Vitamin D inhibits cox-2 expression and inflammatory response by targeting thioesterase superfamily member 4

Qingsong Wang; Yuhu He; Yujun Shen; Qianqian Zhang; Di Chen; Caojian Zuo; Jing Qin; Hui Wang; Junwen Wang; Ying Yu

doi:10.1074/jbc.M113.517581

Vitamin D inhibits cox-2 expression and inflammatory response by targeting thioesterase superfamily member 4

Qingsong Wang, Yuhu He, Yujun Shen, Qianqian Zhang, Di Chen, Caojian Zuo, Jing Qin, Hui Wang, Junwen Wang, Ying Yu

Research

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Background: Vitamin D insufficiency has been associated with chronic inflammatory diseases. However, the underlying mechanisms remain unclear. Results: Vitamin D inhibits COX-2-mediated inflammatory response by modulating the Akt/NF-_κB signaling pathway via direct up-regulation of thioesterase superfamily member 4. Conclusion: Vitamin D plays novel roles in anti-inflammation. Significance: Supplemental vitamin D could protect against chronic inflammatory diseases by targeting THEM4/Akt/NF-_κB signaling.

Original language	English (US)
Pages (from-to)	11681-11694
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M113.517581
State	Published - Apr 25 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.517581

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title = "Vitamin D inhibits cox-2 expression and inflammatory response by targeting thioesterase superfamily member 4",

abstract = "Background: Vitamin D insufficiency has been associated with chronic inflammatory diseases. However, the underlying mechanisms remain unclear. Results: Vitamin D inhibits COX-2-mediated inflammatory response by modulating the Akt/NF-κB signaling pathway via direct up-regulation of thioesterase superfamily member 4. Conclusion: Vitamin D plays novel roles in anti-inflammation. Significance: Supplemental vitamin D could protect against chronic inflammatory diseases by targeting THEM4/Akt/NF-κB signaling.",

author = "Qingsong Wang and Yuhu He and Yujun Shen and Qianqian Zhang and Di Chen and Caojian Zuo and Jing Qin and Hui Wang and Junwen Wang and Ying Yu",

year = "2014",

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doi = "10.1074/jbc.M113.517581",

language = "English (US)",

volume = "289",

pages = "11681--11694",

journal = "Journal of Biological Chemistry",

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T1 - Vitamin D inhibits cox-2 expression and inflammatory response by targeting thioesterase superfamily member 4

AU - Wang, Qingsong

AU - He, Yuhu

AU - Shen, Yujun

AU - Zhang, Qianqian

AU - Chen, Di

AU - Zuo, Caojian

AU - Qin, Jing

AU - Wang, Hui

AU - Wang, Junwen

AU - Yu, Ying

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: Vitamin D insufficiency has been associated with chronic inflammatory diseases. However, the underlying mechanisms remain unclear. Results: Vitamin D inhibits COX-2-mediated inflammatory response by modulating the Akt/NF-κB signaling pathway via direct up-regulation of thioesterase superfamily member 4. Conclusion: Vitamin D plays novel roles in anti-inflammation. Significance: Supplemental vitamin D could protect against chronic inflammatory diseases by targeting THEM4/Akt/NF-κB signaling.

AB - Background: Vitamin D insufficiency has been associated with chronic inflammatory diseases. However, the underlying mechanisms remain unclear. Results: Vitamin D inhibits COX-2-mediated inflammatory response by modulating the Akt/NF-κB signaling pathway via direct up-regulation of thioesterase superfamily member 4. Conclusion: Vitamin D plays novel roles in anti-inflammation. Significance: Supplemental vitamin D could protect against chronic inflammatory diseases by targeting THEM4/Akt/NF-κB signaling.

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SN - 0021-9258

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SP - 11681

EP - 11694

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 17

ER -

Vitamin D inhibits cox-2 expression and inflammatory response by targeting thioesterase superfamily member 4

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