@inbook{339569bfe2f04686b15f218ef1abb48a,
title = "Virological and cellular roles of the transcriptional coactivator LEDGF/p75",
abstract = "The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.",
author = "Manuel Llano and James Morrison and Poeschla, {Eric M.}",
note = "Funding Information: We are grateful for support from N.I.H. grants 1SC2GM082301 to M. L. and AI77344 to E.M.P. We thank P. Spearman for editorial advice, and patience.",
year = "2009",
doi = "10.1007/978-3-642-02175-6_7",
language = "English (US)",
isbn = "9783642021749",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Verlag",
number = "1",
pages = "125--146",
booktitle = "HIV Interactions with Host Cell Proteins",
edition = "1",
}