Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging

Bruce M. Buerk, Jose S Pulido, Ignacio Chiong, Robert Folberg, Deepak P. Edward, Mark T. Duffy, Keith R. Thulborn, James J. Augsburger, Gerhard W. Cibis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Because signal-to-noise performance improves with increased magnetic field strength, the quality of magnetic resonance images is greater at 3.0 tesla (T) than at 1.5 T. Because of the longer T1 values at higher field strength, intravenously administered magnetic resonance contrast agents provide improved T1 enhancement at 3.0 T. We have used these factors to obtain high-quality contrast-enhanced imaging of small intraocular lesions using a standard head radiofrequency volume coil. Specifically, we have examined lesion size and magnitude of maximum contrast enhancement in a series of intraocular melanomas before and during therapy. Methods: Eighteen patients with intraocular masses were examined by 3.0 T magnetic resonance imaging (MRI) including intravenous contrast enhancement. Precontrast images were acquired through the orbits followed by sequential postcontrast images at 1-minute intervals for 5 minutes. The magnitude of contrast enhancement of the lesion, extraocular muscles, and brain parenchyma was measured as a percentage increase in magnetic resonance signal over the preenhancement signal intensity. Results: Lesions demonstrated different levels of enhancement ranging up to 130%. Three patterns of enhancement - 0% to 20%, 20% to 50%, and >50% - were identified. Brain parenchyma, benign lesions, and responsive tumors following brachytherapy with 125I demonstrated enhancement of less than 20%. Four choroidal melanomas showed intermediate (20% to 50%) levels of enhancement. Four malignant lesions (three melanomas, one metastatic tumor), as well as the extraocular muscles, showed strong, rapid enhancement (>50%). Four patients who had MRI studies before and following plaque brachytherapy ultimately demonstrated a decline in the contrast enhancement following treatment. Conclusions: Contrast enhancement of intraocular lesions measured by 3.0 T MRI demonstrates different patterns of enhancement that may be useful for indicating the degree of malignancy and in monitoring response to therapy.

Original languageEnglish (US)
Pages (from-to)209-217
Number of pages9
JournalTransactions of the American Ophthalmological Society
Volume102
StatePublished - 2004
Externally publishedYes

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Oculomotor Muscles
Blood Vessels
Melanoma
Magnetic Resonance Spectroscopy
Perfusion
Brachytherapy
Magnetic Resonance Imaging
Neoplasms
Brain
Orbit
Magnetic Fields
Contrast Media
Noise
Therapeutics
Head

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Buerk, B. M., Pulido, J. S., Chiong, I., Folberg, R., Edward, D. P., Duffy, M. T., ... Cibis, G. W. (2004). Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging. Transactions of the American Ophthalmological Society, 102, 209-217.

Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging. / Buerk, Bruce M.; Pulido, Jose S; Chiong, Ignacio; Folberg, Robert; Edward, Deepak P.; Duffy, Mark T.; Thulborn, Keith R.; Augsburger, James J.; Cibis, Gerhard W.

In: Transactions of the American Ophthalmological Society, Vol. 102, 2004, p. 209-217.

Research output: Contribution to journalArticle

Buerk, BM, Pulido, JS, Chiong, I, Folberg, R, Edward, DP, Duffy, MT, Thulborn, KR, Augsburger, JJ & Cibis, GW 2004, 'Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging', Transactions of the American Ophthalmological Society, vol. 102, pp. 209-217.
Buerk, Bruce M. ; Pulido, Jose S ; Chiong, Ignacio ; Folberg, Robert ; Edward, Deepak P. ; Duffy, Mark T. ; Thulborn, Keith R. ; Augsburger, James J. ; Cibis, Gerhard W. / Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging. In: Transactions of the American Ophthalmological Society. 2004 ; Vol. 102. pp. 209-217.
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title = "Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging",
abstract = "Purpose: Because signal-to-noise performance improves with increased magnetic field strength, the quality of magnetic resonance images is greater at 3.0 tesla (T) than at 1.5 T. Because of the longer T1 values at higher field strength, intravenously administered magnetic resonance contrast agents provide improved T1 enhancement at 3.0 T. We have used these factors to obtain high-quality contrast-enhanced imaging of small intraocular lesions using a standard head radiofrequency volume coil. Specifically, we have examined lesion size and magnitude of maximum contrast enhancement in a series of intraocular melanomas before and during therapy. Methods: Eighteen patients with intraocular masses were examined by 3.0 T magnetic resonance imaging (MRI) including intravenous contrast enhancement. Precontrast images were acquired through the orbits followed by sequential postcontrast images at 1-minute intervals for 5 minutes. The magnitude of contrast enhancement of the lesion, extraocular muscles, and brain parenchyma was measured as a percentage increase in magnetic resonance signal over the preenhancement signal intensity. Results: Lesions demonstrated different levels of enhancement ranging up to 130{\%}. Three patterns of enhancement - 0{\%} to 20{\%}, 20{\%} to 50{\%}, and >50{\%} - were identified. Brain parenchyma, benign lesions, and responsive tumors following brachytherapy with 125I demonstrated enhancement of less than 20{\%}. Four choroidal melanomas showed intermediate (20{\%} to 50{\%}) levels of enhancement. Four malignant lesions (three melanomas, one metastatic tumor), as well as the extraocular muscles, showed strong, rapid enhancement (>50{\%}). Four patients who had MRI studies before and following plaque brachytherapy ultimately demonstrated a decline in the contrast enhancement following treatment. Conclusions: Contrast enhancement of intraocular lesions measured by 3.0 T MRI demonstrates different patterns of enhancement that may be useful for indicating the degree of malignancy and in monitoring response to therapy.",
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T1 - Vascular perfusion of choroidal melanoma by 3.0 Tesla magnetic resonance imaging

