TY - JOUR
T1 - Variability in Humoral Immunity to Measles Vaccine
T2 - New Developments
AU - Haralambieva, Iana H.
AU - Kennedy, Richard B.
AU - Ovsyannikova, Inna G.
AU - Whitaker, Jennifer A.
AU - Poland, Gregory A.
N1 - Funding Information:
We thank Caroline Vitse for assistance in preparing the manuscript. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award R37AI048793 (which recently received a MERIT Award) and AI033144. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Despite the existence of an effective measles vaccine, resurgence in measles cases in the USA and across Europe has occurred, including in individuals vaccinated with two doses of the vaccine. Host genetic factors result in inter-individual variation in measles vaccine-induced antibodies, and play a role in vaccine failure. Studies have identified HLA (human leukocyte antigen) and non-HLA genetic influences that individually or jointly contribute to the observed variability in the humoral response to vaccination among healthy individuals. In this exciting era, new high-dimensional approaches and techniques including vaccinomics, systems biology, GWAS, epitope prediction and sophisticated bioinformatics/statistical algorithms provide powerful tools to investigate immune response mechanisms to the measles vaccine. These might predict, on an individual basis, outcomes of acquired immunity post measles vaccination.
AB - Despite the existence of an effective measles vaccine, resurgence in measles cases in the USA and across Europe has occurred, including in individuals vaccinated with two doses of the vaccine. Host genetic factors result in inter-individual variation in measles vaccine-induced antibodies, and play a role in vaccine failure. Studies have identified HLA (human leukocyte antigen) and non-HLA genetic influences that individually or jointly contribute to the observed variability in the humoral response to vaccination among healthy individuals. In this exciting era, new high-dimensional approaches and techniques including vaccinomics, systems biology, GWAS, epitope prediction and sophisticated bioinformatics/statistical algorithms provide powerful tools to investigate immune response mechanisms to the measles vaccine. These might predict, on an individual basis, outcomes of acquired immunity post measles vaccination.
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U2 - 10.1016/j.molmed.2015.10.005
DO - 10.1016/j.molmed.2015.10.005
M3 - Review article
C2 - 26602762
AN - SCOPUS:84949625327
VL - 21
SP - 789
EP - 801
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 12
ER -