Vesicular Stomatitis Virus Encoding a Destabilized Tumor Antigen Improves Activation of Anti-tumor T Cell Responses

Amanda L. Huff, Laura Evgin, Jill Thompson, Tim Kottke, Christopher B. Driscoll, Jason Tonne, Phonphimon Wongthida, Matthew Schuelke, Kevin G. Shim, Georges Mer, Marina Ramirez-Alvarado, Richard Vile

Research output: Contribution to journalArticle

Abstract

Enhancing the activation of anti-tumor T cell responses is critical for improved treatment outcomes with cancer vaccines. Here, Huff and colleagues demonstrate that modulation of protein stability through structure-disrupting point mutations of a VSV-encoded tumor antigen enhances the activation of antigen-specific T cell responses and improves long-term survival benefit.

Original languageEnglish (US)
JournalMolecular Therapy
DOIs
StateAccepted/In press - 2020

Keywords

  • anti-tumor T cell response, oncolytic virus, viral immunotherapy
  • antigen presentation
  • protein degradation
  • vesicular stomatitis virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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