AU - Buerk, Bruce M.

AU - Pulido, Jose S

AU - Chiong, Ignacio

AU - Folberg, Robert

AU - Edward, Deepak P.

AU - Duffy, Mark T.

AU - Thulborn, Keith R.

AU - Augsburger, James J.

AU - Cibis, Gerhard W.

PY - 2004

Y1 - 2004

N2 - Purpose: Because signal-to-noise performance improves with increased magnetic field strength, the quality of magnetic resonance images is greater at 3.0 tesla (T) than at 1.5 T. Because of the longer T1 values at higher field strength, intravenously administered magnetic resonance contrast agents provide improved T1 enhancement at 3.0 T. We have used these factors to obtain high-quality contrast-enhanced imaging of small intraocular lesions using a standard head radiofrequency volume coil. Specifically, we have examined lesion size and magnitude of maximum contrast enhancement in a series of intraocular melanomas before and during therapy. Methods: Eighteen patients with intraocular masses were examined by 3.0 T magnetic resonance imaging (MRI) including intravenous contrast enhancement. Precontrast images were acquired through the orbits followed by sequential postcontrast images at 1-minute intervals for 5 minutes. The magnitude of contrast enhancement of the lesion, extraocular muscles, and brain parenchyma was measured as a percentage increase in magnetic resonance signal over the preenhancement signal intensity. Results: Lesions demonstrated different levels of enhancement ranging up to 130%. Three patterns of enhancement - 0% to 20%, 20% to 50%, and >50% - were identified. Brain parenchyma, benign lesions, and responsive tumors following brachytherapy with 125I demonstrated enhancement of less than 20%. Four choroidal melanomas showed intermediate (20% to 50%) levels of enhancement. Four malignant lesions (three melanomas, one metastatic tumor), as well as the extraocular muscles, showed strong, rapid enhancement (>50%). Four patients who had MRI studies before and following plaque brachytherapy ultimately demonstrated a decline in the contrast enhancement following treatment. Conclusions: Contrast enhancement of intraocular lesions measured by 3.0 T MRI demonstrates different patterns of enhancement that may be useful for indicating the degree of malignancy and in monitoring response to therapy.

AB - Purpose: Because signal-to-noise performance improves with increased magnetic field strength, the quality of magnetic resonance images is greater at 3.0 tesla (T) than at 1.5 T. Because of the longer T1 values at higher field strength, intravenously administered magnetic resonance contrast agents provide improved T1 enhancement at 3.0 T. We have used these factors to obtain high-quality contrast-enhanced imaging of small intraocular lesions using a standard head radiofrequency volume coil. Specifically, we have examined lesion size and magnitude of maximum contrast enhancement in a series of intraocular melanomas before and during therapy. Methods: Eighteen patients with intraocular masses were examined by 3.0 T magnetic resonance imaging (MRI) including intravenous contrast enhancement. Precontrast images were acquired through the orbits followed by sequential postcontrast images at 1-minute intervals for 5 minutes. The magnitude of contrast enhancement of the lesion, extraocular muscles, and brain parenchyma was measured as a percentage increase in magnetic resonance signal over the preenhancement signal intensity. Results: Lesions demonstrated different levels of enhancement ranging up to 130%. Three patterns of enhancement - 0% to 20%, 20% to 50%, and >50% - were identified. Brain parenchyma, benign lesions, and responsive tumors following brachytherapy with 125I demonstrated enhancement of less than 20%. Four choroidal melanomas showed intermediate (20% to 50%) levels of enhancement. Four malignant lesions (three melanomas, one metastatic tumor), as well as the extraocular muscles, showed strong, rapid enhancement (>50%). Four patients who had MRI studies before and following plaque brachytherapy ultimately demonstrated a decline in the contrast enhancement following treatment. Conclusions: Contrast enhancement of intraocular lesions measured by 3.0 T MRI demonstrates different patterns of enhancement that may be useful for indicating the degree of malignancy and in monitoring response to therapy.

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