Varicella-zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens

Clayton T. Cowl; Udaya B.S. Prakash; P. Shawn Mitchell; Michael R. Migden

doi:10.1164/ajrccm.162.2.9912039

Varicella-zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens

Clayton T. Cowl, Udaya B.S. Prakash, P. Shawn Mitchell, Michael R. Migden

Preventive Medicine, Occupational, and Aerospace Medicine

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

We report the use of polymerase chain reaction (PCR) techniques from a bronchoalveolar lavage (BAL) specimen for the successful early diagnosis in a case of atypical but severe varicella-zoster virus (VZV) pneumonitis. Atypical presentations of disseminated VZV frequently prolong the time required for accurate diagnosis, resulting in increased morbidity, or mortality. Although further investigation is necessary to determine the sensitivity and positive predictive value of this test, PCR analysis of bronchoscopic specimens may expedite the diagnosis of disseminated VZV.

Original language	English (US)
Pages (from-to)	753-754
Number of pages	2
Journal	American journal of respiratory and critical care medicine
Volume	162
Issue number	2 I
DOIs	https://doi.org/10.1164/ajrccm.162.2.9912039
State	Published - Jan 1 2000

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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10.1164/ajrccm.162.2.9912039

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title = "Varicella-zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens",

abstract = "We report the use of polymerase chain reaction (PCR) techniques from a bronchoalveolar lavage (BAL) specimen for the successful early diagnosis in a case of atypical but severe varicella-zoster virus (VZV) pneumonitis. Atypical presentations of disseminated VZV frequently prolong the time required for accurate diagnosis, resulting in increased morbidity, or mortality. Although further investigation is necessary to determine the sensitivity and positive predictive value of this test, PCR analysis of bronchoscopic specimens may expedite the diagnosis of disseminated VZV.",

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AU - Shawn Mitchell, P.

AU - Migden, Michael R.

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N2 - We report the use of polymerase chain reaction (PCR) techniques from a bronchoalveolar lavage (BAL) specimen for the successful early diagnosis in a case of atypical but severe varicella-zoster virus (VZV) pneumonitis. Atypical presentations of disseminated VZV frequently prolong the time required for accurate diagnosis, resulting in increased morbidity, or mortality. Although further investigation is necessary to determine the sensitivity and positive predictive value of this test, PCR analysis of bronchoscopic specimens may expedite the diagnosis of disseminated VZV.

AB - We report the use of polymerase chain reaction (PCR) techniques from a bronchoalveolar lavage (BAL) specimen for the successful early diagnosis in a case of atypical but severe varicella-zoster virus (VZV) pneumonitis. Atypical presentations of disseminated VZV frequently prolong the time required for accurate diagnosis, resulting in increased morbidity, or mortality. Although further investigation is necessary to determine the sensitivity and positive predictive value of this test, PCR analysis of bronchoscopic specimens may expedite the diagnosis of disseminated VZV.

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Varicella-zoster virus detection by polymerase chain reaction using bronchoalveolar lavage specimens

Abstract

ASJC Scopus subject areas

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