Vitamin C for Vasoplegia After Cardiopulmonary Bypass

A Case Series

Patrick M. Wieruszewski, Scott D. Nei, Simon Maltais, Hartzell V Schaff, Erica D. Wittwer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalA&A practice
Volume11
Issue number4
DOIs
StatePublished - Aug 15 2018
Externally publishedYes

Fingerprint

Vasoplegia
Cardiopulmonary Bypass
Ascorbic Acid
Norepinephrine
Vasopressins
Epinephrine
Thoracic Surgery
Catecholamines
Prospective Studies
Morbidity
Mortality
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vitamin C for Vasoplegia After Cardiopulmonary Bypass : A Case Series. / Wieruszewski, Patrick M.; Nei, Scott D.; Maltais, Simon; Schaff, Hartzell V; Wittwer, Erica D.

In: A&A practice, Vol. 11, No. 4, 15.08.2018, p. 96-99.

Research output: Contribution to journalArticle

Wieruszewski, Patrick M. ; Nei, Scott D. ; Maltais, Simon ; Schaff, Hartzell V ; Wittwer, Erica D. / Vitamin C for Vasoplegia After Cardiopulmonary Bypass : A Case Series. In: A&A practice. 2018 ; Vol. 11, No. 4. pp. 96-99.
@article{a596827f9af24e6d8c6ade763d7ee4f4,
title = "Vitamin C for Vasoplegia After Cardiopulmonary Bypass: A Case Series",
abstract = "Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.",
author = "Wieruszewski, {Patrick M.} and Nei, {Scott D.} and Simon Maltais and Schaff, {Hartzell V} and Wittwer, {Erica D.}",
year = "2018",
month = "8",
day = "15",
doi = "10.1213/XAA.0000000000000752",
language = "English (US)",
volume = "11",
pages = "96--99",
journal = "A&A practice",
issn = "2325-7237",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Vitamin C for Vasoplegia After Cardiopulmonary Bypass

T2 - A Case Series

AU - Wieruszewski, Patrick M.

AU - Nei, Scott D.

AU - Maltais, Simon

AU - Schaff, Hartzell V

AU - Wittwer, Erica D.

PY - 2018/8/15

Y1 - 2018/8/15

N2 - Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.

AB - Cardiac vasoplegia remains a significant contributor of morbidity and mortality in cardiac surgery patients after cardiopulmonary bypass. Effective therapeutic options for vasopressor-refractory vasoplegia are limited. We report 3 patients in whom we administered high-dose intravenous ascorbic acid (vitamin C), a cofactor for endogenous catecholamine synthesis, to treat vasoplegia refractory to epinephrine, vasopressin, and norepinephrine after surgery requiring cardiopulmonary bypass. Reductions in vasopressor requirements were observed in all 3 patients, and, in 2 patients, norepinephrine was completely discontinued within 24 hours. Ascorbic acid is a novel potential therapeutic option for cardiac vasoplegia that warrants rigorous prospective studies.

UR - http://www.scopus.com/inward/record.url?scp=85056409760&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056409760&partnerID=8YFLogxK

U2 - 10.1213/XAA.0000000000000752

DO - 10.1213/XAA.0000000000000752

M3 - Article

VL - 11

SP - 96

EP - 99

JO - A&A practice

JF - A&A practice

SN - 2325-7237

IS - 4

ER -