Vasoconstrictor activity of coronary sinus plasma from patients with coronary artery disease

Gabor M. Rubanyi, Robert L. Frye, David Holmes, Paul M. Vanhoutte

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Vasoactive properties of plasma samples taken from the coronary sinus, a systemic artery and the superior vena cava of 13 patients with angiographically proven coronary artery disease and from 5 patients with normal coronary arteriograms were assayed in vitro by measurement of the changes in tension of rings of isolated canine coronary arteries. Addition of 1 ml samples of platelet-rich plasma from the coronary sinus of patients with coronary artery disease into a 20 ml organ bath induced an initial relaxation followed by sustained constriction in bioassay coronary artery rings with endothelium and only vasoconstriction in rings without endothelium. The vasoconstrictor activity of the coronary sinus plasma showed positive correlation with the severity and extent of coronary artery narrowing. Systemic arterial and venous plasma samples from patients with coronary artery disease and the coronary sinus plasma from patients with no coronary artery disease evoked only endothelium-dependent relaxations. These vasoactive properties of the various plasma samples were similar whether the samples were taken during rest or during supine bicycle exercise. The serotoninergic receptor antagonist methiothepin prevented the vasoconstriction induced by the coronary sinus plasma samples. These data demonstrate that the coronary sinus blood of patients with atheromatous coronary artery disease exhibits vasoconstrictor activity that may be associated with 5-hydroxytryptamine (serotonin), presumably released from platelets.

Original languageEnglish (US)
Pages (from-to)1243-1249
Number of pages7
JournalJournal of the American College of Cardiology
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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