Voltage-gated calcium channel γ2 subunit gene is not deleted in velo-cardio-facial syndrome

J. L. Black, L. E. Krahn, S. M. Jalal

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Velo-cardio-facial syndrome (VCFS) has been associated with schizophrenic symptoms in some patients and is caused by a deletion of 22q11.21-q11.23.1-4 The voltage-gated calcium channel (VGCC) γ2 subunit is located on chromosome 225 and is telemeric to the most commonly observed VCFS deletion region but is near a putative marker for schizophrenia (D22S278)6,7 Metaphase spreads of four controls, four patients with VCFS, and one patient with VCFS and schizophrenia were evaluated for the VCFS deletion using the VCFS-diagnostic probe, TUPLE 1, and for deletion of VGCC γ2 subunit gene using probes for that gene's exon 1 and exons 3 and 4.8 All of the VCFS patients had deletion of the TUPLE 1 probe on one chromosome of the chromosome 22 pair. None showed deletion of the γ2 subunit exons studied. The location of the γ2 subunit gene at 22q13.1 was confirmed by FISH in all cases. This study did not show a deletion of the γ2 subunit gene as a distinguishing feature of our patient with VCFS and schizophrenia.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalMolecular Psychiatry
Volume6
Issue number4
DOIs
StatePublished - Jul 4 2001

Keywords

  • Deletion
  • Linkage
  • Schizophrenia
  • Velo-cardio-facial syndrome
  • Voltage-gated calcium channel
  • γ2 subunit

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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