Vitamin D inhibits cox-2 expression and inflammatory response by targeting thioesterase superfamily member 4

Qingsong Wang, Yuhu He, Yujun Shen, Qianqian Zhang, Di Chen, Caojian Zuo, Jing Qin, Hui Wang, Junwen Wang, Ying Yu

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Background: Vitamin D insufficiency has been associated with chronic inflammatory diseases. However, the underlying mechanisms remain unclear. Results: Vitamin D inhibits COX-2-mediated inflammatory response by modulating the Akt/NF-κB signaling pathway via direct up-regulation of thioesterase superfamily member 4. Conclusion: Vitamin D plays novel roles in anti-inflammation. Significance: Supplemental vitamin D could protect against chronic inflammatory diseases by targeting THEM4/Akt/NF-κB signaling.

Original languageEnglish (US)
Pages (from-to)11681-11694
Number of pages14
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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