - Body Mass Index
KW - Obesity
KW - Ovarian Carcinoma
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U2 - 10.1016/j.annepidem.2006.07.011
DO - 10.1016/j.annepidem.2006.07.011
M3 - Article
C2 - 17027285
AN - SCOPUS:33845204509
SN - 1047-2797
VL - 16
SP - 869
EP - 876
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 12
ER -