Weight changes after hospitalization for worsening heart failure and subsequent re-hospitalization and mortality in the EVEREST trial

John E.A. Blair, Sadiya Khan, Marvin A. Konstam, Karl Swedberg, Faiez Zannad, John C. Burnett, Liliana Grinfeld, Aldo P. Maggioni, James E. Udelson, Christopher A. Zimmer, John Ouyang, Chien Feng Chen, Mihai Gheorghiade

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Aims increases in body weight (BW) are important determinants for hospitalization in ambulatory patients with heart failure (HF), but have not yet been explored in patients hospitalized for worsening HF. We explore the relationship between change in BW after hospitalization for worsening HF and risk for repeat hospitalization and mortality in the EVEREST trial.Methods and resultsThe EVEREST trial randomized 4133 patients hospitalized for worsening HF and low ejection fraction (≤40) to tolvaptan, a vasopressin antagonist, or placebo. Following discharge, BW was assessed at 1, 4, and 8 weeks, and every 8 weeks thereafter. A time-dependent Cox proportional Hazard model explored the relationship between change in BW at 60, 120, and 180 days from discharge and the risks of HF hospitalization, cardiovascular (CV) hospitalization, and all-cause mortality. For subjects re-hospitalized for heart failure at 60, 120, and 180 days after discharge, mean BW increase prior to the event was 1.96, 2.07, and 1.97 kg, respectively, compared with 0.74, 0.90, and 1.04 kg in patients without re-hospitalization (P < 0.001 all groups). A similar pattern was observed with CV hospitalization. However, increases in BW were not predictive of all-cause mortality.ConclusionIncreases in BW after hospitalization for worsening HF was predictive of repeat hospitalization events, but not mortality in the post-discharge period.

Original languageEnglish (US)
Pages (from-to)1666-1673
Number of pages8
JournalEuropean heart journal
Volume30
Issue number13
DOIs
StatePublished - Jul 2009

Keywords

  • Body weight
  • Heart failure hospitalizations
  • Outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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