Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans

Nisha Charkoudian, Michael Joseph Joyner, L. A. Sokolnicki, C. P. Johnson, J. H. Eisenach, N. M. Dietz, Timothy B Curry, B. G. Wallin

Research output: Contribution to journalArticle

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Abstract

In humans, sympathetic nerve activity (SNA) at rest can vary several-fold among normotensive individuals with similar blood pressures. We recently showed that a balance exists between SNA and cardiac output, which may contribute to the maintenance of normal blood pressures over the range of resting SNA levels. In the present studies, we assessed whether variability in vascular adrenergic responsiveness has a role in this balance. We tested the hypothesis that forearmvascular responses to noradrenaline (NA) and tyramine (TYR) are related to SNA such that individuals with lower resting SNA have greater adrenergic responsiveness, and vice-versa. We measured multifibre muscle SNA (MSNA; microneurography), arterial pressure (brachial catheter)and forearm blood flow (plethysmography) in19healthy subjects at baseline and during intrabrachial infusions of NA and TYR. Resting MSNA ranged from 6 to 34 bursts min -1, and was inversely related to vasoconstrictor responsiveness to both NA (r = 0.61, P = 0.01) and TYR (r = 0.52, P = 0.02), such that subjects with lower resting MSNA were more responsive to NA and TYR. We conclude that interindividual variability in vascular adrenergic responsiveness contributes to the balance of factors that maintain normal blood pressure in individuals with differing levels of sympathetic neural activity. Further understanding of this balance may have important implications for our understanding of the pathophysiology of hypertension.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalJournal of Physiology
Volume572
Issue number3
DOIs
StatePublished - May 1 2006

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Tyramine
Vasoconstrictor Agents
Adrenergic Agents
Blood Vessels
Norepinephrine
Blood Pressure
Plethysmography
Forearm
Cardiac Output
Arterial Pressure
Arm
Catheters
Maintenance
Hypertension
Muscles

ASJC Scopus subject areas

  • Physiology

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Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans. / Charkoudian, Nisha; Joyner, Michael Joseph; Sokolnicki, L. A.; Johnson, C. P.; Eisenach, J. H.; Dietz, N. M.; Curry, Timothy B; Wallin, B. G.

In: Journal of Physiology, Vol. 572, No. 3, 01.05.2006, p. 821-827.

Research output: Contribution to journalArticle

Charkoudian, Nisha ; Joyner, Michael Joseph ; Sokolnicki, L. A. ; Johnson, C. P. ; Eisenach, J. H. ; Dietz, N. M. ; Curry, Timothy B ; Wallin, B. G. / Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans. In: Journal of Physiology. 2006 ; Vol. 572, No. 3. pp. 821-827.
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