Validation and comparison of contemporary prognostic models in primary myelofibrosis: Analysis based on 334 patients from a single institution

Ayalew Tefferi, Jocelin Huang, Susan Schwager, Chin Yang Li, Wenting Wu, Animesh Pardanani, Ruben A. Mesa

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58 Scopus citations


BACKGROUND. Survival in primary myelofibrosis (PMF) is predicted by several prognostic scoring systems (PSSs); the most widely recognized is that of Dupriez. Two other PSSs, Cervantes and Mayo, were recently reported as being more useful in younger patients. The current study compares these 3 PSSs among all age groups. METHODS. The Mayo Clinic PMF database was queried to identify a consecutive series of patients in whom pretreatment bone marrow and complete blood count (CBC), obtained within 6 months of diagnosis, were available for review. RESULTS. Among 334 study patients (median age, 57 years), median survival was 70 months. Multivariable analysis of all 6 adverse prognostic factors utilized in the aforementioned PSSs (ie, hemoglobin <10 g/dL, leukocyte count <4 or >30 × 109/L, constitutional symptoms, circulating blasts ≥1%, platelet count <100 × 10 9/L, absolute monocyte count ≥1 × 109/L) identified all but platelet count as being significant. The Mayo PSS, which is based on the 4 CBC-derived parameters (ie, hemoglobin, platelet, leukocyte, and monocyte counts), displayed a better hazard ratio profile compared with the other 2 PSSs in identifying long-lived patients as well as delineating intermediate-risk disease category. The latter effect was even more pronounced in patients younger than age 60 years. CONCLUSIONS. The Mayo PSS for survival in PMF is an objective CBC-derived prognostic model that might be superior in its performance over that of either the Dupriez and Cervantes PSSs.

Original languageEnglish (US)
Pages (from-to)2083-2088
Number of pages6
Issue number10
StatePublished - May 15 2007



  • Primary myelofibrosis
  • Prognostic scoring systems

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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