Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series

Patrick M. Wieruszewski; Scott D. Nei; Simon Maltais; Hartzell V. Schaff; Erica D. Wittwer

doi:10.1213/XAA.0000000000000752

Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series

Patrick M. Wieruszewski, Scott D. Nei, Simon Maltais, Hartzell V. Schaff, Erica D. Wittwer

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.

Original language	English (US)
Pages (from-to)	96-99
Number of pages	4
Journal	A&A practice
Volume	11
Issue number	4
DOIs	https://doi.org/10.1213/XAA.0000000000000752
State	Published - Aug 15 2018

ASJC Scopus subject areas

General Medicine

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abstract = "Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.",

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Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series

Abstract

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