Variability in Humoral Immunity to Measles Vaccine: New Developments

Iana H. Haralambieva, Richard B Kennedy, Inna G. Ovsyannikova, Jennifer A. Whitaker, Gregory A. Poland

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Despite the existence of an effective measles vaccine, resurgence in measles cases in the USA and across Europe has occurred, including in individuals vaccinated with two doses of the vaccine. Host genetic factors result in inter-individual variation in measles vaccine-induced antibodies, and play a role in vaccine failure. Studies have identified HLA (human leukocyte antigen) and non-HLA genetic influences that individually or jointly contribute to the observed variability in the humoral response to vaccination among healthy individuals. In this exciting era, new high-dimensional approaches and techniques including vaccinomics, systems biology, GWAS, epitope prediction and sophisticated bioinformatics/statistical algorithms provide powerful tools to investigate immune response mechanisms to the measles vaccine. These might predict, on an individual basis, outcomes of acquired immunity post measles vaccination.

Original languageEnglish (US)
Pages (from-to)789-801
Number of pages13
JournalTrends in Molecular Medicine
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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    Haralambieva, I. H., Kennedy, R. B., Ovsyannikova, I. G., Whitaker, J. A., & Poland, G. A. (2015). Variability in Humoral Immunity to Measles Vaccine: New Developments. Trends in Molecular Medicine, 21(12), 789-801. https://doi.org/10.1016/j.molmed.2015.10.005