Virological and cellular roles of the transcriptional coactivator LEDGF/p75

Manuel Llano, James Morrison, Eric M. Poeschla

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Scopus citations

Abstract

The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.

Original languageEnglish (US)
Title of host publicationHIV Interactions with Host Cell Proteins
EditorsPaul Spearman, Eric Freed
Pages125-146
Number of pages22
Edition1
DOIs
StatePublished - Dec 1 2009

Publication series

NameCurrent Topics in Microbiology and Immunology
Number1
Volume339
ISSN (Print)0070-217X

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Llano, M., Morrison, J., & Poeschla, E. M. (2009). Virological and cellular roles of the transcriptional coactivator LEDGF/p75. In P. Spearman, & E. Freed (Eds.), HIV Interactions with Host Cell Proteins (1 ed., pp. 125-146). (Current Topics in Microbiology and Immunology; Vol. 339, No. 1). https://doi.org/10.1007/978-3-642-02175-6-7