TY - JOUR
T1 - Vasculitis in patients with inflammatory bowel diseases
T2 - A study of 32 patients and systematic review of the literature
AU - Vasculitis Clinical Research Consortium(VCRC) and the Canadian Vasculitis Network(CanVasc)
AU - Sy, Alice
AU - Khalidi, Nader
AU - Dehghan, Natasha
AU - Barra, Lillian
AU - Carette, Simon
AU - Cuthbertson, David
AU - Hoffman, Gary S.
AU - Koening, Curry L.
AU - Langford, Carol A.
AU - McAlear, Carol
AU - Moreland, Larry
AU - Monach, Paul A.
AU - Seo, Philip
AU - Specks, Ulrich
AU - Sreih, Antoine
AU - Ytterberg, Steven R.
AU - Van Assche, Gert
AU - Merkel, Peter A.
AU - Pagnoux, Christian
N1 - Funding Information:
Financial support: Alice Sy was funded by the Abbott Summer studentship granted by the Canadian Rheumatology Association. The Vasculitis Clinical Research Consortium has received support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases , USA ( U54AR057319 and U01AR5187404 ), the National Center for Research Resources , USA ( U54RR019497 ), the Office of Rare Diseases Research, and the National Center for Advancing Translational Science , USA.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: Published small case series suggest that inflammatory bowel disease [IBD; Crohn's disease (CD) or ulcerative colitis (UC)] and vasculitis co-occur more frequently than would be expected by chance. Objectives: To describe this association by an analysis of a large cohort of carefully studied patients and through a systematic literature review. Methods: Patients with both IBD and vasculitis enrolled in the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Studies, followed in Canadian Vasculitis research network (CanVasc) centers and/or in the University of Toronto's IBD clinic were included in this case series. A systematic literature review of patients with IBD and vasculitis involved a PubMed search through February 2014. The main characteristics of patients with Takayasu arteritis (TAK) and IBD were compared to those in patients with TAK without IBD followed in the VCRC. Results: The study identified 32 patients with IBD and vasculitis: 13 with large-vessel vasculitis [LVV; 12 with TAK, 1 with giant cell arteritis (GCA); 8 with CD, 5 with UC]; 8 with ANCA-associated vasculitis [AAV; 6 granulomatosis with polyangiitis (GPA), 2 with eosinophilic granulomatosis with polyangiitis (EGPA)]; 5 with isolated cutaneous vasculitis; and 6 with other vasculitides. Patients with LVV and AAV were mostly female (18/21). The diagnosis of IBD preceded that of vasculitis in 12/13 patients with LVV and 8/8 patients with AAV. The review of the literature identified 306 patients with IBD and vasculitis: 144 with LVV (133 TAK; 87 with IBD preceding LVV), 19 with AAV [14 GPA, 1 EGPA, 4 microscopic polyangiitis (MPA)], 66 with isolated cutaneous vasculitis, and 77 with other vasculitides. Patients with IBD and TAK were younger and had more frequent headaches, constitutional symptoms, or gastrointestinal symptoms compared to those patients in the VCRC who had TAK without IBD. Conclusions: These findings highlight the risk of vasculitis, especially TAK, in patients with IBD (both CD and UC).
AB - Background: Published small case series suggest that inflammatory bowel disease [IBD; Crohn's disease (CD) or ulcerative colitis (UC)] and vasculitis co-occur more frequently than would be expected by chance. Objectives: To describe this association by an analysis of a large cohort of carefully studied patients and through a systematic literature review. Methods: Patients with both IBD and vasculitis enrolled in the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Studies, followed in Canadian Vasculitis research network (CanVasc) centers and/or in the University of Toronto's IBD clinic were included in this case series. A systematic literature review of patients with IBD and vasculitis involved a PubMed search through February 2014. The main characteristics of patients with Takayasu arteritis (TAK) and IBD were compared to those in patients with TAK without IBD followed in the VCRC. Results: The study identified 32 patients with IBD and vasculitis: 13 with large-vessel vasculitis [LVV; 12 with TAK, 1 with giant cell arteritis (GCA); 8 with CD, 5 with UC]; 8 with ANCA-associated vasculitis [AAV; 6 granulomatosis with polyangiitis (GPA), 2 with eosinophilic granulomatosis with polyangiitis (EGPA)]; 5 with isolated cutaneous vasculitis; and 6 with other vasculitides. Patients with LVV and AAV were mostly female (18/21). The diagnosis of IBD preceded that of vasculitis in 12/13 patients with LVV and 8/8 patients with AAV. The review of the literature identified 306 patients with IBD and vasculitis: 144 with LVV (133 TAK; 87 with IBD preceding LVV), 19 with AAV [14 GPA, 1 EGPA, 4 microscopic polyangiitis (MPA)], 66 with isolated cutaneous vasculitis, and 77 with other vasculitides. Patients with IBD and TAK were younger and had more frequent headaches, constitutional symptoms, or gastrointestinal symptoms compared to those patients in the VCRC who had TAK without IBD. Conclusions: These findings highlight the risk of vasculitis, especially TAK, in patients with IBD (both CD and UC).
KW - Crohn's disease
KW - Inflammatory bowel disease
KW - Takayasu arteritis
KW - Ulcerative colitis
KW - Vasculitis
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U2 - 10.1016/j.semarthrit.2015.07.006
DO - 10.1016/j.semarthrit.2015.07.006
M3 - Article
C2 - 26315859
AN - SCOPUS:84959535266
SN - 0049-0172
VL - 45
SP - 475
EP - 482
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
IS - 4
ER -